Genetic Epidemiology, Translational Neurogenomics, Psychiatric Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
26414677
TITLE
Large-scale genomic analyses link reproductive aging to hypothalamic signaling, breast cancer susceptibility and BRCA1-mediated DNA repair.
ABSTRACT
Menopause timing has a substantial impact on infertility and risk of disease, including breast cancer, but the underlying mechanisms are poorly understood. We report a dual strategy in ∼70,000 women to identify common and low-frequency protein-coding variation associated with age at natural menopause (ANM). We identified 44 regions with common variants, including two regions harboring additional rare missense alleles of large effect. We found enrichment of signals in or near genes involved in delayed puberty, highlighting the first molecular links between the onset and end of reproductive lifespan. Pathway analyses identified major association with DNA damage response (DDR) genes, including the first common coding variant in BRCA1 associated with any complex trait. Mendelian randomization analyses supported a causal effect of later ANM on breast cancer risk (∼6% increase in risk per year; P = 3 × 10(-14)), likely mediated by prolonged sex hormone exposure rather than DDR mechanisms.
DATE PUBLISHED
2015 Nov
HISTORY
PUBSTATUS PUBSTATUSDATE
received 2015/02/17
accepted 2015/09/02
entrez 2015/09/29 06:00
pubmed 2015/09/29 06:00
medline 2016/03/08 06:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Day FR Day Felix R FR MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Box 285 Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, CB2 0QQ, UK.
Ruth KS Ruth Katherine S KS Genetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter, EX2 5DW, UK.
Thompson DJ Thompson Deborah J DJ Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, CB1 8RN, UK.
Lunetta KL Lunetta Kathryn L KL NHLBI's and Boston University's Framingham Heart Study, Framingham, Massachusetts 01702-5827, USA.
Pervjakova N Pervjakova Natalia N Institute of Molecular and Cell Biology, University of Tartu, Tartu 51010, Estonia.
Chasman DI Chasman Daniel I DI Harvard Medical School, Boston, MA 02115, USA.
Stolk L Stolk Lisette L Netherlands Consortium on Health Aging and National Genomics Initiative, 2300 RC Leiden, the Netherlands.
Finucane HK Finucane Hilary K HK Department of Mathematics, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139-4307, USA.
Sulem P Sulem Patrick P deCODE genetics/Amgen, Inc., IS-101 Reykjavik, Iceland.
Bulik-Sullivan B Bulik-Sullivan Brendan B Medical and Population Genetics, Broad Institute, Cambridge, MA 02142, US.
Esko T Esko Tõnu T Broad Institute of the Massachusetts Institute of Technology and Harvard University, 140 Cambridge 02142, MA, USA.
Johnson AD Johnson Andrew D AD NHLBI's and Boston University's Framingham Heart Study, Framingham, Massachusetts 01702-5827, USA.
Elks CE Elks Cathy E CE MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Box 285 Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, CB2 0QQ, UK.
Franceschini N Franceschini Nora N Department of Epidemiology, University of North Carolina, Chapel Hill, NC 27599, USA.
He C He Chunyan C Indiana University Melvin and Bren Simon Cancer Center, Indianapolis, IN 46202, USA.
Altmaier E Altmaier Elisabeth E Institute of Epidemiology II, Helmholtz Zentrum München - German Research Center for Environmental Health, 85764 Neuherberg, Germany.
Brody JA Brody Jennifer A JA Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle Washington 98101 USA.
Franke LL Franke Lude L LL Department of Genetics, University of Groningen, University Medical Centre Groningen, Groningen, The Netherlands.
Huffman JE Huffman Jennifer E JE Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh EH4 2XU, UK.
Keller MF Keller Margaux F MF Merck Pharmaceuticals, 33 Avenue Louis Pasteur, Boston, MA 02115, United States.
McArdle PF McArdle Patrick F PF Program in Personalized Medicine, Division of Endocrinology, Diabetes and Nutrition - University of Maryland School of Medicine, USA. Baltimore, MD 21201.
