Genetic Epidemiology, Psychiatric Genetics, Asthma Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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26658930
TITLE
ENIGMA and the individual: Predicting factors that affect the brain in 35 countries worldwide.
ABSTRACT
NlmCategory: UNASSIGNED
In this review, we discuss recent work by the ENIGMA Consortium (http://enigma.ini.usc.edu) - a global alliance of over 500 scientists spread across 200 institutions in 35 countries collectively analyzing brain imaging, clinical, and genetic data. Initially formed to detect genetic influences on brain measures, ENIGMA has grown to over 30 working groups studying 12 major brain diseases by pooling and comparing brain data. In some of the largest neuroimaging studies to date - of schizophrenia and major depression - ENIGMA has found replicable disease effects on the brain that are consistent worldwide, as well as factors that modulate disease effects. In partnership with other consortia including ADNI, CHARGE, IMAGEN and others(1), ENIGMA's genomic screens - now numbering over 30,000 MRI scans - have revealed at least 8 genetic loci that affect brain volumes. Downstream of gene findings, ENIGMA has revealed how these individual variants - and genetic variants in general - may affect both the brain and risk for a range of diseases. The ENIGMA consortium is discovering factors that consistently affect brain structure and function that will serve as future predictors linking individual brain scans and genomic data. It is generating vast pools of normative data on brain measures - from tens of thousands of people - that may help detect deviations from normal development or aging in specific groups of subjects. We discuss challenges and opportunities in applying these predictors to individual subjects and new cohorts, as well as lessons we have learned in ENIGMA's efforts so far.
Copyright 2016 The Authors. Published by Elsevier Inc. All rights reserved.
DATE PUBLISHED
2015 Dec 4
HISTORY
PUBSTATUS PUBSTATUSDATE
received 2015/08/14
revised 2015/10/16
accepted 2015/11/23
entrez 2015/12/15 06:00
pubmed 2015/12/15 06:00
medline 2015/12/15 06:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Thompson PM Thompson Paul M PM Imaging Genetics Center, Mark and Mary Stevens Institute for Neuroimaging & Informatics, Keck School of Medicine of the University of Southern California, Marina del Rey 90292, USA; Departments of Neurosciences, Radiology, Psychiatry, and Cognitive Science, University of California, San Diego 92093, CA, USA.
Andreassen OA Andreassen Ole A OA NORMENT-KG Jebsen Centre, Institute of Clinical Medicine, University of Oslo, Oslo 0315, Norway; NORMENT-KG Jebsen Centre, Division of Mental Health and Addiction, Oslo University Hospital, Oslo 0315, Norway.
Arias-Vasquez A Arias-Vasquez Alejandro A Donders Center for Cognitive Neuroscience, Departments of Psychiatry, Human Genetics & Cognitive Neuroscience, Radboud University Medical Center, Nijmegen 6525, The Netherlands.
Bearden CE Bearden Carrie E CE Department of Psychiatry & Biobehavioral Sciences, University of California, Los Angeles, CA 90095, USA; Dept. of Psychology, University of California, Los Angeles, CA 90095, USA; Brain Research Institute, University of California, Los Angeles, CA 90095, USA.
Boedhoe PS Boedhoe Premika S PS Department of Anatomy & Neurosciences, VU University Medical Center, Amsterdam, The Netherlands; Department of Psychiatry, VU University Medical Center (VUMC), Amsterdam, The Netherlands; Neuroscience Campus Amsterdam, VU/VUMC, Amsterdam, The Netherlands.
Brouwer RM Brouwer Rachel M RM Brain Center Rudolf Magnus, Department of Psychiatry, UMC Utrecht, Utrecht 3584 CX, The Netherlands.
Buckner RL Buckner Randy L RL Department of Psychiatry, Massachusetts General Hospital, Boston 02114, USA.
Buitelaar JK Buitelaar Jan K JK Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen 6500 HB, The Netherlands; Department of Psychology, Center for Brain Science, Harvard University, Cambridge, MA 02138, USA.
Bulayeva KB Bulayeva Kazima B KB N.I. Vavilov Institute of General Genetics, Russian Academy of Sciences, Gubkin str. 3, Moscow 119991, Russia.
