Genetic Epidemiology, Psychiatric Genetics, Asthma Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
26414677
TITLE
Large-scale genomic analyses link reproductive aging to hypothalamic signaling, breast cancer susceptibility and BRCA1-mediated DNA repair.
ABSTRACT
NlmCategory: UNASSIGNED
Menopause timing has a substantial impact on infertility and risk of disease, including breast cancer, but the underlying mechanisms are poorly understood. We report a dual strategy in ∼70,000 women to identify common and low-frequency protein-coding variation associated with age at natural menopause (ANM). We identified 44 regions with common variants, including two regions harboring additional rare missense alleles of large effect. We found enrichment of signals in or near genes involved in delayed puberty, highlighting the first molecular links between the onset and end of reproductive lifespan. Pathway analyses identified major association with DNA damage response (DDR) genes, including the first common coding variant in BRCA1 associated with any complex trait. Mendelian randomization analyses supported a causal effect of later ANM on breast cancer risk (∼6% increase in risk per year; P = 3 × 10(-14)), likely mediated by prolonged sex hormone exposure rather than DDR mechanisms.
DATE PUBLISHED
2015 Sep 28
HISTORY
PUBSTATUS PUBSTATUSDATE
received 2015/02/17
accepted 2015/09/02
entrez 2015/09/29 06:00
pubmed 2015/09/29 06:00
medline 2015/09/29 06:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Day FR Day Felix R FR Medical Research Council (MRC) Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, UK.
Ruth KS Ruth Katherine S KS Genetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter, UK.
Thompson DJ Thompson Deborah J DJ Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
Lunetta KL Lunetta Kathryn L KL National Heart, Lung, and Blood Institute and Boston University's Framingham Heart Study, Framingham, Massachusetts, USA.
Pervjakova N Pervjakova Natalia N Institute of Molecular and Cell Biology, University of Tartu, Tartu, Estonia.
Chasman DI Chasman Daniel I DI Harvard Medical School, Boston, Massachusetts, USA.
Stolk L Stolk Lisette L Netherlands Consortium on Health Aging and National Genomics Initiative, Leiden, the Netherlands.
Finucane HK Finucane Hilary K HK Department of Mathematics, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.
Sulem P Sulem Patrick P deCODE Genetics/Amgen, Inc., Reykjavik, Iceland.
Bulik-Sullivan B Bulik-Sullivan Brendan B Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, USA.
Esko T Esko Tõnu T Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.
Johnson AD Johnson Andrew D AD National Heart, Lung, and Blood Institute and Boston University's Framingham Heart Study, Framingham, Massachusetts, USA.
Elks CE Elks Cathy E CE Medical Research Council (MRC) Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, UK.
Franceschini N Franceschini Nora N Department of Epidemiology, University of North Carolina, Chapel Hill, North Carolina, USA.
He C He Chunyan C Indiana University Melvin and Bren Simon Cancer Center, Indianapolis, Indiana, USA.
Altmaier E Altmaier Elisabeth E Institute of Epidemiology II, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.
Brody JA Brody Jennifer A JA Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, Washington, USA.
Franke LL Franke Lude L LL Department of Genetics, University of Groningen, University Medical Centre Groningen, Groningen, the Netherlands.
Huffman JE Huffman Jennifer E JE MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.
Keller MF Keller Margaux F MF Merck Pharmaceuticals, Boston, Massachusetts, USA.
McArdle PF McArdle Patrick F PF Program in Personalized Medicine, Division of Endocrinology, Diabetes and Nutrition, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Nutile T Nutile Teresa T Institute of Genetics and Biophysics, National Research Council, Naples, Italy.
Porcu E Porcu Eleonora E Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, USA.
Robino A Robino Antonietta A Institute for Maternal and Child Health, Scientific Institute for Research, Hospitalisation and Health Care 'Burlo Garofolo', Trieste, Italy.
Rose LM Rose Lynda M LM Division of Preventive Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA.
Schick UM Schick Ursula M UM Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.
Smith JA Smith Jennifer A JA Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, Michigan, USA.
Teumer A Teumer Alexander A Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany.
Traglia M Traglia Michela M Division of Genetics and Cell Biology, San Raffaele Scientific Institute, Milan, Italy.
Vuckovic D Vuckovic Dragana D Department of Clinical Medical Sciences, Surgical and Health, University of Trieste, Trieste, Italy.
Yao J Yao Jie J Institute for Translational Genomics and Population Sciences, Department of Pediatrics, LABioMed at Harbor-UCLA Medical Center, Torrance, California, USA.
