|
|
| PMID |
|
|
| TITLE |
|
| Genetic basis of a cognitive complexity metric. |
|
| ABSTRACT |
|
|
|
| Relational complexity (RC) is a metric reflecting capacity limitation in relational processing. It plays a crucial role in higher cognitive processes and is an endophenotype for several disorders. However, the genetic underpinnings of complex relational processing have not been investigated. Using the classical twin model, we estimated the heritability of RC and genetic overlap with intelligence (IQ), reasoning, and working memory in a twin and sibling sample aged 15-29 years (N = 787). Further, in an exploratory search for genetic loci contributing to RC, we examined associated genetic markers and genes in our Discovery sample and selected loci for replication in four independent samples (ALSPAC, LBC1936, NTR, NCNG), followed by meta-analysis (N>6500) at the single marker level. Twin modelling showed RC is highly heritable (67%), has considerable genetic overlap with IQ (59%), and is a major component of genetic covariation between reasoning and working memory (72%). At the molecular level, we found preliminary support for four single-marker loci (one in the gene DGKB), and at a gene-based level for the NPS gene, having influence on cognition. These results indicate that genetic sources influencing relational processing are a key component of the genetic architecture of broader cognitive abilities. Further, they suggest a genetic cascade, whereby genetic factors influencing capacity limitation in relational processing have a flow-on effect to more complex cognitive traits, including reasoning and working memory, and ultimately, IQ. |
|
| DATE PUBLISHED |
|
|
| HISTORY |
|
| PUBSTATUS |
PUBSTATUSDATE |
| received |
2014/12/07 |
| accepted |
2015/02/23 |
| entrez |
2015/04/11 06:00 |
| pubmed |
2015/04/11 06:00 |
| medline |
2015/12/24 06:00 |
|
| AUTHORS |
|
| NAME |
COLLECTIVENAME |
LASTNAME |
FORENAME |
INITIALS |
AFFILIATION |
AFFILIATIONINFO |
| Hansell NK |
|
Hansell |
Narelle K |
NK |
|
Neuroimaging Genetics, QIMR Berghofer Medical Research Institute, Brisbane, Australia. |
| Halford GS |
|
Halford |
Graeme S |
GS |
|
School of Applied Psychology, Griffith University, Mt Gravatt Campus, Brisbane, Australia; Behavioural Basis of Health Program, Griffith Health Institute and School of Applied Psychology, Griffith University, Brisbane, Australia. |
| Andrews G |
|
Andrews |
Glenda |
G |
|
School of Applied Psychology, Griffith University, Gold Coast Campus, Southport, Australia; Behavioural Basis of Health Program, Griffith Health Institute and School of Applied Psychology, Griffith University, Brisbane, Australia. |
| Shum DH |
|
Shum |
David H K |
DH |
|
Behavioural Basis of Health Program, Griffith Health Institute and School of Applied Psychology, Griffith University, Brisbane, Australia. |
| Harris SE |
|
Harris |
Sarah E |
SE |
|
Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, United Kingdom; Centre for Genomic and Experimental Medicine, University of Edinburgh, Edinburgh, United Kingdom. |
| Davies G |
|
Davies |
Gail |
G |
|
Centre for Genomic and Experimental Medicine, University of Edinburgh, Edinburgh, United Kingdom; Department of Psychology, University of Edinburgh, Edinburgh, United Kingdom. |
| Franic S |
|
Franic |
Sanja |
S |
|
Department of Biological Psychology, Vrije Universiteit, Amsterdam, The Netherlands. |
| Christoforou A |
|
Christoforou |
Andrea |