Nutile T Nutile Teresa T Institute of Genetics and Biophysics - CNR, via Pietro Castellino 111, 80131, Naples, Italy.
Porcu E Porcu Eleonora E Center for Statistical Genetics, Ann Arbor, University of Michigan, Michigan 48109-2029, USA.
Robino A Robino Antonietta A Institute for Maternal and Child Health - IRCCS "Burlo Garofolo", 34137 Trieste, Italy.
Rose LM Rose Lynda M LM Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA 02215.
Schick UM Schick Ursula M UM Fred Hutchinson Cancer Research Center, Public Health Sciences Division, Seattle, WA 98109-1024, USA.
Smith JA Smith Jennifer A JA Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA.
Teumer A Teumer Alexander A Institute for Community Medicine, University Medicine Greifswald, 17475 Greifswald, Germany.
Traglia M Traglia Michela M Division of Genetics and Cell Biology, San Raffaele Scientific Institute, 20132 Milano, Italy.
Vuckovic D Vuckovic Dragana D Department of Clinical Medical Sciences, Surgical and Health, University of Trieste, 34149 Trieste, Italy.
Yao J Yao Jie J The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, LABioMed at Harbor-UCLA Medical Center, Torrance, California, USA.
Zhao W Zhao Wei W Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA.
Albrecht E Albrecht Eva E Institute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, 85764 Neuherberg, Germany.
Amin N Amin Najaf N Genetic Epidemiology Unit Department of Epidemiology, Erasmus MC, 3015 GE, Rotterdam, the Netherlands.
Corre T Corre Tanguy T Swiss Institute of Bioinformatics, CH-1015, Lausanne, Switzerland.
Hottenga JJ Hottenga Jouke-Jan JJ Department of Biological Psychology, VU University Amsterdam, van der Boechorststraat 1, 1081 BT, Amsterdam, The Netherlands.
Mangino M Mangino Massimo M National Institute for Health Research (NIHR) Biomedical Research Centre at Guy's and St. Thomas' Foundation Trust, London, UK.
Smith AV Smith Albert V AV Faculty of Medicine, University of Iceland, IS-101 Reykjavik, Iceland.
Tanaka T Tanaka Toshiko T Longitudinal Studies Section, Translational Gerontology Branch, National Institute on Aging, Baltimore, Maryland 21224, United States of America.
Abecasis G Abecasis Goncalo G Center for Statistical Genetics, Ann Arbor, University of Michigan, Michigan 48109-2029, USA.
Andrulis IL Andrulis Irene L IL Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada.
Anton-Culver H Anton-Culver Hoda H Department of Epidemiology, University of California Irvine, Irvine, California, USA.
Antoniou AC Antoniou Antonis C AC Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, CB1 8RN, UK.
Arndt V Arndt Volker V Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Arnold AM Arnold Alice M AM Department of Biostatistics, University of Washington, Seattle, WA, USA.
Barbieri C Barbieri Caterina C Division of Genetics and Cell Biology, San Raffaele Scientific Institute, 20132 Milano, Italy.
Beckmann MW Beckmann Matthias W MW Department of Gynaecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen, Germany.
Beeghly-Fadiel A Beeghly-Fadiel Alicia A Division of Epidemiology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN, USA.
Benitez J Benitez Javier J Centro de Investigación en Red de Enfermedades Raras (CIBERER), Valencia, Spain.
Bernstein L Bernstein Leslie L Beckman Research Institute of City of Hope, Duarte, CA, USA.
Bielinski SJ Bielinski Suzette J SJ Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, USA.
Blomqvist C Blomqvist Carl C Department of Oncology, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland.
Boerwinkle E Boerwinkle Eric E Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX 77030, USA.
Bogdanova NV Bogdanova Natalia V NV Department of Radiation Oncology, Hannover Medical School, Hannover, Germany.
