Genetic Epidemiology, Translational Neurogenomics, Psychiatric Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
26482879
TITLE
Multi-ancestry genome-wide association study of 21,000 cases and 95,000 controls identifies new risk loci for atopic dermatitis.
ABSTRACT
Genetic association studies have identified 21 loci associated with atopic dermatitis risk predominantly in populations of European ancestry. To identify further susceptibility loci for this common, complex skin disease, we performed a meta-analysis of >15 million genetic variants in 21,399 cases and 95,464 controls from populations of European, African, Japanese and Latino ancestry, followed by replication in 32,059 cases and 228,628 controls from 18 studies. We identified ten new risk loci, bringing the total number of known atopic dermatitis risk loci to 31 (with new secondary signals at four of these loci). Notably, the new loci include candidate genes with roles in the regulation of innate host defenses and T cell function, underscoring the important contribution of (auto)immune mechanisms to atopic dermatitis pathogenesis.
DATE PUBLISHED
2015 Dec
HISTORY
PUBSTATUS PUBSTATUSDATE
received 2015/03/20
accepted 2015/09/25
aheadofprint 2015/10/19
entrez 2015/10/21 06:00
pubmed 2015/10/21 06:00
medline 2015/10/21 06:00
pmc-release 2016/06/01 00:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
EArly Genetics and Lifecourse Epidemiology (EAGLE) Eczema Consortium
Australian Asthma Genetics Consortium(AAGC)
Australian Asthma Genetics Consortium AAGC
INVESTIGATORS
LASTNAME FORENAME INITIALS AFFILIATION
Ried Janina S JS
Li Jin J
Zuo Xian Bo XB
Zheng Xiao Dong XD
Yin Xian Yong XY
Sun Liang Dan LD
McAleer Maeve A MA
O'Regan Grainne M GM
Fahy Caoimhe M R CM
Campbell Linda E LE
Macek Milan M
Kurek Michael M
Hu Donglei D
Eng Celeste C
Postma Dirkje S DS
Feenstra Bjarke B
Geller Frank F
Hottenga Jouke Jan JJ
Middeldorp Christel M CM
Hysi Pirro P
Bataille Veronique V
Spector Tim T
Tiesler Carla M T CM
Thiering Elisabeth E
Pahukasahasram Badri B
Yang James J JJ
Imboden Medea M
Huntsman Scott S
Vilor-Tejedor Natàlia N
Relton Caroline L CL
Myhre Ronny R
Nystad Wenche W
Custovic Adnan A
Weiss Scott T ST
Meyers Deborah A DA
Söderhäll Cilla C
Melén Erik E
Ober Carole C
Raby Benjamin A BA
Simpson Angela A
Jacobsson Bo B
Holloway John W JW
Bisgaard Hans H
Sunyer Jordi J
Probst-Hensch Nicole M NM
Williams L Keoki LK
Godfrey Keith M KM
Wang Carol A CA
Boomsma Dorret I DI
Melbye Mads M
Koppelman Gerard H GH
Jarvis Deborah D
McLean W H Irwin WH
Irvine Alan D AD
Zhang Xue Jun XJ
Hakonarson Hakon H
Gieger Christian C
Burchard Esteban G EG
Martin Nicholas G NG
Duijts Liesbeth L
Linneberg Allan A
Jarvelin Marjo-Riitta MR
Nöthen Markus M MM
Lau Susanne S
Hübner Norbert N
Lee Young-Ae YA
Tamari Mayumi M
Hinds David A DA
Glass Daniel D
Brown Sara J SJ
Heinrich Joachim J
Evans David M DM
Weidinger Stephan S
JOURNAL
VOLUME: 47
ISSUE: 12
TITLE: Nature genetics
ISOABBREVIATION: Nat. Genet.
YEAR: 2015
MONTH: Dec
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN: 1546-1718
ISSNTYPE: Electronic
MEDLINE JOURNAL
MEDLINETA: Nat Genet
COUNTRY: United States
ISSNLINKING: 1061-4036
NLMUNIQUEID: 9216904
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
COMMENTS AND CORRECTIONS
REFTYPE REFSOURCE REFPMID NOTE
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GRANTS
GRANTID AGENCY COUNTRY
MC_UU_12013/2 Medical Research Council United Kingdom
MR/J012165/1 Medical Research Council United Kingdom
R01 AI118833 NIAID NIH HHS United States
GENERAL NOTE
KEYWORDS
MESH HEADINGS
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
OTHER ID's
OTHERID SOURCE
EMS65321 [Available on 06/01/16] NLM
PMC4753676 [Available on 06/01/16] NLM
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