A |
|
K.G. Jebsen Centre for Psychosis Research and the Norwegian Center for Mental Disorders Research (NORMENT), Department of Clinical Science, University of Bergen, Bergen, Norway; Dr Einar Martens Research Group for Biological Psychiatry, Center for Medical Genetics and Molecular Medicine, Haukeland University Hospital, Bergen, Norway. |
| Zietsch B |
|
Zietsch |
Brendan |
B |
|
Genetic Epidemiology, QIMR Berghofer Medical Research Institute, Brisbane, Australia; School of Psychology, University of Queensland, St Lucia, Brisbane, Australia. |
| Painter J |
|
Painter |
Jodie |
J |
|
Molecular Genetic Epidemiology, QIMR Berghofer Medical Research Institute, Brisbane, Australia. |
| Medland SE |
|
Medland |
Sarah E |
SE |
|
Quantitative Genetics, QIMR Berghofer Medical Research Institute, Brisbane, Australia. |
| Ehli EA |
|
Ehli |
Erik A |
EA |
|
Avera Institute for Human Genetics, Avera McKennan Hospital & University Health Center, Sioux Falls, South Dakota, United States of America. |
| Davies GE |
|
Davies |
Gareth E |
GE |
|
Avera Institute for Human Genetics, Avera McKennan Hospital & University Health Center, Sioux Falls, South Dakota, United States of America. |
| Steen VM |
|
Steen |
Vidar M |
VM |
|
K.G. Jebsen Centre for Psychosis Research and the Norwegian Center for Mental Disorders Research (NORMENT), Department of Clinical Science, University of Bergen, Bergen, Norway; Dr Einar Martens Research Group for Biological Psychiatry, Center for Medical Genetics and Molecular Medicine, Haukeland University Hospital, Bergen, Norway. |
| Lundervold AJ |
|
Lundervold |
Astri J |
AJ |
|
K.G. Jebsen Center for Research on Neuropsychiatric Disorders, University of Bergen, Bergen, Norway; Department of Biological and Medical Psychology, University of Bergen, Bergen, Norway; Center for Research on Aging and Dementia, Haraldsplass Deaconess Hospital, Bergen, Norway. |
| Reinvang I |
|
Reinvang |
Ivar |
I |
|
Department of Psychology, University of Oslo, Oslo, Norway. |
| Montgomery GW |
|
Montgomery |
Grant W |
GW |
|
Molecular Epidemiology, QIMR Berghofer Medical Research Institute, Brisbane, Australia. |
| Espeseth T |
|
Espeseth |
Thomas |
T |
|
Department of Psychology, University of Oslo, Oslo, Norway; Norwegian Center for Mental Disorders Research (NORMENT) and the K.G. Jebsen Center for Psychosis Research, Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway. |
| Hulshoff Pol HE |
|
Hulshoff Pol |
Hilleke E |
HE |
|
Brain Center Rudolf Magnus, Department of Psychiatry, University Medical Center Utrecht, Utrecht, The Netherlands. |
| Starr JM |
|
Starr |
John M |
JM |
|
Department of Psychology, University of Edinburgh, Edinburgh, United Kingdom; Alzheimer Scotland Dementia Research Centre, University of Edinburgh, Edinburgh, United Kingdom. |
| Martin NG |
|
Martin |
Nicholas G |
NG |
|
Genetic Epidemiology, QIMR Berghofer Medical Research Institute, Brisbane, Australia. |
| Le Hellard S |
|
Le Hellard |
Stephanie |
S |
|
K.G. Jebsen Centre for Psychosis Research and the Norwegian Center for Mental Disorders Research (NORMENT), Department of Clinical Science, University of Bergen, Bergen, Norway; Dr Einar Martens Research Group for Biological Psychiatry, Center for Medical Genetics and Molecular Medicine, Haukeland University Hospital, Bergen, Norway. |
| Boomsma DI |
|
Boomsma |
Dorret I |
DI |
|
Department of Biological Psychology, Vrije Universiteit, Amsterdam, The Netherlands. |
