Genetic Epidemiology, Psychiatric Genetics, Asthma Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
25917230
TITLE
The association between speed of transition from initiation to subsequent use of cannabis and later problematic cannabis use, abuse and dependence.
ABSTRACT
AIMS NlmCategory: OBJECTIVE
To test whether speed of transition from initiation use to subsequent use of cannabis is associated with likelihood of later cannabis dependence and other outcomes, and whether transition speed is attributable to genetic or environmental factors.
DESIGN NlmCategory: METHODS
Cross-sectional interview study.
SETTING NlmCategory: METHODS
Australia.
PARTICIPANTS NlmCategory: METHODS
A total of 2239 twins and siblings who reported using cannabis at least twice [mean age at time of survey = 32.0, 95% confidence interval (CI) = 31.9 - 32.1, range = 22-45].
MEASUREMENTS NlmCategory: METHODS
Time between initiation and subsequent cannabis use (within 1 week; within 3 months; between 3 and 12 months; more than 1 year later), later use of cannabis and symptoms of DSM-IV cannabis abuse/dependence. Multinomial regression analyses (comparison group: more than 1 year later) adjusted the association between speed of transition and the outcomes of cannabis daily use, abuse/dependence and treatment-seeking after controlling for socio-demographic, childhood, mental health, peer and licit drug factors. Twin modelling estimated the proportion of variance in transition speed attributable to genetic (A), common environment (C) and unique environmental (E) factors.
FINDINGS NlmCategory: RESULTS
Subsequent use of cannabis within 1 week of initiation was associated with daily use [odds ratio (OR) = 2.64, 95% CI = 1.75-3.99], abuse and/or dependence (OR = 3.25, 95% CI = 2.31-4.56) and treatment-seeking for cannabis problems (OR = 1.89, 95% CI = 1.03-3.46). Subsequent use within 3 months was associated with abuse and/or dependence (OR = 1.61, 95% CI = 1.18-2.19). The majority of the variation of the speed of transition was accounted for by unique environment factors (0.75).
CONCLUSIONS NlmCategory: CONCLUSIONS
Rapid transition from initiation to subsequent use of cannabis is associated with increased likelihood of subsequent daily cannabis use and abuse/dependence.
2015 Society for the Study of Addiction.
DATE PUBLISHED
2015 Aug
HISTORY
PUBSTATUS PUBSTATUSDATE
received 2014/12/18
revised 2015/01/22
accepted 2015/04/17
aheadofprint 2015/06/03
entrez 2015/04/29 06:00
pubmed 2015/04/29 06:00
medline 2015/04/29 06:00
pmc-release 2016/08/01 00:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Hines LA Hines Lindsey A LA Addictions Department, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
Morley KI Morley Katherine I KI Addictions Department, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
Strang J Strang John J Addictions Department, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
Agrawal A Agrawal Arpana A Department of Psychiatry, Washington University School of Medicine, St Louis, MO, USA.
Nelson EC Nelson Elliot C EC Department of Psychiatry, Washington University School of Medicine, St Louis, MO, USA.
Statham D Statham Dixie D School of Social Sciences, University of the Sunshine Coast, Queensland, Australia.
Martin NG Martin Nicholas G NG QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
Lynskey MT Lynskey Michael T MT Addictions Department, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
INVESTIGATORS
JOURNAL
VOLUME: 110
ISSUE: 8
TITLE: Addiction (Abingdon, England)
ISOABBREVIATION: Addiction
YEAR: 2015
MONTH: Aug
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN: 1360-0443
ISSNTYPE: Electronic
MEDLINE JOURNAL
MEDLINETA: Addiction
COUNTRY: England
ISSNLINKING: 0965-2140
NLMUNIQUEID: 9304118
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
COMMENTS AND CORRECTIONS
REFTYPE REFSOURCE REFPMID NOTE
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GRANTS
GRANTID AGENCY COUNTRY
DA18267 NIDA NIH HHS United States
DA23668 NIDA NIH HHS United States
K02 DA032573 NIDA NIH HHS United States
K02DA32573 NIDA NIH HHS United States
R01 DA018267 NIDA NIH HHS United States
R01 DA023668 NIDA NIH HHS United States
GENERAL NOTE
KEYWORDS
KEYWORD
Cannabis
cannabis abuse
cannabis dependence
initiation
subsequent use
transitions
twin study
MESH HEADINGS
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
OTHER ID's
OTHERID SOURCE
NIHMS685330 [Available on 08/01/16] NLM
PMC4509683 [Available on 08/01/16] NLM