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PMID |
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TITLE |
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Shared genetics underlying epidemiological association between endometriosis and ovarian cancer. |
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ABSTRACT |
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Epidemiological studies have demonstrated associations between endometriosis and certain histotypes of ovarian cancer, including clear cell, low-grade serous and endometrioid carcinomas. We aimed to determine whether the observed associations might be due to shared genetic aetiology. To address this, we used two endometriosis datasets genotyped on common arrays with full-genome coverage (3194 cases and 7060 controls) and a large ovarian cancer dataset genotyped on the customized Illumina Infinium iSelect (iCOGS) arrays (10 065 cases and 21 663 controls). Previous work has suggested that a large number of genetic variants contribute to endometriosis and ovarian cancer (all histotypes combined) susceptibility. Here, using the iCOGS data, we confirmed polygenic architecture for most histotypes of ovarian cancer. This led us to evaluate if the polygenic effects are shared across diseases. We found evidence for shared genetic risks between endometriosis and all histotypes of ovarian cancer, except for the intestinal mucinous type. Clear cell carcinoma showed the strongest genetic correlation with endometriosis (0.51, 95% CI = 0.18-0.84). Endometrioid and low-grade serous carcinomas had similar correlation coefficients (0.48, 95% CI = 0.07-0.89 and 0.40, 95% CI = 0.05-0.75, respectively). High-grade serous carcinoma, which often arises from the fallopian tubes, showed a weaker genetic correlation with endometriosis (0.25, 95% CI = 0.11-0.39), despite the absence of a known epidemiological association. These results suggest that the epidemiological association between endometriosis and ovarian adenocarcinoma may be attributable to shared genetic susceptibility loci. |
© The Author 2015. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com. |
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DATE PUBLISHED |
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HISTORY |
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PUBSTATUS |
PUBSTATUSDATE |
received |
2015/05/19 |
accepted |
2015/07/24 |
entrez |
2015/08/02 06:00 |
pubmed |
2015/08/02 06:00 |
medline |
2016/07/13 06:00 |
|
AUTHORS |
|
NAME |
COLLECTIVENAME |
LASTNAME |
FORENAME |
INITIALS |
AFFILIATION |
AFFILIATIONINFO |
Lu Y |
|
Lu |
Yi |
Y |
|
Statistical Genetics. |
Cuellar-Partida G |
|
Cuellar-Partida |
Gabriel |
G |
|
Statistical Genetics. |
Painter JN |
|
Painter |
Jodie N |
JN |
|
Molecular Cancer Epidemiology. |
Nyholt DR |
|
Nyholt |
Dale R |
DR |
|
Institute of Health and Biomedical Innovation, Queensland University of Technology, Queensland, Australia. |
|
Australian Ovarian Cancer Study |
|
|
|
|
|
|
International Endogene Consortium (IEC) |
|
|
|
|
|
Morris AP |
|
Morris |
Andrew P |
AP |
|
Genetic and Genomic Epidemiology Unit, Wellcome Trust Centre for Human Genetics and Department of Biostatistics, University of Liverpool, Liverpool, UK. |
Fasching PA |
|
Fasching |
Peter A |
PA |
|