Cannon DM Cannon Dara M DM National Institute of Mental Health Intramural Research Program, Bethesda 20892, USA; Neuroimaging & Cognitive Genomics Centre (NICOG), Clinical Neuroimaging Laboratory, NCBES Galway Neuroscience Centre, College of Medicine Nursing and Health Sciences, National University of Ireland Galway, H91 TK33 Galway, Ireland.
Cohen RA Cohen Ronald A RA Institute on Aging, University of Florida, Gainesville, FL 32611, USA.
Conrod PJ Conrod Patricia J PJ Department of Psychological Medicine and Psychiatry, Section of Addiction, King's College London, University of London, UK.
Dale AM Dale Anders M AM Departments of Neurosciences, Radiology, Psychiatry, and Cognitive Science, University of California, San Diego, La Jolla, CA 92093-0841, USA.
Deary IJ Deary Ian J IJ Centre for Cognitive Ageing and Cognitive Epidemiology, Psychology, University of Edinburgh, Edinburgh EH8 9JZ, UK.
Dennis EL Dennis Emily L EL Imaging Genetics Center, Mark and Mary Stevens Institute for Neuroimaging & Informatics, Keck School of Medicine of the University of Southern California, Marina del Rey 90292, USA.
de Reus MA de Reus Marcel A MA Brain Center Rudolf Magnus, Department of Psychiatry, UMC Utrecht, Utrecht 3584 CX, The Netherlands.
Desrivieres S Desrivieres Sylvane S MRC-SGDP Centre, Institute of Psychiatry, King's College London, London SE5 8AF, UK.
Dima D Dima Danai D Institute of Psychiatry, Psychology and Neuroscience, King׳s College London, UK; Clinical Neuroscience Studies (CNS) Center, Department of Psychiatry, Icahn School of Medicine at Mount Sinai, USA.
Donohoe G Donohoe Gary G Neuroimaging and Cognitive Genomics center (NICOG), School of Psychology, National University of Ireland, Galway, Ireland.
Fisher SE Fisher Simon E SE Language and Genetics Department, Max Planck Institute for Psycholinguistics, Nijmegen 6525 XD, The Netherlands; Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen 6500 HB, The Netherlands.
Fouche JP Fouche Jean-Paul JP Department of Psychiatry and Mental Health, University of Cape Town, Cape Town, South Africa.
Francks C Francks Clyde C Language and Genetics Department, Max Planck Institute for Psycholinguistics, Nijmegen 6525 XD, The Netherlands; Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen 6500 HB, The Netherlands.
Frangou S Frangou Sophia S Clinical Neuroscience Studies (CNS) Center, Department of Psychiatry, Icahn School of Medicine at Mount Sinai, USA.
Franke B Franke Barbara B Department of Human Genetics, Radboud University Medical Center, Nijmegen 6525, The Netherlands; Department of Psychiatry, Radboud University Medical Center, Nijmegen 6525, The Netherlands; Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen 6500 HB, The Netherlands.
Ganjgahi H Ganjgahi Habib H Department of Statistics, The University of Warwick, Coventry, UK.
Garavan H Garavan Hugh H Psychiatry Department, University of Vermont, VT, USA.
Glahn DC Glahn David C DC Department of Psychiatry, Yale University, New Haven, CT 06511, USA; Olin Neuropsychiatric Research Center, Hartford, CT 06114, USA.
Grabe HJ Grabe Hans J HJ Department of Psychiatry, University Medicine Greifswald, Greifswald 17489, Germany; Department of Psychiatry and Psychotherapy, HELIOS Hospital, Stralsund 18435, Germany.
Guadalupe T Guadalupe Tulio T Language and Genetics Department, Max Planck Institute for Psycholinguistics, Nijmegen 6525 XD, The Netherlands; International Max Planck Research School for Language Sciences, Nijmegen 6525 XD, The Netherlands.
Gutman BA Gutman Boris A BA Imaging Genetics Center, Mark and Mary Stevens Institute for Neuroimaging & Informatics, Keck School of Medicine of the University of Southern California, Marina del Rey 90292, USA.
Hashimoto R Hashimoto Ryota R Molecular Research Center for Children's Mental Development, United Graduate School of Child Development, Osaka University, Japan.
Hibar DP Hibar Derrek P DP Imaging Genetics Center, Mark and Mary Stevens Institute for Neuroimaging & Informatics, Keck School of Medicine of the University of Southern California, Marina del Rey 90292, USA.
