Genetic Epidemiology, Translational Neurogenomics, Psychiatric Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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26231222
TITLE
Shared genetics underlying epidemiological association between endometriosis and ovarian cancer.
ABSTRACT
Epidemiological studies have demonstrated associations between endometriosis and certain histotypes of ovarian cancer, including clear cell, low-grade serous and endometrioid carcinomas. We aimed to determine whether the observed associations might be due to shared genetic aetiology. To address this, we used two endometriosis datasets genotyped on common arrays with full-genome coverage (3194 cases and 7060 controls) and a large ovarian cancer dataset genotyped on the customized Illumina Infinium iSelect (iCOGS) arrays (10 065 cases and 21 663 controls). Previous work has suggested that a large number of genetic variants contribute to endometriosis and ovarian cancer (all histotypes combined) susceptibility. Here, using the iCOGS data, we confirmed polygenic architecture for most histotypes of ovarian cancer. This led us to evaluate if the polygenic effects are shared across diseases. We found evidence for shared genetic risks between endometriosis and all histotypes of ovarian cancer, except for the intestinal mucinous type. Clear cell carcinoma showed the strongest genetic correlation with endometriosis (0.51, 95% CI = 0.18-0.84). Endometrioid and low-grade serous carcinomas had similar correlation coefficients (0.48, 95% CI = 0.07-0.89 and 0.40, 95% CI = 0.05-0.75, respectively). High-grade serous carcinoma, which often arises from the fallopian tubes, showed a weaker genetic correlation with endometriosis (0.25, 95% CI = 0.11-0.39), despite the absence of a known epidemiological association. These results suggest that the epidemiological association between endometriosis and ovarian adenocarcinoma may be attributable to shared genetic susceptibility loci.
© The Author 2015. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.
DATE PUBLISHED
2015 Oct 15
HISTORY
PUBSTATUS PUBSTATUSDATE
received 2015/05/19
accepted 2015/07/24
entrez 2015/08/02 06:00
pubmed 2015/08/02 06:00
medline 2016/07/13 06:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Lu Y Lu Yi Y Statistical Genetics.
Cuellar-Partida G Cuellar-Partida Gabriel G Statistical Genetics.
Painter JN Painter Jodie N JN Molecular Cancer Epidemiology.
Nyholt DR Nyholt Dale R DR Institute of Health and Biomedical Innovation, Queensland University of Technology, Queensland, Australia.
Australian Ovarian Cancer Study
International Endogene Consortium (IEC)
Morris AP Morris Andrew P AP Genetic and Genomic Epidemiology Unit, Wellcome Trust Centre for Human Genetics and Department of Biostatistics, University of Liverpool, Liverpool, UK.
Fasching PA Fasching Peter A PA Division of Hematology and Oncology, Department of Medicine, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA, USA, Department of Gynecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen Nuremberg, Universitaetsstrasse 21-23, 91054 Erlangen, Germany.
Hein A Hein Alexander A Department of Gynecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen Nuremberg, Universitaetsstrasse 21-23, 91054 Erlangen, Germany.
Burghaus S Burghaus Stefanie S Department of Gynecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen Nuremberg, Universitaetsstrasse 21-23, 91054 Erlangen, Germany.
Beckmann MW Beckmann Matthias W MW Department of Gynecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen Nuremberg, Universitaetsstrasse 21-23, 91054 Erlangen, Germany.
Lambrechts D Lambrechts Diether D Laboratory for Translational Genetics, Department of Oncology, University of Leuven, Leuven, Belgium, Vesalius Research Center, VIB, Leuven, Belgium.
Van Nieuwenhuysen E Van Nieuwenhuysen Els E Division of Gynecologic Oncology, Department of Obstetrics and Gynaecology and Leuven Cancer Institute, University Hospitals Leuven, Leuven, Belgium.
Vergote I Vergote Ignace I Division of Gynecologic Oncology, Department of Obstetrics and Gynaecology and Leuven Cancer Institute, University Hospitals Leuven, Leuven, Belgium.
Vanderstichele A Vanderstichele Adriaan A Division of Gynecologic Oncology, Department of Obstetrics and Gynaecology and Leuven Cancer Institute, University Hospitals Leuven, Leuven, Belgium.
