Genetic Epidemiology, Psychiatric Genetics, Asthma Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
26375212
TITLE
Genes influence the amplitude and timing of brain hemodynamic responses.
ABSTRACT
In functional magnetic resonance imaging (fMRI), the hemodynamic response function (HRF) reflects regulation of regional cerebral blood flow in response to neuronal activation. The HRF varies significantly between individuals. This study investigated the genetic contribution to individual variation in HRF using fMRI data from 125 monozygotic (MZ) and 149 dizygotic (DZ) twin pairs. The resemblance in amplitude, latency, and duration of the HRF in six regions in the frontal and parietal lobes was compared between MZ and DZ twin pairs. Heritability was estimated using an ACE (Additive genetic, Common environmental, and unique Environmental factors) model. The genetic influence on the temporal profile and amplitude of HRF was moderate to strong (24%-51%). The HRF may be used in the genetic analysis of diseases with a cerebrovascular etiology.
Copyright 2015 Elsevier Inc. All rights reserved.
DATE PUBLISHED
2016 Jan 1
HISTORY
PUBSTATUS PUBSTATUSDATE
received 2015/05/18
revised 2015/08/31
accepted 2015/09/07
entrez 2015/09/17 06:00
pubmed 2015/09/17 06:00
medline 2015/09/17 06:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Shan ZY Shan Zuyao Y ZY Centre for Advanced Imaging, The University of QLD, Brisbane, QLD 4072, Australia.
Vinkhuyzen AA Vinkhuyzen Anna A E AA Queensland Brain Institute, The University of QLD, Brisbane, QLD 4072, Australia.
Thompson PM Thompson Paul M PM Imaging Genetics Center, Institute of Neuroimaging Informatics, Keck School of Medicine of University of Southern California, Marina del Rey, CA 90292, USA.
McMahon KL McMahon Katie L KL Centre for Advanced Imaging, The University of QLD, Brisbane, QLD 4072, Australia.
Blokland GA Blokland Gabriëlla A M GA Centre for Advanced Imaging, The University of QLD, Brisbane, QLD 4072, Australia; QIMR Berghofer Medical Research Institute, Brisbane, QLD 4029, Australia.
de Zubicaray GI de Zubicaray Greig I GI School of Psychology, The University of QLD, Brisbane, QLD 4072, Australia.
Calhoun V Calhoun Vince V The Mind Research Network, Department of Electrical and Computer Engineering, The University of New Mexico, Albuquerque, NM 87313, USA.
Martin NG Martin Nicholas G NG QIMR Berghofer Medical Research Institute, Brisbane, QLD 4029, Australia.
Visscher PM Visscher Peter M PM Queensland Brain Institute, The University of QLD, Brisbane, QLD 4072, Australia.
Wright MJ Wright Margaret J MJ QIMR Berghofer Medical Research Institute, Brisbane, QLD 4029, Australia.
Reutens DC Reutens David C DC Centre for Advanced Imaging, The University of QLD, Brisbane, QLD 4072, Australia. Electronic address: d.reutens@uq.edu.au.
INVESTIGATORS
JOURNAL
VOLUME: 124
ISSUE: Pt A
TITLE: NeuroImage
ISOABBREVIATION: Neuroimage
YEAR: 2016
MONTH: Jan
DAY: 1
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN: 1095-9572
ISSNTYPE: Electronic
MEDLINE JOURNAL
MEDLINETA: Neuroimage
COUNTRY: United States
ISSNLINKING: 1053-8119
NLMUNIQUEID: 9215515
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
Research Support, N.I.H., Extramural
COMMENTS AND CORRECTIONS
GRANTS
GRANTID AGENCY COUNTRY
R01HD050735 NICHD NIH HHS United States
GENERAL NOTE
KEYWORDS
KEYWORD
Hemodynamic response function (HRF)
Heritability
Neurovascular coupling
Twin study
MESH HEADINGS
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
OTHER ID's