Bojesen SE Bojesen Stig E SE Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, University of Copenhagen, Copenhagen, Denmark.
Bolla MK Bolla Manjeet K MK Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, CB1 8RN, UK.
Borresen-Dale AL Borresen-Dale Anne-Lise AL Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway.
Boutin TS Boutin Thibaud S TS Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh EH4 2XU, UK.
Brauch H Brauch Hiltrud H German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.
Brenner H Brenner Hermann H Division of Preventive Oncology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Brüning T Brüning Thomas T Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute of the Ruhr University Bochum (IPA), Bochum, Germany.
Burwinkel B Burwinkel Barbara B Molecular Biology of Breast Cancer, Department of Obstetrics and Gynecology, University of Heidelberg, Heidelberg, Germany.
Campbell A Campbell Archie A Medical Genetics Section, Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh EH4 2XU, UK.
Campbell H Campbell Harry H Institute for Population Health Sciences and Informatics, University of Edinburgh, Teviot Place, Edinburgh, EH8 9AG, Scotland.
Chanock SJ Chanock Stephen J SJ Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.
Chapman JR Chapman J Ross JR Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.
Chen YI Chen Yii-Der Ida YI The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, LABioMed at Harbor-UCLA Medical Center, Torrance, California, USA.
Chenevix-Trench G Chenevix-Trench Georgia G Department of Genetics, QIMR Berghofer Medical Research Institute, Brisbane, Australia.
Couch FJ Couch Fergus J FJ Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA.
Coviello AD Coviello Andrea D AD Boston University School of Medicine, Department of Medicine, Sections of Preventive Medicine and Endocrinology, Boston, MA.
Cox A Cox Angela A Sheffield Cancer Research, Department of Oncology, University of Sheffield, Sheffield, UK.
Czene K Czene Kamila K Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, 17177 Stockholm, Sweden.
Darabi H Darabi Hatef H Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, 17177 Stockholm, Sweden.
De Vivo I De Vivo Immaculata I Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.
Demerath EW Demerath Ellen W EW Division of Epidemiology & Community Health, University of Minnesotta, Minneapolis MN 55455.
Dennis J Dennis Joe J Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, CB1 8RN, UK.
Devilee P Devilee Peter P Department of Pathology, Leiden University Medical Center, 2300 RC Leiden, The Netherlands.
Dörk T Dörk Thilo T Gynaecology Research Unit, Hannover Medical School, Hannover, Germany.
Dos-Santos-Silva I Dos-Santos-Silva Isabel I Non-communicable Disease Epidemiology Department, London School of Hygiene and Tropical Medicine, London, UK.
Dunning AM Dunning Alison M AM Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, CB1 8RN, UK.
Eicher JD Eicher John D JD NHLBI's and Boston University's Framingham Heart Study, Framingham, Massachusetts 01702-5827, USA.
Fasching PA Fasching Peter A PA David Geffen School of Medicine, Department of Medicine Division of Hematology and Oncology, University of California at Los Angeles, CA, USA.
Faul JD Faul Jessica D JD Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, USA.
Figueroa J Figueroa Jonine J Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA.
Flesch-Janys D Flesch-Janys Dieter D Institute for Medical Biometrics and Epidemiology, University Clinic Hamburg-Eppendorf, Hamburg, Germany.
Gandin I Gandin Ilaria I Department of Clinical Medical Sciences, Surgical and Health, University of Trieste, 34149 Trieste, Italy.
Garcia ME Garcia Melissa E ME Laboratory of Epidemiology and Population Sciences, National Institute on Aging, Bethesda, MD, USA.
García-Closas M García-Closas Montserrat M Division of Cancer Studies, Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, London, UK.
Giles GG Giles Graham G GG Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Australia.
Girotto GG Girotto Giorgia G GG Department of Clinical Medical Sciences, Surgical and Health, University of Trieste, 34149 Trieste, Italy.
