Genetic Epidemiology, Psychiatric Genetics, Asthma Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
QIMR Home Page
GenEpi Home Page
Publications
Contacts
Research
Staff Index
Collaborators
Software Tools
Computing Resources
Studies
Search
GenEpi Intranet
PMID
26973105
TITLE
The effect of increased genetic risk for Alzheimer's disease on hippocampal and amygdala volume.
ABSTRACT
Reduction in hippocampal and amygdala volume measured via structural magnetic resonance imaging is an early marker of Alzheimer's disease (AD). Whether genetic risk factors for AD exert an effect on these subcortical structures independent of clinical status has not been fully investigated. We examine whether increased genetic risk for AD influences hippocampal and amygdala volumes in case-control and population cohorts at different ages, in 1674 older (aged >53 years; 17% AD, 39% mild cognitive impairment [MCI]) and 467 young (16-30 years) adults. An AD polygenic risk score combining common risk variants excluding apolipoprotein E (APOE), and a single nucleotide polymorphism in TREM2, were both associated with reduced hippocampal volume in healthy older adults and those with MCI. APOE ε4 was associated with hippocampal and amygdala volume in those with AD and MCI but was not associated in healthy older adults. No associations were found in young adults. Genetic risk for AD affects the hippocampus before the clinical symptoms of AD, reflecting a neurodegenerative effect before clinical manifestations in older adults.
Copyright 2016 Elsevier Inc. All rights reserved.
DATE PUBLISHED
2016 Apr
HISTORY
PUBSTATUS PUBSTATUSDATE
received 2015/09/16
revised 2015/12/04
accepted 2015/12/29
aheadofprint 2016/01/11
entrez 2016/03/15 06:00
pubmed 2016/03/15 06:00
medline 2016/03/15 06:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Lupton MK Lupton Michelle K MK Genetic Epidemiology, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia. Electronic address: Michelle.Lupton@qimrberghofer.edu.au.
Strike L Strike Lachlan L Genetic Epidemiology, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia; Queensland Brain Institute, The University of Queensland, St Lucia, Queensland, Australia.
Hansell NK Hansell Narelle K NK Genetic Epidemiology, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia; Queensland Brain Institute, The University of Queensland, St Lucia, Queensland, Australia.
Wen W Wen Wei W Centre for Healthy Brain Ageing, University of New South Wales, Sydney, New South Wales, Australia.
Mather KA Mather Karen A KA Centre for Healthy Brain Ageing, University of New South Wales, Sydney, New South Wales, Australia.
Armstrong NJ Armstrong Nicola J NJ Mathematics and Statistics, Murdoch University, Perth, Western Australia, Australia.
Thalamuthu A Thalamuthu Anbupalam A Centre for Healthy Brain Ageing, University of New South Wales, Sydney, New South Wales, Australia.
McMahon KL McMahon Katie L KL Centre for Advanced Imaging, University of Queensland, Brisbane, Queensland, Australia.
de Zubicaray GI de Zubicaray Greig I GI Faculty of Health and Institute of Health and Biomedical Innovation, Queensland University of Technology (QUT), Brisbane, Queensland, Australia.
Assareh AA Assareh Amelia A AA Centre for Healthy Brain Ageing, University of New South Wales, Sydney, New South Wales, Australia.
Simmons A Simmons Andrew A Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
Proitsi P Proitsi Petroula P Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
Powell JF Powell John F JF Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
Montgomery GW Montgomery Grant W GW Genetic Epidemiology, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
Hibar DP Hibar Derrek P DP Imaging Genetics Center, Keck School of Medicine, University of Southern California, Marina del Ray, CA, USA.
Westman E Westman Eric E Division of Clinical Geriatrics, Department of Neurobiology, Care Sciences and Society, Alzheimer's Disease Research Centre, Karolinska Institute, Stockholm, Sweden.
Tsolaki M Tsolaki Magda M Memory and Dementia Centre, Aristotle University of Thessaloniki, Thessaloniki, Greece.
Kloszewska I Kloszewska Iwona I Department of Old Age Psychiatry & Psychotic Disorders, Medical University of Lodz, Lodz, Poland.
Soininen H Soininen Hilkka H Department of Neurology, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland.
Mecocci P Mecocci Patrizia P Section of Gerontology and Geriatrics, Department of Clinical and Experimental Medicine, University of Perugia, Perugia, Italy.
Velas B Velas Bruno B Gerontopole, CHU, UMR INSERM 1027, University of Toulouse, France.
Lovestone S Lovestone Simon S Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK; Department of Psychiatry, Warneford Hospital, University of Oxford, Oxford, UK.
Alzheimer's Disease Neuroimaging Initiative
Brodaty H Brodaty Henry H Centre for Healthy Brain Ageing, University of New South Wales, Sydney, New South Wales, Australia.
Ames D Ames David D National Ageing Research Institute, Parkville, Victoria, Australia; Academic Unit for Psychiatry of Old Age, University of Melbourne, Kew, Victoria, Australia.
Trollor JN Trollor Julian N JN Centre for Healthy Brain Ageing, University of New South Wales, Sydney, New South Wales, Australia.
Martin NG Martin Nicholas G NG Genetic Epidemiology, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
Thompson PM Thompson Paul M PM Imaging Genetics Center, Keck School of Medicine, University of Southern California, Marina del Ray, CA, USA.
Sachdev PS Sachdev Perminder S PS Centre for Healthy Brain Ageing, University of New South Wales, Sydney, New South Wales, Australia.
Wright MJ Wright Margaret J MJ Genetic Epidemiology, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia; Queensland Brain Institute, The University of Queensland, St Lucia, Queensland, Australia; The Centre for Advanced Imaging, The University of Queensland, St Lucia, Queensland, Australia.
INVESTIGATORS
JOURNAL
VOLUME: 40
ISSUE:
TITLE: Neurobiology of aging
ISOABBREVIATION: Neurobiol. Aging
YEAR: 2016
MONTH: Apr
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN: 1558-1497
ISSNTYPE: Electronic
MEDLINE JOURNAL
MEDLINETA: Neurobiol Aging
COUNTRY: United States
ISSNLINKING: 0197-4580
NLMUNIQUEID: 8100437
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
COMMENTS AND CORRECTIONS
GRANTS
GRANTID AGENCY COUNTRY
R01 AG040060 NIA NIH HHS United States
GENERAL NOTE
KEYWORDS
KEYWORD
APOE
Alzheimer's disease
Amygdala
Hippocampus
Polygenic risk score
TREM2
MESH HEADINGS
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
OTHER ID's