Zhao W Zhao Wei W Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, Michigan, USA.
Albrecht E Albrecht Eva E Institute of Genetic Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.
Amin N Amin Najaf N Genetic Epidemiology Unit, Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands.
Corre T Corre Tanguy T Swiss Institute of Bioinformatics, Lausanne, Switzerland.
Hottenga JJ Hottenga Jouke-Jan JJ Department of Biological Psychology, VU University Amsterdam, Amsterdam, the Netherlands.
Mangino M Mangino Massimo M National Institute for Health Research (NIHR) Biomedical Research Centre at Guy's and St Thomas' Foundation Trust, London, UK.
Smith AV Smith Albert V AV Faculty of Medicine, University of Iceland, Reykjavik, Iceland.
Tanaka T Tanaka Toshiko T Longitudinal Studies Section, Translational Gerontology Branch, National Institute on Aging, Baltimore, Maryland, USA.
Abecasis GR Abecasis Gonçalo R GR Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, USA.
Andrulis IL Andrulis Irene L IL Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada.
Anton-Culver H Anton-Culver Hoda H Department of Epidemiology, University of California-Irvine, Irvine, California, USA.
Antoniou AC Antoniou Antonis C AC Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
Arndt V Arndt Volker V Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Arnold AM Arnold Alice M AM Department of Biostatistics, University of Washington, Seattle, Washington, USA.
Barbieri C Barbieri Caterina C Division of Genetics and Cell Biology, San Raffaele Scientific Institute, Milan, Italy.
Beckmann MW Beckmann Matthias W MW Department of Gynaecology and Obstetrics, University Hospital Erlangen, Friedrich Alexander University Erlangen-Nuremberg, Erlangen, Germany.
Beeghly-Fadiel A Beeghly-Fadiel Alicia A Division of Epidemiology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.
Benitez J Benitez Javier J Centro de Investigación en Red de Enfermedades Raras (CIBERER), Valencia, Spain.
Bernstein L Bernstein Leslie L Beckman Research Institute of City of Hope, Duarte, California, USA.
Bielinski SJ Bielinski Suzette J SJ Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, USA.
Blomqvist C Blomqvist Carl C Department of Oncology, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland.
Boerwinkle E Boerwinkle Eric E Human Genome Sequencing Center, Baylor College of Medicine, Houston, Texas, USA.
Bogdanova NV Bogdanova Natalia V NV Department of Radiation Oncology, Hannover Medical School, Hannover, Germany.
Bojesen SE Bojesen Stig E SE Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, University of Copenhagen, Copenhagen, Denmark.
Bolla MK Bolla Manjeet K MK Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
Borresen-Dale AL Borresen-Dale Anne-Lise AL Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway.
Boutin TS Boutin Thibaud S TS MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.
Brauch H Brauch Hiltrud H German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.
Brenner H Brenner Hermann H Division of Preventive Oncology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Brüning T Brüning Thomas T Institute for Prevention and Occupational Medicine of the German Social Accident Insurance Institute of Ruhr University Bochum (IPA), Bochum, Germany.
Burwinkel B Burwinkel Barbara B Molecular Biology of Breast Cancer, Department of Obstetrics and Gynecology, University of Heidelberg, Heidelberg, Germany.
Campbell A Campbell Archie A Medical Genetics Section, Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.
Campbell H Campbell Harry H Institute for Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK.
Chanock SJ Chanock Stephen J SJ Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA.
Chapman JR Chapman J Ross JR Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.
Chen YI Chen Yii-Der Ida YI Institute for Translational Genomics and Population Sciences, Department of Pediatrics, LABioMed at Harbor-UCLA Medical Center, Torrance, California, USA.
Chenevix-Trench G Chenevix-Trench Georgia G Department of Genetics, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
Couch FJ Couch Fergus J FJ Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA.
Coviello AD Coviello Andrea D AD Section of Endocrinology, Department of Medicine, Boston University School of Medicine, Boston, Massachusetts, USA.
Cox A Cox Angela A Sheffield Cancer Research, Department of Oncology, University of Sheffield, Sheffield, UK.
Czene K Czene Kamila K Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Darabi H Darabi Hatef H Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
De Vivo I De Vivo Immaculata I Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.
Demerath EW Demerath Ellen W EW Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, Minnesota, USA.
Dennis J Dennis Joe J Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
Devilee P Devilee Peter P Department of Pathology, Leiden University Medical Center, Leiden, the Netherlands.
