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PMID |
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TITLE |
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Heritability of fractional anisotropy in human white matter: a comparison of Human Connectome Project and ENIGMA-DTI data. |
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ABSTRACT |
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The degree to which genetic factors influence brain connectivity is beginning to be understood. Large-scale efforts are underway to map the profile of genetic effects in various brain regions. The NIH-funded Human Connectome Project (HCP) is providing data valuable for analyzing the degree of genetic influence underlying brain connectivity revealed by state-of-the-art neuroimaging methods. We calculated the heritability of the fractional anisotropy (FA) measure derived from diffusion tensor imaging (DTI) reconstruction in 481 HCP subjects (194/287 M/F) consisting of 57/60 pairs of mono- and dizygotic twins, and 246 siblings. FA measurements were derived using (Enhancing NeuroImaging Genetics through Meta-Analysis) ENIGMA DTI protocols and heritability estimates were calculated using the SOLAR-Eclipse imaging genetic analysis package. We compared heritability estimates derived from HCP data to those publicly available through the ENIGMA-DTI consortium, which were pooled together from five-family based studies across the US, Europe, and Australia. FA measurements from the HCP cohort for eleven major white matter tracts were highly heritable (h(2)=0.53-0.90, p<10(-5)), and were significantly correlated with the joint-analytical estimates from the ENIGMA cohort on the tract and voxel-wise levels. The similarity in regional heritability suggests that the additive genetic contribution to white matter microstructure is consistent across populations and imaging acquisition parameters. It also suggests that the overarching genetic influence provides an opportunity to define a common genetic search space for future gene-discovery studies. Uniquely, the measurements of additive genetic contribution performed in this study can be repeated using online genetic analysis tools provided by the HCP ConnectomeDB web application. |
Copyright © 2015 Elsevier Inc. All rights reserved. |
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DATE PUBLISHED |
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HISTORY |
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PUBSTATUS |
PUBSTATUSDATE |
received |
2014/10/23 |
revised |
2015/01/10 |
accepted |
2015/02/23 |
aheadofprint |
2015/03/04 |
entrez |
2015/03/10 06:00 |
pubmed |
2015/03/10 06:00 |
medline |
2016/04/08 06:00 |
pmc-release |
2016/05/01 00:00 |
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AUTHORS |
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NAME |
COLLECTIVENAME |
LASTNAME |
FORENAME |
INITIALS |
AFFILIATION |
AFFILIATIONINFO |
Kochunov P |
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Kochunov |
Peter |
P |
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Maryland Psychiatric Research Center, University of MD School of Medicine, Baltimore USA. Electronic address: pkochunov@mprc.umaryland.edu. |
Jahanshad N |
|
Jahanshad |
Neda |
N |
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Imaging Genetics Center, Institute for Neuroimaging and Informatics, Department of Neurology Keck School of Medicine, University of Southern CA, Marina del Rey, USA. |
Marcus D |
|
Marcus |
Daniel |
D |
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Department of Radiology, Washington University School of Medicine, St. Louis, USA. |
Winkler A |
|
Winkler |
Anderson |
A |
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FMRIB Centre, Oxford University, Oxford, UK. |
Sprooten E |
|
Sprooten |
Emma |
E |
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Olin Neuropsychiatry Research Center, Institute of Living, Hartford Hospital, Hartford, USA. |
Nichols TE |
|
Nichols |
Thomas E |
TE |
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Department of Statistics, University of Warwick, Warwick, UK. |
Wright SN |
|
Wright |
Susan N |
SN |
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Maryland Psychiatric Research Center, University of MD School of Medicine, Baltimore USA. |
Hong LE |
|
Hong |
L Elliot |
LE |
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Maryland Psychiatric Research Center, University of MD School of Medicine, Baltimore USA. |
Patel B |
|
Patel |
Binish |
B |
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Maryland Psychiatric Research Center, University of MD School of Medicine, Baltimore USA. |
Behrens T |
|
Behrens |
Timothy |
T |
|
FMRIB Centre, Oxford University, Oxford, UK. |
Jbabdi S |
|
Jbabdi |
Saad |
S |
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FMRIB Centre, Oxford University, Oxford, UK. |
Andersson J |
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Andersson |
Jesper |
J |
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FMRIB Centre, Oxford University, Oxford, UK. |
Lenglet C |
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Lenglet |
Christophe |
C |
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Center for Magnetic Resonance Research, Department of Radiology, University of Minnesota Medical School, Minneapolis, MN, USA. |
Yacoub E |
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Yacoub |
Essa |
E |
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Center for Magnetic Resonance Research, Department of Radiology, University of Minnesota Medical School, Minneapolis, MN, USA. |
Moeller S |
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Moeller |