Goldberg MS Goldberg Mark S MS Division of Clinical Epidemiology, Royal Victoria Hospital, McGill University, Montreal, Canada.
González-Neira A González-Neira Anna A Human Genetics Group, Human Cancer Genetics Program, Spanish National Cancer Research Centre (CNIO), Madrid, Spain.
Goodarzi MO Goodarzi Mark O MO Division of Endocrinology, Diabetes and Metabolism, Cedars-Sinai Medical Center, Los Angeles, California, USA.
Grove ML Grove Megan L ML Human Genetics Center, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX 77030, USA.
Gudbjartsson DF Gudbjartsson Daniel F DF School of Engineering and Natural Sciences, University of Iceland, IS-101 Reykjavik, Iceland.
Guénel P Guénel Pascal P University Paris-Sud, UMRS 1018, Villejuif, France.
Guo X Guo Xiuqing X The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, LABioMed at Harbor-UCLA Medical Center, Torrance, California, USA.
Haiman CA Haiman Christopher A CA Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Hall P Hall Per P Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, 17177 Stockholm, Sweden.
Hamann U Hamann Ute U Molecular Genetics of Breast Cancer, Deutsches Krebsforschungszentrum (DKFZ), Heidelberg, Germany.
Henderson BE Henderson Brian E BE Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Hocking LJ Hocking Lynne J LJ Musculoskeletal Research Programme, Division of Applied Medicine, University of Aberdeen, Aberdeen AB25 2ZD, UK.
Hofman A Hofman Albert A Genetic Epidemiology Unit Department of Epidemiology, Erasmus MC, 3015 GE, Rotterdam, the Netherlands.
Homuth G Homuth Georg G Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, 17475 Greifswald, Germany.
Hooning MJ Hooning Maartje J MJ Department of Medical Oncology, Erasmus University Medical Center, Rotterdam, The Netherlands.
Hopper JL Hopper John L JL Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Australia.
Hu FB Hu Frank B FB Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA.
Huang J Huang Jinyan J State Key Laboratory of Medical Genomics,Shanghai Institute of Hematology, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
Humphreys K Humphreys Keith K Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, 17177 Stockholm, Sweden.
Hunter DJ Hunter David J DJ Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA.
Jakubowska A Jakubowska Anna A Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland.
Jones SE Jones Samuel E SE Genetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter, EX2 5DW, UK.
Kabisch M Kabisch Maria M Molecular Genetics of Breast Cancer, Deutsches Krebsforschungszentrum (DKFZ), Heidelberg, Germany.
Karasik D Karasik David D Hebrew SeniorLife Institute for Aging Research, Boston, MA, 02131, USA.
Knight JA Knight Julia A JA Division of Epidemiology, Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada.
Kolcic I Kolcic Ivana I Faculty of Medicine, University of Split, Split, Croatia.
Kooperberg C Kooperberg Charles C Fred Hutchinson Cancer Research Center, Public Health Sciences Division, Seattle, WA 98109-1024, USA.
Kosma VM Kosma Veli-Matti VM Imaging Center, Department of Clinical Pathology, Kuopio University Hospital, Kuopio, Finland.
Kriebel J Kriebel Jennifer J German Center for Diabetes Research, 85764 Neuherberg, Germany.
Kristensen V Kristensen Vessela V Department of Clinical Molecular Biology, Oslo University Hospital, University of Oslo, Oslo, Norway.
Lambrechts D Lambrechts Diether D Laboratory for Translational Genetics, Department of Oncology, University of Leuven, Leuven, Belgium.
Langenberg C Langenberg Claudia C MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Box 285 Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, CB2 0QQ, UK.
Li J Li Jingmei J Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, 17177 Stockholm, Sweden.
Li X Li Xin X Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA.
Lindström S Lindström Sara S Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA.
Liu Y Liu Yongmei Y Center for Human Genetics, Division of Public Health Sciences, Wake Forest School of Medicine.
Luan J Luan Jian'an J MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Box 285 Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, CB2 0QQ, UK.
