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| PMID |
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| TITLE |
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| International Genome-Wide Association Study Consortium Identifies Novel Loci Associated With Blood Pressure in Children and Adolescents. |
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| ABSTRACT |
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| BACKGROUND |
NlmCategory: BACKGROUND |
| -Our aim was to identify genetic variants associated with blood pressure (BP) in childhood and adolescence. |
| METHODS AND RESULTS |
NlmCategory: RESULTS |
| -Genome-wide association study data from participating European ancestry cohorts of the EAGLE ( EA: rly G: enetics and L: ifecourse E: pidemiology) Consortium was meta-analysed across three 'epochs'; pre-puberty [4-7 years], puberty [8-12 years] and post-puberty [13-20 years]. Two novel loci were identified as having genome-wide associations with systolic blood pressure across specific age epochs; rs1563894 (ITGA11, located in active H3K27Ac mark and transcription factor CHiP and CpG methylation site) during pre-puberty (p = 2.86 × 10(-8)) and rs872256 during puberty (p = 8.67 × 10(-9)). Several SNP 'clusters' were also associated with childhood BP at p < 5 × 10(-3). Using a p-value threshold of < 5 × 10(-3) we found some overlap in variants across the different age epochs within our study, and between several SNPs in any of the three epochs and adult BP related SNPs. |
| CONCLUSIONS |
NlmCategory: CONCLUSIONS |
| -Our results suggest that genetic determinants of blood pressure act from childhood, develop over the lifecourse, and show some evidence of age-specific effects. |
| (c) 2016 American Heart Association, Inc. |
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| DATE PUBLISHED |
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| HISTORY |
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| PUBSTATUS |
PUBSTATUSDATE |
| entrez |
2016/03/13 06:00 |
| pubmed |
2016/03/13 06:00 |
| medline |
2016/03/13 06:00 |
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| AUTHORS |
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| NAME |
COLLECTIVENAME |
LASTNAME |
FORENAME |
INITIALS |
AFFILIATION |
AFFILIATIONINFO |
| Parmar PG |
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| Taal HR |
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| Timpson NJ |
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| Thiering E |
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| Lehtimaki T |
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| Marinelli M |
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| Lind PA |
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| Howe LD |
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| Verwoert G |
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| Aalto V |
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| Uitterlinden AG |
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| Briollais L |
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| Evans DM |
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| Wright MJ |
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| Newnham JP |
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| Whitfield JB |
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| Lyytikainen LP |
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| Rivadeneira F |
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| Boomsma DI |
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| Viikari J |
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| Gillman MW |
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| St Pourcain B |
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| Hottenga JJ |
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| Montgomery GW |
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| Hofman A |
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| Kahonen M |
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| Martin NG |
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| Tobin MD |
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| Raitakari O |
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| Vioque J |
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| Jaddoe VW |
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| Jarvelin MR |
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| Beilin LJ |
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| Heinrich J |
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| van Duijn CM |
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| Pennell CE |
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| Lawlor DA |
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| Palmer LJ |
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| Early Genetics and Lifecourse Epidemiology Consortium |
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| INVESTIGATORS |
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| JOURNAL |
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| VOLUME: |
| ISSUE: |
| TITLE: Circulation. Cardiovascular genetics |
| ISOABBREVIATION: Circ Cardiovasc Genet |
| YEAR: 2016 |
| MONTH: Mar |
| DAY: 11 |
| MEDLINEDATE: |
| SEASON: |
| CITEDMEDIUM: Internet |
| ISSN: 1942-3268 |
| ISSNTYPE: Electronic |
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| MEDLINE JOURNAL |
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| MEDLINETA: Circ Cardiovasc Genet |
| COUNTRY: United States |
| ISSNLINKING: 1942-3268 |
| NLMUNIQUEID: 101489144 |
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| PUBLICATION TYPE |
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| PUBLICATIONTYPE TEXT |
| JOURNAL ARTICLE |
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| COMMENTS AND CORRECTIONS |
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| GRANTS |
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| GENERAL NOTE |
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| KEYWORDS |
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| KEYWORD |
| Genome Wide Association Study |
| blood pressure |
| children |
| genetic epidemiology |
| hypertension |
| prehypertension |
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| MESH HEADINGS |
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| SUPPLEMENTARY MESH |
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| GENE SYMBOLS |
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| CHEMICALS |
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| OTHER ID's |
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