Genetic Epidemiology, Psychiatric Genetics, Asthma Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
25984635
TITLE
Trait-based assessment of borderline personality disorder using the NEO Five-Factor Inventory: Phenotypic and genetic support.
ABSTRACT
NlmCategory: UNASSIGNED
[Correction Notice: An Erratum for this article was reported in Vol 28(1) of Psychological Assessment (see record 2015-54029-001). The FFI-BPD values for Sample 3 in Table 2 should read 1.42 (0.44), 0.83.] The aim of the current study was to examine the reliability and validity of a trait-based assessment of borderline personality disorder (BPD) using the NEO Five-Factor Inventory. Correlations between the Five-Factor Inventory-BPD composite (FFI-BPD) and explicit measures of BPD were examined across 6 samples, including undergraduate, community, and clinical samples. The median correlation was .60, which was nearly identical to the correlation between measures of BPD and a BPD composite generated from the full Revised NEO Personality Inventory (i.e., NEO-BPD; r = .61). Correlations between FFI-BPD and relevant measures of psychiatric symptomatology and etiology (e.g., childhood abuse, drug use, depression, and personality disorders) were also examined and compared to those generated using explicit measures of BPD and NEO-BPD. As expected, the FFI-BPD composite correlated most strongly with measures associated with high levels of Neuroticism, such as depression, anxiety, and emotion dysregulation, and the pattern of correlations generated using the FFI-BPD was highly similar to those generated using explicit measures of BPD and NEO-BPD. Finally, genetic analyses estimated that FFI-BPD is 44% heritable, which is comparable to meta-analytic research examining genetics associated with BPD, and revealed that 71% of the genetic influences are shared between FFI-BPD and a self-report measure assessing BPD (Personality Assessment Inventory-Borderline subscale; Morey, 1991). Generally, these results support the use of FFI-BPD as a reasonable proxy for BPD, which has considerable implications, particularly for potential gene-finding efforts in large, epidemiological datasets that include the NEO FFI. (PsycINFO Database Record
(c) 2016 APA, all rights reserved).
DATE PUBLISHED
2016 Jan
HISTORY
PUBSTATUS PUBSTATUSDATE
aheadofprint 2015/05/18
entrez 2015/05/19 06:00
pmc-release 2016/11/18 00:00
pubmed 2015/05/20 06:00
medline 2015/05/20 06:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Few LR Few Lauren R LR Department of Psychiatry, Washington University School of Medicine.
Miller JD Miller Joshua D JD Department of Psychology, University of Georgia.
Grant JD Grant Julia D JD Department of Psychiatry, Washington University School of Medicine.
Maples J Maples Jessica J Department of Psychology, University of Georgia.
Trull TJ Trull Timothy J TJ Department of Psychological Sciences, University of Missouri.
Nelson EC Nelson Elliot C EC Department of Psychiatry, Washington University School of Medicine.
Oltmanns TF Oltmanns Thomas F TF Department of Psychology, Washington University.
Martin NG Martin Nicholas G NG QIMR Medical Research Institute.
Lynskey MT Lynskey Michael T MT Institute of Psychiatry, Psychology & Neuroscience, King's College London.
Agrawal A Agrawal Arpana A Department of Psychiatry, Washington University School of Medicine.
INVESTIGATORS
JOURNAL
VOLUME: 28
ISSUE: 1
TITLE: Psychological assessment
ISOABBREVIATION: Psychol Assess
YEAR: 2016
MONTH: Jan
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN: 1939-134X
ISSNTYPE: Electronic
MEDLINE JOURNAL
MEDLINETA: Psychol Assess
COUNTRY:
ISSNLINKING: 1040-3590
NLMUNIQUEID: 8915253
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
JOURNAL ARTICLE
COMMENTS AND CORRECTIONS
GRANTS
GRANTID AGENCY COUNTRY
F32 AA023693 NIAAA NIH HHS United States
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