|
|
| PMID |
|
|
| TITLE |
|
| Onset of opportunity to use cannabis and progression from opportunity to dependence: Are influences consistent across transitions? |
|
| ABSTRACT |
|
| BACKGROUND |
NlmCategory: BACKGROUND |
| There is a developing body of research looking at cannabis use opportunity, but little research examining timing of opportunity to use cannabis. |
| AIMS |
NlmCategory: OBJECTIVE |
| Identify factors associated with (1) earlier opportunity to use cannabis and (2) faster progression from opportunity to cannabis dependence. |
| METHOD |
NlmCategory: METHODS |
| Cross-sectional study of 3824 Australian twins and siblings, measuring age of onset of cannabis use opportunity and DSM-IV cannabis dependence. Survival analysis identified factors associated with faster progression to opportunity or dependence. |
| RESULTS |
NlmCategory: RESULTS |
| Factors associated with both speed of progression to opportunity and dependence were conduct disorder (opportunity HR 5.57, 95%CI 1.52-20.47; dependence HR 2.49, 95%CI 1.91-3.25), parental drug problems (opportunity HR 7.29, 95%CI 1.74-30.62; dependence HR 3.30, 95%CI 1.63-6.69), weekly tobacco use (opportunity HR 8.57, 95%CI 3.93-18.68; dependence HR 2.76, 95% CI 2.10-3.64), and female gender (opportunity HR 0.69, 95%CI 0.64-0.75; dependence HR 0.44, 95%CI 0.34-0.55). Frequent childhood religious attendance (HR 0.74, 95%CI 0.68-0.80), parental conflict (HR 1.09, 95%CI 1.00-1.18), parental alcohol problems (HR 1.19, 95%CI 1.08-1.30) and childhood sexual abuse (HR 1.17, 95%CI 1.01-1.34) were uniquely associated with transition to opportunity. Depressive episode (HR 1.44, 95%CI 1.12-1.85), tobacco dependence (HR 1.36, 95%CI 1.04-1.78), alcohol dependence (HR 2.64, 95%CI 1.53-4.58), other drug use (HR 2.10, 95%CI 1.64-2.69) and other drug dependence (HR 2.75, 95%CI 1.70-4.43) were uniquely associated with progression to dependence. |
| CONCLUSION |
NlmCategory: CONCLUSIONS |
| The profile of factors associated with opportunity to use cannabis and dependence only partially overlaps, suggesting targeting of interventions may benefit from being tailored to the stages of drug use. |
| Copyright © 2016 Elsevier Ireland Ltd. All rights reserved. |
|
| DATE PUBLISHED |
|
|
| HISTORY |
|
| PUBSTATUS |
PUBSTATUSDATE |
| received |
2015/07/24 |
| revised |
2015/12/10 |
| accepted |
2015/12/11 |
| aheadofprint |
2016/01/06 |
| entrez |
2016/01/27 06:00 |
| pubmed |
2016/01/27 06:00 |
| medline |
2016/01/27 06:00 |
|
| AUTHORS |
|
| NAME |
COLLECTIVENAME |
LASTNAME |
FORENAME |
INITIALS |
AFFILIATION |
AFFILIATIONINFO |
| Hines LA |
|
Hines |
Lindsey A |
LA |
|
Addictions Department, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, England, UK. Electronic address: lindsey.hines@kcl.ac.uk. |
| Morley KI |
|
Morley |
Katherine I |
KI |
|
Addictions Department, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, England, UK. |
| Strang J |
|
Strang |
John |
J |
|
Addictions Department, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, England, UK. |
| Agrawal A |
|
Agrawal |
Arpana |
A |
|
Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA. |
| Nelson EC |
|
Nelson |
Elliot C |
EC |
|
Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA. |
| Statham D |
|
Statham |
Dixie |
D |
|
School of Social Sciences, University of the Sunshine Coast, Queensland, Australia. |
| Martin NG |
|
Martin |
Nicholas G |
NG |
|
QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia. |
| Lynskey MT |
|
Lynskey |
Michael T |
MT |
|
Addictions Department, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, England, UK. |
|
| INVESTIGATORS |
|
|
| JOURNAL |
|
| VOLUME: 160 |
| ISSUE: |
| TITLE: Drug and alcohol dependence |
| ISOABBREVIATION: Drug Alcohol Depend |
| YEAR: 2016 |
| MONTH: Mar |
| DAY: 1 |
| MEDLINEDATE: |
| SEASON: |
| CITEDMEDIUM: Internet |
| ISSN: 1879-0046 |
| ISSNTYPE: Electronic |
|
| MEDLINE JOURNAL |
|
| MEDLINETA: Drug Alcohol Depend |
| COUNTRY: Ireland |
| ISSNLINKING: 0376-8716 |
| NLMUNIQUEID: 7513587 |
|
| PUBLICATION TYPE |
|
| PUBLICATIONTYPE TEXT |
| Journal Article |
|
| COMMENTS AND CORRECTIONS |
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| GRANTS |
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| GENERAL NOTE |
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| KEYWORDS |
|
| KEYWORD |
| Cannabis |
| Dependence |
| Etiology |
| Opportunity |
| Risk factors |
| Substance use |
| Survival analysis |
| Transitions |
|
| MESH HEADINGS |
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|
| SUPPLEMENTARY MESH |
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|
| GENE SYMBOLS |
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| CHEMICALS |
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| OTHER ID's |
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