Lubinski J Lubinski Jan J Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland.
Mägi R Mägi Reedik R Estonian Genome Center, University of Tartu, Tartu, 51010, Estonia.
Mannermaa A Mannermaa Arto A Imaging Center, Department of Clinical Pathology, Kuopio University Hospital, Kuopio, Finland.
Manz J Manz Judith J Institute of Epidemiology II, Helmholtz Zentrum München - German Research Center for Environmental Health, 85764 Neuherberg, Germany.
Margolin S Margolin Sara S Department of Oncology - Pathology, Karolinska Institutet, Stockholm 17177, Sweden.
Marten J Marten Jonathan J Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh EH4 2XU, UK.
Martin NG Martin Nicholas G NG QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
Masciullo C Masciullo Corrado C Division of Genetics and Cell Biology, San Raffaele Scientific Institute, 20132 Milano, Italy.
Meindl A Meindl Alfons A Division of Gynaecology and Obstetrics, Technische Universität München, Munich, Germany.
Michailidou K Michailidou Kyriaki K Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, CB1 8RN, UK.
Mihailov E Mihailov Evelin E Estonian Genome Center, University of Tartu, Tartu, 51010, Estonia.
Milani L Milani Lili L Estonian Genome Center, University of Tartu, Tartu, 51010, Estonia.
Milne RL Milne Roger L RL Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Australia.
Müller-Nurasyid M Müller-Nurasyid Martina M DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance, Munich, Germany.
Nalls M Nalls Michael M Laboratory of Neurogenetics, National Institute on Aging, Bethesda, MD, USA.
Neale BM Neale Ben M BM Medical and Population Genetics, Broad Institute, Cambridge, MA 02142, US.
Nevanlinna H Nevanlinna Heli H Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland.
Neven P Neven Patrick P KULeuven (University of Leuven), Department of Oncology, Multidisciplinary Breast Center, University Hospitals Leuven, Belgium.
Newman AB Newman Anne B AB Department of Clinical and Translational Science, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Nordestgaard BG Nordestgaard Børge G BG Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, University of Copenhagen, Copenhagen, Denmark.
Olson JE Olson Janet E JE Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, USA.
Padmanabhan S Padmanabhan Sandosh S British Heart Foundation Glasgow Cardiovascular Research Centre, Institute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8TA, UK.
Peterlongo P Peterlongo Paolo P IFOM, Fondazione Istituto FIRC di Oncologia Molecolare, Milan, Italy.
Peters U Peters Ulrike U Fred Hutchinson Cancer Research Center, Public Health Sciences Division, Seattle, WA 98109-1024, USA.
Petersmann A Petersmann Astrid A Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, 17475 Greifswald, Germany.
Peto J Peto Julian J Non-communicable Disease Epidemiology Department, London School of Hygiene and Tropical Medicine, London, UK.
Pharoah PDP Pharoah Paul D P PDP Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, CB1 8RN, UK.
Pirastu NN Pirastu Nicola N NN Department of Clinical Medical Sciences, Surgical and Health, University of Trieste, 34149 Trieste, Italy.
Pirie A Pirie Ailith A Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, CB1 8RN, UK.
Pistis G Pistis Giorgio G Center for Statistical Genetics, Ann Arbor, University of Michigan, Michigan 48109-2029, USA.
Polasek O Polasek Ozren O Faculty of Medicine, University of Split, Split, Croatia.
Porteous D Porteous David D Medical Genetics Section, Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh EH4 2XU, UK.
Psaty BM Psaty Bruce M BM Department of Health Services, University of Washington, Seattle, Washington 98101, USA.
Pylkäs K Pylkäs Katri K Laboratory of Cancer Genetics and Tumor Biology, Northern Finland Laboratory Centre NordLab, Oulu, Finland.
Radice P Radice Paolo P Unit of Molecular Bases of Genetic Risk and Genetic Testing, Department of Preventive and Predictive Medicine, Fondazione IRCCS Istituto Nazionale dei Tumori (INT), Milan, Italy.
