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PMID |
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TITLE |
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Multicohort analysis of the maternal age effect on recombination. |
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ABSTRACT |
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Several studies have reported that the number of crossovers increases with maternal age in humans, but others have found the opposite. Resolving the true effect has implications for understanding the maternal age effect on aneuploidies. Here, we revisit this question in the largest sample to date using single nucleotide polymorphism (SNP)-chip data, comprising over 6,000 meioses from nine cohorts. We develop and fit a hierarchical model to allow for differences between cohorts and between mothers. We estimate that over 10 years, the expected number of maternal crossovers increases by 2.1% (95% credible interval (0.98%, 3.3%)). Our results are not consistent with the larger positive and negative effects previously reported in smaller cohorts. We see heterogeneity between cohorts that is likely due to chance effects in smaller samples, or possibly to confounders, emphasizing that care should be taken when interpreting results from any specific cohort about the effect of maternal age on recombination. |
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DATE PUBLISHED |
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HISTORY |
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PUBSTATUS |
PUBSTATUSDATE |
received |
2014/12/19 |
accepted |
2015/06/18 |
entrez |
2015/08/06 06:00 |
pubmed |
2015/08/06 06:00 |
medline |
2015/08/06 06:00 |
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AUTHORS |
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NAME |
COLLECTIVENAME |
LASTNAME |
FORENAME |
INITIALS |
AFFILIATION |
AFFILIATIONINFO |
Martin HC |
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Martin |
Hilary C |
HC |
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Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX17BN, UK. |
Christ R |
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Christ |
Ryan |
R |
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Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX17BN, UK. |
Hussin JG |
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Hussin |
Julie G |
JG |
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Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX17BN, UK. |
O'Connell J |
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O'Connell |
Jared |
J |
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Illumina, Inc., Chesterford Research Park, Little Chesterford CB10 1XL, UK. |
Gordon S |
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Gordon |
Scott |
S |
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QIMR Berghofer Medical Research Institute, Brisbane, Queensland 4006, Australia. |
Mbarek H |
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Mbarek |
Hamdi |
H |
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Department for Biological Psychiatry, Vrije Universiteit, Amsterdam 1081, The Netherlands. |
Hottenga JJ |
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Hottenga |
Jouke-Jan |
JJ |
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Department for Biological Psychiatry, Vrije Universiteit, Amsterdam 1081, The Netherlands. |
McAloney K |
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McAloney |
Kerrie |
K |
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QIMR Berghofer Medical Research Institute, Brisbane, Queensland 4006, Australia. |
Willemsen G |
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Willemsen |
Gonnecke |
G |
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Department for Biological Psychiatry, Vrije Universiteit, Amsterdam 1081, The Netherlands. |
Gasparini P |
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Gasparini |
Paolo |
P |
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Institute for Maternal and Child Health-IRCCS Burlo Garofolo, University of Trieste, Trieste 34137, Italy. |
Pirastu N |
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Pirastu |
Nicola |
N |
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Institute for Maternal and Child Health-IRCCS Burlo Garofolo, University of Trieste, Trieste 34137, Italy. |
Montgomery GW |
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Montgomery |
Grant W |
GW |
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QIMR Berghofer Medical Research Institute, Brisbane, Queensland 4006, Australia. |
Navarro P |
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Navarro |
Pau |
P |
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MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh EH4 2XU, UK. |
Soranzo N |
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Soranzo |
Nicole |
N |
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Wellcome Trust Sanger Institute, Hinxton CB10 1HH, UK. |
Toniolo D |
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Toniolo |
Daniela |
D |
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Division of Genetics and Cell Biology, San Raffaele Scientific Institute, Milan 20132, Italy. |
Vitart V |
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Vitart |
Veronique |
V |
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MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh EH4 2XU, UK. |
Wilson JF |
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Wilson |
James F |
JF |
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1] MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh EH4 2XU, UK [2] Institute for Population Health Sciences and Informatics, University of Edinburgh, Edinburgh EH16 4TJ, UK. |
Marchini J |
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Marchini |
Jonathan |
J |
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1] Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX17BN, UK [2] Department of Statistics, University of Oxford, Oxford OX1 3TG, UK. |
Boomsma DI |
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Boomsma |
Dorret I |
DI |
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Department for Biological Psychiatry, Vrije Universiteit, Amsterdam 1081, The Netherlands. |
Martin NG |
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Martin |
Nicholas G |
NG |
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QIMR Berghofer Medical Research Institute, Brisbane, Queensland 4006, Australia. |
Donnelly P |
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Donnelly |
Peter |
P |
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1] Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX17BN, UK [2] Department of Statistics, University of Oxford, Oxford OX1 3TG, UK. |
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JOURNAL |
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VOLUME: 6 |
ISSUE: |
TITLE: Nature communications |
ISOABBREVIATION: Nat Commun |
YEAR: 2015 |
MONTH: |
DAY: |
MEDLINEDATE: |
SEASON: |
CITEDMEDIUM: Internet |
ISSN: 2041-1723 |
ISSNTYPE: Electronic |
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MEDLINE JOURNAL |
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MEDLINETA: Nat Commun |
COUNTRY: England |
ISSNLINKING: 2041-1723 |
NLMUNIQUEID: 101528555 |
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Journal Article |
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