Genetic Epidemiology, Translational Neurogenomics, Psychiatric Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
26337138
TITLE
Zygosity Differences in Height and Body Mass Index of Twins From Infancy to Old Age: A Study of the CODATwins Project.
ABSTRACT
A trend toward greater body size in dizygotic (DZ) than in monozygotic (MZ) twins has been suggested by some but not all studies, and this difference may also vary by age. We analyzed zygosity differences in mean values and variances of height and body mass index (BMI) among male and female twins from infancy to old age. Data were derived from an international database of 54 twin cohorts participating in the COllaborative project of Development of Anthropometrical measures in Twins (CODATwins), and included 842,951 height and BMI measurements from twins aged 1 to 102 years. The results showed that DZ twins were consistently taller than MZ twins, with differences of up to 2.0 cm in childhood and adolescence and up to 0.9 cm in adulthood. Similarly, a greater mean BMI of up to 0.3 kg/m2 in childhood and adolescence and up to 0.2 kg/m2 in adulthood was observed in DZ twins, although the pattern was less consistent. DZ twins presented up to 1.7% greater height and 1.9% greater BMI than MZ twins; these percentage differences were largest in middle and late childhood and decreased with age in both sexes. The variance of height was similar in MZ and DZ twins at most ages. In contrast, the variance of BMI was significantly higher in DZ than in MZ twins, particularly in childhood. In conclusion, DZ twins were generally taller and had greater BMI than MZ twins, but the differences decreased with age in both sexes.
DATE PUBLISHED
2015 Oct
HISTORY
PUBSTATUS PUBSTATUSDATE
entrez 2015/09/05 06:00
pubmed 2015/09/05 06:00
medline 2016/07/07 06:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Jelenkovic A Jelenkovic Aline A Department of Social Research,University of Helsinki,Helsinki,Finland.
Yokoyama Y Yokoyama Yoshie Y Department of Public Health Nursing,Osaka City University,Osaka,Japan.
Sund R Sund Reijo R Department of Social Research,University of Helsinki,Helsinki,Finland.
Honda C Honda Chika C Osaka University Graduate School of Medicine,Osaka University,Osaka,Japan.
Bogl LH Bogl Leonie H LH Department of Public Health,University of Helsinki,Helsinki,Finland.
Aaltonen S Aaltonen Sari S Department of Social Research,University of Helsinki,Helsinki,Finland.
Ji F Ji Fuling F Department of Noncommunicable Diseases Prevention,Qingdao Centers for Disease Control and Prevention,Qingdao,China.
Ning F Ning Feng F Department of Noncommunicable Diseases Prevention,Qingdao Centers for Disease Control and Prevention,Qingdao,China.
Pang Z Pang Zengchang Z Department of Noncommunicable Diseases Prevention,Qingdao Centers for Disease Control and Prevention,Qingdao,China.
Ordoñana JR Ordoñana Juan R JR Department of Human Anatomy and Psychobiology,University of Murcia,Murcia,Spain.
Sánchez-Romera JF Sánchez-Romera Juan F JF Department of Developmental and Educational Psychology,University of Murcia,Murcia,Spain.
Colodro-Conde L Colodro-Conde Lucia L Department of Human Anatomy and Psychobiology,University of Murcia,Murcia,Spain.
Burt SA Burt S Alexandra SA Michigan State University,East Lansing,MI,USA.
Klump KL Klump Kelly L KL Michigan State University,East Lansing,MI,USA.
Medland SE Medland Sarah E SE QIMR Berghofer Medical Research Institute,Brisbane,Queensland,Australia.
Montgomery GW Montgomery Grant W GW QIMR Berghofer Medical Research Institute,Brisbane,Queensland,Australia.
Kandler C Kandler Christian C Department of Psychology,Bielefeld University,Bielefeld,Germany.
McAdams TA McAdams Tom A TA MRC Social,Genetic & Developmental Psychiatry Centre,Institute of Psychiatry,Psychology & Neuroscience,King's College London,London,UK.
Eley TC Eley Thalia C TC MRC Social,Genetic & Developmental Psychiatry Centre,Institute of Psychiatry,Psychology & Neuroscience,King's College London,London,UK.
Gregory AM Gregory Alice M AM Department of Psychology,Goldsmiths,University of London,New Cross,London,UK.
Saudino KJ Saudino Kimberly J KJ Department of Psychological and Brain Sciencies,Boston University,Boston,MA,USA.
Dubois L Dubois Lise L School of Epidemiology,Public Health and Preventive Medicine,University of Ottawa,Ottawa,Ontario,Canada.
Boivin M Boivin Michel M École de psychologie,Université Laval,Québec,Canada.
