Genetic Epidemiology, Psychiatric Genetics, Asthma Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
27003187
TITLE
Genome-wide polygenic scores for age at onset of alcohol dependence and association with alcohol-related measures.
ABSTRACT
Age at onset of alcohol dependence (AO-AD) is a defining feature of multiple drinking typologies. AO-AD is heritable and likely shares genetic liability with other aspects of alcohol consumption. We examine whether polygenic variation in AO-AD, based on a genome-wide association study (GWAS), was associated with AO-AD and other aspects of alcohol consumption in two independent samples. Genetic risk scores (GRS) were created based on AO-AD GWAS results from a discovery sample of 1788 regular drinkers from extended pedigrees from the Collaborative Study of the Genetics of Alcoholism (COGA). GRS were used to predict AO-AD, AD and Alcohol dependence symptom count (AD-SX), age at onset of intoxication (AO-I), as well as maxdrinks in regular drinking participants from two independent samples-the Study of Addictions: Genes and Environment (SAGE; n=2336) and an Australian sample (OZ-ALC; n=5816). GRS for AO-AD from COGA explained a modest but significant proportion of the variance in all alcohol-related phenotypes in SAGE. Despite including effect sizes associated with large numbers of single nucleotide polymorphisms (SNPs; >110 000), GRS explained, at most, 0.7% of the variance in these alcohol measures in this independent sample. In OZ-ALC, significant but even more modest associations were noted with variance estimates ranging from 0.03 to 0.16%. In conclusion, there is modest evidence that genetic variation in AO-AD is associated with liability to other aspects of alcohol involvement.
DATE PUBLISHED
2016
HISTORY
PUBSTATUS PUBSTATUSDATE
received 2015/08/06
revised 2015/11/25
accepted 2015/12/25
entrez 2016/03/23 06:00
pubmed 2016/03/24 06:00
medline 2016/03/24 06:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Kapoor M Kapoor M M Neuroscience Genetics & Genomics Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Chou YL Chou Y-L YL Washington University School of Medicine, St. Louis, MO, USA.
Edenberg HJ Edenberg H J HJ Indiana University School of Medicine, Indianapolis, IN, USA.
Foroud T Foroud T T Indiana University School of Medicine, Indianapolis, IN, USA.
Martin NG Martin N G NG Queensland Institute of Medical Research, Brisbane, QLD, Australia.
Madden PA Madden P A F PA Washington University School of Medicine, St. Louis, MO, USA.
Wang JC Wang J C JC Neuroscience Genetics & Genomics Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Bertelsen S Bertelsen S S Neuroscience Genetics & Genomics Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Wetherill L Wetherill L L Indiana University School of Medicine, Indianapolis, IN, USA.
Brooks A Brooks A A Rutgers University, New Brunswick, NJ, USA.
Chan G Chan G G University of Connecticut Health Center, Farmington, CT, USA.
Hesselbrock V Hesselbrock V V University of Connecticut Health Center, Farmington, CT, USA.
Kuperman S Kuperman S S University of Iowa Carver College of Medicine, Iowa City, IA, USA.
Medland SE Medland S E SE Queensland Institute of Medical Research, Brisbane, QLD, Australia.
Montgomery G Montgomery G G Queensland Institute of Medical Research, Brisbane, QLD, Australia.
Tischfield J Tischfield J J Rutgers University, New Brunswick, NJ, USA.
Whitfield JB Whitfield J B JB Queensland Institute of Medical Research, Brisbane, QLD, Australia.
Bierut LJ Bierut L J LJ Washington University School of Medicine, St. Louis, MO, USA.
Heath AC Heath A C AC Washington University School of Medicine, St. Louis, MO, USA.
Bucholz KK Bucholz K K KK Washington University School of Medicine, St. Louis, MO, USA.
Goate AM Goate A M AM Neuroscience Genetics & Genomics Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Agrawal A Agrawal A A Washington University School of Medicine, St. Louis, MO, USA.
INVESTIGATORS
JOURNAL
VOLUME: 6
ISSUE:
TITLE: Translational psychiatry
ISOABBREVIATION: Transl Psychiatry
YEAR: 2016
MONTH:
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN: 2158-3188
ISSNTYPE: Electronic
MEDLINE JOURNAL
MEDLINETA: Transl Psychiatry
COUNTRY: United States
ISSNLINKING: 2158-3188
NLMUNIQUEID: 101562664
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
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