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| PMID |
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| TITLE |
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| The variance shared across forms of childhood trauma is strongly associated with liability for psychiatric and substance use disorders. |
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| ABSTRACT |
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| INTRODUCTION |
NlmCategory: BACKGROUND |
| Forms of childhood trauma tend to co-occur and are associated with increased risk for psychiatric and substance use disorders. Commonly used binary measures of trauma exposure have substantial limitations. |
| METHODS |
NlmCategory: METHODS |
| We performed multigroup confirmatory factor analysis (CFA), separately by sex, using data from the Childhood Trauma (CT) Study's sample of twins and siblings (N = 2594) to derive three first-order factors (childhood physical abuse, childhood sexual abuse, and parental partner abuse) and, as hypothesized, one higher order, childhood trauma factor (CTF) representing a measure of their common variance. |
| RESULTS |
NlmCategory: RESULTS |
| CFA produced a good-fitting model in the CT Study; we replicated the model in the Comorbidity and Trauma (CAT) Study's sample (N = 1981) of opioid-dependent cases and controls. In both samples, first-order factors are moderately correlated (indicating they measure largely unique, but related constructs) and their loadings on the CTF suggest it provides a reasonable measure of their common variance. We examined the association of CTF score with risk for psychiatric and substance use disorders in these samples and the OZ-ALC GWAS sample (N = 1538) in which CT Study factor loadings were applied. We found that CTF scores are strongly associated with liability for psychiatric and substance use disorders in all three samples; estimates of risk are extremely consistent across samples. |
| CONCLUSIONS |
NlmCategory: CONCLUSIONS |
| The CTF is a continuous, robust measure that captures the common variance across forms of childhood trauma and provides a means to estimate shared liability while avoiding multicollinearity. |
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| DATE PUBLISHED |
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| HISTORY |
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| PUBSTATUS |
PUBSTATUSDATE |
| ecollection |
2016/01 |
| received |
2015/07/23 |
| revised |
2015/09/25 |
| accepted |
2015/12/16 |
| entrez |
2016/01/27 06:00 |
| pubmed |
2016/01/27 06:00 |
| medline |
2016/01/27 06:00 |
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| AUTHORS |
|
| NAME |
COLLECTIVENAME |
LASTNAME |
FORENAME |
INITIALS |
AFFILIATION |
AFFILIATIONINFO |
| Kristjansson S |
|
Kristjansson |
Sean |
S |
|
Alcoholism Research Center Washington University School of Medicine St. Louis Missouri 63110. |
| McCutcheon VV |
|
McCutcheon |
Vivia V |
VV |
|
Alcoholism Research Center Washington University School of Medicine St. Louis Missouri 63110. |
| Agrawal A |
|
Agrawal |
Arpana |
A |
|
Alcoholism Research Center Washington University School of Medicine St. Louis Missouri 63110. |
| Lynskey MT |
|
Lynskey |
Michael T |
MT |
|
Institute of Psychiatry, Psychology, and Neuroscience King's College London UK. |
| Conroy E |
|
Conroy |
Elizabeth |
E |
|
Centre for Health Research University of Western Sydney Sydney Australia. |
| Statham DJ |
|
Statham |
Dixie J |
DJ |
|
QIMR Berghofer Medical Research Institute Brisbane Australia. |
| Madden PA |
|
Madden |
Pamela A F |
PA |
|
Alcoholism Research Center Washington University School of Medicine St. Louis Missouri 63110. |
| Henders AK |
|
Henders |
Anjali K |
AK |
|
QIMR Berghofer Medical Research Institute Brisbane Australia. |
| Todorov AA |
|
Todorov |
Alexandre A |
AA |
|
Alcoholism Research Center Washington University School of Medicine St. Louis Missouri 63110. |
| Bucholz KK |
|
Bucholz |
Kathleen K |
KK |
|
Alcoholism Research Center Washington University School of Medicine St. Louis Missouri 63110. |
| Degenhardt L |
|
Degenhardt |
Louisa |
L |
|
National Drug and Alcohol Research Center University of New South Wales Sydney Australia. |
| Martin NG |
|
Martin |
Nicholas G |
NG |
|
QIMR Berghofer Medical Research Institute Brisbane Australia. |
| Heath AC |
|
Heath |
Andrew C |
AC |
|
Alcoholism Research Center Washington University School of Medicine St. Louis Missouri 63110. |
| Nelson EC |
|
Nelson |
Elliot C |
EC |
|
Alcoholism Research Center Washington University School of Medicine St. Louis Missouri 63110. |
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| INVESTIGATORS |
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| JOURNAL |
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| VOLUME: |
| ISSUE: |
| TITLE: Brain and behavior |
| ISOABBREVIATION: Brain Behav |
| YEAR: 2016 |
| MONTH: Jan |
| DAY: 21 |
| MEDLINEDATE: |
| SEASON: |
| CITEDMEDIUM: Internet |
| ISSN: 2162-3279 |
| ISSNTYPE: Electronic |
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| MEDLINE JOURNAL |
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| MEDLINETA: Brain Behav |
| COUNTRY: |
| ISSNLINKING: |
| NLMUNIQUEID: 101570837 |
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| PUBLICATION TYPE |
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| PUBLICATIONTYPE TEXT |
| JOURNAL ARTICLE |
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| COMMENTS AND CORRECTIONS |
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| GRANTS |
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| GENERAL NOTE |
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| KEYWORDS |
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| KEYWORD |
| Childhood trauma |
| confirmatory factor analysis |
| substance use disorders |
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| MESH HEADINGS |
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| SUPPLEMENTARY MESH |
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| GENE SYMBOLS |
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| CHEMICALS |
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