Doherty JA Doherty Jennifer Anne JA Department of Community and Family Medicine, Section of Biostatistics & Epidemiology, Geisel School of Medicine, Dartmouth College, Hanover, NH, USA.
Rossing MA Rossing Mary Anne MA Department of Epidemiology, University of Washington, Seattle, WA, USA, Program in Epidemiology, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Wicklund KG Wicklund Kristine G KG Program in Epidemiology, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Chang-Claude J Chang-Claude Jenny J Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany.
Eilber U Eilber Ursula U Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany.
Rudolph A Rudolph Anja A Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany.
Wang-Gohrke S Wang-Gohrke Shan S Department of Obstetrics and Gynecology, University of Ulm, Ulm, Germany.
Goodman MT Goodman Marc T MT Cancer Prevention and Control, Samuel Oschin Comprehensive Cancer Institute and Department of Biomedical Sciences, Community and Population Health Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Bogdanova N Bogdanova Natalia N Radiation Oncology Research Unit.
Dörk T Dörk Thilo T Gynaecology Research Unit and.
Dürst M Dürst Matthias M Department of Gynecology, Jena-University Hospital-Friedrich Schiller University, Jena, Germany.
Hillemanns P Hillemanns Peter P Clinics of Obstetrics and Gynaecology, Hannover Medical School, Hannover, Germany.
Runnebaum IB Runnebaum Ingo B IB Department of Gynecology, Jena-University Hospital-Friedrich Schiller University, Jena, Germany.
Antonenkova N Antonenkova Natalia N N.N. Alexandrov National Cancer Centre of Belarus, Minsk, Belarus.
Butzow R Butzow Ralf R Department of Pathology and.
Leminen A Leminen Arto A Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
Nevanlinna H Nevanlinna Heli H Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
Pelttari LM Pelttari Liisa M LM Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
Edwards RP Edwards Robert P RP Division of Gynecologic Oncology, Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA, Womens Cancer Research Program, Magee-Womens Research Institute and University of Pittsburgh Cancer Institute, Pittsburgh, PA, USA.
Kelley JL Kelley Joseph L JL Division of Gynecologic Oncology, Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Modugno F Modugno Francesmary F Division of Gynecologic Oncology, Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA, Womens Cancer Research Program, Magee-Womens Research Institute and University of Pittsburgh Cancer Institute, Pittsburgh, PA, USA, Department of Epidemiology, University of Pittsburgh Graduate School of Public Health, Pittsburgh, PA, USA.
Moysich KB Moysich Kirsten B KB Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, NY, USA.
Ness RB Ness Roberta B RB The University of Texas School of Public Health, Houston, TX, USA.
Cannioto R Cannioto Rikki R Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, NY, USA.
Høgdall E Høgdall Estrid E Department of Virus, Lifestyle and Genes, Danish Cancer Society Research Center, Copenhagen, Denmark, Molecular Unit, Department of Pathology, Herlev Hospital, Herlev, Denmark.
Jensen A Jensen Allan A Department of Virus, Lifestyle and Genes, Danish Cancer Society Research Center, Copenhagen, Denmark.
Giles GG Giles Graham G GG Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Victoria, Australia, Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Victoria, Australia, Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Australia.
Bruinsma F Bruinsma Fiona F Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Australia.
Kjaer SK Kjaer Susanne K SK Department of Virus, Lifestyle and Genes, Danish Cancer Society Research Center, Copenhagen, Denmark, Department of Gynaecology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
Hildebrandt MA Hildebrandt Michelle A T MA Department of Epidemiology and.
Liang D Liang Dong D College of Pharmacy and Health Sciences, Texas Southern University, Houston, TX, USA.
Lu KH Lu Karen H KH Department of Gynecologic Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Wu X Wu Xifeng X Department of Epidemiology and.
Bisogna M Bisogna Maria M Gynecology Service, Department of Surgery and.
Dao F Dao Fanny F Gynecology Service, Department of Surgery and.
Levine DA Levine Douglas A DA Gynecology Service, Department of Surgery and.