Raffel LJ Raffel Leslie J LJ UCLA Clinical & Translational Science Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA.
Rivadeneira F Rivadeneira Fernando F Genetic Epidemiology Unit Department of Epidemiology, Erasmus MC, 3015 GE, Rotterdam, the Netherlands.
Rudan I Rudan Igor I Institute for Population Health Sciences and Informatics, University of Edinburgh, Teviot Place, Edinburgh, EH8 9AG, Scotland.
Rudolph A Rudolph Anja A Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Ruggiero D Ruggiero Daniela D Institute of Genetics and Biophysics - CNR, via Pietro Castellino 111, 80131, Naples, Italy.
Sala CF Sala Cinzia F CF Division of Genetics and Cell Biology, San Raffaele Scientific Institute, 20132 Milano, Italy.
Sanna S Sanna Serena S Institute of Genetics and Biomedical Research, National Research Council, Cagliari, 09042 Sardinia, Italy.
Sawyer EJ Sawyer Elinor J EJ Research Oncology, Guy's Hospital, King's College London, London, UK.
Schlessinger D Schlessinger David D National Institute on Aging, Intramural Research Program, Baltimore, MD 20892, USA.
Schmidt MK Schmidt Marjanka K MK Netherlands Cancer Institute, Antoni van Leeuwenhoek hospital, Amsterdam, The Netherlands.
Schmidt F Schmidt Frank F Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, 17475 Greifswald, Germany.
Schmutzler RK Schmutzler Rita K RK Center for Integrated Oncology, University Hospital of Cologne, Cologne, Germany.
Schoemaker MJ Schoemaker Minouk J MJ Division of Genetics and Epidemiology, The Institute of Cancer Research, London, UK.
Scott RA Scott Robert A RA MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Box 285 Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, CB2 0QQ, UK.
Seynaeve CM Seynaeve Caroline M CM Department of Medical Oncology, Erasmus University Medical Center, Rotterdam, The Netherlands.
Simard J Simard Jacques J Centre Hospitalier Universitaire de Québec Research Center, Laval University, Québec City, Canada.
Sorice R Sorice Rossella R Institute of Genetics and Biophysics - CNR, via Pietro Castellino 111, 80131, Naples, Italy.
Southey MC Southey Melissa C MC Department of Pathology, The University of Melbourne, Melbourne, Australia.
Stöckl D Stöckl Doris D Institute of Epidemiology II, Helmholtz Zentrum München - German Research Center for Environmental Health, 85764 Neuherberg, Germany.
Strauch K Strauch Konstantin K Institute of Medical Informatics, Biometry and Epidemiology, Chair of Genetic Epidemiology, Ludwig-Maximilians-Universität, 81377 Munich, Germany.
Swerdlow A Swerdlow Anthony A Division of Breast Cancer Research, The Institute of Cancer Research, London, UK.
Taylor KD Taylor Kent D KD The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, LABioMed at Harbor-UCLA Medical Center, Torrance, California, USA.
Thorsteinsdottir U Thorsteinsdottir Unnur U Faculty of Medicine, University of Iceland, IS-101 Reykjavik, Iceland.
Toland AE Toland Amanda E AE Department of Molecular Virology, Immunology and Medical Genetics, Comprehensive Cancer Center, The Ohio State University, Columbus, OH, USA.
Tomlinson I Tomlinson Ian I NIHR Oxford Biomedical Research Centre, Churchill Hospital, OX3 7LE Oxford, UK.
Truong T Truong Thérèse T University Paris-Sud, UMRS 1018, Villejuif, France.
Tryggvadottir L Tryggvadottir Laufey L Icelandic Cancer Registry, Reykjavik, Iceland.
Turner ST Turner Stephen T ST Division of Nephrology and Hypertension, Department of Internal Medicine, Mayo Clinic, Rochester, MN, USA.
