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| PMID |
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| TITLE |
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| HERITABILITY OF BRAIN NETWORK TOPOLOGY IN 853 TWINS AND SIBLINGS. |
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| ABSTRACT |
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NlmCategory: UNASSIGNED |
| Anatomical brain networks change throughout life and with diseases. Genetic analysis of these networks may help identify processes giving rise to heritable brain disorders, but we do not yet know which network measures are promising for genetic analyses. Many factors affect the downstream results, such as the tractography algorithm used to define structural connectivity. We tested nine different tractography algorithms and four normalization methods to compute brain networks for 853 young healthy adults (twins and their siblings). We fitted genetic structural equation models to all nine network measures, after a normalization step to increase network consistency across tractography algorithms. Probabilistic tractography algorithms with global optimization (such as Probtrackx and Hough) yielded higher heritability statistics than "greedy" algorithms (such as FACT) which process small neighborhoods at each step. Some global network measures (probtrackx-derived GLOB and ST) showed significant genetic effects, making them attractive targets for genome-wide association studies. |
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| DATE PUBLISHED |
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| HISTORY |
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| PUBSTATUS |
PUBSTATUSDATE |
| entrez |
2015/09/29 06:00 |
| pubmed |
2015/09/29 06:00 |
| medline |
2015/09/29 06:00 |
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| AUTHORS |
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| NAME |
COLLECTIVENAME |
LASTNAME |
FORENAME |
INITIALS |
AFFILIATION |
AFFILIATIONINFO |
| Zhan L |
|
Zhan |
L |
L |
|
Dept. of Neurology, University of California, Los Angeles, CA 90095, USA ; Imaging Genetics Center, Keck School of Medicine, University of Southern California, Marina Del Rey, CA 90292, USA. |
| Jahanshad N |
|
Jahanshad |
N |
N |
|
Imaging Genetics Center, Keck School of Medicine, University of Southern California, Marina Del Rey, CA 90292, USA. |
| Faskowitz J |
|
Faskowitz |
J |
J |
|
Imaging Genetics Center, Keck School of Medicine, University of Southern California, Marina Del Rey, CA 90292, USA. |
| Zhu D |
|
Zhu |
D |
D |
|
Imaging Genetics Center, Keck School of Medicine, University of Southern California, Marina Del Rey, CA 90292, USA. |
| Prasad G |
|
Prasad |
G |
G |
|
Imaging Genetics Center, Keck School of Medicine, University of Southern California, Marina Del Rey, CA 90292, USA. |
| Martin NG |
|
Martin |
N G |
NG |
|
QIMR Berghofer Medical Research Institute, Brisbane, QLD 4029, Australia. |
| de Zubicaray GI |
|
de Zubicaray |
G I |
GI |
|
School of Psychology, University of Queensland, Brisbane, QLD 4072, Australia. |
| McMahon KL |
|
McMahon |
K L |
KL |
|
Centre for Advanced Imaging, University of Queensland, Brisbane, QLD 4072, Australia. |
| Wright MJ |
|
Wright |
M J |
MJ |
|
QIMR Berghofer Medical Research Institute, Brisbane, QLD 4029, Australia. |
| Thompson PM |
|
Thompson |
P M |
PM |
|
Imaging Genetics Center, Keck School of Medicine, University of Southern California, Marina Del Rey, CA 90292, USA. |
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| INVESTIGATORS |
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| JOURNAL |
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| VOLUME: 2015 |
| ISSUE: |
| TITLE: Proceedings / IEEE International Symposium on Biomedical Imaging: from nano to macro. IEEE International Symposium on Biomedical Imaging |
| ISOABBREVIATION: Proc IEEE Int Symp Biomed Imaging |
| YEAR: 2015 |
| MONTH: Apr |
| DAY: |
| MEDLINEDATE: |
| SEASON: |
| CITEDMEDIUM: Print |
| ISSN: 1945-7928 |
| ISSNTYPE: Print |
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| MEDLINE JOURNAL |
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| MEDLINETA: Proc IEEE Int Symp Biomed Imaging |
| COUNTRY: United States |
| ISSNLINKING: 1945-7928 |
| NLMUNIQUEID: 101492570 |
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| PUBLICATION TYPE |
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| PUBLICATIONTYPE TEXT |
| JOURNAL ARTICLE |
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| COMMENTS AND CORRECTIONS |
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| GRANTS |
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| GENERAL NOTE |
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| KEYWORDS |
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| KEYWORD |
| Brain Network |
| ICC |
| Normalization |
| Tractography |
| diffusion MRI |
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| MESH HEADINGS |
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| SUPPLEMENTARY MESH |
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| GENE SYMBOLS |
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| CHEMICALS |
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| OTHER ID's |
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