Genetic Epidemiology, Psychiatric Genetics, Asthma Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
26969751
TITLE
International Genome-Wide Association Study Consortium Identifies Novel Loci Associated With Blood Pressure in Children and Adolescents.
ABSTRACT
BACKGROUND NlmCategory: BACKGROUND
-Our aim was to identify genetic variants associated with blood pressure (BP) in childhood and adolescence.
METHODS AND RESULTS NlmCategory: RESULTS
-Genome-wide association study data from participating European ancestry cohorts of the EAGLE ( EA: rly G: enetics and L: ifecourse E: pidemiology) Consortium was meta-analysed across three 'epochs'; pre-puberty [4-7 years], puberty [8-12 years] and post-puberty [13-20 years]. Two novel loci were identified as having genome-wide associations with systolic blood pressure across specific age epochs; rs1563894 (ITGA11, located in active H3K27Ac mark and transcription factor CHiP and CpG methylation site) during pre-puberty (p = 2.86 × 10(-8)) and rs872256 during puberty (p = 8.67 × 10(-9)). Several SNP 'clusters' were also associated with childhood BP at p < 5 × 10(-3). Using a p-value threshold of < 5 × 10(-3) we found some overlap in variants across the different age epochs within our study, and between several SNPs in any of the three epochs and adult BP related SNPs.
CONCLUSIONS NlmCategory: CONCLUSIONS
-Our results suggest that genetic determinants of blood pressure act from childhood, develop over the lifecourse, and show some evidence of age-specific effects.
(c) 2016 American Heart Association, Inc.
DATE PUBLISHED
2016 Jun
HISTORY
PUBSTATUS PUBSTATUSDATE
entrez 2016/03/13 06:00
pubmed 2016/03/13 06:00
medline 2016/03/13 06:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Parmar PG
Taal HR
Timpson NJ
Thiering E
Lehtimaki T
Marinelli M
Lind PA
Howe LD
Verwoert G
Aalto V
Uitterlinden AG
Briollais L
Evans DM
Wright MJ
Newnham JP
Whitfield JB
Lyytikainen LP
Rivadeneira F
Boomsma DI
Viikari J
Gillman MW
St Pourcain B
Hottenga JJ
Montgomery GW
Hofman A
Kahonen M
Martin NG
Tobin MD
Raitakari O
Vioque J
Jaddoe VW
Jarvelin MR
Beilin LJ
Heinrich J
van Duijn CM
Pennell CE
Lawlor DA
Palmer LJ
Early Genetics and Lifecourse Epidemiology Consortium
INVESTIGATORS
JOURNAL
VOLUME:
ISSUE:
TITLE: Circulation. Cardiovascular genetics
ISOABBREVIATION: Circ Cardiovasc Genet
YEAR: 2016
MONTH: Mar
DAY: 11
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN: 1942-3268
ISSNTYPE: Electronic
MEDLINE JOURNAL
MEDLINETA: Circ Cardiovasc Genet
COUNTRY: United States
ISSNLINKING: 1942-3268
NLMUNIQUEID: 101489144
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
JOURNAL ARTICLE
COMMENTS AND CORRECTIONS
GRANTS
GENERAL NOTE
KEYWORDS
KEYWORD
Genome Wide Association Study
blood pressure
children
genetic epidemiology
hypertension
prehypertension
MESH HEADINGS
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
OTHER ID's