Genetic Epidemiology, Psychiatric Genetics, Asthma Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
26413210
TITLE
GENETIC ANALYSIS OF STRUCTURAL BRAIN CONNECTIVITY USING DICCCOL MODELS OF DIFFUSION MRI IN 522 TWINS.
ABSTRACT
NlmCategory: UNASSIGNED
Genetic and environmental factors affect white matter connectivity in the normal brain, and they also influence diseases in which brain connectivity is altered. Little is known about genetic influences on brain connectivity, despite wide variations in the brain's neural pathways. Here we applied the "DICCCOL" framework to analyze structural connectivity, in 261 twin pairs (522 participants, mean age: 21.8 y ± 2.7SD). We encoded connectivity patterns by projecting the white matter (WM) bundles of all "DICCCOLs" as a tracemap (TM). Next we fitted an A/C/E structural equation model to estimate additive genetic (A), common environmental (C), and unique environmental/error (E) components of the observed variations in brain connectivity. We found 44 "heritable DICCCOLs" whose connectivity was genetically influenced (a (2)>1%); half of them showed significant heritability (a (2)>20%). Our analysis of genetic influences on WM structural connectivity suggests high heritability for some WM projection patterns, yielding new targets for genome-wide association studies.
DATE PUBLISHED
2015 Apr
HISTORY
PUBSTATUS PUBSTATUSDATE
entrez 2015/09/29 06:00
pubmed 2015/09/29 06:00
medline 2015/09/29 06:00
pmc-release 2016/04/01 00:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Zhu D Zhu Dajiang D Imaging Genetics Center, University of Southern California, CA, USA.
Zhan L Zhan Liang L Imaging Genetics Center, University of Southern California, CA, USA.
Faskowitz J Faskowitz Joshua J Imaging Genetics Center, University of Southern California, CA, USA.
Daianu M Daianu Madelaine M Imaging Genetics Center, University of Southern California, CA, USA.
Jahanshad N Jahanshad Neda N Imaging Genetics Center, University of Southern California, CA, USA.
de Zubicaray GI de Zubicaray Greig I GI School of Psychology, University of Queensland, Brisbane, Australia.
McMahon KL McMahon Katie L KL Center for Advanced Imaging, University of Queensland, Brisbane, Australia.
Martin NG Martin Nicholas G NG QIMR Berghofer Medical Research Institute, Brisbane, Australia.
Wright MJ Wright Margaret J MJ QIMR Berghofer Medical Research Institute, Brisbane, Australia.
Thompson PM Thompson Paul M PM Imaging Genetics Center, University of Southern California, CA, USA.
INVESTIGATORS
JOURNAL
VOLUME: 2015
ISSUE:
TITLE: Proceedings / IEEE International Symposium on Biomedical Imaging: from nano to macro. IEEE International Symposium on Biomedical Imaging
ISOABBREVIATION: Proc IEEE Int Symp Biomed Imaging
YEAR: 2015
MONTH: Apr
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Print
ISSN: 1945-7928
ISSNTYPE: Print
MEDLINE JOURNAL
MEDLINETA: Proc IEEE Int Symp Biomed Imaging
COUNTRY: United States
ISSNLINKING: 1945-7928
NLMUNIQUEID: 101492570
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
JOURNAL ARTICLE
COMMENTS AND CORRECTIONS
GRANTS
GRANTID AGENCY COUNTRY
P41 EB015922 NIBIB NIH HHS United States
U54 EB020403 NIBIB NIH HHS United States
GENERAL NOTE
KEYWORDS
KEYWORD
DICCCOL
heritability
MESH HEADINGS
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
OTHER ID's