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PMID |
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TITLE |
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The transcriptional landscape of age in human peripheral blood. |
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ABSTRACT |
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Disease incidences increase with age, but the molecular characteristics of ageing that lead to increased disease susceptibility remain inadequately understood. Here we perform a whole-blood gene expression meta-analysis in 14,983 individuals of European ancestry (including replication) and identify 1,497 genes that are differentially expressed with chronological age. The age-associated genes do not harbor more age-associated CpG-methylation sites than other genes, but are instead enriched for the presence of potentially functional CpG-methylation sites in enhancer and insulator regions that associate with both chronological age and gene expression levels. We further used the gene expression profiles to calculate the 'transcriptomic age' of an individual, and show that differences between transcriptomic age and chronological age are associated with biological features linked to ageing, such as blood pressure, cholesterol levels, fasting glucose, and body mass index. The transcriptomic prediction model adds biological relevance and complements existing epigenetic prediction models, and can be used by others to calculate transcriptomic age in external cohorts. |
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DATE PUBLISHED |
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HISTORY |
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PUBSTATUS |
PUBSTATUSDATE |
received |
2015/01/16 |
accepted |
2015/09/07 |
entrez |
2015/10/23 06:00 |
pubmed |
2015/10/23 06:00 |
medline |
2015/10/23 06:00 |
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AUTHORS |
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NAME |
COLLECTIVENAME |
LASTNAME |
FORENAME |
INITIALS |
AFFILIATION |
AFFILIATIONINFO |
Peters MJ |
|
Peters |
Marjolein J |
MJ |
|
Department of Internal Medicine, Erasmus Medical Centre Rotterdam, Rotterdam 3000CA, The Netherlands. |
Joehanes R |
|
Joehanes |
Roby |
R |
|
Population Sciences Branch, Division of Intramural Research, National Heart, Lung, and Blood Institute, Bethesda, Maryland 20817, USA. |
Pilling LC |
|
Pilling |
Luke C |
LC |
|
Epidemiology and Public Health, University of Exeter Medical School, Exeter EX4 1DB, UK. |
Schurmann C |
|
Schurmann |
Claudia |
C |
|
The Charles Bronfman Institute for Personalized Medicine, Genetics of Obesity &Related Metabolic Traits Program, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York 10029, USA. |
Conneely KN |
|
Conneely |
Karen N |
KN |
|
Department of Human Genetics, School of Medicine, Emory University, Atlanta, Georgia 30301, USA. |
Powell J |
|
Powell |
Joseph |
J |
|
The Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland 4000, Australia. |
Reinmaa E |
|
Reinmaa |
Eva |
E |
|
Estonian Genome Center, University of Tartu, Tartu 0794, Estonia. |
Sutphin GL |
|
Sutphin |
George L |
GL |
|
Nathan Shock Center of Excellence in the Basic Biology of Aging, The Jackson Laboratory, Bar Harbor, Maine 04609, USA. |
Zhernakova A |
|
Zhernakova |
Alexandra |
A |
|
Department of Genetics, University Medical Center Groningen, University of Groningen, Groningen 9700RB, The Netherlands. |
Schramm K |
|
Schramm |
Katharina |
K |
|
Institute of Human Genetics, Technical University Munich, Munich 85540, Germany. |