Steen |
S |
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Center for Magnetic Resonance Research, Department of Radiology, University of Minnesota Medical School, Minneapolis, MN, USA. |
Auerbach E |
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Auerbach |
Eddie |
E |
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Center for Magnetic Resonance Research, Department of Radiology, University of Minnesota Medical School, Minneapolis, MN, USA. |
Ugurbil K |
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Ugurbil |
Kamil |
K |
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Center for Magnetic Resonance Research, Department of Radiology, University of Minnesota Medical School, Minneapolis, MN, USA. |
Sotiropoulos SN |
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Sotiropoulos |
Stamatios N |
SN |
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FMRIB Centre, Oxford University, Oxford, UK. |
Brouwer RM |
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Brouwer |
Rachel M |
RM |
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University Medical Center Utrecht, Utrecht, The Netherlands. |
Landman B |
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Landman |
Bennett |
B |
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Vanderbilt University, Nashville, TN, USA. |
Lemaitre H |
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Lemaitre |
Hervé |
H |
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INSERM-CEA-Faculté de Médecine Paris-Sud, Orsay France. |
den Braber A |
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den Braber |
Anouk |
A |
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VU University, Amsterdam, The Netherlands. |
Zwiers MP |
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Zwiers |
Marcel P |
MP |
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Radboud University, Nijmegen, The Netherlands. |
Ritchie S |
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Ritchie |
Stuart |
S |
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University of Edinburgh, Edinburgh, UK. |
van Hulzen K |
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van Hulzen |
Kimm |
K |
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Radboud University, Nijmegen, The Netherlands. |
Almasy L |
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Almasy |
Laura |
L |
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Texas Biomedical Research Institute, San Antonio, TX, USA. |
Curran J |
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Curran |
Joanne |
J |
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Texas Biomedical Research Institute, San Antonio, TX, USA. |
deZubicaray GI |
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deZubicaray |
Greig I |
GI |
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University of Queensland, Brisbane, Australia. |
Duggirala R |
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Duggirala |
Ravi |
R |
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Texas Biomedical Research Institute, San Antonio, TX, USA. |
Fox P |
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Fox |
Peter |
P |
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University of Texas Health Science Center San Antonio, San Antonio, TX, USA. |
Martin NG |
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Martin |
Nicholas G |
NG |
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QIMR Berghofer, Brisbane, Australia. |
McMahon KL |
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McMahon |
Katie L |
KL |
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University of Queensland, Brisbane, Australia. |
Mitchell B |
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Mitchell |
Braxton |
B |
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University of Maryland, Baltimore, MD, USA. |
Olvera RL |
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Olvera |
Rene L |
RL |
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University of Texas Health Science Center San Antonio, San Antonio, TX, USA. |
Peterson C |
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Peterson |
Charles |
C |
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Texas Biomedical Research Institute, San Antonio, TX, USA. |
Starr J |
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Starr |
John |
J |
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University of Edinburgh, Edinburgh, UK. |
Sussmann J |
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Sussmann |
Jessika |
J |
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University of Edinburgh, Edinburgh, UK. |
Wardlaw J |
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Wardlaw |
Joanna |
J |
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University of Edinburgh, Edinburgh, UK. |
Wright M |
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Wright |
Margie |
M |
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QIMR Berghofer, Brisbane, Australia. |
Boomsma DI |
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Boomsma |
Dorret I |
DI |
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VU University, Amsterdam, The Netherlands. |
Kahn R |
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Kahn |
Rene |
R |
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University Medical Center Utrecht, Utrecht, The Netherlands. |
de Geus EJ |
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de Geus |
Eco J C |
EJ |
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VU University, Amsterdam, The Netherlands. |
Williamson DE |
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Williamson |
