Genetic Epidemiology, Psychiatric Genetics, Asthma Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
26098047
TITLE
Progression in Substance Use Initiation: A Multilevel Discordant Monozygotic Twin Design.
ABSTRACT
NlmCategory: UNASSIGNED
Considerable attention has been paid to the "gateway" pattern of drug use initiation in which individuals progress from tobacco and alcohol use to cannabis and other illicit drugs. The extent to which this sequence reflects a causal impact of licit substance use on illicit substance involvement remains unclear. Clarifying the mechanisms underlying substance use initiation may help inform our understanding of risk for psychopathology, as increasing research is demonstrating associations between initiation patterns and heavier involvement. This study examined patterns of substance use initiation using a discordant twin design. Participants were 3,476 monozygotic twins (37% male) from the Australian Twin Registry who reported on their ages of tobacco, alcohol, and cannabis initiation. Multilevel proportional hazard regression models were used to (a) estimate within-twin-pair and between-twin-pair contributions to associations between the ages of onset of different drugs; and (b) examine whether the magnitude of effects differed as a function of the order of substance use initiation. Finding significant effects within twin pairs would support the hypothesis that the age of initiation of a substance causally influences the age of initiation of a subsequent substance. Finding significant effects between twin pairs would support the operation of familial influences that explain variation in the ages of initiation of multiple drugs. Within-twin-pair effects for typical patterns were modest. When initiation was atypical, however, larger within-twin-pair effects were observed and causal influences were more strongly implicated. Results support the utility of examining the timing and ordering of substance use initiation within sophisticated, genetically informative designs. (PsycINFO Database Record
(c) 2015 APA, all rights reserved).
DATE PUBLISHED
2015 Jun 22
HISTORY
PUBSTATUS PUBSTATUSDATE
entrez 2015/06/23 06:00
pubmed 2015/06/23 06:00
medline 2015/06/23 06:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Richmond-Rakerd LS Richmond-Rakerd Leah S LS
Slutske WS Slutske Wendy S WS
Deutsch AR Deutsch Arielle R AR
Lynskey MT Lynskey Michael T MT
Agrawal A Agrawal Arpana A
Madden PA Madden Pamela A F PA
Bucholz KK Bucholz Kathleen K KK
Heath AC Heath Andrew C AC
Martin NG Martin Nicholas G NG
INVESTIGATORS
JOURNAL
VOLUME:
ISSUE:
TITLE: Journal of abnormal psychology
ISOABBREVIATION: J Abnorm Psychol
YEAR: 2015
MONTH: Jun
DAY: 22
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN: 1939-1846
ISSNTYPE: Electronic
MEDLINE JOURNAL
MEDLINETA: J Abnorm Psychol
COUNTRY: United States
ISSNLINKING: 0021-843X
NLMUNIQUEID: 0034461
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
JOURNAL ARTICLE
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