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PMID |
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TITLE |
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Population genetic differentiation of height and body mass index across Europe. |
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ABSTRACT |
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NlmCategory: UNASSIGNED |
Across-nation differences in the mean values for complex traits are common, but the reasons for these differences are unknown. Here we find that many independent loci contribute to population genetic differences in height and body mass index (BMI) in 9,416 individuals across 14 European countries. Using discovery data on over 250,000 individuals and unbiased effect size estimates from 17,500 sibling pairs, we estimate that 24% (95% credible interval (CI) = 9%, 41%) and 8% (95% CI = 4%, 16%) of the captured additive genetic variance for height and BMI, respectively, reflect population genetic differences. Population genetic divergence differed significantly from that in a null model (height, P < 3.94 x 10(-8); BMI, P < 5.95 x 10(-4)), and we find an among-population genetic correlation for tall and slender individuals (r = -0.80, 95% CI = -0.95, -0.60), consistent with correlated selection for both phenotypes. Observed differences in height among populations reflected the predicted genetic means (r = 0.51; P < 0.001), but environmental differences across Europe masked genetic differentiation for BMI (P < 0.58). |
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DATE PUBLISHED |
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HISTORY |
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PUBSTATUS |
PUBSTATUSDATE |
received |
2015/06/26 |
accepted |
2015/08/19 |
entrez |
2015/09/15 06:00 |
pubmed |
2015/09/15 06:00 |
medline |
2015/09/15 06:00 |
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AUTHORS |
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NAME |
COLLECTIVENAME |
LASTNAME |
FORENAME |
INITIALS |
AFFILIATION |
AFFILIATIONINFO |
Robinson MR |
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Robinson |
Matthew R |
MR |
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Queensland Brain Institute, University of Queensland, Brisbane, Queensland, Australia. |
Hemani G |
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Hemani |
Gibran |
G |
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Queensland Brain Institute, University of Queensland, Brisbane, Queensland, Australia. |
Medina-Gomez C |
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Medina-Gomez |
Carolina |
C |
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Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, the Netherlands. |
Mezzavilla M |
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Mezzavilla |
Massimo |
M |
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Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, UK. |
Esko T |
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Esko |
Tonu |
T |
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Department of Genetics, Harvard Medical School, Boston, Massachusetts, USA. |
Shakhbazov K |
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Shakhbazov |
Konstantin |
K |
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Queensland Brain Institute, University of Queensland, Brisbane, Queensland, Australia. |
Powell JE |
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Powell |
Joseph E |
JE |
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University of Queensland Diamantina Institute, University of Queensland, Translational Research Institute, Brisbane, Queensland, Australia. |
Vinkhuyzen A |
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Vinkhuyzen |
Anna |
A |
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Queensland Brain Institute, University of Queensland, Brisbane, Queensland, Australia. |
Berndt SI |
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Berndt |
Sonja I |
SI |
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Division of Cancer Epidemiology and Genetics, National Cancer Institute, US National Institutes of Health, Bethesda, Maryland, USA. |
Gustafsson S |
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Gustafsson |
Stefan |
S |
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Department of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory, Uppsala University, Uppsala, Sweden. |
Justice AE |
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Justice |
Anne E |
AE |
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Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA. |
Kahali B |
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Kahali |
Bratati |
B |
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Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, Michigan, USA. |
Locke AE |
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Locke |
Adam E |
AE |
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Center for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, Michigan, USA. |
Pers TH |
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Pers |
Tune H |
TH |
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Center for Biological Sequence Analysis, Department of Systems Biology, Technical University of Denmark, Lyngby, Denmark. |
Vedantam S |
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Vedantam |
Sailaja |
S |
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Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA. |
Wood AR |
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Wood |
Andrew R |
AR |
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Genetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter, UK. |
van Rheenen W |
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van Rheenen |
Wouter |
W |
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Department of Neurology and Neurosurgery, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, the Netherlands. |
Andreassen OA |
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Andreassen |
Ole A |
OA |
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Norwegian Centre for Mental Disorders Research (NORMENT), KG Jebsen Centre for Psychosis Research, Division of Mental Health and Addiction, Oslo University Hospital and Institute of Clinical Medicine, University of Oslo, Oslo, Norway. |