| Deary IJ |
|
Deary |
Ian J |
IJ |
|
Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, United Kingdom; Centre for Genomic and Experimental Medicine, University of Edinburgh, Edinburgh, United Kingdom. |
| Wright MJ |
|
Wright |
Margaret J |
MJ |
|
Neuroimaging Genetics, QIMR Berghofer Medical Research Institute, Brisbane, Australia. |
|
| INVESTIGATORS |
|
|
| JOURNAL |
|
| VOLUME: 10 |
| ISSUE: 4 |
| TITLE: PloS one |
| ISOABBREVIATION: PLoS One |
| YEAR: 2015 |
| MONTH: |
| DAY: |
| MEDLINEDATE: |
| SEASON: |
| CITEDMEDIUM: Internet |
| ISSN: 1932-6203 |
| ISSNTYPE: Electronic |
|
| MEDLINE JOURNAL |
|
| MEDLINETA: PLoS One |
| COUNTRY: United States |
| ISSNLINKING: 1932-6203 |
| NLMUNIQUEID: 101285081 |
|
| PUBLICATION TYPE |
|
| PUBLICATIONTYPE TEXT |
| Journal Article |
| Research Support, N.I.H., Extramural |
| Research Support, Non-U.S. Gov't |
| Twin Study |
|
| COMMENTS AND CORRECTIONS |
|
| REFTYPE |
REFSOURCE |
REFPMID |
NOTE |
| Cites |
Twin Res Hum Genet. 2007 Feb;10(1):3-11 |
17539360 |
|
| Cites |
Twin Res Hum Genet. 2007 Jun;10(3):423-33 |
17564500 |
|
| Cites |
Am J Hum Genet. 2007 Nov;81(5):913-26 |
17924335 |
|
| Cites |
Mol Psychiatry. 2008 Jan;13(1):36-64 |
17912248 |
|
| Cites |
BMC Geriatr. 2007;7:28 |
18053258 |
|
| Cites |
Dev Med Child Neurol. 2008 Mar;50(3):168-81 |
18190537 |
|
| Cites |
Biol Psychiatry. 2008 Jul 1;64(1):18-25 |
18495087 |
|
| Cites |
Bioinformatics. 2008 Dec 15;24(24):2938-9 |
18974171 |
|
| Cites |
Science. 2009 May 1;324(5927):605 |
19407193 |
|
| Cites |
Behav Genet. 2009 Sep;39(5):472-95 |
19404731 |
|
| Cites |
BMC Neurosci. 2009;10:99 |
19691842 |
|
| Cites |
Am J Hum Genet. 2009 Nov;85(5):750-5 |
19896111 |
|
| Cites |
Diabetes. 2010 May;59(5):1266-75 |
20185807 |
|
| Cites |
Am J Hum Genet. 2010 Jul 9;87(1):139-45 |
20598278 |
|
| Cites |
PLoS One. 2010;5(7):e11602 |
20657643 |
|
| Cites |
Bioinformatics. 2010 Sep 1;26(17):2190-1 |
20616382 |
|
| Cites |
Nucleic Acids Res. 2010 Sep;38(16):e164 |
20601685 |
|
| Cites |
Mem Cognit. 2010 Oct;38(7):928-40 |
20921105 |
|
| Cites |
Mol Psychiatry. 2010 Nov;15(11):1112-20 |
19488046 |
|
| Cites |
Schizophr Bull. 2010 Nov;36(6):1187-200 |
19460878 |
|
| Cites |
Trends Cogn Sci. 2010 Nov;14(11):497-505 |
20884275 |
|
| Cites |
J Am Acad Child Adolesc Psychiatry. 2010 Dec;49(12):1189-201; quiz 1285 |
21093769 |
|
| Cites |
Am J Hum Genet. 2011 Jan 7;88(1):76-82 |
21167468 |
|
| Cites |
Neuropsychopharmacology. 2011 Mar;36(4):744-52 |
21150909 |
|
| Cites |
Cortex. 2011 May;47(5):588-97 |
20537619 |
|
| Cites |
Behav Neurosci. 2011 Jun;125(3):282-96 |
21480691 |
|
| Cites |
Mol Psychiatry. 2011 Oct;16(10):996-1005 |
21826061 |
|
| Cites |
Nat Genet. 2011 Oct;43(10):969-76 |
21926974 |
|
| Cites |
Schizophr Bull. 2012 Jan;38(1):114-24 |
22124089 |
|
| Cites |
Nature. 2012 Feb 9;482(7384):212-5 |
22258510 |
|
| Cites |
Dev Neuropsychol. 2012;37(2):134-52 |
22339227 |
|
| Cites |
PLoS One. 2012;7(2):e31687 |
22384057 |
|
| Cites |
Schizophr Bull. 2012 May;38(3):622-9 |
21134974 |
|
| Cites |
Nat Genet. 2012 May;44(5):552-61 |
22504417 |
|
| Cites |
Twin Res Hum Genet. 2012 Jun;15(3):442-52 |
22856377 |
|
| Cites |
Int J Neuropsychopharmacol. 2012 Oct;15(9):1205-15 |
22078257 |
|
| Cites |
Brain Cogn. 2013 Feb;81(1):44-51 |
23174427 |
|
| Cites |
Int J Epidemiol. 2012 Dec;41(6):1576-84 |
22253310 |
|
| Cites |
Behav Genet. 2013 Jan;43(1):1-12 |
22927095 |
|
| Cites |
Int J Epidemiol. 2013 Feb;42(1):111-27 |
