Genetic Epidemiology, Psychiatric Genetics, Asthma Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
25945699
TITLE
Does shared genetic risk contribute to the co-occurrence of eating disorders and suicidality?
ABSTRACT
OBJECTIVE NlmCategory: OBJECTIVE
There is a high level of co-occurrence of suicidality with eating disorders (EDs) but the reason for this is unknown. To test the hypothesis that suicidality and EDs share genetic risk contributing to the expression of both phenotypes.
METHOD NlmCategory: METHODS
Female twins (N = 1,002) from the Australian Twin Registry, aged 28-40 years, were interviewed with diagnostic interviews. Lifetime diagnostic information relating to eating disorders [anorexia nervosa (AN), bulimia nervosa (BN), binge eating disorder, and purging disorder (PD)], suicidality (ranging transitory thoughts to suicide attempts), and major depression.
RESULTS NlmCategory: RESULTS
Any suicidal thoughts were reported by 24% of the sample, but prevalence of lifetime suicidality among female twins with EDs was much higher (43%), presence of an ED diagnosis more than doubling likelihood of suicidality (OR = 2.32, 95% CI: 1.63-3.31). AN and BN conveyed greatest risk of suicidality (OR = 2.03, 95% CI: 1.06-3.87; OR = 3.97, 95% CI: 2.01-7.85, respectively). Twin phenotype correlations showed monozygotic twins had uniformly higher estimates than dizygotic counterparts. A trivariate Cholesky model indicated a common genetic influence on suicidality and ED phenotypes (but not depression), and no nonshared environmental source.
DISCUSSION NlmCategory: CONCLUSIONS
Both cross twin phenotypic correlations and genetic modeling infer a common genetic pathway for suicidality and EDs, but further investigation is needed to elucidate whether this may constitute emotional dysregulation or other temperament-linked factors. Study findings also indicate that ED clients must be routinely assessed for presence of suicidality, independent of depression status.
2015 Wiley Periodicals, Inc.
DATE PUBLISHED
2015 Sep
HISTORY
PUBSTATUS PUBSTATUSDATE
accepted 2015/04/08
aheadofprint 2015/05/06
entrez 2015/05/07 06:00
pubmed 2015/05/07 06:00
medline 2016/03/08 06:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Wade TD Wade Tracey D TD School of Psychology, Flinders University, Adelaide, South Australia, Australia.
Fairweather-Schmidt AK Fairweather-Schmidt A Kate AK School of Psychology, Flinders University, Adelaide, South Australia, Australia.
Zhu G Zhu Gu G Genetic Epidemiology Laboratory, QIMR Berghofer Medical Research Institute, Brisbane, Australia.
Martin NG Martin Nicholas G NG Genetic Epidemiology Laboratory, QIMR Berghofer Medical Research Institute, Brisbane, Australia.
INVESTIGATORS
JOURNAL
VOLUME: 48
ISSUE: 6
TITLE: The International journal of eating disorders
ISOABBREVIATION: Int J Eat Disord
YEAR: 2015
MONTH: Sep
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN: 1098-108X
ISSNTYPE: Electronic
MEDLINE JOURNAL
MEDLINETA: Int J Eat Disord
COUNTRY: United States
ISSNLINKING: 0276-3478
NLMUNIQUEID: 8111226
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
Research Support, Non-U.S. Gov't
Twin Study
COMMENTS AND CORRECTIONS
GRANTS
GENERAL NOTE
KEYWORDS
KEYWORD
eating disorders
genetic risk
major depression
suicidality
twins
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Adult
Anorexia Nervosa psychology
Bulimia Nervosa psychology
Depressive Disorder, Major psychology
Diseases in Twins psychology
Feeding and Eating Disorders psychology
Female psychology
Genetic Predisposition to Disease psychology
Humans psychology
Male psychology
Risk Factors psychology
Suicide psychology
Twins, Monozygotic psychology
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
OTHER ID's