Genetic Epidemiology, Translational Neurogenomics, Psychiatric Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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26362575
TITLE
Meta-analysis of Genome-Wide Association Studies for Extraversion: Findings from the Genetics of Personality Consortium.
ABSTRACT
Extraversion is a relatively stable and heritable personality trait associated with numerous psychosocial, lifestyle and health outcomes. Despite its substantial heritability, no genetic variants have been detected in previous genome-wide association (GWA) studies, which may be due to relatively small sample sizes of those studies. Here, we report on a large meta-analysis of GWA studies for extraversion in 63,030 subjects in 29 cohorts. Extraversion item data from multiple personality inventories were harmonized across inventories and cohorts. No genome-wide significant associations were found at the single nucleotide polymorphism (SNP) level but there was one significant hit at the gene level for a long non-coding RNA site (LOC101928162). Genome-wide complex trait analysis in two large cohorts showed that the additive variance explained by common SNPs was not significantly different from zero, but polygenic risk scores, weighted using linkage information, significantly predicted extraversion scores in an independent cohort. These results show that extraversion is a highly polygenic personality trait, with an architecture possibly different from other complex human traits, including other personality traits. Future studies are required to further determine which genetic variants, by what modes of gene action, constitute the heritable nature of extraversion.
DATE PUBLISHED
2016 Mar
HISTORY
PUBSTATUS PUBSTATUSDATE
received 2014/10/30
accepted 2015/08/10
entrez 2015/09/13 06:00
pubmed 2015/09/13 06:00
medline 2017/01/10 06:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
van den Berg SM van den Berg Stéphanie M SM Department of Research Methodology, Measurement and Data-Analysis (OMD), Faculty of Behavioural, Management, and Social Sciences, University of Twente, PO Box 217, 7500 AE, Enschede, The Netherlands. stephanie.vandenberg@utwente.nl.
de Moor MH de Moor Marleen H M MH Department of Methods, VU University Amsterdam, Amsterdam, The Netherlands.
Verweij KJ Verweij Karin J H KJ Department of Developmental Psychology and EMGO Institute for Health and Care Research, VU University Amsterdam, Amsterdam, The Netherlands.
Krueger RF Krueger Robert F RF Department of Psychology, University of Minnesota, Minneapolis, USA.
Luciano M Luciano Michelle M Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK.
Arias Vasquez A Arias Vasquez Alejandro A Department of Cognitive Neuroscience, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands.
Matteson LK Matteson Lindsay K LK Department of Psychology, University of Minnesota, Minneapolis, USA.
Derringer J Derringer Jaime J Department of Psychology, University of Illinois at Urbana-Champaign, Champaign, IL, USA.
Esko T Esko Tõnu T Estonian Genome Center, University of Tartu, Tartu, Estonia.
Amin N Amin Najaf N Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands.
Gordon SD Gordon Scott D SD QIMR Berghofer Medical Research Institute, Brisbane, Australia.
Hansell NK Hansell Narelle K NK QIMR Berghofer Medical Research Institute, Brisbane, Australia.
Hart AB Hart Amy B AB Department of Human Genetics, University of Chicago, Chicago, IL, USA.
Seppälä I Seppälä Ilkka I Department of Clinical Chemistry, Fimlab Laboratories and School of Medicine, University of Tampere, Tampere, Finland.
Huffman JE Huffman Jennifer E JE MRC Human Genetics Unit, MRC IGMM, Western General Hospital, University of Edinburgh, Edinburgh, UK.
Konte B Konte Bettina B Department of Psychiatry, University of Halle, Halle, Germany.
Lahti J Lahti Jari J Folkhälsan Research Center, Helsinki, Finland.
Lee M Lee Minyoung M Department of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA, USA.
Miller M Miller Mike M Department of Psychology, University of Minnesota, Minneapolis, USA.
Nutile T Nutile Teresa T Institute of Genetics and Biophysics "A. Buzzati-Traverso" - CNR, Naples, Italy.
