Genetic Epidemiology, Psychiatric Genetics, Asthma Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
25860228
TITLE
Genetic basis of a cognitive complexity metric.
ABSTRACT
Relational complexity (RC) is a metric reflecting capacity limitation in relational processing. It plays a crucial role in higher cognitive processes and is an endophenotype for several disorders. However, the genetic underpinnings of complex relational processing have not been investigated. Using the classical twin model, we estimated the heritability of RC and genetic overlap with intelligence (IQ), reasoning, and working memory in a twin and sibling sample aged 15-29 years (N = 787). Further, in an exploratory search for genetic loci contributing to RC, we examined associated genetic markers and genes in our Discovery sample and selected loci for replication in four independent samples (ALSPAC, LBC1936, NTR, NCNG), followed by meta-analysis (N>6500) at the single marker level. Twin modelling showed RC is highly heritable (67%), has considerable genetic overlap with IQ (59%), and is a major component of genetic covariation between reasoning and working memory (72%). At the molecular level, we found preliminary support for four single-marker loci (one in the gene DGKB), and at a gene-based level for the NPS gene, having influence on cognition. These results indicate that genetic sources influencing relational processing are a key component of the genetic architecture of broader cognitive abilities. Further, they suggest a genetic cascade, whereby genetic factors influencing capacity limitation in relational processing have a flow-on effect to more complex cognitive traits, including reasoning and working memory, and ultimately, IQ.
DATE PUBLISHED
2015
HISTORY
PUBSTATUS PUBSTATUSDATE
ecollection 2015
received 2014/12/07
accepted 2015/02/23
epublish 2015/04/10
entrez 2015/04/11 06:00
pubmed 2015/04/11 06:00
medline 2015/12/24 06:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Hansell NK Hansell Narelle K NK Neuroimaging Genetics, QIMR Berghofer Medical Research Institute, Brisbane, Australia.
Halford GS Halford Graeme S GS School of Applied Psychology, Griffith University, Mt Gravatt Campus, Brisbane, Australia; Behavioural Basis of Health Program, Griffith Health Institute and School of Applied Psychology, Griffith University, Brisbane, Australia.
Andrews G Andrews Glenda G School of Applied Psychology, Griffith University, Gold Coast Campus, Southport, Australia; Behavioural Basis of Health Program, Griffith Health Institute and School of Applied Psychology, Griffith University, Brisbane, Australia.
Shum DH Shum David H K DH Behavioural Basis of Health Program, Griffith Health Institute and School of Applied Psychology, Griffith University, Brisbane, Australia.
Harris SE Harris Sarah E SE Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, United Kingdom; Centre for Genomic and Experimental Medicine, University of Edinburgh, Edinburgh, United Kingdom.
Davies G Davies Gail G Centre for Genomic and Experimental Medicine, University of Edinburgh, Edinburgh, United Kingdom; Department of Psychology, University of Edinburgh, Edinburgh, United Kingdom.
Franic S Franic Sanja S Department of Biological Psychology, Vrije Universiteit, Amsterdam, The Netherlands.
Christoforou A Christoforou Andrea A K.G. Jebsen Centre for Psychosis Research and the Norwegian Center for Mental Disorders Research (NORMENT), Department of Clinical Science, University of Bergen, Bergen, Norway; Dr Einar Martens Research Group for Biological Psychiatry, Center for Medical Genetics and Molecular Medicine, Haukeland University Hospital, Bergen, Norway.
Zietsch B Zietsch Brendan B Genetic Epidemiology, QIMR Berghofer Medical Research Institute, Brisbane, Australia; School of Psychology, University of Queensland, St Lucia, Brisbane, Australia.
Painter J Painter Jodie J Molecular Genetic Epidemiology, QIMR Berghofer Medical Research Institute, Brisbane, Australia.
Medland SE Medland Sarah E SE Quantitative Genetics, QIMR Berghofer Medical Research Institute, Brisbane, Australia.
Ehli EA Ehli Erik A EA Avera Institute for Human Genetics, Avera McKennan Hospital & University Health Center, Sioux Falls, South Dakota, United States of America.
Davies GE Davies Gareth E GE Avera Institute for Human Genetics, Avera McKennan Hospital & University Health Center, Sioux Falls, South Dakota, United States of America.