22507743 |
|
| Cites |
Psychol Sci. 2013 Apr;24(4):562-8 |
23501967 |
|
| Cites |
Schizophr Res. 2013 Jul;147(2-3):320-5 |
23623175 |
|
| Cites |
Science. 2013 Jun 21;340(6139):1467-71 |
23722424 |
|
| Cites |
J Psychiatr Res. 2013 Sep;47(9):1240-6 |
23743135 |
|
| Cites |
Eur J Pharmacol. 2013 Nov 5;719(1-3):170-9 |
24070815 |
|
| Cites |
Psicothema. 2014;26(1):1-9 |
24444722 |
|
| Cites |
Mol Psychiatry. 2014 Feb;19(2):253-8 |
23358156 |
|
| Cites |
Mol Brain. 2014;7:13 |
24552281 |
|
| Cites |
Scand J Psychol. 2014 Jun;55(3):255-62 |
24605886 |
|
| Cites |
Psychol Bull. 2014 Jul;140(4):949-79 |
24611582 |
|
| Cites |
Cereb Cortex. 2014 Sep;24(9):2283-96 |
23563963 |
|
| Cites |
Genes Brain Behav. 2014 Sep;13(7):663-74 |
24975275 |
|
| Cites |
Behav Genet. 2000 Mar;30(2):147-58 |
10979605 |
|
| Cites |
Behav Brain Sci. 2001 Feb;24(1):87-114; discussion 114-85 |
11515286 |
|
| Cites |
Neuroimage. 2001 Nov;14(5):1136-49 |
11697945 |
|
| Cites |
Behav Genet. 2001 Nov;31(6):581-92 |
11838535 |
|
| Cites |
Cogn Psychol. 2002 Sep;45(2):153-219 |
12528901 |
|
| Cites |
J Neurocytol. 2002 Mar-Jun;31(3-5):373-85 |
12815254 |
|
| Cites |
Neuropsychology. 2004 Apr;18(2):296-305 |
15099152 |
|
| Cites |
Behav Neurosci. 2004 Aug;118(4):667-75 |
15301594 |
|
| Cites |
Science. 1997 Jun 6;276(5318):1560-3 |
9171059 |
|
| Cites |
Dev Psychol. 1998 Nov;34(6):1400-13 |
9823519 |
|
| Cites |
Behav Brain Sci. 1998 Dec;21(6):803-31; discussion 831-64 |
10191879 |
|
| Cites |
Dev Psychol. 2005 Jan;41(1):3-16 |
15656733 |
|
| Cites |
Psychol Sci. 2005 Jan;16(1):70-6 |
15660854 |
|
| Cites |
Mem Cognit. 2006 Sep;34(6):1325-40 |
17225512 |
|
| Cites |
Twin Res Hum Genet. 2006 Dec;9(6):849-57 |
17254420 |
|
| Cites |
Curr Opin Neurobiol. 2007 Apr;17(2):251-7 |
17383865 |
|
| Cites |
Trends Cogn Sci. 2007 Jun;11(6):236-42 |
17475538 |
|
|
| GRANTS |
|
| GRANTID |
AGENCY |
COUNTRY |
| RC2 MH089951 |
NIMH NIH HHS |
United States |
| 092731 |
Wellcome Trust |
United Kingdom |
| R01 MH081802 |
NIMH NIH HHS |
United States |
| MC_PC_15018 |
Medical Research Council |
United Kingdom |
| U24 MH068457 |
NIMH NIH HHS |
United States |
| BB/C514623/1 |
Biotechnology and Biological Sciences Research Council |
United Kingdom |
| MH081802 |
NIMH NIH HHS |
United States |
| RC2 MH089995 |
NIMH NIH HHS |
United States |
| 1RC2 MH089951 |
NIMH NIH HHS |
United States |
| R01 HD042157-01A1 |
NICHD NIH HHS |
United States |
| R01 HD042157 |
NICHD NIH HHS |
United States |
| MR/K026992/1 |
Medical Research Council |
United Kingdom |
| 102215 |
Wellcome Trust |
United Kingdom |
| 1RC2 MH089995 |
NIMH NIH HHS |
United States |
| BB/F019394/1 |
Biotechnology and Biological Sciences Research Council |
United Kingdom |
| G0700704 |
Medical Research Council |
United Kingdom |
| U24 MH068457-06 |
NIMH NIH HHS |
United States |
|
Wellcome Trust |
United Kingdom |
|
| GENERAL NOTE |
|
|
| KEYWORDS |
|
|
| MESH HEADINGS |
|
| DESCRIPTORNAME |
QUALIFIERNAME |
| Adolescent |
|
| Adult |
|
| Cognition |
|
| Female |
|
| Genetic Association Studies |
|
| Genome-Wide Association Study |
methods |
| Humans |
methods |
| Male |
methods |
| Meta-Analysis as Topic |
methods |
| Models, Biological |
methods |
| Polymorphism, Single Nucleotide |
methods |
| Quantitative Trait, Heritable |
methods |
| Twins |
methods |
| Young Adult |
methods |
|
| SUPPLEMENTARY MESH |
|
|
| GENE SYMBOLS |
|
|
| CHEMICALS |
|
|
| OTHER ID's |
|
|
|
