|
|
| PMID |
|
|
| TITLE |
|
| Early onset alcohol use and self-harm: a discordant twin analysis. |
|
| ABSTRACT |
|
| BACKGROUND |
NlmCategory: BACKGROUND |
| Self-harm has considerable societal and economic costs and has been extensively studied in relation to alcohol involvement. Although early onset alcohol use (EAU) has been causally linked to maladaptive clinical outcomes, its association with self-harm is less well characterized. This study aimed to further examine the link between EAU and both nonsuicidal self-injury (NSSI) and suicide attempt (SA), and elucidate shared familial and causal/individual-specific pathways that explain this co-occurrence. |
| METHODS |
NlmCategory: METHODS |
| Using data from 6,082 Australian same-sex twin pairs (1,732 monozygotic [MZ] and 1,309 dizygotic [DZ]), ages 23 to 40, we examined prevalence rates of NSSI and SA among twin pairs concordant and discordant for EAU. Conditional logistic regression, controlling for early clinical covariates and the influence of zygosity on EAU, was used to examine the odds ratio (OR) of self-harm within twin pairs discordant for EAU. |
| RESULTS |
NlmCategory: RESULTS |
| Prevalence rates of both NSSI and SA were highest among twin pairs concordant for EAU and for twins who reported EAU within discordant twin pairs. Results from discordant twin analyses revealed nearly 4-fold increased odds of SA for the twin who endorsed EAU, and this OR was equal across MZ and DZ twins. EAU also was associated with elevated odds of NSSI (OR = 7.62), although this was only the case for DZ twins in discordant pairs. |
| CONCLUSIONS |
NlmCategory: CONCLUSIONS |
| The equivalent increase in odds of SA for both MZ and DZ twins suggests that causal or individual-specific influences explain the link between EAU and SA. For NSSI, elevated odds for DZ twins and nonsignificant findings for MZ twins implicate correlated genetic factors in the association between EAU and NSSI. Future studies should test mechanisms through which EAU may causally influence SA, as well as examine whether genetic risk for third variables (e.g., negative urgency, stress reactivity) may explain the genetic overlap between EAU and NSSI. |
| Copyright © 2015 by the Research Society on Alcoholism. |
|
| DATE PUBLISHED |
|
|
| HISTORY |
|
| PUBSTATUS |
PUBSTATUSDATE |
| received |
2015/05/19 |
| accepted |
2015/08/26 |
| aheadofprint |
2015/10/14 |
| entrez |
2015/10/15 06:00 |
| pubmed |
2015/10/16 06:00 |
| medline |
2015/10/16 06:00 |
| pmc-release |
2016/11/01 00:00 |
|
| AUTHORS |
|
| NAME |
COLLECTIVENAME |
LASTNAME |
FORENAME |
INITIALS |
AFFILIATION |
AFFILIATIONINFO |
| Few LR |
|
Few |
Lauren R |
LR |
|
Department of Psychiatry, Washington University School of Medicine, Saint Louis, Missouri. |
| Werner KB |
|
Werner |
Kimberly B |
KB |
|
George Warren Brown School of Social Work, Washington University, Saint Louis, Missouri. |
| Sartor CE |
|
Sartor |
Carolyn E |
CE |
|
Department of Psychiatry, Yale University School of Medicine, West Haven, Connecticut. |
| Grant JD |
|
Grant |
Julia D |
JD |
|
Department of Psychiatry, Washington University School of Medicine, Saint Louis, Missouri. |
| Trull TJ |
|
Trull |
Timothy J |
TJ |
|
Department of Psychological Sciences, University of Missouri, Columbia, Missouri. |
| Nock MK |
|
Nock |
Matthew K |
MK |
|
Department of Psychology, Harvard University, Cambridge, Massachusetts. |
| Bucholz KK |
|
Bucholz |
Kathleen K |
KK |
|
Department of Psychiatry, Washington University School of Medicine, Saint Louis, Missouri. |
| Deitz SK |
|
Deitz |
Sarah K |
SK |
|
Department of Psychiatry, Washington University School of Medicine, Saint Louis, Missouri. |
| Glowinski AL |
|
Glowinski |
Anne L |
AL |
|
Department of Psychiatry, Washington University School of Medicine, Saint Louis, Missouri. |
| Martin NG |
|
Martin |
Nicholas G |
NG |
|
QIMR Medical Research Institute, Brisbane, Queensland, Australia. |
| Nelson EC |
|
Nelson |
Elliot C |
EC |
|
Department of Psychiatry, Washington University School of Medicine, Saint Louis, Missouri. |
| Statham DJ |
|
Statham |
Dixie J |
DJ |
|
School of Social Sciences, University of the Sunshine Coast, Sippy Downs, Queensland, Australia. |
| Madden PA |
|
Madden |
Pamela A F |
PA |
|
Department of Psychiatry, Washington University School of Medicine, Saint Louis, Missouri. |
| Heath AC |
|
Heath |
Andrew C |
AC |
|
Department of Psychiatry, Washington University School of Medicine, Saint Louis, Missouri. |
| Lynskey MT |
|
Lynskey |
Michael T |
MT |
|
Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, United Kingdom. |
| Agrawal A |
|
Agrawal |
Arpana |
A |
|
Department of Psychiatry, Washington University School of Medicine, Saint Louis, Missouri. |
|
| INVESTIGATORS |
|
|
| JOURNAL |
|
| VOLUME: 39 |
| ISSUE: 11 |
| TITLE: Alcoholism, clinical and experimental research |
| ISOABBREVIATION: Alcohol. Clin. Exp. Res. |
| YEAR: 2015 |
| MONTH: Nov |
| DAY: |
| MEDLINEDATE: |
| SEASON: |
| CITEDMEDIUM: Internet |
| ISSN: 1530-0277 |
| ISSNTYPE: Electronic |
|
| MEDLINE JOURNAL |
|
| MEDLINETA: Alcohol Clin Exp Res |
| COUNTRY: England |
| ISSNLINKING: 0145-6008 |
| NLMUNIQUEID: 7707242 |
|
| PUBLICATION TYPE |
|
| PUBLICATIONTYPE TEXT |
| Journal Article |
| Research Support, N.I.H., Extramural |
| Research Support, Non-U.S. Gov't |
|
| COMMENTS AND CORRECTIONS |
|
| REFTYPE |
REFSOURCE |
REFPMID |
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|
|
| GRANTS |
|
| GRANTID |
AGENCY |
COUNTRY |
| AA017921 |
NIAAA NIH HHS |
United States |
| AA023549 |
NIAAA NIH HHS |
United States |
| AA023693 |
NIAAA NIH HHS |
United States |
| AA07728 |
NIAAA NIH HHS |
United States |
| AA11998 |
NIAAA NIH HHS |
United States |
| AA13221 |
NIAAA NIH HHS |
United States |
| AA21235 |
NIAAA NIH HHS |
United States |
| DA18267 |
NIDA NIH HHS |
United States |
| F32 AA023693 |
NIAAA NIH HHS |
United States |
|
| GENERAL NOTE |
|
|
| KEYWORDS |
|
| KEYWORD |
| Early Alcohol Use |
| Self-Harm |
|
| MESH HEADINGS |
|
|
| SUPPLEMENTARY MESH |
|
|
| GENE SYMBOLS |
|
|
| CHEMICALS |
|
|
| OTHER ID's |
|
| OTHERID |
SOURCE |
| NIHMS719363 [Available on 11/01/16] |
NLM |
| PMC4729363 [Available on 11/01/16] |
NLM |
|
|
