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| PMID |
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| TITLE |
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| Genes influence the amplitude and timing of brain hemodynamic responses. |
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| ABSTRACT |
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| In functional magnetic resonance imaging (fMRI), the hemodynamic response function (HRF) reflects regulation of regional cerebral blood flow in response to neuronal activation. The HRF varies significantly between individuals. This study investigated the genetic contribution to individual variation in HRF using fMRI data from 125 monozygotic (MZ) and 149 dizygotic (DZ) twin pairs. The resemblance in amplitude, latency, and duration of the HRF in six regions in the frontal and parietal lobes was compared between MZ and DZ twin pairs. Heritability was estimated using an ACE (Additive genetic, Common environmental, and unique Environmental factors) model. The genetic influence on the temporal profile and amplitude of HRF was moderate to strong (24%-51%). The HRF may be used in the genetic analysis of diseases with a cerebrovascular etiology. |
| Copyright © 2015 Elsevier Inc. All rights reserved. |
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| DATE PUBLISHED |
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| HISTORY |
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| PUBSTATUS |
PUBSTATUSDATE |
| received |
2015/05/18 |
| revised |
2015/08/31 |
| accepted |
2015/09/07 |
| entrez |
2015/09/17 06:00 |
| pubmed |
2015/09/17 06:00 |
| medline |
2015/09/17 06:00 |
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| AUTHORS |
|
| NAME |
COLLECTIVENAME |
LASTNAME |
FORENAME |
INITIALS |
AFFILIATION |
AFFILIATIONINFO |
| Shan ZY |
|
Shan |
Zuyao Y |
ZY |
|
Centre for Advanced Imaging, The University of QLD, Brisbane, QLD 4072, Australia. |
| Vinkhuyzen AA |
|
Vinkhuyzen |
Anna A E |
AA |
|
Queensland Brain Institute, The University of QLD, Brisbane, QLD 4072, Australia. |
| Thompson PM |
|
Thompson |
Paul M |
PM |
|
Imaging Genetics Center, Institute of Neuroimaging Informatics, Keck School of Medicine of University of Southern California, Marina del Rey, CA 90292, USA. |
| McMahon KL |
|
McMahon |
Katie L |
KL |
|
Centre for Advanced Imaging, The University of QLD, Brisbane, QLD 4072, Australia. |
| Blokland GA |
|
Blokland |
Gabriëlla A M |
GA |
|
Centre for Advanced Imaging, The University of QLD, Brisbane, QLD 4072, Australia; QIMR Berghofer Medical Research Institute, Brisbane, QLD 4029, Australia. |
| de Zubicaray GI |
|
de Zubicaray |
Greig I |
GI |
|
School of Psychology, The University of QLD, Brisbane, QLD 4072, Australia. |
| Calhoun V |
|
Calhoun |
Vince |
V |
|
The Mind Research Network, Department of Electrical and Computer Engineering, The University of New Mexico, Albuquerque, NM 87313, USA. |
| Martin NG |
|
Martin |
Nicholas G |
NG |
|
QIMR Berghofer Medical Research Institute, Brisbane, QLD 4029, Australia. |
| Visscher PM |
|
Visscher |
Peter M |
PM |
|
Queensland Brain Institute, The University of QLD, Brisbane, QLD 4072, Australia. |
| Wright MJ |
|
Wright |
Margaret J |
MJ |
|
QIMR Berghofer Medical Research Institute, Brisbane, QLD 4029, Australia. |
| Reutens DC |
|
Reutens |
David C |
DC |
|
Centre for Advanced Imaging, The University of QLD, Brisbane, QLD 4072, Australia. Electronic address: d.reutens@uq.edu.au. |
|
| INVESTIGATORS |
|
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| JOURNAL |
|
| VOLUME: 124 |
| ISSUE: Pt A |
| TITLE: NeuroImage |
| ISOABBREVIATION: Neuroimage |
| YEAR: 2016 |
| MONTH: Jan |
| DAY: 1 |
| MEDLINEDATE: |
| SEASON: |
| CITEDMEDIUM: Internet |
| ISSN: 1095-9572 |
| ISSNTYPE: Electronic |
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| MEDLINE JOURNAL |
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| MEDLINETA: Neuroimage |
| COUNTRY: United States |
| ISSNLINKING: 1053-8119 |
| NLMUNIQUEID: 9215515 |
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| PUBLICATION TYPE |
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| PUBLICATIONTYPE TEXT |
| Journal Article |
| Research Support, N.I.H., Extramural |
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| COMMENTS AND CORRECTIONS |
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| GRANTS |
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| GRANTID |
AGENCY |
COUNTRY |
| R01HD050735 |
NICHD NIH HHS |
United States |
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| GENERAL NOTE |
|
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| KEYWORDS |
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| KEYWORD |
| Hemodynamic response function (HRF) |
| Heritability |
| Neurovascular coupling |
| Twin study |
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| MESH HEADINGS |
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| SUPPLEMENTARY MESH |
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| GENE SYMBOLS |
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| CHEMICALS |
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| OTHER ID's |
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