Tarnoki AD Tarnoki Adam D AD Department of Radiology and Oncotherapy,Semmelweis University,Budapest,Hungary.
Tarnoki DL Tarnoki David L DL Department of Radiology and Oncotherapy,Semmelweis University,Budapest,Hungary.
Haworth CM Haworth Claire M A CM MRC Integrative Epidemiology Unit,University of Bristol,Bristol,UK.
Plomin R Plomin Robert R MRC Social,Genetic & Developmental Psychiatry Centre,Institute of Psychiatry,Psychology & Neuroscience,King's College London,London,UK.
Öncel SY Öncel Sevgi Y SY Department of Statistics,Faculty of Arts and Sciences,Kırıkkale University,Kırıkkale,Turkey.
Aliev F Aliev Fazil F Departments of Psychiatry,Psychology,and Human and Molecular Genetics,Virginia Institute for Psychiatric and Behavioral Genetics,Virginia Commonwealth University,Richmond,VA,USA.
Stazi MA Stazi Maria A MA Istituto Superiore di Sanità - National Center for Epidemiology,Surveillance and Health Promotion,Rome,Italy.
Fagnani C Fagnani Corrado C Istituto Superiore di Sanità - National Center for Epidemiology,Surveillance and Health Promotion,Rome,Italy.
D'Ippolito C D'Ippolito Cristina C Istituto Superiore di Sanità - National Center for Epidemiology,Surveillance and Health Promotion,Rome,Italy.
Craig JM Craig Jeffrey M JM Murdoch Childrens Research Institute,Royal Children's Hospital,Melbourne,Victoria,Australia.
Saffery R Saffery Richard R Murdoch Childrens Research Institute,Royal Children's Hospital,Melbourne,Victoria,Australia.
Siribaddana SH Siribaddana Sisira H SH Institute of Research & Development,Battaramulla,Sri Lanka.
Hotopf M Hotopf Matthew M NIHR Mental Health Biomedical Research Centre,South London and Maudsley NHS Foundation Trust, andInstitute of Psychiatry Psychology and Neuroscience,King's College London,London,UK.
Sumathipala A Sumathipala Athula A Institute of Research & Development,Battaramulla,Sri Lanka.
Rijsdijk F Rijsdijk Fruhling F MRC Social,Genetic & Developmental Psychiatry Centre,Institute of Psychiatry,Psychology & Neuroscience,King's College London,London,UK.
Spector T Spector Timothy T Department of Twin Research and Genetic Epidemiology,King's College London,London,UK.
Mangino M Mangino Massimo M Department of Twin Research and Genetic Epidemiology,King's College London,London,UK.
Lachance G Lachance Genevieve G Department of Twin Research and Genetic Epidemiology,King's College London,London,UK.
Gatz M Gatz Margaret M Department of Psychology,University of Southern California,Los Angeles,CA,USA.
Butler DA Butler David A DA Institute of Medicine,National Academy of Sciences Washington,DC,WA,USA.
Bayasgalan G Bayasgalan Gombojav G Healthy Twin Association of Mongolia,Ulaanbaatar,Mongolia.
Narandalai D Narandalai Danshiitsoodol D Graduate School of Biomedical and Health Sciences,Hiroshima University,Hiroshima,Japan.
Freitas DL Freitas Duarte L DL Department of Physical Education and Sport,University of Madeira,Funchal,Portugal.
Maia JA Maia José Antonio JA CIFI2D,Faculty of Sport,University of Porto,Porto,Portugal.
Harden KP Harden K Paige KP Department of Psychology,University of Texas at Austin,Austin,TX,USA.
Tucker-Drob EM Tucker-Drob Elliot M EM Department of Psychology,University of Texas at Austin,Austin,TX,USA.
Kim B Kim Bia B Department of Psychology,Pusan National University,Busan,SouthKorea.
Chong Y Chong Youngsook Y Department of Psychology,Pusan National University,Busan,SouthKorea.
Hong C Hong Changhee C Department of Psychology,Pusan National University,Busan,SouthKorea.
Shin HJ Shin Hyun Jung HJ Department of Psychology,Pusan National University,Busan,SouthKorea.
Christensen K Christensen Kaare K The Danish Twin Registry,Institute of Public Health,Epidemiology,Biostatistics & Biodemography,University of Southern Denmark,Odense,Denmark.
Skytthe A Skytthe Axel A The Danish Twin Registry,Institute of Public Health,Epidemiology,Biostatistics & Biodemography,University of Southern Denmark,Odense,Denmark.
Kyvik KO Kyvik Kirsten O KO Department of Clinical Research,University of Southern Denmark,Odense,Denmark.