Holland D Holland Dominic D Departments of Neurosciences, Radiology, Psychiatry, and Cognitive Science, University of California, San Diego, La Jolla, CA 92093-0841, USA.
Hoogman M Hoogman Martine M Department of Human Genetics, Radboud University Medical Center, Nijmegen 6525, The Netherlands; Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen 6500 HB, The Netherlands.
Pol HE Pol Hilleke E Hulshoff HE Brain Center Rudolf Magnus, Department of Psychiatry, UMC Utrecht, Utrecht 3584 CX, The Netherlands.
Hosten N Hosten Norbert N Department of Radiology University Medicine Greifswald, Greifswald 17475, Germany.
Jahanshad N Jahanshad Neda N Imaging Genetics Center, Mark and Mary Stevens Institute for Neuroimaging & Informatics, Keck School of Medicine of the University of Southern California, Marina del Rey 90292, USA.
Kelly S Kelly Sinead S Imaging Genetics Center, Mark and Mary Stevens Institute for Neuroimaging & Informatics, Keck School of Medicine of the University of Southern California, Marina del Rey 90292, USA.
Kochunov P Kochunov Peter P Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
Kremen WS Kremen William S WS Department of Psychiatry, University of California, San Diego, La Jolla, CA 92093, USA.
Lee PH Lee Phil H PH Center for Human Genetic Research, Massachusetts General Hospital, USA; Department of Psychiatry, Harvard Medical School, USA; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, USA.
Mackey S Mackey Scott S Department of Psychiatry, University of Vermont, Burlington 05401, VT, USA.
Martin NG Martin Nicholas G NG QIMR Berghofer Medical Research Institute, Brisbane 4006, Australia.
Mazoyer B Mazoyer Bernard B Groupe d'imagerie Neurofonctionnelle, UMR5296 CNRS CEA Université de Bordeaux, France.
McDonald C McDonald Colm C Neuroimaging & Cognitive Genomics Centre (NICOG), Clinical Neuroimaging Laboratory, NCBES Galway Neuroscience Centre, College of Medicine Nursing and Health Sciences, National University of Ireland Galway, H91 TK33 Galway, Ireland.
Medland SE Medland Sarah E SE QIMR Berghofer Medical Research Institute, Brisbane 4006, Australia.
Morey RA Morey Rajendra A RA Duke Institute for Brain Sciences, Duke University, NC 27710, USA.
Nichols TE Nichols Thomas E TE Department of Statistics & WMG, University of Warwick, Coventry CV4 7AL, UK; FMRIB Centre, University of Oxford, Oxford OX3 9DU, UK.
Paus T Paus Tomas T Rotman Research Institute, Baycrest, Toronto, ON, Canada; Departments of Psychology and Psychiatry, University of Toronto, Toronto, Canada; Child Mind Institute, NY, USA.
Pausova Z Pausova Zdenka Z The Hospital for Sick Children, University of Toronto, Toronto, Canada; Departments of Physiology and Nutritional Sciences, University of Toronto, Toronto, Canada.
Schmaal L Schmaal Lianne L Department of Psychiatry, VU University Medical Center (VUMC), Amsterdam, The Netherlands; Neuroscience Campus Amsterdam, VU/VUMC, Amsterdam, The Netherlands.
Schumann G Schumann Gunter G MRC-SGDP Centre, Institute of Psychiatry, King's College London, London SE5 8AF, UK.
Shen L Shen Li L Center for Neuroimaging, Dept. of Radiology and Imaging Sciences, Indiana University School of Medicine, 355 W. 16th Street, Suite 4100, Indianapolis, IN 46202, USA; Center for Computational Biology and Bioinformatics, Indiana University School of Medicine, 355 W. 16th Street, Suite 4100, Indianapolis, IN 46202, USA.
Sisodiya SM Sisodiya Sanjay M SM Department of Clinical and Experimental Epilepsy, UCL Institute of Neurology, London WC1N 3BG, UK and Epilepsy Society, Bucks, UK.
Smit DJ Smit Dirk J A DJ Department of Biological Psychology, VU University Amsterdam, Amsterdam, The Netherlands; Neuroscience Campus Amsterdam, VU/VUMC, Amsterdam, The Netherlands.
Smoller JW Smoller Jordan W JW Psychiatric and Neurodevelopmental Genetics Unit, Center for Human Genetic Research, Massachusetts General Hospital, USA.