Tanaka T Tanaka Toshiko T National Institute on Aging, NIH, Baltimore, MD, USA.
Teumer A Teumer Alexander A Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany.
Viktorin A Viktorin Alexander A Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Wedenoja J Wedenoja Juho J Department of Public Health, University of Helsinki, Helsinki, Finland.
Abdellaoui A Abdellaoui Abdel A Department of Biological Psychology, VU University Amsterdam, Amsterdam, The Netherlands.
Abecasis GR Abecasis Goncalo R GR Department of Biostatistics, Center for Statistical Genetics, University of Michigan School of Public Health, Ann Arbor, MI, USA.
Adkins DE Adkins Daniel E DE Pharmacotherapy & Outcomes Science, Virginia Commonwealth University, Richmond, VA, USA.
Agrawal A Agrawal Arpana A Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA.
Allik J Allik Jüri J Estonian Academy of Sciences, Tallinn, Estonia.
Appel K Appel Katja K Department of Psychiatry and Psychotherapy, University Medicine Greifswald, Greifswald, Germany.
Bigdeli TB Bigdeli Timothy B TB Department of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA, USA.
Busonero F Busonero Fabio F Istituto di Ricerca Genetica e Biomedica (IRGB), CNR, Monserrato, Italy.
Campbell H Campbell Harry H Usher Institute for Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK.
Costa PT Costa Paul T PT Behavioral Medicine Research Center, Duke University School of Medicine, Durham, NC, USA.
Smith GD Smith George Davey GD Medical Research Council Integrative Epidemiology Unit, School of Social and Community Medicine, University of Bristol, Bristol, UK.
Davies G Davies Gail G Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK.
de Wit H de Wit Harriet H Department of Psychiatry and Behavioral Neuroscience, University of Chicago, Chicago, USA.
Ding J Ding Jun J Laboratory of Genetics, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA.
Engelhardt BE Engelhardt Barbara E BE Department of Biostatistics and Bioinformatics, Duke University, Durham, NC, USA.
Eriksson JG Eriksson Johan G JG Vasa Central Hospital, Vaasa, Finland.
Fedko IO Fedko Iryna O IO Department of Biological Psychology, VU University Amsterdam, Amsterdam, The Netherlands.
Ferrucci L Ferrucci Luigi L National Institute on Aging, NIH, Baltimore, MD, USA.
Franke B Franke Barbara B Department of Human Genetics, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands.
Giegling I Giegling Ina I Department of Psychiatry, University of Halle, Halle, Germany.
Grucza R Grucza Richard R Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA.
Hartmann AM Hartmann Annette M AM Department of Psychiatry, University of Halle, Halle, Germany.
Heath AC Heath Andrew C AC Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA.
Heinonen K Heinonen Kati K Institute of Behavioural Sciences, University of Helsinki, Helsinki, Finland.
Henders AK Henders Anjali K AK QIMR Berghofer Medical Research Institute, Brisbane, Australia.
Homuth G Homuth Georg G Interfaculty Institute for Genetics and Functional Genomics, University of Greifswald, Greifswald, Germany.
Hottenga JJ Hottenga Jouke-Jan JJ Department of Biological Psychology, VU University Amsterdam, Amsterdam, The Netherlands.
Iacono WG Iacono William G WG Department of Psychology, University of Minnesota, Minneapolis, USA.
Janzing J Janzing Joost J Department of Psychiatry, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands.
Jokela M Jokela Markus M Institute of Behavioural Sciences, University of Helsinki, Helsinki, Finland.
Karlsson R Karlsson Robert R Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Kemp JP Kemp John P JP Translational Research Institute, University of Queensland Diamantina Institute, Brisbane, Australia.
Kirkpatrick MG Kirkpatrick Matthew G MG Department of Psychiatry and Behavioral Neuroscience, University of Chicago, Chicago, USA.
Latvala A Latvala Antti A National Institute for Health and Welfare (THL), Helsinki, Finland.