Wilson YA |
|
Wilson |
Yana A |
YA |
|
Neuroscience Division, Garvan Institute of Medical Research, Australia and Charles Perkins Centre and School of Molecular Bioscience, The University of Sydney, Sydney, New South Wales 2006, Australia. |
Kobes S |
|
Kobes |
Sayuko |
S |
|
Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Disease, National Institutes of Health, Phoenix, Arizona 85001, USA. |
Tukiainen T |
|
Tukiainen |
Taru |
T |
|
Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki 00131, Finland. |
|
NABEC/UKBEC Consortium |
|
|
|
|
|
Ramos YF |
|
Ramos |
Yolande F |
YF |
|
Department of Molecular Epidemiology, Leiden University Medical Center, Leiden 2300RC, The Netherlands. |
Göring HH |
|
Göring |
Harald H H |
HH |
|
Department of Genetics, Texas Biomedical Research Institute, San Antonio, Texas 78201, USA. |
Fornage M |
|
Fornage |
Myriam |
M |
|
Institute of Molecular Medicine, University of Texas Health Sciences Center at Houston, Houston, Texas 77001, USA. |
Liu Y |
|
Liu |
Yongmei |
Y |
|
Department of Epidemiology and Prevention, Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, North Carolina 27101, USA. |
Gharib SA |
|
Gharib |
Sina A |
SA |
|
Computational Medicine Core, Center for Lung Biology, University of Washington, Seattle, Washington 98101, USA. |
Stranger BE |
|
Stranger |
Barbara E |
BE |
|
Section of Genetic Medicine, Institute for Genomics and Systems Biology, University of Chicago, Chicago, Illinois 60290, USA. |
De Jager PL |
|
De Jager |
Philip L |
PL |
|
Program in Translational NeuroPsychiatric Genomics, Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02108, USA. |
Aviv A |
|
Aviv |
Abraham |
A |
|
Center of Human Development and Aging, New Jersey Medical School, Newark 07101, USA. |
Levy D |
|
Levy |
Daniel |
D |
|
Population Sciences Branch, Division of Intramural Research, National Heart, Lung, and Blood Institute, Bethesda, Maryland 20817, USA. |
Murabito JM |
|
Murabito |
Joanne M |
JM |
|
General Internal Medicine Section, Boston University, Boston, Massachusetts 02108, USA. |
Munson PJ |
|
Munson |
Peter J |
PJ |
|
The Mathematical and Statistical Computing Laboratory, Center for Information Technology, National Institutes of Health, Bethesda, Maryland 20817, USA. |
Huan T |
|
Huan |
Tianxiao |
T |
|
Population Sciences Branch, Division of Intramural Research, National Heart, Lung, and Blood Institute, Bethesda, Maryland 20817, USA. |
Hofman A |
|
Hofman |
Albert |
A |
|
Department of Epidemiology, Erasmus Medical Center, Rotterdam 3000CA, The Netherlands. |
Uitterlinden AG |
|
Uitterlinden |
André G |
AG |
|
Department of Epidemiology, Erasmus Medical Center, Rotterdam 3000CA, The Netherlands. |
Rivadeneira F |
|
Rivadeneira |
Fernando |
F |
|
Department of Epidemiology, Erasmus Medical Center, Rotterdam 3000CA, The Netherlands. |
van Rooij J |
|
van Rooij |
Jeroen |
J |
|
Department of Internal Medicine, Erasmus Medical Centre Rotterdam, Rotterdam 3000CA, The Netherlands. |
Stolk L |
|
Stolk |
Lisette |
L |
|
Department of Internal Medicine, Erasmus Medical Centre Rotterdam, Rotterdam 3000CA, The Netherlands. |
Broer L |
|
Broer |
Linda |
L |
|
Department of Internal Medicine, Erasmus Medical Centre Rotterdam, Rotterdam 3000CA, The Netherlands. |
Verbiest MM |
|
Verbiest |
Michael M P J |
MM |
|
Department of Internal Medicine, Erasmus Medical Centre Rotterdam, Rotterdam 3000CA, The Netherlands. |
Jhamai M |
|
Jhamai |
Mila |
M |
|
Department of Internal Medicine, Erasmus Medical Centre Rotterdam, Rotterdam 3000CA, The Netherlands. |