Dörk T Dörk Thilo T Gynaecology Research Unit, Hannover Medical School, Hannover, Germany.
Dos-Santos-Silva I Dos-Santos-Silva Isabel I Non-Communicable Disease Epidemiology Department, London School of Hygiene and Tropical Medicine, London, UK.
Dunning AM Dunning Alison M AM Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK.
Eicher JD Eicher John D JD National Heart, Lung, and Blood Institute and Boston University's Framingham Heart Study, Framingham, Massachusetts, USA.
Fasching PA Fasching Peter A PA Division of Hematology and Oncology, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California, USA.
Faul JD Faul Jessica D JD Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, Michigan, USA.
Figueroa J Figueroa Jonine J Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland, USA.
Flesch-Janys D Flesch-Janys Dieter D Institute for Medical Biometrics and Epidemiology, University Clinic Hamburg-Eppendorf, Hamburg, Germany.
Gandin I Gandin Ilaria I Department of Clinical Medical Sciences, Surgical and Health, University of Trieste, Trieste, Italy.
Garcia ME Garcia Melissa E ME Laboratory of Epidemiology and Population Sciences, National Institute on Aging, Bethesda, Maryland, USA.
García-Closas M García-Closas Montserrat M Division of Cancer Studies, Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, London, UK.
Giles GG Giles Graham G GG Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Victoria, Australia.
Girotto GG Girotto Giorgia G GG Department of Clinical Medical Sciences, Surgical and Health, University of Trieste, Trieste, Italy.
Goldberg MS Goldberg Mark S MS Division of Clinical Epidemiology, Royal Victoria Hospital, McGill University, Montreal, Quebec, Canada.
González-Neira A González-Neira Anna A Human Genetics Group, Human Cancer Genetics Program, Spanish National Cancer Research Centre (CNIO), Madrid, Spain.
Goodarzi MO Goodarzi Mark O MO Division of Endocrinology, Diabetes and Metabolism, Cedars-Sinai Medical Center, Los Angeles, California, USA.
Grove ML Grove Megan L ML Human Genetics Center, School of Public Health, University of Texas Health Science Center at Houston, Houston, Texas, USA.
Gudbjartsson DF Gudbjartsson Daniel F DF School of Engineering and Natural Sciences, University of Iceland, Reykjavik, Iceland.
Guénel P Guénel Pascal P University Paris-Sud, UMRS 1018, Villejuif, France.
Guo X Guo Xiuqing X Institute for Translational Genomics and Population Sciences, Department of Pediatrics, LABioMed at Harbor-UCLA Medical Center, Torrance, California, USA.
Haiman CA Haiman Christopher A CA Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
Hall P Hall Per P Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Hamann U Hamann Ute U Molecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Henderson BE Henderson Brian E BE Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
Hocking LJ Hocking Lynne J LJ Musculoskeletal Research Programme, Division of Applied Medicine, University of Aberdeen, Aberdeen, UK.
Hofman A Hofman Albert A Genetic Epidemiology Unit, Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands.
Homuth G Homuth Georg G Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, Germany.
Hooning MJ Hooning Maartje J MJ Department of Medical Oncology, Erasmus University Medical Center, Rotterdam, the Netherlands.
Hopper JL Hopper John L JL Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Melbourne, Victoria, Australia.
Hu FB Hu Frank B FB Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, USA.
Huang J Huang Jinyan J State Key Laboratory of Medical Genomics, Shanghai Institute of Hematology, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Humphreys K Humphreys Keith K Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Hunter DJ Hunter David J DJ Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, USA.
Jakubowska A Jakubowska Anna A Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland.
Jones SE Jones Samuel E SE Genetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter, UK.
Kabisch M Kabisch Maria M Molecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Karasik D Karasik David D Hebrew SeniorLife Institute for Aging Research, Boston, Massachusetts, USA.
Knight JA Knight Julia A JA Division of Epidemiology, Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada.
Kolcic I Kolcic Ivana I Faculty of Medicine, University of Split, Split, Croatia.
Kooperberg C Kooperberg Charles C Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.
Kosma VM Kosma Veli-Matti VM Imaging Center, Department of Clinical Pathology, Kuopio University Hospital, Kuopio, Finland.
Kriebel J Kriebel Jennifer J German Center for Diabetes Research, Neuherberg, Germany.
Kristensen V Kristensen Vessela V Department of Clinical Molecular Biology, Oslo University Hospital, University of Oslo, Oslo, Norway.
Lambrechts D Lambrechts Diether D Laboratory for Translational Genetics, Department of Oncology, University of Leuven, Leuven, Belgium.