Derom CA Derom Catherine A CA Centre of Human Genetics,University Hospitals Leuven,Leuven,Belgium.
Vlietinck RF Vlietinck Robert F RF Centre of Human Genetics,University Hospitals Leuven,Leuven,Belgium.
Loos RJ Loos Ruth J F RJ The Charles Bronfman Institute for Personalized Medicine,The Mindich Child Health and Development Institute,Icahn School of Medicine at Mount Sinai,New York,NY,USA.
Cozen W Cozen Wendy W Department of Preventive Medicine,Keck School of Medicine of USC,University of Southern California,Los Angeles,CA,USA.
Hwang AE Hwang Amie E AE Department of Preventive Medicine,Keck School of Medicine of USC,University of Southern California,Los Angeles,CA,USA.
Mack TM Mack Thomas M TM Department of Preventive Medicine,Keck School of Medicine of USC,University of Southern California,Los Angeles,CA,USA.
He M He Mingguang M State Key Laboratory of Ophthalmology,Zhongshan Ophthalmic Center,Sun Yat-Sen University,Guangzhou,China.
Ding X Ding Xiaohu X State Key Laboratory of Ophthalmology,Zhongshan Ophthalmic Center,Sun Yat-Sen University,Guangzhou,China.
Chang B Chang Billy B State Key Laboratory of Ophthalmology,Zhongshan Ophthalmic Center,Sun Yat-Sen University,Guangzhou,China.
Silberg JL Silberg Judy L JL Department of Human and Molecular Genetics,Virginia Institute for Psychiatric and Behavioral Genetics,Virginia Commonwealth University,Richmond,VA,USA.
Eaves LJ Eaves Lindon J LJ Department of Human and Molecular Genetics,Virginia Institute for Psychiatric and Behavioral Genetics,Virginia Commonwealth University,Richmond,VA,USA.
Maes HH Maes Hermine H HH Department of Human and Molecular Genetics,Psychiatry & Massey Cancer Center,Virginia Commonwealth University,Richmond,VA,USA.
Cutler TL Cutler Tessa L TL The Australian Twin Registry,Centre for Epidemiology and Biostatistics,The University of Melbourne,Melbourne,Victoria,Australia.
Hopper JL Hopper John L JL The Australian Twin Registry,Centre for Epidemiology and Biostatistics,The University of Melbourne,Melbourne,Victoria,Australia.
Aujard K Aujard Kelly K Centre for Epidemiology and Biostatistics,The University of Melbourne,Melbourne,Victoria,Australia.
Magnusson PK Magnusson Patrik K E PK Department of Medical Epidemiology and Biostatistics,Karolinska Institutet,Stockholm,Sweden.
Pedersen NL Pedersen Nancy L NL Department of Medical Epidemiology and Biostatistics,Karolinska Institutet,Stockholm,Sweden.
Aslan AK Aslan Anna K Dahl AK Department of Medical Epidemiology and Biostatistics,Karolinska Institutet,Stockholm,Sweden.
Song YM Song Yun-Mi YM Department of Family Medicine,Samsung Medical Center,School of Medicine,Sungkyunkwan University,Seoul,South Korea.
Yang S Yang Sarah S Department of Epidemiology,School of Public Health,Seoul National University,Seoul,SouthKorea.
Lee K Lee Kayoung K Department of Family Medicine,Busan Paik Hospital,Inje University College of Medicine,Busan,South Korea.
Baker LA Baker Laura A LA Department of Psychology,University of Southern California,Los Angeles,CA,USA.
Tuvblad C Tuvblad Catherine C Department of Psychology,University of Southern California,Los Angeles,CA,USA.
Bjerregaard-Andersen M Bjerregaard-Andersen Morten M Bandim Health Project,INDEPTH Network,Bissau,Guinea-Bissau.
Beck-Nielsen H Beck-Nielsen Henning H Department of Endocrinology,Odense University Hospital,Odense,Denmark.
Sodemann M Sodemann Morten M Department of Infectious Diseases,Odense University Hospital,Odense,Denmark.
Heikkilä K Heikkilä Kauko K Department of Public Health,University of Helsinki,Helsinki,Finland.
Tan Q Tan Qihua Q Epidemiology,Biostatistics and Biodemography,Institute of Public Health,University of Southern Denmark,Odense,Denmark.
Zhang D Zhang Dongfeng D Department of Public Health,Qingdao University Medical College,Qingdao,China.
Swan GE Swan Gary E GE Department of Medicine,Stanford Prevention Research Center,Stanford University School of Medicine,Stanford,CA,USA.