Arp P |
|
Arp |
Pascal |
P |
|
Department of Internal Medicine, Erasmus Medical Centre Rotterdam, Rotterdam 3000CA, The Netherlands. |
Metspalu A |
|
Metspalu |
Andres |
A |
|
Estonian Genome Center, University of Tartu, Tartu 0794, Estonia. |
Tserel L |
|
Tserel |
Liina |
L |
|
Molecular Pathology, Institute of Biomedicine, University of Tartu, Tartu 0794, Estonia. |
Milani L |
|
Milani |
Lili |
L |
|
Estonian Genome Center, University of Tartu, Tartu 0794, Estonia. |
Samani NJ |
|
Samani |
Nilesh J |
NJ |
|
National Institute for Health Research Leicester Cardiovascular Biomedical Research Unit, Glenfield Hospital, Leicester LE1, UK. |
Peterson P |
|
Peterson |
Pärt |
P |
|
Molecular Pathology, Institute of Biomedicine, University of Tartu, Tartu 0794, Estonia. |
Kasela S |
|
Kasela |
Silva |
S |
|
Institute of Molecular and Cell Biology, Estonian Genome Center, University of Tartu, Tartu 0794, Estonia. |
Codd V |
|
Codd |
Veryan |
V |
|
National Institute for Health Research Leicester Cardiovascular Biomedical Research Unit, Glenfield Hospital, Leicester LE1, UK. |
Peters A |
|
Peters |
Annette |
A |
|
Research Unit of Molecular Epidemiology, Helmholtz Zentrum Muenchen, German Research Center for Environmental Health, Neuherberg 85764, Germany. |
Ward-Caviness CK |
|
Ward-Caviness |
Cavin K |
CK |
|
Institute of Epidemiologie II, Helmholtz Zentrum Muenchen, German Research Center for Environmental Health, Neuherberg 85764, Germany. |
Herder C |
|
Herder |
Christian |
C |
|
Institute of Clinical Diabetology, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University Düsseldorf, Düsseldorf 40593, Germany. |
Waldenberger M |
|
Waldenberger |
Melanie |
M |
|
Research Unit of Molecular Epidemiology, Helmholtz Zentrum Muenchen, German Research Center for Environmental Health, Neuherberg 85764, Germany. |
Roden M |
|
Roden |
Michael |
M |
|
Division of Endocrinology and Diabetology, University Hospital Düsseldorf, Heinrich Heine University, Düsseldorf 40593, Germany. |
Singmann P |
|
Singmann |
Paula |
P |
|
Research Unit of Molecular Epidemiology, Helmholtz Zentrum Muenchen, German Research Center for Environmental Health, Neuherberg 85764, Germany. |
Zeilinger S |
|
Zeilinger |
Sonja |
S |
|
Research Unit of Molecular Epidemiology, Helmholtz Zentrum Muenchen, German Research Center for Environmental Health, Neuherberg 85764, Germany. |
Illig T |
|
Illig |
Thomas |
T |
|
Hannover Unified Biobank, Hannover Medical School, Hannover 30519, Germany. |
Homuth G |
|
Homuth |
Georg |
G |
|
Department of Functional Genomics, Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald 17493, Germany. |
Grabe HJ |
|
Grabe |
Hans-Jörgen |
HJ |
|
Department of Psychiatry and Psychotherapy, Helios Hospital Stralsund, University Medicine Greifswald, Greifswald 17489, Germany. |
Völzke H |
|
Völzke |
Henry |
H |
|
Institute for Community Medicine, University Medicine Greifswald, Greifswald 17489, Germany. |
Steil L |
|
Steil |
Leif |
L |
|
Department of Functional Genomics, Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald 17493, Germany. |
Kocher T |
|
Kocher |
Thomas |
T |
|
Unit of Periodontology, Department of Restorative Dentistry, Periodontology and Endodontology, University Medicine Greifswald, Greifswald 17489, Germany. |
Murray A |
|
Murray |
Anna |
A |
|
Epidemiology and Public Health, University of Exeter Medical School, Exeter EX4 1DB, UK. |
Melzer D |
|
Melzer |
David |
D |
|
Epidemiology and Public Health, University of Exeter Medical School, Exeter EX4 1DB, UK. |
Yaghootkar H |
|
Yaghootkar |
