Genetic Epidemiology, Psychiatric Genetics, Asthma Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
26912939
TITLE
Examining non-syndromic autosomal recessive intellectual disability (NS-ARID) genes for an enriched association with intelligence differences.
ABSTRACT
NlmCategory: UNASSIGNED
Two themes are emerging regarding the molecular genetic aetiology of intelligence. The first is that intelligence is influenced by many variants and those that are tagged by common single nucleotide polymorphisms account for around 30% of the phenotypic variation. The second, in line with other polygenic traits such as height and schizophrenia, is that these variants are not randomly distributed across the genome but cluster in genes that work together. Less clear is whether the very low range of cognitive ability (intellectual disability) is simply one end of the normal distribution describing individual differences in cognitive ability across a population. Here, we examined 40 genes with a known association with non-syndromic autosomal recessive intellectual disability (NS-ARID) to determine if they are enriched for common variants associated with the normal range of intelligence differences. The current study used the 3511 individuals of the Cognitive Ageing Genetics in England and Scotland (CAGES) consortium. In addition, a text mining analysis was used to identify gene sets biologically related to the NS-ARID set. Gene-based tests indicated that genes implicated in NS-ARID were not significantly enriched for quantitative trait loci (QTL) associated with intelligence. These findings suggest that genes in which mutations can have a large and deleterious effect on intelligence are not associated with variation across the range of intelligence differences.
DATE PUBLISHED
2016 Jan-Feb
HISTORY
PUBSTATUS PUBSTATUSDATE
entrez 2016/02/26 06:00
pubmed 2016/02/26 06:00
medline 2016/02/26 06:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Hill WD Hill W D WD Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK; Department of Psychology, University of Edinburgh, Edinburgh, UK.
Davies G Davies G G Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK; Department of Psychology, University of Edinburgh, Edinburgh, UK.
Liewald DC Liewald D C DC Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK; Department of Psychology, University of Edinburgh, Edinburgh, UK.
Payton A Payton A A Centre for Integrated Genomic Medical Research, University of Manchester, Manchester, UK.
McNeil CJ McNeil C J CJ Aberdeen Biomedical Imaging Centre, University of Aberdeen, UK.
Whalley LJ Whalley L J LJ Aberdeen Biomedical Imaging Centre, University of Aberdeen, UK.
Horan M Horan M M Centre for Clinical and Cognitive Neurosciences, Institute Brain, Behaviour and Mental Health, University of Manchester, Manchester, UK.
Ollier W Ollier W W Centre for Integrated Genomic Medical Research, University of Manchester, Manchester, UK.
Starr JM Starr J M JM Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK.
Pendleton N Pendleton N N Centre for Integrated Genomic Medical Research, University of Manchester, Manchester, UK.
Hansel NK Hansel N K NK QIMR, Berghofer Medical Research Institution, Brisbane, Australia.
Montgomery GW Montgomery G W GW QIMR, Berghofer Medical Research Institution, Brisbane, Australia.
Medland SE Medland S E SE QIMR, Berghofer Medical Research Institution, Brisbane, Australia.
Martin NG Martin N G NG QIMR, Berghofer Medical Research Institution, Brisbane, Australia.
Wright MJ Wright M J MJ QIMR, Berghofer Medical Research Institution, Brisbane, Australia.
Bates TC Bates T C TC Department of Psychology, University of Edinburgh, Edinburgh, UK.
Deary IJ Deary I J IJ Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK; Department of Psychology, University of Edinburgh, Edinburgh, UK.
INVESTIGATORS
JOURNAL
VOLUME: 54
ISSUE:
TITLE: Intelligence
ISOABBREVIATION: Intelligence
YEAR:
MONTH:
DAY:
MEDLINEDATE: 2016 Jan-Feb
SEASON:
CITEDMEDIUM: Print
ISSN: 0160-2896
ISSNTYPE: Print
MEDLINE JOURNAL
MEDLINETA: Intelligence
COUNTRY:
ISSNLINKING: 0160-2896
NLMUNIQUEID: 7707496
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
JOURNAL ARTICLE
COMMENTS AND CORRECTIONS
GRANTS
GRANTID AGENCY COUNTRY
G1001375 Medical Research Council United Kingdom
GENERAL NOTE
KEYWORDS
KEYWORD
GWAS
Gene set analysis
Genetics
Intellectual disabilities
MESH HEADINGS
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
OTHER ID's