|
|
| PMID |
|
|
| TITLE |
|
| The relationship between cannabis involvement and suicidal thoughts and behaviors. |
|
| ABSTRACT |
|
| BACKGROUND |
NlmCategory: BACKGROUND |
| In the present study, we examined the relationship between cannabis involvement and suicidal ideation (SI), plan and attempt, differentiating the latter into planned and unplanned attempt, taking into account other substance involvement and psychopathology. |
| METHODS |
NlmCategory: METHODS |
| We used two community-based twin samples from the Australian Twin Registry, including 9583 individuals (58.5% female, aged between 27 and 40). The Semi-Structured Assessment of the Genetics of Alcoholism (SSAGA) was used to assess cannabis involvement which was categorized into: (0) no cannabis use (reference category); (1) cannabis use only; (2) 1-2 cannabis use disorder symptoms; (3) 3 or more symptoms. Separate multinomial logistic regression analyses were conducted for SI and suicide attempt with or without a plan. Twin analyses examined the genetic overlap between cannabis involvement and SI. |
| RESULTS |
NlmCategory: RESULTS |
| All levels of cannabis involvement were related to SI, regardless of duration (odds ratios [ORs]=1.28-2.00, p<0.01). Cannabis use and endorsing ≥3 symptoms were associated with unplanned (SANP; ORs=1.95 and 2.51 respectively, p<0.05), but not planned suicide attempts (p>0.10). Associations persisted even after controlling for other psychiatric disorders and substance involvement. Overlapping genetic (rG=0.45) and environmental (rE=0.21) factors were responsible for the covariance between cannabis involvement and SI. |
| CONCLUSIONS |
NlmCategory: CONCLUSIONS |
| Cannabis involvement is associated, albeit modestly, with SI and unplanned suicide attempts. Such attempts are difficult to prevent and their association with cannabis use and cannabis use disorder symptoms requires further study, including in different samples and with additional attention to confounders. |
| Copyright © 2015. Published by Elsevier Ireland Ltd. |
|
| DATE PUBLISHED |
|
|
| HISTORY |
|
| PUBSTATUS |
PUBSTATUSDATE |
| received |
2014/09/22 |
| revised |
2015/02/05 |
| accepted |
2015/02/14 |
| aheadofprint |
2015/02/26 |
| entrez |
2015/03/17 06:00 |
| pubmed |
2015/03/17 06:00 |
| medline |
2015/10/24 06:00 |
| pmc-release |
2016/05/01 00:00 |
|
| AUTHORS |
|
| NAME |
COLLECTIVENAME |
LASTNAME |
FORENAME |
INITIALS |
AFFILIATION |
AFFILIATIONINFO |
| Delforterie MJ |
|
Delforterie |
M J |
MJ |
|
VU University, Department of Developmental Psychology and EMGO Institute for Health and Care Research, Amsterdam, The Netherlands. |
| Lynskey MT |
|
Lynskey |
M T |
MT |
|
Addictions Department, Institute of Psychiatry, King's College London, United Kingdom. |
| Huizink AC |
|
Huizink |
A C |
AC |
|
VU University, Department of Developmental Psychology and EMGO Institute for Health and Care Research, Amsterdam, The Netherlands. |
| Creemers HE |
|
Creemers |
H E |
HE |
|
Research Institute of Child Development and Education, University of Amsterdam, Amsterdam, The Netherlands. |
| Grant JD |
|
Grant |
J D |
JD |
|
Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA. |
| Few LR |
|
Few |
L R |
LR |
|
Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA. |
| Glowinski AL |
|
Glowinski |
A L |
AL |
|
Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA. |
| Statham DJ |
|
Statham |
D J |
DJ |
|
School of Social Sciences, University of the Sunshine Coast, Queensland, Australia. |
| Trull TJ |
|
Trull |
T J |
TJ |
|
University of Missouri, Department of Psychological Sciences, Columbia, MO, USA. |
| Bucholz KK |
|
Bucholz |
K K |
KK |
|
Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA. |
| Madden PA |
|
Madden |
P A F |
PA |
|
Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA. |
| Martin NG |
|
Martin |
N G |
NG |
|
QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia. |
| Heath AC |
|
Heath |
A C |
AC |
|
Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA. |
| Agrawal A |
|
Agrawal |
A |
A |
|
Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA. Electronic address: arpana@wustl.edu. |
|
| INVESTIGATORS |
|
|
| JOURNAL |
|
| VOLUME: 150 |
| ISSUE: |
| TITLE: Drug and alcohol dependence |
| ISOABBREVIATION: Drug Alcohol Depend |
| YEAR: 2015 |
| MONTH: May |
| DAY: 1 |
| MEDLINEDATE: |
| SEASON: |
| CITEDMEDIUM: Internet |
| ISSN: 1879-0046 |
| ISSNTYPE: Electronic |
|
| MEDLINE JOURNAL |
|
| MEDLINETA: Drug Alcohol Depend |
| COUNTRY: Ireland |
| ISSNLINKING: 0376-8716 |
| NLMUNIQUEID: 7513587 |
|
| PUBLICATION TYPE |
|
| PUBLICATIONTYPE TEXT |
| Journal Article |
| Research Support, N.I.H., Extramural |
| Research Support, Non-U.S. Gov't |
| Twin Study |
|
| COMMENTS AND CORRECTIONS |
|
| REFTYPE |
REFSOURCE |
REFPMID |
NOTE |
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|
|
| GRANTS |
|
| GRANTID |
AGENCY |
COUNTRY |
| AA07728 |
NIAAA NIH HHS |
United States |
| AA11998 |
NIAAA NIH HHS |
United States |
| AA13221 |
NIAAA NIH HHS |
United States |
| DA12854 |
NIDA NIH HHS |
United States |
| DA18267 |
NIDA NIH HHS |
United States |
| DA23668 |
NIDA NIH HHS |
United States |
| DA32573 |
NIDA NIH HHS |
United States |
| F32 AA023693 |
NIAAA NIH HHS |
United States |
| K02 DA032573 |
NIDA NIH HHS |
United States |
| K21DA00272 |
NIDA NIH HHS |
United States |
| P60 AA011998 |
NIAAA NIH HHS |
United States |
| R01 AA007728 |
NIAAA NIH HHS |
United States |
| R01 AA013321 |
NIAAA NIH HHS |
United States |
| R01 DA012854 |
NIDA NIH HHS |
United States |
| R01 DA018267 |
NIDA NIH HHS |
United States |
| R01 DA023668 |
NIDA NIH HHS |
United States |
| T32DA007313 |
NIDA NIH HHS |
United States |
|
| GENERAL NOTE |
|
|
| KEYWORDS |
|
| KEYWORD |
| Cannabis use |
| Cannabis use disorder symptoms |
| Suicidal thoughts and behaviors |
|
| MESH HEADINGS |
|
| DESCRIPTORNAME |
QUALIFIERNAME |
| Adult |
|
| Australia |
|
| Female |
|
| Humans |
|
| Male |
|
| Marijuana Abuse |
psychology |
| Marijuana Smoking |
psychology |
| Suicidal Ideation |
psychology |
| Suicide |
psychology |
| Suicide, Attempted |
psychology |
| Twins |
psychology |
|
| SUPPLEMENTARY MESH |
|
|
| GENE SYMBOLS |
|
|
| CHEMICALS |
|
|
| OTHER ID's |
|
| OTHERID |
SOURCE |
| NIHMS694618 [Available on 05/01/16] |
NLM |
| PMC4460828 [Available on 05/01/16] |
NLM |
|
|