Stein DJ Stein Dan J DJ Department of Psychiatry and Mental Health, University of Cape Town, Cape Town, South Africa; MRC Research Unit on Anxiety & Stress Disorders, South Africa.
Stein JL Stein Jason L JL Imaging Genetics Center, Mark and Mary Stevens Institute for Neuroimaging & Informatics, Keck School of Medicine of the University of Southern California, Marina del Rey 90292, USA; Neurogenetics Program, Department of Neurology, UCLA School of Medicine, Los Angeles 90095, USA.
Toro R Toro Roberto R Institut Pasteur, Paris, 75015, France.
Turner JA Turner Jessica A JA Departments of Psychology and Neuroscience, Georgia State University, Atlanta, GA 30302, USA.
van den Heuvel MP van den Heuvel Martijn P MP Brain Center Rudolf Magnus, Department of Psychiatry, UMC Utrecht, Utrecht 3584 CX, The Netherlands.
van den Heuvel OL van den Heuvel Odile L OL Department of Anatomy & Neurosciences, VU University Medical Center, Amsterdam, The Netherlands; Department of Psychiatry, VU University Medical Center (VUMC), Amsterdam, The Netherlands; Neuroscience Campus Amsterdam, VU/VUMC, Amsterdam, The Netherlands.
van Erp TG van Erp Theo G M TG Department of Psychiatry and Human Behavior, University of California, Irvine, CA 92617, USA.
van Rooij D van Rooij Daan D Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen 6500 HB, The Netherlands.
Veltman DJ Veltman Dick J DJ Department of Anatomy & Neurosciences, VU University Medical Center, Amsterdam, The Netherlands; Department of Psychiatry, VU University Medical Center (VUMC), Amsterdam, The Netherlands; Neuroscience Campus Amsterdam, VU/VUMC, Amsterdam, The Netherlands.
Walter H Walter Henrik H Department of Psychiatry and Psychotherapy, Charité Universitätsmedizin Berlin, CCM, Berlin 10117, Germany.
Wang Y Wang Yalin Y School of Computing, Informatics and Decision Systems Engineering, Arizona State University, AZ 85281, USA.
Wardlaw JM Wardlaw Joanna M JM Brain Research Imaging Centre, University of Edinburgh, Edinburgh EH4 2XU, UK; Centre for Cognitive Ageing and Cognitive Epidemiology, Psychology, University of Edinburgh, Edinburgh EH8 9JZ, UK; Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh EH4 2XU, UK.
Whelan CD Whelan Christopher D CD Imaging Genetics Center, Mark and Mary Stevens Institute for Neuroimaging & Informatics, Keck School of Medicine of the University of Southern California, Marina del Rey 90292, USA.
Wright MJ Wright Margaret J MJ Queensland Brain Institute, University of Queensland, Brisbane 4072, Australia.
Ye J Ye Jieping J Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI 48109, USA; Department of Electrical Engineering and Computer Science, University of Michigan, Ann Arbor, MI 48109, USA.
ENIGMA Consortium
INVESTIGATORS
JOURNAL
VOLUME:
ISSUE:
TITLE: NeuroImage
ISOABBREVIATION: Neuroimage
YEAR: 2015
MONTH: Dec
DAY: 4
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN: 1095-9572
ISSNTYPE: Electronic
MEDLINE JOURNAL
MEDLINETA: Neuroimage
COUNTRY: United States
ISSNLINKING: 1053-8119
NLMUNIQUEID: 9215515
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
JOURNAL ARTICLE
COMMENTS AND CORRECTIONS
GRANTS
GRANTID AGENCY COUNTRY
G0701120 Medical Research Council United Kingdom
G1001245 Medical Research Council United Kingdom
MR/K026992/1 Medical Research Council United Kingdom
P01 AA019072 NIAAA NIH HHS United States
R01 AG018384 NIA NIH HHS United States
R01 AG018386 NIA NIH HHS United States
R01 AG022381 NIA NIH HHS United States
R01 AG040060 NIA NIH HHS United States
R01 AG050595 NIA NIH HHS United States
R01 EB015611 NIBIB NIH HHS United States
U54 EB020403 NIBIB NIH HHS United States
100309 Wellcome Trust United Kingdom
GENERAL NOTE
KEYWORDS
MESH HEADINGS
SUPPLEMENTARY MESH
GENE SYMBOLS
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OTHER ID's