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| PMID |
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| TITLE |
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| Sharing a Placenta is Associated With a Greater Similarity in DNA Methylation in Monochorionic Versus Dichorionic Twin Pars in Blood at Age 14. |
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| ABSTRACT |
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| Monozygotic (MZ) twins provide a natural system for investigating developmental plasticity and the potential epigenetic origins of disease. A major difference in the intrauterine environment between MZ pairs is whether they share a common placenta or have separate placentas. Using DNA methylation measured at >400,000 points in the genome on the Illumina HumanMethylation450 array, we demonstrate that the co-twins of MZ pairs (average age of 14) that shared a common placenta (n = 18 pairs) have more similar DNA methylation levels in blood throughout the genome relative to those with separate placentas (n = 16 pairs). Functional annotation of the genomic regions that show significantly different correlation between monochorionic (MC) and dichorionic (DC) MZ pairs found an over-representation of genes involved in the regulation of transcription, neuronal development, and cellular differentiation. These results support the idea that prenatal environmental exposures may have a lasting effect on an individual's epigenetic landscape, and the potential for these changes to have functional consequences. |
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| DATE PUBLISHED |
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| HISTORY |
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| PUBSTATUS |
PUBSTATUSDATE |
| entrez |
2015/12/19 06:00 |
| pubmed |
2015/12/19 06:00 |
| medline |
2015/12/19 06:00 |
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| AUTHORS |
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| NAME |
COLLECTIVENAME |
LASTNAME |
FORENAME |
INITIALS |
AFFILIATION |
AFFILIATIONINFO |
| Bui M |
|
Bui |
Masato |
M |
|
The Queensland Brain Institute,University of Queensland,Brisbane,Queensland,Australia. |
| Benyamin B |
|
Benyamin |
Beben |
B |
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The Queensland Brain Institute,University of Queensland,Brisbane,Queensland,Australia. |
| Shah S |
|
Shah |
Sonia |
S |
|
The Queensland Brain Institute,University of Queensland,Brisbane,Queensland,Australia. |
| Henders AK |
|
Henders |
Anjali K |
AK |
|
The Queensland Brain Institute,University of Queensland,Brisbane,Queensland,Australia. |
| Martin NG |
|
Martin |
Nicholas G |
NG |
|
QIMR Berghofer Medical Research Institute,Brisbane,Queensland,Australia. |
| Montgomery GW |
|
Montgomery |
Grant W |
GW |
|
QIMR Berghofer Medical Research Institute,Brisbane,Queensland,Australia. |
| McRae AF |
|
McRae |
Allan F |
AF |
|
The Queensland Brain Institute,University of Queensland,Brisbane,Queensland,Australia. |
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| INVESTIGATORS |
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| JOURNAL |
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| VOLUME: 18 |
| ISSUE: 6 |
| TITLE: Twin research and human genetics : the official journal of the International Society for Twin Studies |
| ISOABBREVIATION: Twin Res Hum Genet |
| YEAR: 2015 |
| MONTH: Dec |
| DAY: |
| MEDLINEDATE: |
| SEASON: |
| CITEDMEDIUM: Internet |
| ISSN: 1832-4274 |
| ISSNTYPE: Print |
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| MEDLINE JOURNAL |
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| MEDLINETA: Twin Res Hum Genet |
| COUNTRY: England |
| ISSNLINKING: 1832-4274 |
| NLMUNIQUEID: 101244624 |
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| PUBLICATION TYPE |
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| PUBLICATIONTYPE TEXT |
| Journal Article |
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| COMMENTS AND CORRECTIONS |
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| GRANTS |
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| GENERAL NOTE |
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| KEYWORDS |
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| KEYWORD |
| DNA methylation |
| chorionicity |
| monozygotic twins |
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| MESH HEADINGS |
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| SUPPLEMENTARY MESH |
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| GENE SYMBOLS |
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| CHEMICALS |
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