Vozzi D Vozzi Diego D Institute for Maternal and Child Health - IRCCS "Burlo Garofolo", 34137 Trieste, Italy.
Wang Q Wang Qin Q Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, CB1 8RN, UK.
Wellons M Wellons Melissa M Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, 37203, USA.
Willemsen G Willemsen Gonneke G Department of Biological Psychology, VU University Amsterdam, van der Boechorststraat 1, 1081 BT, Amsterdam, The Netherlands.
Wilson JF Wilson James F JF Institute for Population Health Sciences and Informatics, University of Edinburgh, Teviot Place, Edinburgh, EH8 9AG, Scotland.
Winqvist R Winqvist Robert R Laboratory of Cancer Genetics and Tumor Biology, Northern Finland Laboratory Centre NordLab, Oulu, Finland.
Wolffenbuttel BBHR Wolffenbuttel Bruce B H R BBHR LifeLines Cohort Study and Biobank, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Wright AF Wright Alan F AF Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh EH4 2XU, UK.
Yannoukakos D Yannoukakos Drakoulis D Molecular Diagnostics Laboratory, IRRP, National Centre for Scientific Research "Demokritos", Athens, Greece.
Zemunik T Zemunik Tatijana T Faculty of Medicine, University of Split, Split, Croatia.
Zheng W Zheng Wei W Division of Epidemiology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN, USA.
Zygmunt M Zygmunt Marek M Department of Obstetrics and Gynecology, University Medicine Greifswald, 17475 Greifswald, Germany.
Bergmann S Bergmann Sven S Swiss Institute of Bioinformatics, CH-1015, Lausanne, Switzerland.
Boomsma DI Boomsma Dorret I DI Department of Biological Psychology, VU University Amsterdam, van der Boechorststraat 1, 1081 BT, Amsterdam, The Netherlands.
Buring JE Buring Julie E JE Harvard Medical School, Boston, MA 02115, USA.
Ferrucci L Ferrucci Luigi L Longitudinal Studies Section, Translational Gerontology Branch, National Institute on Aging, Baltimore, Maryland 21224, United States of America.
Montgomery GW Montgomery Grant W GW QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
Gudnason V Gudnason Vilmundur V Faculty of Medicine, University of Iceland, IS-101 Reykjavik, Iceland.
Spector TD Spector Tim D TD Department of Twin Research and Genetic Epidemiology, King's College London, London SE1 7EH, UK.
van Duijn CM van Duijn Cornelia M CM Genetic Epidemiology Unit Department of Epidemiology, Erasmus MC, 3015 GE, Rotterdam, the Netherlands.
Alizadeh BZ Alizadeh Behrooz Z BZ Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Ciullo M Ciullo Marina M Institute of Genetics and Biophysics - CNR, via Pietro Castellino 111, 80131, Naples, Italy.
Crisponi L Crisponi Laura L Institute of Genetics and Biomedical Research, National Research Council, Cagliari, 09042 Sardinia, Italy.
Easton DF Easton Douglas F DF Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, CB1 8RN, UK.
Gasparini PP Gasparini Paolo P PP Department of Clinical Medical Sciences, Surgical and Health, University of Trieste, 34149 Trieste, Italy.
Gieger C Gieger Christian C Institute of Epidemiology II, Helmholtz Zentrum München - German Research Center for Environmental Health, 85764 Neuherberg, Germany.
Harris TB Harris Tamara B TB Laboratory of Epidemiology and Population Sciences, National Institute on Aging, Bethesda, MD, USA.
Hayward C Hayward Caroline C Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh EH4 2XU, UK.
Kardia SLR Kardia Sharon L R SLR Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA.
Kraft P Kraft Peter P Department of Biostatistics, Harvard School of Public Health, Boston, MA 02115, USA.
McKnight B McKnight Barbara B Department of Biostatistics, University of Washington, Seattle, WA, USA.