Langenberg C Langenberg Claudia C Medical Research Council (MRC) Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, UK.
Li J Li Jingmei J Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Li X Li Xin X Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA.
Lindström S Lindström Sara S Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA.
Liu Y Liu Yongmei Y Center for Human Genetics, Division of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA.
Luan J Luan Jian'an J Medical Research Council (MRC) Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, UK.
Lubinski J Lubinski Jan J Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland.
Mägi R Mägi Reedik R Estonian Genome Center, University of Tartu, Tartu, Estonia.
Mannermaa A Mannermaa Arto A Imaging Center, Department of Clinical Pathology, Kuopio University Hospital, Kuopio, Finland.
Manz J Manz Judith J Institute of Epidemiology II, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.
Margolin S Margolin Sara S Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden.
Marten J Marten Jonathan J MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.
Martin NG Martin Nicholas G NG QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
Masciullo C Masciullo Corrado C Division of Genetics and Cell Biology, San Raffaele Scientific Institute, Milan, Italy.
Meindl A Meindl Alfons A Division of Gynaecology and Obstetrics, Technische Universität München, Munich, Germany.
Michailidou K Michailidou Kyriaki K Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
Mihailov E Mihailov Evelin E Estonian Genome Center, University of Tartu, Tartu, Estonia.
Milani L Milani Lili L Estonian Genome Center, University of Tartu, Tartu, Estonia.
Milne RL Milne Roger L RL Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Victoria, Australia.
Müller-Nurasyid M Müller-Nurasyid Martina M German Center for Cardiovascular Research (DZHK), partner site Munich Heart Alliance, Munich, Germany.
Nalls M Nalls Michael M Laboratory of Neurogenetics, National Institute on Aging, Bethesda, Maryland, USA.
Neale BM Neale Benjamin M BM Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, USA.
Nevanlinna H Nevanlinna Heli H Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland.
Neven P Neven Patrick P Department of Oncology, University Hospitals Leuven, Leuven, Belgium.
Newman AB Newman Anne B AB Department of Clinical and Translational Science, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Nordestgaard BG Nordestgaard Børge G BG Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, University of Copenhagen, Copenhagen, Denmark.
Olson JE Olson Janet E JE Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, USA.
Padmanabhan S Padmanabhan Sandosh S British Heart Foundation Glasgow Cardiovascular Research Centre, Institute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK.
Peterlongo P Peterlongo Paolo P Fondazione Istituto FIRC di Oncologia Molecolare (IFOM), Milan, Italy.
Peters U Peters Ulrike U Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.
Petersmann A Petersmann Astrid A Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Greifswald, Germany.
Peto J Peto Julian J Non-Communicable Disease Epidemiology Department, London School of Hygiene and Tropical Medicine, London, UK.
Pharoah PD Pharoah Paul D P PD Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK.
Pirastu NN Pirastu Nicola N NN Department of Clinical Medical Sciences, Surgical and Health, University of Trieste, Trieste, Italy.
Pirie A Pirie Ailith A Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
Pistis G Pistis Giorgio G Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, USA.
Polasek O Polasek Ozren O Faculty of Medicine, University of Split, Split, Croatia.
Porteous D Porteous David D Medical Genetics Section, Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.
Psaty BM Psaty Bruce M BM Department of Health Services, University of Washington, Seattle, Washington, USA.
Pylkäs K Pylkäs Katri K Laboratory of Cancer Genetics and Tumor Biology, Northern Finland Laboratory Centre NordLab, Oulu, Finland.
Radice P Radice Paolo P Unit of Molecular Bases of Genetic Risk and Genetic Testing, Department of Preventive and Predictive Medicine, Fondazione IRCCS Istituto Nazionale dei Tumori (INT), Milan, Italy.
Raffel LJ Raffel Leslie J LJ UCLA Clinical and Translational Science Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA.
Rivadeneira F Rivadeneira Fernando F Genetic Epidemiology Unit, Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands.
Rudan I Rudan Igor I Institute for Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK.
Rudolph A Rudolph Anja A Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Ruggiero D Ruggiero Daniela D Institute of Genetics and Biophysics, National Research Council, Naples, Italy.
Sala CF Sala Cinzia F CF Division of Genetics and Cell Biology, San Raffaele Scientific Institute, Milan, Italy.
Sanna S Sanna Serena S Institute of Genetics and Biomedical Research, National Research Council, Cagliari, Italy.
Sawyer EJ Sawyer Elinor J EJ Research Oncology, Guy's Hospital, King's College London, London, UK.