Division of Hematology and Oncology, Department of Medicine, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA, USA, Department of Gynecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen Nuremberg, Universitaetsstrasse 21-23, 91054 Erlangen, Germany. |
Hein A |
|
Hein |
Alexander |
A |
|
Department of Gynecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen Nuremberg, Universitaetsstrasse 21-23, 91054 Erlangen, Germany. |
Burghaus S |
|
Burghaus |
Stefanie |
S |
|
Department of Gynecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen Nuremberg, Universitaetsstrasse 21-23, 91054 Erlangen, Germany. |
Beckmann MW |
|
Beckmann |
Matthias W |
MW |
|
Department of Gynecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen Nuremberg, Universitaetsstrasse 21-23, 91054 Erlangen, Germany. |
Lambrechts D |
|
Lambrechts |
Diether |
D |
|
Laboratory for Translational Genetics, Department of Oncology, University of Leuven, Leuven, Belgium, Vesalius Research Center, VIB, Leuven, Belgium. |
Van Nieuwenhuysen E |
|
Van Nieuwenhuysen |
Els |
E |
|
Division of Gynecologic Oncology, Department of Obstetrics and Gynaecology and Leuven Cancer Institute, University Hospitals Leuven, Leuven, Belgium. |
Vergote I |
|
Vergote |
Ignace |
I |
|
Division of Gynecologic Oncology, Department of Obstetrics and Gynaecology and Leuven Cancer Institute, University Hospitals Leuven, Leuven, Belgium. |
Vanderstichele A |
|
Vanderstichele |
Adriaan |
A |
|
Division of Gynecologic Oncology, Department of Obstetrics and Gynaecology and Leuven Cancer Institute, University Hospitals Leuven, Leuven, Belgium. |
Doherty JA |
|
Doherty |
Jennifer Anne |
JA |
|
Department of Community and Family Medicine, Section of Biostatistics & Epidemiology, Geisel School of Medicine, Dartmouth College, Hanover, NH, USA. |
Rossing MA |
|
Rossing |
Mary Anne |
MA |
|
Department of Epidemiology, University of Washington, Seattle, WA, USA, Program in Epidemiology, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA. |
Wicklund KG |
|
Wicklund |
Kristine G |
KG |
|
Program in Epidemiology, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA. |
Chang-Claude J |
|
Chang-Claude |
Jenny |
J |
|
Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany. |
Eilber U |
|
Eilber |
Ursula |
U |
|
Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany. |
Rudolph A |
|
Rudolph |
Anja |
A |
|
Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany. |
Wang-Gohrke S |
|
Wang-Gohrke |
Shan |
S |
|
Department of Obstetrics and Gynecology, University of Ulm, Ulm, Germany. |
Goodman MT |
|
Goodman |
Marc T |
MT |
|
Cancer Prevention and Control, Samuel Oschin Comprehensive Cancer Institute and Department of Biomedical Sciences, Community and Population Health Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA. |
Bogdanova N |
|
Bogdanova |
Natalia |
N |
|
Radiation Oncology Research Unit. |
Dörk T |
|
Dörk |
Thilo |
T |
|
Gynaecology Research Unit and. |
Dürst M |
|
Dürst |
Matthias |
M |
|
Department of Gynecology, Jena-University Hospital-Friedrich Schiller University, Jena, Germany. |
Hillemanns P |
|
Hillemanns |
Peter |
P |
|
Clinics of Obstetrics and Gynaecology, Hannover Medical School, Hannover, Germany. |
Runnebaum IB |
|
Runnebaum |
Ingo B |
IB |
|
Department of Gynecology, Jena-University Hospital-Friedrich Schiller University, Jena, Germany. |
Antonenkova N |
|
Antonenkova |
Natalia |
N |
|
N.N. Alexandrov National Cancer Centre of Belarus, Minsk, Belarus. |
Butzow R |
|
Butzow |
Ralf |
R |
|
Department of Pathology and. |