Cramer DW Cramer Daniel W DW Obstetrics and Gynecology Epidemiology Center, Brigham and Women's Hospital, Boston, MA, USA.
Terry KL Terry Kathryn L KL Obstetrics and Gynecology Epidemiology Center, Brigham and Women's Hospital, Boston, MA, USA, Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Tworoger SS Tworoger Shelley S SS Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA, Channing Division of Network Medicine, Department of Medicine and.
Missmer S Missmer Stacey S Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA, Channing Division of Network Medicine, Department of Medicine and Department of Obstetrics and Gynecology, Gynecology and Reproductive Biology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Bjorge L Bjorge Line L Department of Gynecology and Obstetrics, Haukeland University Hospital, Bergen, Norway, Department of Clinical Science, Centre for Cancer Biomarkers, University of Bergen, Bergen, Norway.
Salvesen HB Salvesen Helga B HB Department of Gynecology and Obstetrics, Haukeland University Hospital, Bergen, Norway, Department of Clinical Science, Centre for Cancer Biomarkers, University of Bergen, Bergen, Norway.
Kopperud RK Kopperud Reidun K RK Department of Gynecology and Obstetrics, Haukeland University Hospital, Bergen, Norway, Department of Clinical Science, Centre for Cancer Biomarkers, University of Bergen, Bergen, Norway.
Bischof K Bischof Katharina K Department of Gynecology and Obstetrics, Haukeland University Hospital, Bergen, Norway, Department of Clinical Science, Centre for Cancer Biomarkers, University of Bergen, Bergen, Norway.
Aben KK Aben Katja K H KK Radboud University Medical Centre, Radboud Institute for Health Sciences, Nijmegen, The Netherlands, Netherlands Comprehensive Cancer Organisation, Utrecht, The Netherlands.
Kiemeney LA Kiemeney Lambertus A LA Radboud University Medical Centre, Radboud Institute for Health Sciences, Nijmegen, The Netherlands.
Massuger LF Massuger Leon F A G LF Department of Obstetrics and Gynaecology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, The Netherlands.
Brooks-Wilson A Brooks-Wilson Angela A Canada's Michael Smith Genome Sciences Centre and Department of Biomedical Physiology and Kinesiology, Simon Fraser University, Burnaby, BC, Canada.
Olson SH Olson Sara H SH Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
McGuire V McGuire Valerie V Department of Health Research and Policy-Epidemiology, Stanford University School of Medicine, Stanford, CA, USA.
Rothstein JH Rothstein Joseph H JH Department of Health Research and Policy-Epidemiology, Stanford University School of Medicine, Stanford, CA, USA.
Sieh W Sieh Weiva W Department of Health Research and Policy-Epidemiology, Stanford University School of Medicine, Stanford, CA, USA.
Whittemore AS Whittemore Alice S AS Department of Health Research and Policy-Epidemiology, Stanford University School of Medicine, Stanford, CA, USA.
Cook LS Cook Linda S LS Division of Epidemiology and Biostatistics, Department of Internal Medicine, University of New Mexico, Albuquerque, NM, USA.
Le ND Le Nhu D ND Cancer Control Research, BC Cancer Agency, Vancouver, BC, Canada.
Gilks CB Gilks C Blake CB Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada.
Gronwald J Gronwald Jacek J Department of Genetics and Pathology, International Hereditary Cancer Center, Pomeranian Medical University, Szczecin, Poland.
Jakubowska A Jakubowska Anna A Department of Genetics and Pathology, International Hereditary Cancer Center, Pomeranian Medical University, Szczecin, Poland.
Lubiński J Lubiński Jan J Department of Genetics and Pathology, International Hereditary Cancer Center, Pomeranian Medical University, Szczecin, Poland.
Gawełko J Gawełko Jan J Medical Faculty, Institute of Nursing and Health Sciences, University of Rzeszów, Rzeszów, Poland.
Song H Song Honglin H Department of Oncology and.
Tyrer JP Tyrer Jonathan P JP Department of Oncology and.
Wentzensen N Wentzensen Nicolas N Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.
Brinton L Brinton Louise L Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.
Trabert B Trabert Britton B Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.
