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| PMID |
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| TITLE |
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| Examining non-syndromic autosomal recessive intellectual disability (NS-ARID) genes for an enriched association with intelligence differences. |
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| ABSTRACT |
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NlmCategory: UNASSIGNED |
| Two themes are emerging regarding the molecular genetic aetiology of intelligence. The first is that intelligence is influenced by many variants and those that are tagged by common single nucleotide polymorphisms account for around 30% of the phenotypic variation. The second, in line with other polygenic traits such as height and schizophrenia, is that these variants are not randomly distributed across the genome but cluster in genes that work together. Less clear is whether the very low range of cognitive ability (intellectual disability) is simply one end of the normal distribution describing individual differences in cognitive ability across a population. Here, we examined 40 genes with a known association with non-syndromic autosomal recessive intellectual disability (NS-ARID) to determine if they are enriched for common variants associated with the normal range of intelligence differences. The current study used the 3511 individuals of the Cognitive Ageing Genetics in England and Scotland (CAGES) consortium. In addition, a text mining analysis was used to identify gene sets biologically related to the NS-ARID set. Gene-based tests indicated that genes implicated in NS-ARID were not significantly enriched for quantitative trait loci (QTL) associated with intelligence. These findings suggest that genes in which mutations can have a large and deleterious effect on intelligence are not associated with variation across the range of intelligence differences. |
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| DATE PUBLISHED |
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| HISTORY |
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| PUBSTATUS |
PUBSTATUSDATE |
| entrez |
2016/02/26 06:00 |
| pubmed |
2016/02/26 06:00 |
| medline |
2016/02/26 06:00 |
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| AUTHORS |
|
| NAME |
COLLECTIVENAME |
LASTNAME |
FORENAME |
INITIALS |
AFFILIATION |
AFFILIATIONINFO |
| Hill WD |
|
Hill |
W D |
WD |
|
Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK; Department of Psychology, University of Edinburgh, Edinburgh, UK. |
| Davies G |
|
Davies |
G |
G |
|
Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK; Department of Psychology, University of Edinburgh, Edinburgh, UK. |
| Liewald DC |
|
Liewald |
D C |
DC |
|
Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK; Department of Psychology, University of Edinburgh, Edinburgh, UK. |
| Payton A |
|
Payton |
A |
A |
|
Centre for Integrated Genomic Medical Research, University of Manchester, Manchester, UK. |
| McNeil CJ |
|
McNeil |
C J |
CJ |
|
Aberdeen Biomedical Imaging Centre, University of Aberdeen, UK. |
| Whalley LJ |
|
Whalley |
L J |
LJ |
|
Aberdeen Biomedical Imaging Centre, University of Aberdeen, UK. |
| Horan M |
|
Horan |
M |
M |
|
Centre for Clinical and Cognitive Neurosciences, Institute Brain, Behaviour and Mental Health, University of Manchester, Manchester, UK. |
| Ollier W |
|
Ollier |
W |
W |
|
Centre for Integrated Genomic Medical Research, University of Manchester, Manchester, UK. |
| Starr JM |
|
Starr |
J M |
JM |
|
Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK. |
| Pendleton N |
|
Pendleton |
N |
N |
|
Centre for Integrated Genomic Medical Research, University of Manchester, Manchester, UK. |
| Hansel NK |
|
Hansel |
N K |
NK |
|
QIMR, Berghofer Medical Research Institution, Brisbane, Australia. |
| Montgomery GW |
|
Montgomery |
G W |
GW |
|
QIMR, Berghofer Medical Research Institution, Brisbane, Australia. |
| Medland SE |
|
Medland |
S E |
SE |
|
QIMR, Berghofer Medical Research Institution, Brisbane, Australia. |
| Martin NG |
|
Martin |
N G |
NG |
|
QIMR, Berghofer Medical Research Institution, Brisbane, Australia. |
| Wright MJ |
|
Wright |
M J |
MJ |
|
QIMR, Berghofer Medical Research Institution, Brisbane, Australia. |
| Bates TC |
|
Bates |
T C |
TC |
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Department of Psychology, University of Edinburgh, Edinburgh, UK. |
| Deary IJ |
|
Deary |
I J |
IJ |
|
Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK; Department of Psychology, University of Edinburgh, Edinburgh, UK. |
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| INVESTIGATORS |
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| JOURNAL |
|
| VOLUME: 54 |
| ISSUE: |
| TITLE: Intelligence |
| ISOABBREVIATION: Intelligence |
| YEAR: |
| MONTH: |
| DAY: |
| MEDLINEDATE: 2016 Jan-Feb |
| SEASON: |
| CITEDMEDIUM: Print |
| ISSN: 0160-2896 |
| ISSNTYPE: Print |
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| MEDLINE JOURNAL |
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| MEDLINETA: Intelligence |
| COUNTRY: |
| ISSNLINKING: 0160-2896 |
| NLMUNIQUEID: 7707496 |
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| PUBLICATION TYPE |
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| PUBLICATIONTYPE TEXT |
| JOURNAL ARTICLE |
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| COMMENTS AND CORRECTIONS |
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| GRANTS |
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| GRANTID |
AGENCY |
COUNTRY |
| G1001375 |
Medical Research Council |
United Kingdom |
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| GENERAL NOTE |
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| KEYWORDS |
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| KEYWORD |
| GWAS |
| Gene set analysis |
| Genetics |
| Intellectual disabilities |
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| MESH HEADINGS |
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| SUPPLEMENTARY MESH |
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| GENE SYMBOLS |
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| CHEMICALS |
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| OTHER ID's |
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