Genetic Epidemiology, Psychiatric Genetics, Asthma Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
26811121
TITLE
Onset of opportunity to use cannabis and progression from opportunity to dependence: Are influences consistent across transitions?
ABSTRACT
BACKGROUND NlmCategory: BACKGROUND
There is a developing body of research looking at cannabis use opportunity, but little research examining timing of opportunity to use cannabis.
AIMS NlmCategory: OBJECTIVE
Identify factors associated with (1) earlier opportunity to use cannabis and (2) faster progression from opportunity to cannabis dependence.
METHOD NlmCategory: METHODS
Cross-sectional study of 3824 Australian twins and siblings, measuring age of onset of cannabis use opportunity and DSM-IV cannabis dependence. Survival analysis identified factors associated with faster progression to opportunity or dependence.
RESULTS NlmCategory: RESULTS
Factors associated with both speed of progression to opportunity and dependence were conduct disorder (opportunity HR 5.57, 95%CI 1.52-20.47; dependence HR 2.49, 95%CI 1.91-3.25), parental drug problems (opportunity HR 7.29, 95%CI 1.74-30.62; dependence HR 3.30, 95%CI 1.63-6.69), weekly tobacco use (opportunity HR 8.57, 95%CI 3.93-18.68; dependence HR 2.76, 95% CI 2.10-3.64), and female gender (opportunity HR 0.69, 95%CI 0.64-0.75; dependence HR 0.44, 95%CI 0.34-0.55). Frequent childhood religious attendance (HR 0.74, 95%CI 0.68-0.80), parental conflict (HR 1.09, 95%CI 1.00-1.18), parental alcohol problems (HR 1.19, 95%CI 1.08-1.30) and childhood sexual abuse (HR 1.17, 95%CI 1.01-1.34) were uniquely associated with transition to opportunity. Depressive episode (HR 1.44, 95%CI 1.12-1.85), tobacco dependence (HR 1.36, 95%CI 1.04-1.78), alcohol dependence (HR 2.64, 95%CI 1.53-4.58), other drug use (HR 2.10, 95%CI 1.64-2.69) and other drug dependence (HR 2.75, 95%CI 1.70-4.43) were uniquely associated with progression to dependence.
CONCLUSION NlmCategory: CONCLUSIONS
The profile of factors associated with opportunity to use cannabis and dependence only partially overlaps, suggesting targeting of interventions may benefit from being tailored to the stages of drug use.
Copyright 2016 Elsevier Ireland Ltd. All rights reserved.
DATE PUBLISHED
2016 Mar 1
HISTORY
PUBSTATUS PUBSTATUSDATE
received 2015/07/24
revised 2015/12/10
accepted 2015/12/11
aheadofprint 2016/01/06
entrez 2016/01/27 06:00
pubmed 2016/01/27 06:00
medline 2016/01/27 06:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Hines LA Hines Lindsey A LA Addictions Department, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, England, UK. Electronic address: lindsey.hines@kcl.ac.uk.
Morley KI Morley Katherine I KI Addictions Department, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, England, UK.
Strang J Strang John J Addictions Department, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, England, UK.
Agrawal A Agrawal Arpana A Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA.
Nelson EC Nelson Elliot C EC Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA.
Statham D Statham Dixie D School of Social Sciences, University of the Sunshine Coast, Queensland, Australia.
Martin NG Martin Nicholas G NG QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
Lynskey MT Lynskey Michael T MT Addictions Department, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, England, UK.
INVESTIGATORS
JOURNAL
VOLUME: 160
ISSUE:
TITLE: Drug and alcohol dependence
ISOABBREVIATION: Drug Alcohol Depend
YEAR: 2016
MONTH: Mar
DAY: 1
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN: 1879-0046
ISSNTYPE: Electronic
MEDLINE JOURNAL
MEDLINETA: Drug Alcohol Depend
COUNTRY: Ireland
ISSNLINKING: 0376-8716
NLMUNIQUEID: 7513587
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
COMMENTS AND CORRECTIONS
GRANTS
GENERAL NOTE
KEYWORDS
KEYWORD
Cannabis
Dependence
Etiology
Opportunity
Risk factors
Substance use
Survival analysis
Transitions
MESH HEADINGS
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
OTHER ID's