Lehtimäki T Lehtimäki Terho T Department of Clinical Chemistry, Fimlab Laboratories and School of Medicine, University of Tampere, Tampere, Finland.
Liewald DC Liewald David C DC Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK.
Madden PA Madden Pamela A F PA Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA.
Magri C Magri Chiara C Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy.
Magnusson PK Magnusson Patrik K E PK Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Marten J Marten Jonathan J MRC Human Genetics Unit, MRC IGMM, Western General Hospital, University of Edinburgh, Edinburgh, UK.
Maschio A Maschio Andrea A Istituto di Ricerca Genetica e Biomedica (IRGB), CNR, Monserrato, Italy.
Mbarek H Mbarek Hamdi H Department of Biological Psychology, VU University Amsterdam, Amsterdam, The Netherlands.
Medland SE Medland Sarah E SE QIMR Berghofer Medical Research Institute, Brisbane, Australia.
Mihailov E Mihailov Evelin E Department of Biotechnology, University of Tartu, Tartu, Estonia.
Milaneschi Y Milaneschi Yuri Y Department of Psychiatry, EMGO+ Institute, Neuroscience Campus Amsterdam, VU University Medical Center, Amsterdam, The Netherlands.
Montgomery GW Montgomery Grant W GW QIMR Berghofer Medical Research Institute, Brisbane, Australia.
Nauck M Nauck Matthias M Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Greifswald, Germany.
Nivard MG Nivard Michel G MG Department of Biological Psychology, VU University Amsterdam, Amsterdam, The Netherlands.
Ouwens KG Ouwens Klaasjan G KG Department of Biological Psychology, VU University Amsterdam, Amsterdam, The Netherlands.
Palotie A Palotie Aarno A Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland.
Pettersson E Pettersson Erik E Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Polasek O Polasek Ozren O Department of Public Health, Faculty of Medicine, University of Split, Split, Croatia.
Qian Y Qian Yong Y Laboratory of Genetics, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA.
Pulkki-Råback L Pulkki-Råback Laura L Institute of Behavioural Sciences, University of Helsinki, Helsinki, Finland.
Raitakari OT Raitakari Olli T OT Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland.
Realo A Realo Anu A Department of Psychology, University of Tartu, Tartu, Estonia.
Rose RJ Rose Richard J RJ Department of Psychological & Brain Sciences, Indiana University, Bloomington, IN, USA.
Ruggiero D Ruggiero Daniela D Institute of Genetics and Biophysics "A. Buzzati-Traverso" - CNR, Naples, Italy.
Schmidt CO Schmidt Carsten O CO Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany.
Slutske WS Slutske Wendy S WS Department of Psychological Sciences and Missouri Alcoholism Research Center, University of Missouri, Columbia, MO, USA.
Sorice R Sorice Rossella R Institute of Genetics and Biophysics "A. Buzzati-Traverso" - CNR, Naples, Italy.
Starr JM Starr John M JM Alzheimer Scotland Dementia Research Centre, University of Edinburgh, Edinburgh, UK.
St Pourcain B St Pourcain Beate B School of Experimental Psychology, University of Bristol, Bristol, UK.
Sutin AR Sutin Angelina R AR College of Medicine, Florida State University, Tallahassee, FL, USA.
Timpson NJ Timpson Nicholas J NJ Medical Research Council Integrative Epidemiology Unit, School of Social and Community Medicine, University of Bristol, Bristol, UK.
Trochet H Trochet Holly H MRC Human Genetics Unit, MRC IGMM, Western General Hospital, University of Edinburgh, Edinburgh, UK.
Vermeulen S Vermeulen Sita S Department for Health Evidence, Radboud University Medical Center, Nijmegen, The Netherlands.
Vuoksimaa E Vuoksimaa Eero E Department of Public Health, University of Helsinki, Helsinki, Finland.
Widen E Widen Elisabeth E Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland.
Wouda J Wouda Jasper J Department of Biological Psychology, VU University Amsterdam, Amsterdam, The Netherlands.