Schlessinger D Schlessinger David D National Institute on Aging, Intramural Research Program, Baltimore, Maryland, USA.
Schmidt MK Schmidt Marjanka K MK Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Amsterdam, the Netherlands.
Schmidt F Schmidt Frank F Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, Germany.
Schmutzler RK Schmutzler Rita K RK Center for Integrated Oncology, University Hospital of Cologne, Cologne, Germany.
Schoemaker MJ Schoemaker Minouk J MJ Division of Genetics and Epidemiology, The Institute of Cancer Research, London, UK.
Scott RA Scott Robert A RA Medical Research Council (MRC) Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, UK.
Seynaeve CM Seynaeve Caroline M CM Department of Medical Oncology, Erasmus University Medical Center, Rotterdam, the Netherlands.
Simard J Simard Jacques J Centre Hospitalier Universitaire de Québec Research Center, Laval University, Quebec City, Quebec, Canada.
Sorice R Sorice Rossella R Institute of Genetics and Biophysics, National Research Council, Naples, Italy.
Southey MC Southey Melissa C MC Department of Pathology, University of Melbourne, Melbourne, Victoria, Australia.
Stöckl D Stöckl Doris D Institute of Epidemiology II, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.
Strauch K Strauch Konstantin K Chair of Genetic Epidemiology, Institute of Medical Informatics, Biometry and Epidemiology, Ludwig Maximilians Universität, Munich, Germany.
Swerdlow A Swerdlow Anthony A Division of Breast Cancer Research, The Institute of Cancer Research, London, UK.
Taylor KD Taylor Kent D KD Institute for Translational Genomics and Population Sciences, Department of Pediatrics, LABioMed at Harbor-UCLA Medical Center, Torrance, California, USA.
Thorsteinsdottir U Thorsteinsdottir Unnur U Faculty of Medicine, University of Iceland, Reykjavik, Iceland.
Toland AE Toland Amanda E AE Department of Molecular Virology, Immunology and Medical Genetics, Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio, USA.
Tomlinson I Tomlinson Ian I NIHR Oxford Biomedical Research Centre, Churchill Hospital, Oxford, UK.
Truong T Truong Thérèse T University Paris-Sud, UMRS 1018, Villejuif, France.
Tryggvadottir L Tryggvadottir Laufey L Icelandic Cancer Registry, Reykjavik, Iceland.
Turner ST Turner Stephen T ST Division of Nephrology and Hypertension, Department of Internal Medicine, Mayo Clinic, Rochester, Minnesota, USA.
Vozzi D Vozzi Diego D Institute for Maternal and Child Health, Scientific Institute for Research, Hospitalisation and Health Care 'Burlo Garofolo', Trieste, Italy.
Wang Q Wang Qin Q Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
Wellons M Wellons Melissa M Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Willemsen G Willemsen Gonneke G Department of Biological Psychology, VU University Amsterdam, Amsterdam, the Netherlands.
Wilson JF Wilson James F JF Institute for Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK.
Winqvist R Winqvist Robert R Laboratory of Cancer Genetics and Tumor Biology, Northern Finland Laboratory Centre NordLab, Oulu, Finland.
Wolffenbuttel BB Wolffenbuttel Bruce B H R BB LifeLines Cohort Study and Biobank, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.
Wright AF Wright Alan F AF MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.
Yannoukakos D Yannoukakos Drakoulis D Molecular Diagnostics Laboratory, Institute of Radioisotopes and Radiodiagnostic Products, National Centre for Scientific Research 'Demokritos', Athens, Greece.
Zemunik T Zemunik Tatijana T Faculty of Medicine, University of Split, Split, Croatia.
Zheng W Zheng Wei W Division of Epidemiology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.
Zygmunt M Zygmunt Marek M Department of Obstetrics and Gynecology, University Medicine Greifswald, Greifswald, Germany.
Bergmann S Bergmann Sven S Swiss Institute of Bioinformatics, Lausanne, Switzerland.
Boomsma DI Boomsma Dorret I DI Department of Biological Psychology, VU University Amsterdam, Amsterdam, the Netherlands.
Buring JE Buring Julie E JE Harvard Medical School, Boston, Massachusetts, USA.
Ferrucci L Ferrucci Luigi L Longitudinal Studies Section, Translational Gerontology Branch, National Institute on Aging, Baltimore, Maryland, USA.