Hanieh |
H |
|
Genetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter EX2 5DW, UK. |
Bandinelli S |
|
Bandinelli |
Stefania |
S |
|
Geriatric Unit, Azienda Sanitaria di Firenze, Florence 50123, Italy. |
Moses EK |
|
Moses |
Eric K |
EK |
|
Centre for Genetic Origins of Health and Disease, The University of Western Australia, and Faculty of Health Sciences, Curtin University, Perth, Western Australia 9011, Australia. |
Kent JW |
|
Kent |
Jack W |
JW |
|
Department of Genetics, Texas Biomedical Research Institute, San Antonio, Texas 78201, USA. |
Curran JE |
|
Curran |
Joanne E |
JE |
|
Department of Genetics, Texas Biomedical Research Institute, San Antonio, Texas 78201, USA. |
Johnson MP |
|
Johnson |
Matthew P |
MP |
|
Department of Genetics, Texas Biomedical Research Institute, San Antonio, Texas 78201, USA. |
Williams-Blangero S |
|
Williams-Blangero |
Sarah |
S |
|
Department of Genetics, Texas Biomedical Research Institute, San Antonio, Texas 78201, USA. |
Westra HJ |
|
Westra |
Harm-Jan |
HJ |
|
Partners Center for Personalized Genetic Medicine, Boston, Massachusetts 02108, USA. |
McRae AF |
|
McRae |
Allan F |
AF |
|
University of Queensland Diamantina Institute, University of Queensland, Princess Alexandra Hospital, Brisbane, Queensland 4000, Australia. |
Smith JA |
|
Smith |
Jennifer A |
JA |
|
Department of Epidemiology, University of Michigan, Ann Arbor, Michigan 48103, USA. |
Kardia SL |
|
Kardia |
Sharon L R |
SL |
|
Department of Epidemiology, University of Michigan, Ann Arbor, Michigan 48103, USA. |
Hovatta I |
|
Hovatta |
Iiris |
I |
|
Department of Mental Health and Substance Abuse Services, National Institute for Health and Welfare, Helsinki 00100, Finland. |
Perola M |
|
Perola |
Markus |
M |
|
Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki 00131, Finland. |
Ripatti S |
|
Ripatti |
Samuli |
S |
|
Department of Public Health, Hjelt Institute, University of Helsinki, Helsinki 00100, Finland. |
Salomaa V |
|
Salomaa |
Veikko |
V |
|
Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki 00131, Finland. |
Henders AK |
|
Henders |
Anjali K |
AK |
|
The Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland 4000, Australia. |
Martin NG |
|
Martin |
Nicholas G |
NG |
|
QIMR Berghofer Medical Research Institute, Brisbane, Queensland 4000, Australia. |
Smith AK |
|
Smith |
Alicia K |
AK |
|
Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia 30301, USA. |
Mehta D |
|
Mehta |
Divya |
D |
|
Max-Planck Institute of Psychiatry, Munich 80331, Germany. |
Binder EB |
|
Binder |
Elisabeth B |
EB |
|
Max-Planck Institute of Psychiatry, Munich 80331, Germany. |
Nylocks KM |
|
Nylocks |
K Maria |
KM |
|
Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia 30301, USA. |
Kennedy EM |
|
Kennedy |
Elizabeth M |
EM |
|
Department of Human Genetics, School of Medicine, Emory University, Atlanta, Georgia 30301, USA. |
Klengel T |
|
Klengel |
Torsten |
T |
|
Max-Planck Institute of Psychiatry, Munich 80331, Germany. |
Ding J |
|
Ding |
Jingzhong |
J |
|
Department of Internal Medicine, Wake Forest School of Medicine, Winston-Salem, North Carolina 27101, USA. |
Suchy-Dicey AM |
|
Suchy-Dicey |
Astrid M |
AM |
|
Department of Epidemiology, University of Washington, Seattle, Washington 98101, USA. |
Enquobahrie DA |
|
Enquobahrie |
Daniel A |
DA |
|
Department of Epidemiology, University of Washington, Seattle, Washington 98101, USA. |
Brody J |
|
Brody |
Jennifer |
J |
|
Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, Washington 98101, USA. |
Rotter JI |
|
Rotter |
Jerome I |
JI |