Gasparini P |
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Gasparini |
Paolo |
P |
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Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, UK. |
Metspalu A |
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Metspalu |
Andres |
A |
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Estonian Genome Center, University of Tartu, Tartu, Estonia. |
Berg LH |
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Berg |
Leonard H van den |
LH |
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Department of Neurology and Neurosurgery, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, the Netherlands. |
Veldink JH |
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Veldink |
Jan H |
JH |
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Department of Neurology and Neurosurgery, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, the Netherlands. |
Rivadeneira F |
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Rivadeneira |
Fernando |
F |
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Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, the Netherlands. |
Werge TM |
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Werge |
Thomas M |
TM |
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Lundbeck Foundation Initiative for Integrative Psychiatric Research, (iPSYCH), Aarhus, Denmark. |
Abecasis GR |
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Abecasis |
Goncalo R |
GR |
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Center for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, Michigan, USA. |
Boomsma DI |
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Boomsma |
Dorret I |
DI |
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Department of Biological Psychology, VU University Amsterdam, Amsterdam, the Netherlands. |
Chasman DI |
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Chasman |
Daniel I |
DI |
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Division of Preventive Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA. |
de Geus EJ |
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de Geus |
Eco J C |
EJ |
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Department of Biological Psychology, VU University Amsterdam, Amsterdam, the Netherlands. |
Frayling TM |
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Frayling |
Timothy M |
TM |
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Genetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter, UK. |
Hirschhorn JN |
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Hirschhorn |
Joel N |
JN |
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Department of Genetics, Harvard Medical School, Boston, Massachusetts, USA. |
Hottenga JJ |
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Hottenga |
Jouke Jan |
JJ |
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Department of Biological Psychology, VU University Amsterdam, Amsterdam, the Netherlands. |
Ingelsson E |
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Ingelsson |
Erik |
E |
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Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK. |
Loos RJ |
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Loos |
Ruth J F |
RJ |
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Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA. |
Magnusson PK |
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Magnusson |
Patrik K E |
PK |
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Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden. |
Martin NG |
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Martin |
Nicholas G |
NG |
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QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia. |
Montgomery GW |
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Montgomery |
Grant W |
GW |
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QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia. |
North KE |
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North |
Kari E |
KE |
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Carolina Center for Genome Sciences, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA. |
Pedersen NL |
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Pedersen |
Nancy L |
NL |
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Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden. |
Spector TD |
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Spector |
Timothy D |
TD |
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Department of Twin Research and Genetic Epidemiology, King's College London, St. Thomas' Hospital, London, UK. |
Speliotes EK |
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Speliotes |
Elizabeth K |
EK |
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Center for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, Michigan, USA. |
Goddard ME |
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Goddard |
Michael E |
ME |
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Department of Food and Agricultural Systems, University of Melbourne, Melbourne, Victoria, Australia. |
Yang J |
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Yang |
Jian |
J |
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University of Queensland Diamantina Institute, University of Queensland, Translational Research Institute, Brisbane, Queensland, Australia. |
Visscher PM |
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Visscher |
Peter M |
PM |
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University of Queensland Diamantina Institute, University of Queensland, Translational Research Institute, Brisbane, Queensland, Australia. |
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JOURNAL |
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VOLUME: |
ISSUE: |
TITLE: Nature genetics |
ISOABBREVIATION: Nat. Genet. |
YEAR: 2015 |
MONTH: Sep |
DAY: 14 |
MEDLINEDATE: |
SEASON: |
CITEDMEDIUM: Internet |
ISSN: 1546-1718 |
ISSNTYPE: Electronic |
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MEDLINE JOURNAL |
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MEDLINETA: Nat Genet |
COUNTRY: United States |
ISSNLINKING: 1061-4036 |
NLMUNIQUEID: 9216904 |
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