Genetic Epidemiology, Translational Neurogenomics, Psychiatric Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
26542096
TITLE
Meta-analysis identifies seven susceptibility loci involved in the atopic march.
ABSTRACT
Eczema often precedes the development of asthma in a disease course called the 'atopic march'. To unravel the genes underlying this characteristic pattern of allergic disease, we conduct a multi-stage genome-wide association study on infantile eczema followed by childhood asthma in 12 populations including 2,428 cases and 17,034 controls. Here we report two novel loci specific for the combined eczema plus asthma phenotype, which are associated with allergic disease for the first time; rs9357733 located in EFHC1 on chromosome 6p12.3 (OR 1.27; P=2.1 × 10(-8)) and rs993226 between TMTC2 and SLC6A15 on chromosome 12q21.3 (OR 1.58; P=5.3 × 10(-9)). Additional susceptibility loci identified at genome-wide significance are FLG (1q21.3), IL4/KIF3A (5q31.1), AP5B1/OVOL1 (11q13.1), C11orf30/LRRC32 (11q13.5) and IKZF3 (17q21). We show that predominantly eczema loci increase the risk for the atopic march. Our findings suggest that eczema may play an important role in the development of asthma after eczema.
DATE PUBLISHED
2015
HISTORY
PUBSTATUS PUBSTATUSDATE
received 2015/07/20
accepted 2015/10/06
entrez 2015/11/07 06:00
pubmed 2015/11/07 06:00
medline 2015/11/07 06:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Marenholz I Marenholz Ingo I Clinic for Pediatric Allergy, Experimental and Clinical Research Center, Charité University Medical Center, Berlin, Germany.
Esparza-Gordillo J Esparza-Gordillo Jorge J Clinic for Pediatric Allergy, Experimental and Clinical Research Center, Charité University Medical Center, Berlin, Germany.
Rüschendorf F Rüschendorf Franz F Max-Delbrück-Center (MDC) for Molecular Medicine, Berlin, Germany.
Bauerfeind A Bauerfeind Anja A Max-Delbrück-Center (MDC) for Molecular Medicine, Berlin, Germany.
Strachan DP Strachan David P DP Population Health Research Institute, St George's, University of London, London, UK.
Spycher BD Spycher Ben D BD Institute of Social and Preventive Medicine, University of Bern, Bern, Switzerland.
Baurecht H Baurecht Hansjörg H Department of Dermatology, Allergology, and Venerology, University Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany.
Margaritte-Jeannin P Margaritte-Jeannin Patricia P Université Paris Diderot, Sorbonne Paris Cité, Institut Universitaire d'Hématologie, F-75007 Paris, France.
Sääf A Sääf Annika A Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
Kerkhof M Kerkhof Marjan M University of Groningen, University Medical Center Groningen, GRIAC Research Institute, Groningen, The Netherlands.
Ege M Ege Markus M Dr von Hauner Children's Hospital, Ludwig Maximilians University Munich, Member of the German Center for Lung Research (DZL), Munich, Germany.
Baltic S Baltic Svetlana S Lung Institute of Western Australia, University of Western Australia, Perth, Western Australia, Australia.
Matheson MC Matheson Melanie C MC Centre for Molecular, Environmental, Genetic and Analytic Epidemiology, University of Melbourne, Melbourne, Victoria, Australia.
Li J Li Jin J Center for Applied Genomics, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
Michel S Michel Sven S Department of Pediatric Pneumology and Allergy, University Children`s Hospital Regensburg (KUNO), Regensburg, Germany.
Ang WQ Ang Wei Q WQ School of Women and Infant's Health, University of Western Australia, Perth, Western Australia, Australia.
McArdle W McArdle Wendy W School of Social and Community Medicine, University of Bristol, Bristol, UK.
Arnold A Arnold Andreas A Clinic and Polyclinic of Dermatology, University Medicine Greifswald, Greifswald, Germany.
Homuth G Homuth Georg G Department of Functional Genomics, Interfaculty Institute for Genetics and Functional Genomics, University Medicine and Ernst-Moritz-Arndt-University Greifswald, Greifswald, Germany.
Demenais F Demenais Florence F Université Paris Diderot, Sorbonne Paris Cité, Institut Universitaire d'Hématologie, F-75007 Paris, France.
Bouzigon E Bouzigon Emmanuelle E Université Paris Diderot, Sorbonne Paris Cité, Institut Universitaire d'Hématologie, F-75007 Paris, France.
Söderhäll C Söderhäll Cilla C Department of Biosciences and Nutrition, and Center for Innovative Medicine (CIMED), Karolinska Institutet, Stockholm, Sweden.
Pershagen G Pershagen Göran G Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
de Jongste JC de Jongste Johan C JC Department of Pediatrics, Pediatric Chest Center, Erasmus University Medical Center, Rotterdam, The Netherlands.
Postma DS Postma Dirkje S DS Department of Pulmonology and GRIAC Research Institute, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Braun-Fahrländer C Braun-Fahrländer Charlotte C Swiss Tropical and Public Health Institute and the University of Basel, Basel, Switzerland.
Horak E Horak Elisabeth E Division of Pediatric Cardiology and Pulmonology, Department of Pediatrics, Innsbruck Medical University, Innsbruck, Austria.
Ogorodova LM Ogorodova Ludmila M LM Siberian State Medical University, Tomsk, Russia.
Puzyrev VP Puzyrev Valery P VP Research Institute of Medical Genetics, Tomsk, Russia.
Bragina EY Bragina Elena Yu EY Research Institute of Medical Genetics, Tomsk, Russia.
Hudson TJ Hudson Thomas J TJ Ontario Institute for Cancer Research, Toronto, Ontario, Canada.
