Genetic Epidemiology, Psychiatric Genetics, Asthma Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
26678052
TITLE
Sharing a Placenta is Associated With a Greater Similarity in DNA Methylation in Monochorionic Versus Dichorionic Twin Pars in Blood at Age 14.
ABSTRACT
Monozygotic (MZ) twins provide a natural system for investigating developmental plasticity and the potential epigenetic origins of disease. A major difference in the intrauterine environment between MZ pairs is whether they share a common placenta or have separate placentas. Using DNA methylation measured at >400,000 points in the genome on the Illumina HumanMethylation450 array, we demonstrate that the co-twins of MZ pairs (average age of 14) that shared a common placenta (n = 18 pairs) have more similar DNA methylation levels in blood throughout the genome relative to those with separate placentas (n = 16 pairs). Functional annotation of the genomic regions that show significantly different correlation between monochorionic (MC) and dichorionic (DC) MZ pairs found an over-representation of genes involved in the regulation of transcription, neuronal development, and cellular differentiation. These results support the idea that prenatal environmental exposures may have a lasting effect on an individual's epigenetic landscape, and the potential for these changes to have functional consequences.
DATE PUBLISHED
2015 Dec
HISTORY
PUBSTATUS PUBSTATUSDATE
entrez 2015/12/19 06:00
pubmed 2015/12/19 06:00
medline 2015/12/19 06:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Bui M Bui Masato M The Queensland Brain Institute,University of Queensland,Brisbane,Queensland,Australia.
Benyamin B Benyamin Beben B The Queensland Brain Institute,University of Queensland,Brisbane,Queensland,Australia.
Shah S Shah Sonia S The Queensland Brain Institute,University of Queensland,Brisbane,Queensland,Australia.
Henders AK Henders Anjali K AK The Queensland Brain Institute,University of Queensland,Brisbane,Queensland,Australia.
Martin NG Martin Nicholas G NG QIMR Berghofer Medical Research Institute,Brisbane,Queensland,Australia.
Montgomery GW Montgomery Grant W GW QIMR Berghofer Medical Research Institute,Brisbane,Queensland,Australia.
McRae AF McRae Allan F AF The Queensland Brain Institute,University of Queensland,Brisbane,Queensland,Australia.
INVESTIGATORS
JOURNAL
VOLUME: 18
ISSUE: 6
TITLE: Twin research and human genetics : the official journal of the International Society for Twin Studies
ISOABBREVIATION: Twin Res Hum Genet
YEAR: 2015
MONTH: Dec
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN: 1832-4274
ISSNTYPE: Print
MEDLINE JOURNAL
MEDLINETA: Twin Res Hum Genet
COUNTRY: England
ISSNLINKING: 1832-4274
NLMUNIQUEID: 101244624
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
COMMENTS AND CORRECTIONS
GRANTS
GENERAL NOTE
KEYWORDS
KEYWORD
DNA methylation
chorionicity
monozygotic twins
MESH HEADINGS
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
OTHER ID's