|
|
| PMID |
|
|
| TITLE |
|
| Identification of STOML2 as a putative novel asthma risk gene associated with IL6R. |
|
| ABSTRACT |
|
| BACKGROUND |
NlmCategory: BACKGROUND |
| Functional variants in the interleukin-6 receptor gene (IL6R) are associated with asthma risk. We hypothesized that genes co-expressed with IL6R might also be regulated by genetic polymorphisms that are associated with asthma risk. The aim of this study was to identify such genes. |
| METHODS |
NlmCategory: METHODS |
| To identify genes whose expression was correlated with that of IL6R, we analyzed gene expression levels generated for 373 human lymphoblastoid cell lines by the Geuvadis consortium, and for 38 hematopoietic cell types by the Differentiation Map Portal (DMAP) project. Genes correlated with IL6R were then screened for nearby single nucleotide polymorphisms (SNPs) that were significantly associated with both variation in gene expression levels (eSNPs) and asthma risk. |
| RESULTS |
NlmCategory: RESULTS |
| We identified 90 genes with expression levels correlated with those of IL6R and that also had a nearby eSNP associated with disease risk in a published asthma GWAS (N=20,776). For 16 (18%) genes, the association between the eSNP and asthma risk replicated with the same direction of effect in a further independent published asthma GWAS (N=27,378). Amongst the top replicated associations (FDR<0.05) were eSNPs for four known (IL18R1, IL18RAP, BCL6 and STAT6) and one putative novel asthma risk gene, Stomatin-like protein 2 (STOML2). The expression of STOML2 was negatively correlated with IL6R, while eSNPs that increased the expression of STOML2 were associated with increased asthma risk. |
| CONCLUSION |
NlmCategory: CONCLUSIONS |
| The expression of STOML2, a gene that plays a key role in mitochondrial function and T-cell activation, is associated with both IL-6 signaling and asthma risk. This article is protected by copyright. All rights reserved. |
| This article is protected by copyright. All rights reserved. |
|
| DATE PUBLISHED |
|
|
| HISTORY |
|
| PUBSTATUS |
PUBSTATUSDATE |
| received |
2015/12/14 |
| revised |
2016/02/08 |
| accepted |
2016/02/25 |
| entrez |
2016/03/03 06:00 |
| pubmed |
2016/03/05 06:00 |
| medline |
2016/03/05 06:00 |
|
| AUTHORS |
|
| NAME |
COLLECTIVENAME |
LASTNAME |
FORENAME |
INITIALS |
AFFILIATION |
AFFILIATIONINFO |
| Revez JA |
|
Revez |
Joana A |
JA |
|
QIMR Berghofer Medical Research Institute, Brisbane, Australia. |
| Matheson MC |
|
Matheson |
Melanie C |
MC |
|
Melbourne School of Population and Global Health, University of Melbourne, Melbourne, Australia. |
| Hui J |
|
Hui |
Jennie |
J |
|
Busselton Population Medical Research Institute, Sir Charles Gairdner Hospital, Perth, Australia. |
| Baltic S |
|
Baltic |
Svetlana |
S |
|
Institute for Respiratory Health, University of WA, Perth, Australia. |
|
AAGC collaborators |
|
|
|
|
|
| James A |
|
James |
Alan |
A |
|
Department of Pulmonary Physiology, West Australian Sleep Disorders Research Institute, Nedlands, Australia. |
| Upham JW |
|
Upham |
John W |
JW |
|
School of Medicine, Translational Research Institute, The University of Queensland, Australia. |
| Dharmage S |
|
Dharmage |
Shyamali |
S |
|
Melbourne School of Population and Global Health, University of Melbourne, Melbourne, Australia. |
| Thompson PJ |
|
Thompson |
Philip J |
PJ |
|
Institute for Respiratory Health, University of WA, Perth, Australia. |
| Martin NG |
|
Martin |
Nicholas G |
NG |
|
QIMR Berghofer Medical Research Institute, Brisbane, Australia. |
| Hopper JL |
|
Hopper |
John L |
JL |
|
Melbourne School of Population and Global Health, University of Melbourne, Melbourne, Australia. |
| Ferreira MA |
|
Ferreira |
Manuel A R |
MA |
|
QIMR Berghofer Medical Research Institute, Brisbane, Australia. |
|
| INVESTIGATORS |
|
|
| JOURNAL |
|
| VOLUME: |
| ISSUE: |
| TITLE: Allergy |
| ISOABBREVIATION: Allergy |
| YEAR: 2016 |
| MONTH: Mar |
| DAY: 2 |
| MEDLINEDATE: |
| SEASON: |
| CITEDMEDIUM: Internet |
| ISSN: 1398-9995 |
| ISSNTYPE: Electronic |
|
| MEDLINE JOURNAL |
|
| MEDLINETA: Allergy |
| COUNTRY: Denmark |
| ISSNLINKING: 0105-4538 |
| NLMUNIQUEID: 7804028 |
|
| PUBLICATION TYPE |
|
| PUBLICATIONTYPE TEXT |
| JOURNAL ARTICLE |
|
| COMMENTS AND CORRECTIONS |
|
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| GRANTS |
|
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| GENERAL NOTE |
|
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| KEYWORDS |
|
| KEYWORD |
| Allergy |
| IL-6 |
| IL-6R |
| Mitochondria |
| SLP2 |
|
| MESH HEADINGS |
|
|
| SUPPLEMENTARY MESH |
|
|
| GENE SYMBOLS |
|
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| CHEMICALS |
|
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| OTHER ID's |
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