Morin C Morin Charles C Centre de santé et de services sociaux de Chicoutimi, Saguenay, Québec, Canada.
Duffy DL Duffy David L DL QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
Marks GB Marks Guy B GB Woolcock Institute of Medical Research, University of Sydney, Sydney, New South Wales, Australia.
Robertson CF Robertson Colin F CF Department of Respiratory Medicine, Murdoch Children's Research Institute, Melbourne, Victoria, Australia.
Montgomery GW Montgomery Grant W GW QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
Musk B Musk Bill B Busselton Population Medical Research Foundation, Sir Charles Gairdner Hospital, Perth, Western Australia, Australia.
Thompson PJ Thompson Philip J PJ Lung Institute of Western Australia, University of Western Australia, Perth, Western Australia, Australia.
Martin NG Martin Nicholas G NG QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
James A James Alan A Busselton Population Medical Research Foundation, Sir Charles Gairdner Hospital, Perth, Western Australia, Australia.
Sleiman P Sleiman Patrick P Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Toskala E Toskala Elina E Department of Otolaryngology-Head and Neck Surgery, Temple University, School of Medicine, Philadelphia, Pennsylvania, USA.
Rodriguez E Rodriguez Elke E Department of Dermatology, Allergology, and Venerology, University Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany.
Fölster-Holst R Fölster-Holst Regina R Department of Dermatology, Allergology, and Venerology, University Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany.
Franke A Franke Andre A Institute of Clinical Molecular Biology, Christian-Albrechts-University of Kiel, Kiel, Germany.
Lieb W Lieb Wolfgang W Institute of Epidemiology, Christian-Albrechts-University of Kiel, Kiel, Germany.
Gieger C Gieger Christian C Research Unit of Molecular Epidemiology and Institute of Epidemiology II, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.
Heinzmann A Heinzmann Andrea A University Children's Hospital, Albert Ludwigs University, Freiburg, Germany.
Rietschel E Rietschel Ernst E University Children's Hospital, University of Cologne, Cologne, Germany.
Keil T Keil Thomas T Institute for Clinical Epidemiology and Biometry, University of Würzburg, Würzburg, Germany.
Cichon S Cichon Sven S Institute of Neuroscience and Medicine (INM-1), Structural and Functional Organisation of the Brain, Genomic Imaging, Research Centre Jülich, Jülich, Germany.
Nöthen MM Nöthen Markus M MM Department of Genomics, Life &Brain Center, University of Bonn, Bonn, Germany.
Pennell CE Pennell Craig E CE School of Women and Infant's Health, University of Western Australia, Perth, Western Australia, Australia.
Sly PD Sly Peter D PD Queensland Children's Medical Research Institute, University of Queensland, Brisbane, Queensland, Australia.
Schmidt CO Schmidt Carsten O CO Institute for Community Medicine, Study of Health in Pomerania/KEF, University Medicine Greifswald, Greifswald, Germany.
Matanovic A Matanovic Anja A Clinic for Pediatric Allergy, Experimental and Clinical Research Center, Charité University Medical Center, Berlin, Germany.
Schneider V Schneider Valentin V Max-Delbrück-Center (MDC) for Molecular Medicine, Berlin, Germany.
Heinig M Heinig Matthias M Max Planck Institute for Molecular Genetics, Berlin, Germany.
Hübner N Hübner Norbert N Max-Delbrück-Center (MDC) for Molecular Medicine, Berlin, Germany.
Holt PG Holt Patrick G PG Telethon Kids Institute, University of Western Australia, Perth, Western Australia, Australia.
Lau S Lau Susanne S Department of Pediatric Pneumology and Immunology, Charité University Medical Center, Berlin, Germany.
Kabesch M Kabesch Michael M Department of Pediatric Pneumology and Allergy, University Children`s Hospital Regensburg (KUNO), Regensburg, Germany.
Weidinger S Weidinger Stefan S Department of Dermatology, Allergology, and Venerology, University Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany.
Hakonarson H Hakonarson Hakon H Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Ferreira MA Ferreira Manuel A R MA QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
Laprise C Laprise Catherine C Université du Québec à Chicoutimi, Saguenay, Québec, Canada.
Freidin MB Freidin Maxim B MB Research Institute of Medical Genetics, Tomsk, Russia.
Genuneit J Genuneit Jon J Institute of Epidemiology and Medical Biometry, Ulm University, Ulm, Germany.
Koppelman GH Koppelman Gerard H GH Department of Pediatric Pulmonology and Pediatric Allergology, University of Groningen, University Medical Center Groningen, Beatrix Children's Hospital and GRIAC Research Institute, Groningen, The Netherlands.
Melén E Melén Erik E Sachs' Children's Hospital, Stockholm, Sweden.
Dizier MH Dizier Marie-Hélène MH Université Paris Diderot, Sorbonne Paris Cité, Institut Universitaire d'Hématologie, F-75007 Paris, France.
Henderson AJ Henderson A John AJ School of Social and Community Medicine, University of Bristol, Bristol, UK.
Lee YA Lee Young Ae YA Clinic for Pediatric Allergy, Experimental and Clinical Research Center, Charité University Medical Center, Berlin, Germany.
INVESTIGATORS
JOURNAL
VOLUME: 6
ISSUE:
TITLE: Nature communications
ISOABBREVIATION: Nat Commun
YEAR: 2015
MONTH:
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN: 2041-1723
ISSNTYPE: Electronic
MEDLINE JOURNAL
MEDLINETA: Nat Commun
COUNTRY: England
ISSNLINKING: 2041-1723
NLMUNIQUEID: 101528555
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
COMMENTS AND CORRECTIONS
REFTYPE REFSOURCE REFPMID NOTE
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