Krasnow R Krasnow Ruth R Center for Health Sciences,SRI International,Menlo Park,CA,USA.
Jang KL Jang Kerry L KL Department of Psychiatry,University of British Columbia,Vancouver,British Columbia,Canada.
Knafo-Noam A Knafo-Noam Ariel A The Hebrew University of Jerusalem,Jerusalem,Israel.
Mankuta D Mankuta David D Department of Obstetrics and Gynecology,Hadassah Hospital,Hebrew University Medical School,Jerusalem,Israel.
Abramson L Abramson Lior L The Hebrew University of Jerusalem,Jerusalem,Israel.
Lichtenstein P Lichtenstein Paul P Department of Medical Epidemiology and Biostatistics,Karolinska Institutet,Stockholm,Sweden.
Krueger RF Krueger Robert F RF Department of Psychology,University of Minnesota,Minneapolis,MN,USA.
McGue M McGue Matt M Department of Psychology,University of Minnesota,Minneapolis,MN,USA.
Pahlen S Pahlen Shandell S Department of Psychology,University of Minnesota,Minneapolis,MN,USA.
Tynelius P Tynelius Per P Department of Public Health Sciences,Karolinska Institutet,Stockholm,Sweden.
Duncan GE Duncan Glen E GE Center for Clinical and Epidemiological Research,University of Washington,Seattle,WA,USA.
Buchwald D Buchwald Dedra D Center for Clinical and Epidemiological Research,University of Washington,Seattle,WA,USA.
Corley RP Corley Robin P RP Institute for Behavioral Genetics,Boulder,CO,USA.
Huibregtse BM Huibregtse Brooke M BM Institute for Behavioral Genetics,Boulder,CO,USA.
Nelson TL Nelson Tracy L TL Department of Health and Exercise Sciences and Colorado School of Public Health,Colorado State University,CO,USA.
Whitfield KE Whitfield Keith E KE Psychology and Neuroscience,Duke University,Durham,NC,USA.
Franz CE Franz Carol E CE Department of Psychiatry,University of California,San Diego,CA,USA.
Kremen WS Kremen William S WS Department of Psychiatry,University of California,San Diego,CA,USA.
Lyons MJ Lyons Michael J MJ Department of Psychology,Boston University,Boston,MA,USA.
Ooki S Ooki Syuichi S Department of Health Science,Ishikawa Prefectural Nursing University,Kahoku,Ishikawa,Japan.
Brandt I Brandt Ingunn I Department of Genes and Environment,Division of Epidemiology,Norwegian Institute of Public Health,Oslo,Norway.
Nilsen TS Nilsen Thomas Sevenius TS Department of Genes and Environment,Division of Epidemiology,Norwegian Institute of Public Health,Oslo,Norway.
Inui F Inui Fujio F Faculty of Health Science,Kio University,Nara,Japan.
Watanabe M Watanabe Mikio M Osaka University Graduate School of Medicine,Osaka University,Osaka,Japan.
Bartels M Bartels Meike M Department of Biological Psychology,VU University Amsterdam,Amsterdam,The Netherlands.
van Beijsterveldt TC van Beijsterveldt Toos C E M TC Department of Biological Psychology,VU University Amsterdam,Amsterdam,The Netherlands.
Wardle J Wardle Jane J Department of Epidemiology and Public Health,Health Behaviour Research Centre,Institute of Epidemiology and Health Care,University College London,London,UK.
Llewellyn CH Llewellyn Clare H CH Department of Epidemiology and Public Health,Health Behaviour Research Centre,Institute of Epidemiology and Health Care,University College London,London,UK.
Fisher A Fisher Abigail A Department of Epidemiology and Public Health,Health Behaviour Research Centre,Institute of Epidemiology and Health Care,University College London,London,UK.
Rebato E Rebato Esther E Department of Genetics,Physical Anthropology and Animal Physiology,University of the Basque Country UPV/EHU,Leioa,Spain.
Martin NG Martin Nicholas G NG QIMR Berghofer Medical Research Institute,Brisbane,Queensland,Australia.
Iwatani Y Iwatani Yoshinori Y Osaka University Graduate School of Medicine,Osaka University,Osaka,Japan.
Hayakawa K Hayakawa Kazuo K Osaka University Graduate School of Medicine,Osaka University,Osaka,Japan.
Sung J Sung Joohon J Department of Epidemiology,School of Public Health,Seoul National University,Seoul,SouthKorea.
Harris JR Harris Jennifer R JR Department of Genes and Environment,Division of Epidemiology,Norwegian Institute of Public Health,Oslo,Norway.
Willemsen G Willemsen Gonneke G Department of Biological Psychology,VU University Amsterdam,Amsterdam,The Netherlands.