Montgomery GW Montgomery Grant W GW QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
Gudnason V Gudnason Vilmundur V Faculty of Medicine, University of Iceland, Reykjavik, Iceland.
Spector TD Spector Tim D TD Department of Twin Research and Genetic Epidemiology, King's College London, London, UK.
van Duijn CM van Duijn Cornelia M CM Genetic Epidemiology Unit, Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands.
Alizadeh BZ Alizadeh Behrooz Z BZ Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
Ciullo M Ciullo Marina M Institute of Genetics and Biophysics, National Research Council, Naples, Italy.
Crisponi L Crisponi Laura L Institute of Genetics and Biomedical Research, National Research Council, Cagliari, Italy.
Easton DF Easton Douglas F DF Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK.
Gasparini PP Gasparini Paolo P PP Department of Clinical Medical Sciences, Surgical and Health, University of Trieste, Trieste, Italy.
Gieger C Gieger Christian C Institute of Epidemiology II, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.
Harris TB Harris Tamara B TB Laboratory of Epidemiology and Population Sciences, National Institute on Aging, Bethesda, Maryland, USA.
Hayward C Hayward Caroline C MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.
Kardia SL Kardia Sharon L R SL Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, Michigan, USA.
Kraft P Kraft Peter P Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts, USA.
McKnight B McKnight Barbara B Department of Biostatistics, University of Washington, Seattle, Washington, USA.
Metspalu A Metspalu Andres A Estonian Genome Center, University of Tartu, Tartu, Estonia.
Morrison AC Morrison Alanna C AC Human Genetics Center, School of Public Health, University of Texas Health Science Center at Houston, Houston, Texas, USA.
Reiner AP Reiner Alex P AP Department of Epidemiology, School of Public Health, University of Washington, Seattle, Washington, USA.
Ridker PM Ridker Paul M PM Harvard Medical School, Boston, Massachusetts, USA.
Rotter JI Rotter Jerome I JI Institute for Translational Genomics and Population Sciences, Department of Pediatrics, LABioMed at Harbor-UCLA Medical Center, Torrance, California, USA.
Toniolo D Toniolo Daniela D Division of Genetics and Cell Biology, San Raffaele Scientific Institute, Milan, Italy.
Uitterlinden AG Uitterlinden André G AG Genetic Epidemiology Unit, Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands.
Ulivi S Ulivi Sheila S Institute for Maternal and Child Health, Scientific Institute for Research, Hospitalisation and Health Care 'Burlo Garofolo', Trieste, Italy.
Völzke H Völzke Henry H Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany.
Wareham NJ Wareham Nicholas J NJ Medical Research Council (MRC) Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, UK.
Weir DR Weir David R DR Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, Michigan, USA.
Yerges-Armstrong LM Yerges-Armstrong Laura M LM Program in Personalized Medicine, Division of Endocrinology, Diabetes and Nutrition, University of Maryland School of Medicine, Baltimore, Maryland, USA.
PRACTICAL Consortium
kConFab Investigators
AOCS Investigators
Generation Scotland
EPIC-InterAct Consortium
LifeLines Cohort Study
Price AL Price Alkes L AL Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA.
Stefansson K Stefansson Kari K Faculty of Medicine, University of Iceland, Reykjavik, Iceland.
Visser JA Visser Jenny A JA Department of Internal Medicine, Erasmus Medical Center, Rotterdam, the Netherlands.
Ong KK Ong Ken K KK Department of Paediatrics, University of Cambridge, Cambridge, UK.
Chang-Claude J Chang-Claude Jenny J Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Murabito JM Murabito Joanne M JM Section of General Internal Medicine, Department of Medicine, Boston University School of Medicine, Boston, Massachusetts, USA.
Perry JR Perry John R B JR Medical Research Council (MRC) Epidemiology Unit, University of Cambridge School of Clinical Medicine, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, UK.
Murray A Murray Anna A Genetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter, UK.
INVESTIGATORS
JOURNAL
VOLUME:
ISSUE:
TITLE: Nature genetics
ISOABBREVIATION: Nat. Genet.
YEAR: 2015
MONTH: Sep
DAY: 28
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN: 1546-1718
ISSNTYPE: Electronic
MEDLINE JOURNAL
MEDLINETA: Nat Genet
COUNTRY: United States
ISSNLINKING: 1061-4036
NLMUNIQUEID: 9216904
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
JOURNAL ARTICLE
COMMENTS AND CORRECTIONS
GRANTS
GENERAL NOTE
KEYWORDS
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SUPPLEMENTARY MESH
GENE SYMBOLS
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