Lissowska J Lissowska Jolanta J M. Sklodowska-Curie Memorial Cancer Center, Warsaw, Poland.
Mclaughlin JR Mclaughlin John R JR Public Health Ontario, Toronto, ON, Canada.
Narod SA Narod Steven A SA Women's College Research Institute, University of Toronto, Toronto, ON, Canada.
Phelan C Phelan Catherine C Department of Cancer Epidemiology, Moffitt Cancer Center, Tampa, FL, USA.
Anton-Culver H Anton-Culver Hoda H Department of Epidemiology and Center for Cancer Genetics Research & Prevention, School of Medicine, University of California Irvine, Irvine, CA, USA.
Ziogas A Ziogas Argyrios A Department of Epidemiology and.
Eccles D Eccles Diana D Faculty of Medicine, University of Southampton, Southampton, UK.
Gayther SA Gayther Simon A SA Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, CA, USA.
Gentry-Maharaj A Gentry-Maharaj Aleksandra A Women's Cancer, Institute for Women's Health, University College London, London, UK.
Menon U Menon Usha U Women's Cancer, Institute for Women's Health, University College London, London, UK.
Ramus SJ Ramus Susan J SJ Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, CA, USA.
Wu AH Wu Anna H AH Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, CA, USA.
Dansonka-Mieszkowska A Dansonka-Mieszkowska Agnieszka A Department of Pathology and Laboratory Diagnostics, The Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Warsaw, Poland.
Kupryjanczyk J Kupryjanczyk Jolanta J Department of Pathology and Laboratory Diagnostics, The Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Warsaw, Poland.
Timorek A Timorek Agnieszka A Department of Obstetrics, Gynecology and Oncology, IInd Faculty of Medicine, Warsaw Medical University and Brodnowski Hospital, Warsaw, Poland.
Szafron L Szafron Lukasz L Department of Pathology and Laboratory Diagnostics, The Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Warsaw, Poland.
Cunningham JM Cunningham Julie M JM Division of Experimental Pathology, Department of Laboratory Medicine and Pathology.
Fridley BL Fridley Brooke L BL Department of Biostatistics, University of Kansas, Kansas City, KS, USA.
Winham SJ Winham Stacey J SJ Division of Biomedical Statistics and Informatics, Department of Health Sciences Research and.
Bandera EV Bandera Elisa V EV Rutgers Cancer Institute of New Jersey, New Brunswick, NJ, USA.
Poole EM Poole Elizabeth M EM Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA, Channing Division of Network Medicine, Department of Medicine and.
Morgan TK Morgan Terry K TK Department of Pathology and Department of Obstetrics and Gynecology, OHSU, Portland, OR, USA.
Risch HA Risch Harvey A HA Department of Chronic Disease Epidemiology, Yale School of Public Health, New Haven, CT, USA.
Goode EL Goode Ellen L EL Division of Epidemiology, Department of Health Science Research, Mayo Clinic, Rochester, MN, USA.
Schildkraut JM Schildkraut Joellen M JM Department of Community and Family Medicine and Cancer Control and Population Sciences, Duke Cancer Institute, Durham, NC, USA.
Webb PM Webb Penelope M PM Population Health Department.
Pearce CL Pearce Celeste L CL Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, CA, USA, Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, MI, USA and.
Berchuck A Berchuck Andrew A Duke Cancer Institute, Duke University Medical Center, Durham, NC, USA.
Pharoah PD Pharoah Paul D P PD Department of Oncology and Department of Public Health and Primary Care, The Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge, UK.
Montgomery GW Montgomery Grant W GW Molecular Epidemiology and.
Zondervan KT Zondervan Krina T KT Genetic and Genomic Epidemiology Unit, Wellcome Trust Centre for Human Genetics and Endometriosis CaRe Centre, Nuffield Dept of Obstetrics & Gynaecology, University of Oxford, Oxford, UK.
Chenevix-Trench G Chenevix-Trench Georgia G Genetics and Computational Biology Department, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, QLD 4006, Australia.
MacGregor S MacGregor Stuart S Statistical Genetics, stuart.macgregor@qimrberghofer.edu.au.