Leminen A |
|
Leminen |
Arto |
A |
|
Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland. |
Nevanlinna H |
|
Nevanlinna |
Heli |
H |
|
Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland. |
Pelttari LM |
|
Pelttari |
Liisa M |
LM |
|
Department of Obstetrics and Gynecology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland. |
Edwards RP |
|
Edwards |
Robert P |
RP |
|
Division of Gynecologic Oncology, Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA, Womens Cancer Research Program, Magee-Womens Research Institute and University of Pittsburgh Cancer Institute, Pittsburgh, PA, USA. |
Kelley JL |
|
Kelley |
Joseph L |
JL |
|
Division of Gynecologic Oncology, Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA. |
Modugno F |
|
Modugno |
Francesmary |
F |
|
Division of Gynecologic Oncology, Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA, Womens Cancer Research Program, Magee-Womens Research Institute and University of Pittsburgh Cancer Institute, Pittsburgh, PA, USA, Department of Epidemiology, University of Pittsburgh Graduate School of Public Health, Pittsburgh, PA, USA. |
Moysich KB |
|
Moysich |
Kirsten B |
KB |
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Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, NY, USA. |
Ness RB |
|
Ness |
Roberta B |
RB |
|
The University of Texas School of Public Health, Houston, TX, USA. |
Cannioto R |
|
Cannioto |
Rikki |
R |
|
Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, NY, USA. |
Høgdall E |
|
Høgdall |
Estrid |
E |
|
Department of Virus, Lifestyle and Genes, Danish Cancer Society Research Center, Copenhagen, Denmark, Molecular Unit, Department of Pathology, Herlev Hospital, Herlev, Denmark. |
Jensen A |
|
Jensen |
Allan |
A |
|
Department of Virus, Lifestyle and Genes, Danish Cancer Society Research Center, Copenhagen, Denmark. |
Giles GG |
|
Giles |
Graham G |
GG |
|
Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Victoria, Australia, Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Victoria, Australia, Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Australia. |
Bruinsma F |
|
Bruinsma |
Fiona |
F |
|
Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Australia. |
Kjaer SK |
|
Kjaer |
Susanne K |
SK |
|
Department of Virus, Lifestyle and Genes, Danish Cancer Society Research Center, Copenhagen, Denmark, Department of Gynaecology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark. |
Hildebrandt MA |
|
Hildebrandt |
Michelle A T |
MA |
|
Department of Epidemiology and. |
Liang D |
|
Liang |
Dong |
D |
|
College of Pharmacy and Health Sciences, Texas Southern University, Houston, TX, USA. |
Lu KH |
|
Lu |
Karen H |
KH |
|
Department of Gynecologic Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. |
Wu X |
|
Wu |
Xifeng |
X |
|
Department of Epidemiology and. |
Bisogna M |
|
Bisogna |
Maria |
M |
|
Gynecology Service, Department of Surgery and. |
Dao F |
|
Dao |
Fanny |
F |
|
Gynecology Service, Department of Surgery and. |
Levine DA |
|
Levine |
Douglas A |
DA |
|
Gynecology Service, Department of Surgery and. |
Cramer DW |
|
Cramer |
Daniel W |
DW |
|
Obstetrics and Gynecology Epidemiology Center, Brigham and Women's Hospital, Boston, MA, USA. |
Terry KL |
|
Terry |
Kathryn L |
KL |
|
Obstetrics and Gynecology Epidemiology Center, Brigham and Women's Hospital, Boston, MA, USA, Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA. |