Wright MJ Wright Margaret J MJ QIMR Berghofer Medical Research Institute, Brisbane, Australia.
Zgaga L Zgaga Lina L Department of Public Health and Primary Care, Trinity College Dublin, Dublin, Ireland.
Generation Scotland
Porteous D Porteous David D Medical Genetics Section, Centre for Genomics and Experimental Medicine, Institute of Genetics and Molecular Medicine, Western General Hospital, The University of Edinburgh, Edinburgh, UK.
Minelli A Minelli Alessandra A Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy.
Palmer AA Palmer Abraham A AA Department of Psychiatry and Behavioral Neuroscience, University of Chicago, Chicago, USA.
Rujescu D Rujescu Dan D Department of Psychiatry, University of Halle, Halle, Germany.
Ciullo M Ciullo Marina M Institute of Genetics and Biophysics "A. Buzzati-Traverso" - CNR, Naples, Italy.
Hayward C Hayward Caroline C MRC Human Genetics Unit, MRC IGMM, Western General Hospital, University of Edinburgh, Edinburgh, UK.
Rudan I Rudan Igor I Usher Institute for Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK.
Metspalu A Metspalu Andres A Estonian Academy of Sciences, Tallinn, Estonia.
Kaprio J Kaprio Jaakko J Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland.
Deary IJ Deary Ian J IJ Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK.
Räikkönen K Räikkönen Katri K Institute of Behavioural Sciences, University of Helsinki, Helsinki, Finland.
Wilson JF Wilson James F JF Usher Institute for Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK.
Keltikangas-Järvinen L Keltikangas-Järvinen Liisa L Institute of Behavioural Sciences, University of Helsinki, Helsinki, Finland.
Bierut LJ Bierut Laura J LJ Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA.
Hettema JM Hettema John M JM Department of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA, USA.
Grabe HJ Grabe Hans J HJ Department of Psychiatry and Psychotherapy, HELIOS Hospital Stralsund, Stralsund, Germany.
Penninx BW Penninx Brenda W J H BW Department of Psychiatry, EMGO+ Institute, Neuroscience Campus Amsterdam, VU University Medical Center, Amsterdam, The Netherlands.
van Duijn CM van Duijn Cornelia M CM Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands.
Evans DM Evans David M DM Medical Research Council Integrative Epidemiology Unit, School of Social and Community Medicine, University of Bristol, Bristol, UK.
Schlessinger D Schlessinger David D Laboratory of Genetics, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA.
Pedersen NL Pedersen Nancy L NL Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Terracciano A Terracciano Antonio A National Institute on Aging, NIH, Baltimore, MD, USA.
McGue M McGue Matt M Institute of Public Health, University of Southern Denmark, Odense, Denmark.
Martin NG Martin Nicholas G NG QIMR Berghofer Medical Research Institute, Brisbane, Australia.
Boomsma DI Boomsma Dorret I DI Department of Biological Psychology, VU University Amsterdam, Amsterdam, The Netherlands.
INVESTIGATORS
JOURNAL
VOLUME: 46
ISSUE: 2
TITLE: Behavior genetics
ISOABBREVIATION: Behav Genet
YEAR: 2016
MONTH: Mar
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN: 1573-3297
ISSNTYPE: Electronic
MEDLINE JOURNAL
MEDLINETA: Behav Genet
COUNTRY: United States
ISSNLINKING: 0001-8244
NLMUNIQUEID: 0251711
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
Meta-Analysis
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
COMMENTS AND CORRECTIONS
REFTYPE REFSOURCE REFPMID NOTE
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GENERAL NOTE
KEYWORDS
KEYWORD
Common genetic variants
Imputation
Personality
Phenotype harmonization
Polygenic risk
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Cohort Studies
Extraversion, Psychological
Genome-Wide Association Study
Humans
Multifactorial Inheritance genetics
Personality genetics
Polymorphism, Single Nucleotide genetics
Risk Factors genetics
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
OTHER ID's
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