Genetic Epidemiology, Psychiatric Genetics, Asthma Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
26996222
TITLE
Twin's Birth-Order Differences in Height and Body Mass Index From Birth to Old Age: A Pooled Study of 26 Twin Cohorts Participating in the CODATwins Project.
ABSTRACT
We analyzed birth order differences in means and variances of height and body mass index (BMI) in monozygotic (MZ) and dizygotic (DZ) twins from infancy to old age. The data were derived from the international CODATwins database. The total number of height and BMI measures from 0.5 to 79.5 years of age was 397,466. As expected, first-born twins had greater birth weight than second-born twins. With respect to height, first-born twins were slightly taller than second-born twins in childhood. After adjusting the results for birth weight, the birth order differences decreased and were no longer statistically significant. First-born twins had greater BMI than the second-born twins over childhood and adolescence. After adjusting the results for birth weight, birth order was still associated with BMI until 12 years of age. No interaction effect between birth order and zygosity was found. Only limited evidence was found that birth order influenced variances of height or BMI. The results were similar among boys and girls and also in MZ and DZ twins. Overall, the differences in height and BMI between first- and second-born twins were modest even in early childhood, while adjustment for birth weight reduced the birth order differences but did not remove them for BMI.
DATE PUBLISHED
2016 Apr
HISTORY
PUBSTATUS PUBSTATUSDATE
entrez 2016/03/22 06:00
pubmed 2016/03/22 06:00
medline 2016/03/22 06:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Yokoyama Y
Jelenkovic A
Sund R
Sung J
Hopper JL
Ooki S
Heikkila K
Aaltonen S
Tarnoki AD
Tarnoki DL
Willemsen G
Bartels M
van Beijsterveldt TC
Saudino KJ
Cutler TL
Nelson TL
Whitfield KE
Wardle J
Llewellyn CH
Fisher A
He M
Ding X
Bjerregaard-Andersen M
Beck-Nielsen H
Sodemann M
Song YM
Yang S
Lee K
Jeong HU
Knafo-Noam A
Mankuta D
Abramson L
Burt SA
Klump KL
Ordonana JR
Sanchez-Romera JF
Colodro-Conde L
Harris JR
Brandt I
Nilsen TS
Craig JM
Saffery R
Ji F
Ning F
Pang Z
Dubois L
Boivin M
Brendgen M
Dionne G
Vitaro F
Martin NG
Medland SE
Montgomery GW
Magnusson PK
Pedersen NL
Aslan AK
Tynelius P
Haworth CM
Plomin R
Rebato E
Rose RJ
Goldberg JH
Rasmussen F
Hur YM
Sorensen TI
Boomsma DI
Kaprio J
Silventoinen K
INVESTIGATORS
JOURNAL
VOLUME: 19
ISSUE: 2
TITLE: Twin research and human genetics : the official journal of the International Society for Twin Studies
ISOABBREVIATION: Twin Res Hum Genet
YEAR: 2016
MONTH: Apr
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN: 1832-4274
ISSNTYPE: Print
MEDLINE JOURNAL
MEDLINETA: Twin Res Hum Genet
COUNTRY: England
ISSNLINKING: 1832-4274
NLMUNIQUEID: 101244624
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
COMMENTS AND CORRECTIONS
GRANTS
GENERAL NOTE
KEYWORDS
KEYWORD
BMI
birth order
height
zygosity
MESH HEADINGS
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
OTHER ID's