|
Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, California 90501, USA. |
Chen YD |
|
Chen |
Yii-Der I |
YD |
|
Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, California 90501, USA. |
Houwing-Duistermaat J |
|
Houwing-Duistermaat |
Jeanine |
J |
|
Department of Medical Statistics, Leiden University Medical Center, Leiden 2300RC, The Netherlands. |
Kloppenburg M |
|
Kloppenburg |
Margreet |
M |
|
Department of Clinical Epidemiology, Leiden University Medical Center, Leiden 2300RC, The Netherlands. |
Slagboom PE |
|
Slagboom |
P Eline |
PE |
|
Department of Molecular Epidemiology, Leiden University Medical Center, Leiden 2300RC, The Netherlands. |
Helmer Q |
|
Helmer |
Quinta |
Q |
|
Department of Medical Statistics, Leiden University Medical Center, Leiden 2300RC, The Netherlands. |
den Hollander W |
|
den Hollander |
Wouter |
W |
|
Department of Molecular Epidemiology, Leiden University Medical Center, Leiden 2300RC, The Netherlands. |
Bean S |
|
Bean |
Shannon |
S |
|
Nathan Shock Center of Excellence in the Basic Biology of Aging, The Jackson Laboratory, Bar Harbor, Maine 04609, USA. |
Raj T |
|
Raj |
Towfique |
T |
|
Division of Immunology, Department of Microbiology and Immunobiology, Harvard Medical School, Boston, Massachusetts 02138, USA. |
Bakhshi N |
|
Bakhshi |
Noman |
N |
|
Neuroscience Division, Garvan Institute of Medical Research, Australia and Charles Perkins Centre and School of Molecular Bioscience, The University of Sydney, Sydney, New South Wales 2006, Australia. |
Wang QP |
|
Wang |
Qiao Ping |
QP |
|
Neuroscience Division, Garvan Institute of Medical Research, Australia and Charles Perkins Centre and School of Molecular Bioscience, The University of Sydney, Sydney, New South Wales 2006, Australia. |
Oyston LJ |
|
Oyston |
Lisa J |
LJ |
|
Neuroscience Division, Garvan Institute of Medical Research, Australia and Charles Perkins Centre and School of Molecular Bioscience, The University of Sydney, Sydney, New South Wales 2006, Australia. |
Psaty BM |
|
Psaty |
Bruce M |
BM |
|
Group Health Research Institute, Group Health Cooperative, Seattle, Washington 98195, USA. |
Tracy RP |
|
Tracy |
Russell P |
RP |
|
Department of Pathology, University of Vermont College of Medicine, Colchester, Vermont 98195, USA. |
Montgomery GW |
|
Montgomery |
Grant W |
GW |
|
QIMR Berghofer Medical Research Institute, Brisbane, Queensland 4000, Australia. |
Turner ST |
|
Turner |
Stephen T |
ST |
|
Division of Nephrology and Hypertension, Department of Medicine, Mayo Clinic, Rochester, Minnesota 55901, USA. |
Blangero J |
|
Blangero |
John |
J |
|
Department of Genetics, Texas Biomedical Research Institute, San Antonio, Texas 78201, USA. |
Meulenbelt I |
|
Meulenbelt |
Ingrid |
I |
|
Department of Molecular Epidemiology, Leiden University Medical Center, Leiden 2300RC, The Netherlands. |
Ressler KJ |
|
Ressler |
Kerry J |
KJ |
|
Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia 30301, USA. |
Yang J |
|
Yang |
Jian |
J |
|
University of Queensland Diamantina Institute, University of Queensland, Princess Alexandra Hospital, Brisbane, Queensland 4000, Australia. |
Franke L |
|
Franke |
Lude |
L |
|
Department of Genetics, University Medical Center Groningen, University of Groningen, Groningen 9700RB, The Netherlands. |
Kettunen J |
|
Kettunen |
Johannes |
J |
|
Computational Medicine, Institute of Health Sciences, Faculty of Medicine, University of Oulu, Oulu 90570, Finland. |
Visscher PM |
|
Visscher |
Peter M |
PM |
|
