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| PMID |
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| TITLE |
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| A Common Genetic Influence on Human Intensity Ratings of Sugars and High-Potency Sweeteners. |
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| ABSTRACT |
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NlmCategory: UNASSIGNED |
| The perception of sweetness varies among individuals but the sources of this variation are not fully understood. Here, in a sample of 1,901 adolescent and young adults (53.8% female; 243 MZ and 452 DZ twin pairs, 511 unpaired individuals; mean age 16.2 �� 2.8, range 12���26 years), we studied the variation in the perception of sweetness intensity of two monosaccharides and two high-potency sweeteners: glucose, fructose, neohesperidine dihydrochalcone (NHDC), and aspartame. Perceived intensity for all sweeteners decreased with age (2���5% per year) and increased with the history of otitis media (6���9%). Males rated aspartame slightly stronger than females (7%). We found similar heritabilities for sugars (glucose: h 2 = 0.31, fructose: h 2 = 0.34) and high-potency sweeteners (NHDC: h 2 = 0.31, aspartame: h 2 = 0.30); all were in the modest range. Multivariate modeling showed that a common genetic factor accounted for >75% of the genetic variance in the four sweeteners, suggesting that individual differences in perceived sweet intensity, which are partly due to genetic factors, may be attributed to a single set of genes. This study provided evidence of the shared genetic pathways between the perception of sugars and high-potency sweeteners. |
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| DATE PUBLISHED |
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| HISTORY |
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| PUBSTATUS |
PUBSTATUSDATE |
| entrez |
2015/07/17 06:00 |
| pubmed |
2015/07/17 06:00 |
| medline |
2015/07/17 06:00 |
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| AUTHORS |
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| NAME |
COLLECTIVENAME |
LASTNAME |
FORENAME |
INITIALS |
AFFILIATION |
AFFILIATIONINFO |
| Hwang LD |
|
Hwang |
Liang-Dar |
LD |
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QIMR Berghofer Medical Research Institute,Brisbane,Queensland,Australia. |
| Zhu G |
|
Zhu |
Gu |
G |
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QIMR Berghofer Medical Research Institute,Brisbane,Queensland,Australia. |
| Breslin PA |
|
Breslin |
Paul A S |
PA |
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Monell Chemical Senses Center,Philadelphia,Pennsylvania,USA. |
| Reed DR |
|
Reed |
Danielle R |
DR |
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Monell Chemical Senses Center,Philadelphia,Pennsylvania,USA. |
| Martin NG |
|
Martin |
Nicholas G |
NG |
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QIMR Berghofer Medical Research Institute,Brisbane,Queensland,Australia. |
| Wright MJ |
|
Wright |
Margaret J |
MJ |
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QIMR Berghofer Medical Research Institute,Brisbane,Queensland,Australia. |
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| INVESTIGATORS |
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| JOURNAL |
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| VOLUME: |
| ISSUE: |
| TITLE: Twin research and human genetics : the official journal of the International Society for Twin Studies |
| ISOABBREVIATION: Twin Res Hum Genet |
| YEAR: 2015 |
| MONTH: Jul |
| DAY: 17 |
| MEDLINEDATE: |
| SEASON: |
| CITEDMEDIUM: Print |
| ISSN: 1832-4274 |
| ISSNTYPE: Print |
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| MEDLINE JOURNAL |
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| MEDLINETA: Twin Res Hum Genet |
| COUNTRY: England |
| ISSNLINKING: 1832-4274 |
| NLMUNIQUEID: 101244624 |
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| PUBLICATION TYPE |
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| PUBLICATIONTYPE TEXT |
| JOURNAL ARTICLE |
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