Tworoger SS |
|
Tworoger |
Shelley S |
SS |
|
Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA, Channing Division of Network Medicine, Department of Medicine and. |
Missmer S |
|
Missmer |
Stacey |
S |
|
Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA, Channing Division of Network Medicine, Department of Medicine and Department of Obstetrics and Gynecology, Gynecology and Reproductive Biology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA. |
Bjorge L |
|
Bjorge |
Line |
L |
|
Department of Gynecology and Obstetrics, Haukeland University Hospital, Bergen, Norway, Department of Clinical Science, Centre for Cancer Biomarkers, University of Bergen, Bergen, Norway. |
Salvesen HB |
|
Salvesen |
Helga B |
HB |
|
Department of Gynecology and Obstetrics, Haukeland University Hospital, Bergen, Norway, Department of Clinical Science, Centre for Cancer Biomarkers, University of Bergen, Bergen, Norway. |
Kopperud RK |
|
Kopperud |
Reidun K |
RK |
|
Department of Gynecology and Obstetrics, Haukeland University Hospital, Bergen, Norway, Department of Clinical Science, Centre for Cancer Biomarkers, University of Bergen, Bergen, Norway. |
Bischof K |
|
Bischof |
Katharina |
K |
|
Department of Gynecology and Obstetrics, Haukeland University Hospital, Bergen, Norway, Department of Clinical Science, Centre for Cancer Biomarkers, University of Bergen, Bergen, Norway. |
Aben KK |
|
Aben |
Katja K H |
KK |
|
Radboud University Medical Centre, Radboud Institute for Health Sciences, Nijmegen, The Netherlands, Netherlands Comprehensive Cancer Organisation, Utrecht, The Netherlands. |
Kiemeney LA |
|
Kiemeney |
Lambertus A |
LA |
|
Radboud University Medical Centre, Radboud Institute for Health Sciences, Nijmegen, The Netherlands. |
Massuger LF |
|
Massuger |
Leon F A G |
LF |
|
Department of Obstetrics and Gynaecology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, The Netherlands. |
Brooks-Wilson A |
|
Brooks-Wilson |
Angela |
A |
|
Canada's Michael Smith Genome Sciences Centre and Department of Biomedical Physiology and Kinesiology, Simon Fraser University, Burnaby, BC, Canada. |
Olson SH |
|
Olson |
Sara H |
SH |
|
Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY, USA. |
McGuire V |
|
McGuire |
Valerie |
V |
|
Department of Health Research and Policy-Epidemiology, Stanford University School of Medicine, Stanford, CA, USA. |
Rothstein JH |
|
Rothstein |
Joseph H |
JH |
|
Department of Health Research and Policy-Epidemiology, Stanford University School of Medicine, Stanford, CA, USA. |
Sieh W |
|
Sieh |
Weiva |
W |
|
Department of Health Research and Policy-Epidemiology, Stanford University School of Medicine, Stanford, CA, USA. |
Whittemore AS |
|
Whittemore |
Alice S |
AS |
|
Department of Health Research and Policy-Epidemiology, Stanford University School of Medicine, Stanford, CA, USA. |
Cook LS |
|
Cook |
Linda S |
LS |
|
Division of Epidemiology and Biostatistics, Department of Internal Medicine, University of New Mexico, Albuquerque, NM, USA. |
Le ND |
|
Le |
Nhu D |
ND |
|
Cancer Control Research, BC Cancer Agency, Vancouver, BC, Canada. |
Gilks CB |
|
Gilks |
C Blake |
CB |
|
Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada. |
Gronwald J |
|
Gronwald |
Jacek |
J |
|
Department of Genetics and Pathology, International Hereditary Cancer Center, Pomeranian Medical University, Szczecin, Poland. |
Jakubowska A |
|
Jakubowska |