Metspalu A Metspalu Andres A Estonian Genome Center, University of Tartu, Tartu, 51010, Estonia.
Morrison AC Morrison Alanna C AC Human Genetics Center, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX 77030, USA.
Reiner AP Reiner Alex P AP Department of Epidemiology, School of Public Health, University of Washington, Seattle, WA 98195, USA.
Ridker PM Ridker Paul M PM Harvard Medical School, Boston, MA 02115, USA.
Rotter JI Rotter Jerome I JI The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, LABioMed at Harbor-UCLA Medical Center, Torrance, California, USA.
Toniolo D Toniolo Daniela D Division of Genetics and Cell Biology, San Raffaele Scientific Institute, 20132 Milano, Italy.
Uitterlinden AG Uitterlinden André G AG Genetic Epidemiology Unit Department of Epidemiology, Erasmus MC, 3015 GE, Rotterdam, the Netherlands.
Ulivi S Ulivi Sheila S Institute for Maternal and Child Health - IRCCS "Burlo Garofolo", 34137 Trieste, Italy.
Völzke H Völzke Henry H Institute for Community Medicine, University Medicine Greifswald, 17475 Greifswald, Germany.
Wareham NJ Wareham Nicholas J NJ MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Box 285 Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, CB2 0QQ, UK.
Weir DR Weir David R DR Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, USA.
Yerges-Armstrong LM Yerges-Armstrong Laura M LM Program in Personalized Medicine, Division of Endocrinology, Diabetes and Nutrition - University of Maryland School of Medicine, USA. Baltimore, MD 21201.
PRACTICAL consortium
kConFab Investigators
AOCS Investigators
Generation Scotland
EPIC-InterAct Consortium
LifeLines Cohort Study
Price AL Price Alkes L AL Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA.
Stefansson K Stefansson Kari K Faculty of Medicine, University of Iceland, IS-101 Reykjavik, Iceland.
Visser JA Visser Jenny A JA Department of Internal Medicine, Erasmus MC, 3015GE Rotterdam, the Netherlands.
Ong KK Ong Ken K KK Department of Paediatrics,University of Cambridge,Cambridge, CB2 0QQ, UK.
Chang-Claude J Chang-Claude Jenny J Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Murabito JM Murabito Joanne M JM Boston University School of Medicine, Department of Medicine, Section of General Internal Medicine, Boston, MA 02118, USA.
Perry JRB Perry John R B JRB MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Box 285 Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, CB2 0QQ, UK.
Murray A Murray Anna A Genetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter, EX2 5DW, UK.
INVESTIGATORS
JOURNAL
VOLUME: 47
ISSUE: 11
TITLE: Nature genetics
ISOABBREVIATION: Nat Genet
YEAR: 2015
MONTH: Nov
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN: 1546-1718
ISSNTYPE: Electronic
MEDLINE JOURNAL
MEDLINETA: Nat Genet
COUNTRY: United States
ISSNLINKING: 1061-4036
NLMUNIQUEID: 9216904
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
Research Support, American Recovery and Reinvestment Act
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
COMMENTS AND CORRECTIONS
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HG007089 NHGRI NIH HHS United States
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10124 Cancer Research UK United Kingdom
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GENERAL NOTE
KEYWORDS
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Adult
Age Factors
Aging genetics
BRCA1 Protein genetics
Breast Neoplasms genetics
DNA Repair genetics
Female genetics
Gene Regulatory Networks genetics
Genetic Predisposition to Disease genetics
Genetic Variation genetics
Genome-Wide Association Study methods
Genomics methods
Genotype methods
Humans methods
Hypothalamus metabolism
Menopause genetics
Middle Aged genetics
Models, Genetic genetics
Phenotype genetics
Reproduction genetics
Signal Transduction genetics
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
REGISTRYNUMBER NAMEOFSUBSTANCE
0 BRCA1 Protein
OTHER ID's
OTHERID SOURCE
EMS64932 NLM
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