Steen VM Steen Vidar M VM K.G. Jebsen Centre for Psychosis Research and the Norwegian Center for Mental Disorders Research (NORMENT), Department of Clinical Science, University of Bergen, Bergen, Norway; Dr Einar Martens Research Group for Biological Psychiatry, Center for Medical Genetics and Molecular Medicine, Haukeland University Hospital, Bergen, Norway.
Lundervold AJ Lundervold Astri J AJ K.G. Jebsen Center for Research on Neuropsychiatric Disorders, University of Bergen, Bergen, Norway; Department of Biological and Medical Psychology, University of Bergen, Bergen, Norway; Center for Research on Aging and Dementia, Haraldsplass Deaconess Hospital, Bergen, Norway.
Reinvang I Reinvang Ivar I Department of Psychology, University of Oslo, Oslo, Norway.
Montgomery GW Montgomery Grant W GW Molecular Epidemiology, QIMR Berghofer Medical Research Institute, Brisbane, Australia.
Espeseth T Espeseth Thomas T Department of Psychology, University of Oslo, Oslo, Norway; Norwegian Center for Mental Disorders Research (NORMENT) and the K.G. Jebsen Center for Psychosis Research, Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway.
Hulshoff Pol HE Hulshoff Pol Hilleke E HE Brain Center Rudolf Magnus, Department of Psychiatry, University Medical Center Utrecht, Utrecht, The Netherlands.
Starr JM Starr John M JM Department of Psychology, University of Edinburgh, Edinburgh, United Kingdom; Alzheimer Scotland Dementia Research Centre, University of Edinburgh, Edinburgh, United Kingdom.
Martin NG Martin Nicholas G NG Genetic Epidemiology, QIMR Berghofer Medical Research Institute, Brisbane, Australia.
Le Hellard S Le Hellard Stephanie S K.G. Jebsen Centre for Psychosis Research and the Norwegian Center for Mental Disorders Research (NORMENT), Department of Clinical Science, University of Bergen, Bergen, Norway; Dr Einar Martens Research Group for Biological Psychiatry, Center for Medical Genetics and Molecular Medicine, Haukeland University Hospital, Bergen, Norway.
Boomsma DI Boomsma Dorret I DI Department of Biological Psychology, Vrije Universiteit, Amsterdam, The Netherlands.
Deary IJ Deary Ian J IJ Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, United Kingdom; Centre for Genomic and Experimental Medicine, University of Edinburgh, Edinburgh, United Kingdom.
Wright MJ Wright Margaret J MJ Neuroimaging Genetics, QIMR Berghofer Medical Research Institute, Brisbane, Australia.
INVESTIGATORS
JOURNAL
VOLUME: 10
ISSUE: 4
TITLE: PloS one
ISOABBREVIATION: PLoS ONE
YEAR: 2015
MONTH:
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN: 1932-6203
ISSNTYPE: Electronic
MEDLINE JOURNAL
MEDLINETA: PLoS One
COUNTRY: United States
ISSNLINKING: 1932-6203
NLMUNIQUEID: 101285081
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Twin Study
COMMENTS AND CORRECTIONS
REFTYPE REFSOURCE REFPMID NOTE
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GRANTS
GRANTID AGENCY COUNTRY
092731 Wellcome Trust United Kingdom
1RC2 MH089951 NIMH NIH HHS United States
1RC2 MH089995 NIMH NIH HHS United States
BB/C514623/1 Biotechnology and Biological Sciences Research Council United Kingdom
BB/F019394/1 Biotechnology and Biological Sciences Research Council United Kingdom
G0700704 Medical Research Council United Kingdom
MH081802 NIMH NIH HHS United States
MR/K026992/1 Medical Research Council United Kingdom
R01 HD042157-01A1 NICHD NIH HHS United States
U24 MH068457-06 NIMH NIH HHS United States
GENERAL NOTE
KEYWORDS
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Adolescent
Adult
Cognition
Female
Genetic Association Studies
Genome-Wide Association Study methods
Humans methods
Male methods
Meta-Analysis as Topic methods
Models, Biological methods
Polymorphism, Single Nucleotide methods
Quantitative Trait, Heritable methods
Twins methods
Young Adult methods
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
OTHER ID's
OTHERID SOURCE
PMC4393228 NLM