Anna |
A |
|
Department of Genetics and Pathology, International Hereditary Cancer Center, Pomeranian Medical University, Szczecin, Poland. |
Lubiński J |
|
Lubiński |
Jan |
J |
|
Department of Genetics and Pathology, International Hereditary Cancer Center, Pomeranian Medical University, Szczecin, Poland. |
Gawełko J |
|
Gawełko |
Jan |
J |
|
Medical Faculty, Institute of Nursing and Health Sciences, University of Rzeszów, Rzeszów, Poland. |
Song H |
|
Song |
Honglin |
H |
|
Department of Oncology and. |
Tyrer JP |
|
Tyrer |
Jonathan P |
JP |
|
Department of Oncology and. |
Wentzensen N |
|
Wentzensen |
Nicolas |
N |
|
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA. |
Brinton L |
|
Brinton |
Louise |
L |
|
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA. |
Trabert B |
|
Trabert |
Britton |
B |
|
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA. |
Lissowska J |
|
Lissowska |
Jolanta |
J |
|
M. Sklodowska-Curie Memorial Cancer Center, Warsaw, Poland. |
Mclaughlin JR |
|
Mclaughlin |
John R |
JR |
|
Public Health Ontario, Toronto, ON, Canada. |
Narod SA |
|
Narod |
Steven A |
SA |
|
Women's College Research Institute, University of Toronto, Toronto, ON, Canada. |
Phelan C |
|
Phelan |
Catherine |
C |
|
Department of Cancer Epidemiology, Moffitt Cancer Center, Tampa, FL, USA. |
Anton-Culver H |
|
Anton-Culver |
Hoda |
H |
|
Department of Epidemiology and Center for Cancer Genetics Research & Prevention, School of Medicine, University of California Irvine, Irvine, CA, USA. |
Ziogas A |
|
Ziogas |
Argyrios |
A |
|
Department of Epidemiology and. |
Eccles D |
|
Eccles |
Diana |
D |
|
Faculty of Medicine, University of Southampton, Southampton, UK. |
Gayther SA |
|
Gayther |
Simon A |
SA |
|
Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, CA, USA. |
Gentry-Maharaj A |
|
Gentry-Maharaj |
Aleksandra |
A |
|
Women's Cancer, Institute for Women's Health, University College London, London, UK. |
Menon U |
|
Menon |
Usha |
U |
|
Women's Cancer, Institute for Women's Health, University College London, London, UK. |
Ramus SJ |
|
Ramus |
Susan J |
SJ |
|
Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, CA, USA. |
Wu AH |
|
Wu |
Anna H |
AH |
|
Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, CA, USA. |
Dansonka-Mieszkowska A |
|
Dansonka-Mieszkowska |
Agnieszka |
A |
|
Department of Pathology and Laboratory Diagnostics, The Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Warsaw, Poland. |
Kupryjanczyk J |
|
Kupryjanczyk |
Jolanta |
J |
|
Department of Pathology and Laboratory Diagnostics, The Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Warsaw, Poland. |
Timorek A |
|
Timorek |
Agnieszka |
A |
|
Department of Obstetrics, Gynecology and Oncology, IInd Faculty of Medicine, Warsaw Medical University and Brodnowski Hospital, Warsaw, Poland. |
Szafron L |
|
Szafron |
Lukasz |
L |
|
Department of Pathology and Laboratory Diagnostics, The Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Warsaw, Poland. |
Cunningham JM |
|
Cunningham |
Julie M |
JM |
|
Division of Experimental Pathology, Department of Laboratory Medicine and Pathology. |
Fridley BL |
|
Fridley |
Brooke L |
BL |
|
Department of Biostatistics, University of Kansas, Kansas City, KS, USA. |
Winham SJ |
|
Winham |
Stacey J |
SJ |
|
Division of Biomedical Statistics and Informatics, Department of Health Sciences Research and. |
Bandera EV |
|
Bandera |
Elisa V |
EV |