Busjahn A Busjahn Andreas A HealthTwiSt GmbH,Berlin,Germany.
Goldberg JH Goldberg Jack H JH Department of Epidemiology,School of Public Health,University of Washington,Seattle,WA,USA.
Rasmussen F Rasmussen Finn F Department of Public Health Sciences,Karolinska Institutet,Stockholm,Sweden.
Hur YM Hur Yoon-Mi YM Department of Education,Mokpo National University,Jeonnam,South Korea.
Boomsma DI Boomsma Dorret I DI Department of Biological Psychology,VU University Amsterdam,Amsterdam,The Netherlands.
Sørensen TI Sørensen Thorkild I A TI Section on Metabolic Genetics,Novo Nordisk Foundation Centre for Basic Metabolic Research,Faculty of Health and Medical Sciences,University of Copenhagen,Copenhagen,Denmark.
Kaprio J Kaprio Jaakko J Department of Public Health,University of Helsinki,Helsinki,Finland.
Silventoinen K Silventoinen Karri K Department of Social Research,University of Helsinki,Helsinki,Finland.
INVESTIGATORS
JOURNAL
VOLUME: 18
ISSUE: 5
TITLE: Twin research and human genetics : the official journal of the International Society for Twin Studies
ISOABBREVIATION: Twin Res Hum Genet
YEAR: 2015
MONTH: Oct
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN: 1832-4274
ISSNTYPE: Print
MEDLINE JOURNAL
MEDLINETA: Twin Res Hum Genet
COUNTRY: England
ISSNLINKING: 1832-4274
NLMUNIQUEID: 101244624
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Twin Study
COMMENTS AND CORRECTIONS
GRANTS
GRANTID AGENCY COUNTRY
C1418/A7974 Medical Research Council United Kingdom
R21 MH070542 NIMH NIH HHS United States
R01 MH081813 NIMH NIH HHS United States
T32 DA017637 NIDA NIH HHS United States
R01 AG022982 NIA NIH HHS United States
R01 MH092377 NIMH NIH HHS United States
R01 AG018386 NIA NIH HHS United States
G120/635 Medical Research Council United Kingdom
HD10333 NICHD NIH HHS United States
14133 Cancer Research UK United Kingdom
R01 ES015150 NIEHS NIH HHS United States
R01-HD066040 NICHD NIH HHS United States
R01AG018386 NIA NIH HHS United States
R21-MH070542-01 NIMH NIH HHS United States
R01 HD066040 NICHD NIH HHS United States
R01 AA009203 NIAAA NIH HHS United States
R01-MH092377-02 NIMH NIH HHS United States
R01 AG018384 NIA NIH HHS United States
P01AG08761 NIA NIH HHS United States
R03-MH63851-01 NIMH NIH HHS United States
G0901245 Medical Research Council United Kingdom
R01-MH081813 NIMH NIH HHS United States
R01AG018384 NIA NIH HHS United States
R01AG022381 NIA NIH HHS United States
1R01ESO15150-01 PHS HHS United States
R21 AG039572 NIA NIH HHS United States
230374 European Research Council International
DA011015 NIDA NIH HHS United States
RC2 HL103416 NHLBI NIH HHS United States
R01 HD010333 NICHD NIH HHS United States
G19/2 Medical Research Council United Kingdom
R01MH062375 NIMH NIH HHS United States
P01 AG008761 NIA NIH HHS United States
K05 AA000145 NIAAA NIH HHS United States
R01 AA012502 NIAAA NIH HHS United States
G0500079 Medical Research Council United Kingdom
R01 MH58354 NIMH NIH HHS United States
R03 MH063851 NIMH NIH HHS United States
R01-MH0820-54 NIMH NIH HHS United States
1R01-AG13662-01A2 NIA NIH HHS United States
R01 HD068435 NICHD NIH HHS United States
R01 MH062375 NIMH NIH HHS United States
R01 MH058354 NIMH NIH HHS United States
P60 DA011015 NIDA NIH HHS United States
R01 AG022381 NIA NIH HHS United States
R37 AA012502 NIAAA NIH HHS United States
R01 AG050595 NIA NIH HHS United States
GENERAL NOTE
KEYWORDS
KEYWORD
BMI
height
twins
zygosity differences
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Adolescent
Adult
Aged
Aged, 80 and over
Body Height
Body Mass Index
Child
Child, Preschool
Cohort Studies
Databases, Factual
Female
Humans
Infant
Linear Models
Male
Middle Aged
Twins, Dizygotic
Twins, Monozygotic
Young Adult
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
OTHER ID's
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