INVESTIGATORS
LASTNAME FORENAME INITIALS AFFILIATION
Anderson Carl A CA
Gordon Scott D SD
Guo Qun Q
Henders Anjali K AK
Lambert Ann A
Lee Sang Hong SH
Kraft Peter P
Kennedy Stephen H SH
Macgregor Stuart S
Martin Nicholas G NG
Missmer Stacey A SA
Montgomery Grant W GW
Morris Andrew P AP
Nyholt Dale R DR
Painter Jodie N JN
Roseman Fenella F
Treloar Susan A SA
Visscher Peter M PM
Wallace Leanne L
Zondervan Krina T KT
JOURNAL
VOLUME: 24
ISSUE: 20
TITLE: Human molecular genetics
ISOABBREVIATION: Hum Mol Genet
YEAR: 2015
MONTH: Oct
DAY: 15
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN: 1460-2083
ISSNTYPE: Electronic
MEDLINE JOURNAL
MEDLINETA: Hum Mol Genet
COUNTRY: England
ISSNLINKING: 0964-6906
NLMUNIQUEID: 9208958
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
Multicenter Study
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
COMMENTS AND CORRECTIONS
GRANTS
GRANTID AGENCY COUNTRY
R01-CA092044 NCI NIH HHS United States
R03-CA115195 NCI NIH HHS United States
UL1 TR000005 NCATS NIH HHS United States
R01 CA087538 NCI NIH HHS United States
R01-CA058598 NCI NIH HHS United States
R01-CA074850 NCI NIH HHS United States
R01-CA061132 NCI NIH HHS United States
R01-CA063678 NCI NIH HHS United States
N01-PC67001 NCI NIH HHS United States
R01-CA114343 NCI NIH HHS United States
10124 Cancer Research UK United Kingdom
P01-CA017054 NCI NIH HHS United States
R01-CA067262 NCI NIH HHS United States
P50-CA159981 NCI NIH HHS United States
UM1-CA176726 NCI NIH HHS United States
K07-CA80668 NCI NIH HHS United States
K22-CA138563 NCI NIH HHS United States
085235 Wellcome Trust United Kingdom
P30 CA072720 NCI NIH HHS United States
N01-CN55424 NCI NIH HHS United States
R01-CA054419 NCI NIH HHS United States
MO1-RR000056 NCRR NIH HHS United States
R03-CA113148 NCI NIH HHS United States
R01-CA112523 NCI NIH HHS United States
WT084766/Z/08/Z Wellcome Trust United Kingdom
R01-CA049449 NCI NIH HHS United States
N01-PC067010 NCI NIH HHS United States
P30-CA072720 NCI NIH HHS United States
R01-CA126841 NCI NIH HHS United States
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WT098017 Wellcome Trust United Kingdom
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P30 CA076292 NCI NIH HHS United States
UM1-CA186107 NCI NIH HHS United States
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P30 CA014089 NCI NIH HHS United States
MOP-86727 CIHR Canada
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P30 CA015083 NCI NIH HHS United States
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K07-CA143047 NCI NIH HHS United States
R01-CA149429 NCI NIH HHS United States
084766 Wellcome Trust United Kingdom
R01-CA071766 NCI NIH HHS United States
P01-CA087696 NCI NIH HHS United States
P30-CA008748 NCI NIH HHS United States
K07-CA095666 NCI NIH HHS United States
WT085235/Z/08/Z Wellcome Trust United Kingdom
R01-CA061107 NCI NIH HHS United States
P50-CA136393 NCI NIH HHS United States
N01-PC035137 NCI NIH HHS United States
P50 CA136393 NCI NIH HHS United States
P30-CA15083 NCI NIH HHS United States
R01-CA058860 NCI NIH HHS United States
R01-CA080978 NCI NIH HHS United States
GENERAL NOTE
KEYWORDS
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Endometriosis genetics
Female genetics
Genetic Association Studies genetics
Genetic Predisposition to Disease genetics
Humans genetics
Oligonucleotide Array Sequence Analysis genetics
Ovarian Neoplasms genetics
Polymorphism, Single Nucleotide genetics
Risk genetics
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
OTHER ID's
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