|
Rutgers Cancer Institute of New Jersey, New Brunswick, NJ, USA. |
Poole EM |
|
Poole |
Elizabeth M |
EM |
|
Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA, Channing Division of Network Medicine, Department of Medicine and. |
Morgan TK |
|
Morgan |
Terry K |
TK |
|
Department of Pathology and Department of Obstetrics and Gynecology, OHSU, Portland, OR, USA. |
Risch HA |
|
Risch |
Harvey A |
HA |
|
Department of Chronic Disease Epidemiology, Yale School of Public Health, New Haven, CT, USA. |
Goode EL |
|
Goode |
Ellen L |
EL |
|
Division of Epidemiology, Department of Health Science Research, Mayo Clinic, Rochester, MN, USA. |
Schildkraut JM |
|
Schildkraut |
Joellen M |
JM |
|
Department of Community and Family Medicine and Cancer Control and Population Sciences, Duke Cancer Institute, Durham, NC, USA. |
Webb PM |
|
Webb |
Penelope M |
PM |
|
Population Health Department. |
Pearce CL |
|
Pearce |
Celeste L |
CL |
|
Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, CA, USA, Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, MI, USA and. |
Berchuck A |
|
Berchuck |
Andrew |
A |
|
Duke Cancer Institute, Duke University Medical Center, Durham, NC, USA. |
Pharoah PD |
|
Pharoah |
Paul D P |
PD |
|
Department of Oncology and Department of Public Health and Primary Care, The Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge, UK. |
Montgomery GW |
|
Montgomery |
Grant W |
GW |
|
Molecular Epidemiology and. |
Zondervan KT |
|
Zondervan |
Krina T |
KT |
|
Genetic and Genomic Epidemiology Unit, Wellcome Trust Centre for Human Genetics and Endometriosis CaRe Centre, Nuffield Dept of Obstetrics & Gynaecology, University of Oxford, Oxford, UK. |
Chenevix-Trench G |
|
Chenevix-Trench |
Georgia |
G |
|
Genetics and Computational Biology Department, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, QLD 4006, Australia. |
MacGregor S |
|
MacGregor |
Stuart |
S |
|
Statistical Genetics, stuart.macgregor@qimrberghofer.edu.au. |
|
INVESTIGATORS |
|
LASTNAME |
FORENAME |
INITIALS |
AFFILIATION |
Anderson |
Carl A |
CA |
|
Gordon |
Scott D |
SD |
|
Guo |
Qun |
Q |
|
Henders |
Anjali K |
AK |
|
Lambert |
Ann |
A |
|
Lee |
Sang Hong |
SH |
|
Kraft |
Peter |
P |
|
Kennedy |
Stephen H |
SH |
|
Macgregor |
Stuart |
S |
|
Martin |
Nicholas G |
NG |
|
Missmer |
Stacey A |
SA |
|
Montgomery |
Grant W |
GW |
|
Morris |
Andrew P |
AP |
|
Nyholt |
Dale R |
DR |
|
Painter |
Jodie N |
JN |
|
Roseman |
Fenella |
F |
|
Treloar |
Susan A |
SA |
|
Visscher |
Peter M |
PM |
|
Wallace |
Leanne |
L |
|
Zondervan |
Krina T |
KT |
|
|
JOURNAL |
|
VOLUME: 24 |
ISSUE: 20 |
TITLE: Human molecular genetics |
ISOABBREVIATION: Hum Mol Genet |
YEAR: 2015 |
MONTH: Oct |
DAY: 15 |
MEDLINEDATE: |
SEASON: |
CITEDMEDIUM: Internet |
ISSN: 1460-2083 |
ISSNTYPE: Electronic |
|
MEDLINE JOURNAL |
|
MEDLINETA: Hum Mol Genet |
COUNTRY: England |
ISSNLINKING: 0964-6906 |
NLMUNIQUEID: 9208958 |
|
PUBLICATION TYPE |
|
PUBLICATIONTYPE TEXT |
Journal Article |
Multicenter Study |
Research Support, N.I.H., Extramural |
Research Support, Non-U.S. Gov't |
Research Support, U.S. Gov't, Non-P.H.S. |
|
COMMENTS AND CORRECTIONS |
|
|
GRANTS |
|
GRANTID |
AGENCY |
COUNTRY |
R01-CA092044 |
NCI NIH HHS |
United States |
R03-CA115195 |
NCI NIH HHS |
United States |
UL1 TR000005 |
NCATS NIH HHS |
United States |
R01 CA087538 |
NCI NIH HHS |
United States |
R01-CA058598 |
NCI NIH HHS |
United States |
