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| PMID |
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| TITLE |
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| Genome-wide polygenic scores for age at onset of alcohol dependence and association with alcohol-related measures. |
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| ABSTRACT |
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| Age at onset of alcohol dependence (AO-AD) is a defining feature of multiple drinking typologies. AO-AD is heritable and likely shares genetic liability with other aspects of alcohol consumption. We examine whether polygenic variation in AO-AD, based on a genome-wide association study (GWAS), was associated with AO-AD and other aspects of alcohol consumption in two independent samples. Genetic risk scores (GRS) were created based on AO-AD GWAS results from a discovery sample of 1788 regular drinkers from extended pedigrees from the Collaborative Study of the Genetics of Alcoholism (COGA). GRS were used to predict AO-AD, AD and Alcohol dependence symptom count (AD-SX), age at onset of intoxication (AO-I), as well as maxdrinks in regular drinking participants from two independent samples-the Study of Addictions: Genes and Environment (SAGE; n=2336) and an Australian sample (OZ-ALC; n=5816). GRS for AO-AD from COGA explained a modest but significant proportion of the variance in all alcohol-related phenotypes in SAGE. Despite including effect sizes associated with large numbers of single nucleotide polymorphisms (SNPs; >110 000), GRS explained, at most, 0.7% of the variance in these alcohol measures in this independent sample. In OZ-ALC, significant but even more modest associations were noted with variance estimates ranging from 0.03 to 0.16%. In conclusion, there is modest evidence that genetic variation in AO-AD is associated with liability to other aspects of alcohol involvement. |
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| DATE PUBLISHED |
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| HISTORY |
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| PUBSTATUS |
PUBSTATUSDATE |
| received |
2015/08/06 |
| revised |
2015/11/25 |
| accepted |
2015/12/25 |
| entrez |
2016/03/23 06:00 |
| pubmed |
2016/03/24 06:00 |
| medline |
2016/03/24 06:00 |
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| AUTHORS |
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| NAME |
COLLECTIVENAME |
LASTNAME |
FORENAME |
INITIALS |
AFFILIATION |
AFFILIATIONINFO |
| Kapoor M |
|
Kapoor |
M |
M |
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Neuroscience Genetics & Genomics Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA. |
| Chou YL |
|
Chou |
Y-L |
YL |
|
Washington University School of Medicine, St. Louis, MO, USA. |
| Edenberg HJ |
|
Edenberg |
H J |
HJ |
|
Indiana University School of Medicine, Indianapolis, IN, USA. |
| Foroud T |
|
Foroud |
T |
T |
|
Indiana University School of Medicine, Indianapolis, IN, USA. |
| Martin NG |
|
Martin |
N G |
NG |
|
Queensland Institute of Medical Research, Brisbane, QLD, Australia. |
| Madden PA |
|
Madden |
P A F |
PA |
|
Washington University School of Medicine, St. Louis, MO, USA. |
| Wang JC |
|
Wang |
J C |
JC |
|
Neuroscience Genetics & Genomics Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA. |
| Bertelsen S |
|
Bertelsen |
S |
S |
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Neuroscience Genetics & Genomics Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA. |
| Wetherill L |
|
Wetherill |
L |
L |
|
Indiana University School of Medicine, Indianapolis, IN, USA. |
| Brooks A |
|
Brooks |
A |
A |
|
Rutgers University, New Brunswick, NJ, USA. |
| Chan G |
|
Chan |
G |
G |
|
University of Connecticut Health Center, Farmington, CT, USA. |
| Hesselbrock V |
|
Hesselbrock |
V |
V |
|
University of Connecticut Health Center, Farmington, CT, USA. |
| Kuperman S |
|
Kuperman |
S |
S |
|
University of Iowa Carver College of Medicine, Iowa City, IA, USA. |
| Medland SE |
|
Medland |
S E |
SE |
|
Queensland Institute of Medical Research, Brisbane, QLD, Australia. |
| Montgomery G |
|
Montgomery |
G |
G |
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Queensland Institute of Medical Research, Brisbane, QLD, Australia. |
| Tischfield J |
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Tischfield |
J |
J |
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Rutgers University, New Brunswick, NJ, USA. |
| Whitfield JB |
|
Whitfield |
J B |
JB |
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Queensland Institute of Medical Research, Brisbane, QLD, Australia. |
| Bierut LJ |
|
Bierut |
L J |
LJ |
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Washington University School of Medicine, St. Louis, MO, USA. |
| Heath AC |
|
Heath |
A C |
AC |
|
Washington University School of Medicine, St. Louis, MO, USA. |
| Bucholz KK |
|
Bucholz |
K K |
KK |
|
Washington University School of Medicine, St. Louis, MO, USA. |
| Goate AM |
|
Goate |
A M |
AM |
|
Neuroscience Genetics & Genomics Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA. |
| Agrawal A |
|
Agrawal |
A |
A |
|
Washington University School of Medicine, St. Louis, MO, USA. |
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| INVESTIGATORS |
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| JOURNAL |
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| VOLUME: 6 |
| ISSUE: |
| TITLE: Translational psychiatry |
| ISOABBREVIATION: Transl Psychiatry |
| YEAR: 2016 |
| MONTH: |
| DAY: |
| MEDLINEDATE: |
| SEASON: |
| CITEDMEDIUM: Internet |
| ISSN: 2158-3188 |
| ISSNTYPE: Electronic |
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| MEDLINE JOURNAL |
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| MEDLINETA: Transl Psychiatry |
| COUNTRY: United States |
| ISSNLINKING: 2158-3188 |
| NLMUNIQUEID: 101562664 |
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| PUBLICATION TYPE |
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| PUBLICATIONTYPE TEXT |
| Journal Article |
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