University of Queensland Diamantina Institute, University of Queensland, Princess Alexandra Hospital, Brisbane, Queensland 4000, Australia. |
Neely GG |
|
Neely |
G Gregory |
GG |
|
Neuroscience Division, Garvan Institute of Medical Research, Australia and Charles Perkins Centre and School of Molecular Bioscience, The University of Sydney, Sydney, New South Wales 2006, Australia. |
Korstanje R |
|
Korstanje |
Ron |
R |
|
Nathan Shock Center of Excellence in the Basic Biology of Aging, The Jackson Laboratory, Bar Harbor, Maine 04609, USA. |
Hanson RL |
|
Hanson |
Robert L |
RL |
|
Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Disease, National Institutes of Health, Phoenix, Arizona 85001, USA. |
Prokisch H |
|
Prokisch |
Holger |
H |
|
Institute of Human Genetics, Technical University Munich, Munich 85540, Germany. |
Ferrucci L |
|
Ferrucci |
Luigi |
L |
|
Clinical Research Branch, National Institute on Aging, Baltimore, Maryland 21218, USA. |
Esko T |
|
Esko |
Tonu |
T |
|
Department of Genetics, Harvard Medical School, Boston, Massachusetts 02108, USA. |
Teumer A |
|
Teumer |
Alexander |
A |
|
Department of Functional Genomics, Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald 17493, Germany. |
van Meurs JB |
|
van Meurs |
Joyce B J |
JB |
|
Department of Internal Medicine, Erasmus Medical Centre Rotterdam, Rotterdam 3000CA, The Netherlands. |
Johnson AD |
|
Johnson |
Andrew D |
AD |
|
Population Sciences Branch, Division of Intramural Research, National Heart, Lung, and Blood Institute, Bethesda, Maryland 20817, USA. |
|
INVESTIGATORS |
|
LASTNAME |
FORENAME |
INITIALS |
AFFILIATION |
Nalls |
Michael A |
MA |
|
Hernandez |
Dena G |
DG |
|
Cookson |
Mark R |
MR |
|
Gibbs |
Raphael J |
RJ |
|
Hardy |
John |
J |
|
Ramasamy |
Adaikalavan |
A |
|
Zonderman |
Alan B |
AB |
|
Dillman |
Allissa |
A |
|
Traynor |
Bryan |
B |
|
Smith |
Colin |
C |
|
Longo |
Dan L |
DL |
|
Trabzuni |
Daniah |
D |
|
Troncoso |
Juan |
J |
|
van der Brug |
Marcel |
M |
|
Weale |
Michael E |
ME |
|
O'Brien |
Richard |
R |
|
Johnson |
Robert |
R |
|
Walker |
Robert |
R |
|
Zielke |
Ronald H |
RH |
|
Arepalli |
Sampath |
S |
|
Ryten |
Mina |
M |
|
Singleton |
Andrew B |
AB |
|
|
JOURNAL |
|
VOLUME: 6 |
ISSUE: |
TITLE: Nature communications |
ISOABBREVIATION: Nat Commun |
YEAR: 2015 |
MONTH: |
DAY: |
MEDLINEDATE: |
SEASON: |
CITEDMEDIUM: Internet |
ISSN: 2041-1723 |
ISSNTYPE: Electronic |
|
MEDLINE JOURNAL |
|
MEDLINETA: Nat Commun |
COUNTRY: England |
ISSNLINKING: 2041-1723 |
NLMUNIQUEID: 101528555 |
|
PUBLICATION TYPE |
|
PUBLICATIONTYPE TEXT |
Journal Article |
Research Support, N.I.H., Extramural |
Research Support, Non-U.S. Gov't |
|
COMMENTS AND CORRECTIONS |
|
REFTYPE |
REFSOURCE |
REFPMID |
NOTE |
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GRANTS |
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GRANTID |
AGENCY |
COUNTRY |
P30 DK063491 |
NIDDK NIH HHS |
United States |
R01HL105756 |
NHLBI NIH HHS |
United States |
UL1 TR000124 |
NCATS NIH HHS |
United States |
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GENERAL NOTE |
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KEYWORDS |
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MESH HEADINGS |
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SUPPLEMENTARY MESH |
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GENE SYMBOLS |
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CHEMICALS |
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OTHER ID's |
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OTHERID |
SOURCE |
PMC4639797 |
NLM |
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