R01-CA074850 |
NCI NIH HHS |
United States |
R01-CA061132 |
NCI NIH HHS |
United States |
R01-CA063678 |
NCI NIH HHS |
United States |
N01-PC67001 |
NCI NIH HHS |
United States |
R01-CA114343 |
NCI NIH HHS |
United States |
10124 |
Cancer Research UK |
United Kingdom |
P01-CA017054 |
NCI NIH HHS |
United States |
R01-CA067262 |
NCI NIH HHS |
United States |
P50-CA159981 |
NCI NIH HHS |
United States |
UM1-CA176726 |
NCI NIH HHS |
United States |
K07-CA80668 |
NCI NIH HHS |
United States |
K22-CA138563 |
NCI NIH HHS |
United States |
085235 |
Wellcome Trust |
United Kingdom |
P30 CA072720 |
NCI NIH HHS |
United States |
N01-CN55424 |
NCI NIH HHS |
United States |
R01-CA054419 |
NCI NIH HHS |
United States |
MO1-RR000056 |
NCRR NIH HHS |
United States |
R03-CA113148 |
NCI NIH HHS |
United States |
R01-CA112523 |
NCI NIH HHS |
United States |
WT084766/Z/08/Z |
Wellcome Trust |
United Kingdom |
R01-CA049449 |
NCI NIH HHS |
United States |
N01-PC067010 |
NCI NIH HHS |
United States |
P30-CA072720 |
NCI NIH HHS |
United States |
R01-CA126841 |
NCI NIH HHS |
United States |
R01-CA122443 |
NCI NIH HHS |
United States |
R01-CA087538 |
NCI NIH HHS |
United States |
WT098017 |
Wellcome Trust |
United Kingdom |
R01-CA014089 |
NCI NIH HHS |
United States |
P30 CA076292 |
NCI NIH HHS |
United States |
UM1-CA186107 |
NCI NIH HHS |
United States |
R01-CA050385 |
NCI NIH HHS |
United States |
P30 CA014089 |
NCI NIH HHS |
United States |
MOP-86727 |
CIHR |
Canada |
P50-CA105009 |
NCI NIH HHS |
United States |
U01-CA069417 |
NCI NIH HHS |
United States |
R01-CA136924 |
NCI NIH HHS |
United States |
U01-CA071966 |
NCI NIH HHS |
United States |
R01-CA095023 |
NCI NIH HHS |
United States |
R01-CA017054 |
NCI NIH HHS |
United States |
P30 CA015083 |
NCI NIH HHS |
United States |
R01-CA063682 |
NCI NIH HHS |
United States |
R01-CA016056 |
NCI NIH HHS |
United States |
R01-CA083918 |
NCI NIH HHS |
United States |
K07-CA143047 |
NCI NIH HHS |
United States |
R01-CA149429 |
NCI NIH HHS |
United States |
084766 |
Wellcome Trust |
United Kingdom |
R01-CA071766 |
NCI NIH HHS |
United States |
P01-CA087696 |
NCI NIH HHS |
United States |
P30-CA008748 |
NCI NIH HHS |
United States |
K07-CA095666 |
NCI NIH HHS |
United States |
WT085235/Z/08/Z |
Wellcome Trust |
United Kingdom |
R01-CA061107 |
NCI NIH HHS |
United States |
P50-CA136393 |
NCI NIH HHS |
United States |
N01-PC035137 |
NCI NIH HHS |
United States |
P50 CA136393 |
NCI NIH HHS |
United States |
P30-CA15083 |
NCI NIH HHS |
United States |
R01-CA058860 |
NCI NIH HHS |
United States |
R01-CA080978 |
NCI NIH HHS |
United States |
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GENERAL NOTE |
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KEYWORDS |
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|
MESH HEADINGS |
|
DESCRIPTORNAME |
QUALIFIERNAME |
Endometriosis |
genetics |
Female |
genetics |
Genetic Association Studies |
genetics |
Genetic Predisposition to Disease |
genetics |
Humans |
genetics |
Oligonucleotide Array Sequence Analysis |
genetics |
Ovarian Neoplasms |
genetics |
Polymorphism, Single Nucleotide |
genetics |
Risk |
genetics |
|
SUPPLEMENTARY MESH |
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|
GENE SYMBOLS |
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CHEMICALS |
|
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OTHER ID's |
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