Douglas E |
DE |
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University of Texas Health Science Center San Antonio, San Antonio, TX, USA. |
Hariri A |
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Hariri |
Ahmad |
A |
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Duke University, Durham, NC, USA. |
van 't Ent D |
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van 't Ent |
Dennis |
D |
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VU University, Amsterdam, The Netherlands. |
Bastin ME |
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Bastin |
Mark E |
ME |
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University of Edinburgh, Edinburgh, UK. |
McIntosh A |
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McIntosh |
Andrew |
A |
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University of Edinburgh, Edinburgh, UK. |
Deary IJ |
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Deary |
Ian J |
IJ |
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University of Edinburgh, Edinburgh, UK. |
Hulshoff Pol HE |
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Hulshoff Pol |
Hilleke E |
HE |
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University Medical Center Utrecht, Utrecht, The Netherlands. |
Blangero J |
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Blangero |
John |
J |
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Texas Biomedical Research Institute, San Antonio, TX, USA. |
Thompson PM |
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Thompson |
Paul M |
PM |
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Imaging Genetics Center, Institute for Neuroimaging and Informatics, Department of Neurology Keck School of Medicine, University of Southern CA, Marina del Rey, USA. |
Glahn DC |
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Glahn |
David C |
DC |
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Olin Neuropsychiatry Research Center, Institute of Living, Hartford Hospital, Hartford, USA. |
Van Essen DC |
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Van Essen |
David C |
DC |
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Anatomy & Neurobiology Department, Washington University in St. Louis, St. Louis, USA. |
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INVESTIGATORS |
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JOURNAL |
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VOLUME: 111 |
ISSUE: |
TITLE: NeuroImage |
ISOABBREVIATION: Neuroimage |
YEAR: 2015 |
MONTH: May |
DAY: 1 |
MEDLINEDATE: |
SEASON: |
CITEDMEDIUM: Internet |
ISSN: 1095-9572 |
ISSNTYPE: Electronic |
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MEDLINE JOURNAL |
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MEDLINETA: Neuroimage |
COUNTRY: United States |
ISSNLINKING: 1053-8119 |
NLMUNIQUEID: 9215515 |
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PUBLICATION TYPE |
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PUBLICATIONTYPE TEXT |
Comparative Study |
Journal Article |
Research Support, N.I.H., Extramural |
Research Support, Non-U.S. Gov't |
Twin Study |
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COMMENTS AND CORRECTIONS |
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REFTYPE |
REFSOURCE |
REFPMID |
NOTE |
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GRANTS |
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GRANTID |
AGENCY |
COUNTRY |
087727/Z/08/Z |
Wellcome Trust |
United Kingdom |
100309 |
Wellcome Trust |
United Kingdom |
104036 |
Wellcome Trust |
United Kingdom |
EB007813 |
NIBIB NIH HHS |
United States |
G0700704 |
Medical Research Council |
United Kingdom |
MH0708143 |
NIMH NIH HHS |
United States |
MH078111 |
NIMH NIH HHS |
United States |
MH083824 |
NIMH NIH HHS |
United States |
MH59490 |
NIMH NIH HHS |
United States |
MR/K026992/1 |
Medical Research Council |
United Kingdom |
P41 EB015922 |
NIBIB NIH HHS |
United States |
R01 AG040060 |
NIA NIH HHS |
United States |
R01 DA033369 |
NIDA NIH HHS |
United States |
R01 EB008281 |
NIBIB NIH HHS |
United States |
R01 EB008432 |
NIBIB NIH HHS |
United States |
R01 EB015611 |
NIBIB NIH HHS |
United States |
R01 EB015611 |
NIBIB NIH HHS |
United States |
RF1 AG041915 |
NIA NIH HHS |
United States |
U54 EB020403 |
NIBIB NIH HHS |
United States |
U54 EB020403 |
NIBIB NIH HHS |
United States |
U54 MH091657 |
NIMH NIH HHS |
United States |
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GENERAL NOTE |
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KEYWORDS |
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MESH HEADINGS |
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DESCRIPTORNAME |
QUALIFIERNAME |
Adult |
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Anisotropy |
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Cohort Studies |
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Connectome |
methods |
Diffusion Tensor Imaging |
methods |
Female |
methods |
Genetic Phenomena |
methods |
Humans |
methods |
Male |
methods |
Nerve Net |
anatomy & histology |
Registries |
anatomy & histology |
White Matter |
anatomy & histology |
Young Adult |
anatomy & histology |
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SUPPLEMENTARY MESH |
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GENE SYMBOLS |
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CHEMICALS |
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OTHER ID's |
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OTHERID |
SOURCE |
NIHMS669356 [Available on 05/01/16] |
NLM |
PMC4387079 [Available on 05/01/16] |
NLM |
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