Genetic Epidemiology, Translational Neurogenomics, Psychiatric Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
25747917
TITLE
Heritability of fractional anisotropy in human white matter: a comparison of Human Connectome Project and ENIGMA-DTI data.
ABSTRACT
The degree to which genetic factors influence brain connectivity is beginning to be understood. Large-scale efforts are underway to map the profile of genetic effects in various brain regions. The NIH-funded Human Connectome Project (HCP) is providing data valuable for analyzing the degree of genetic influence underlying brain connectivity revealed by state-of-the-art neuroimaging methods. We calculated the heritability of the fractional anisotropy (FA) measure derived from diffusion tensor imaging (DTI) reconstruction in 481 HCP subjects (194/287 M/F) consisting of 57/60 pairs of mono- and dizygotic twins, and 246 siblings. FA measurements were derived using (Enhancing NeuroImaging Genetics through Meta-Analysis) ENIGMA DTI protocols and heritability estimates were calculated using the SOLAR-Eclipse imaging genetic analysis package. We compared heritability estimates derived from HCP data to those publicly available through the ENIGMA-DTI consortium, which were pooled together from five-family based studies across the US, Europe, and Australia. FA measurements from the HCP cohort for eleven major white matter tracts were highly heritable (h(2)=0.53-0.90, p<10(-5)), and were significantly correlated with the joint-analytical estimates from the ENIGMA cohort on the tract and voxel-wise levels. The similarity in regional heritability suggests that the additive genetic contribution to white matter microstructure is consistent across populations and imaging acquisition parameters. It also suggests that the overarching genetic influence provides an opportunity to define a common genetic search space for future gene-discovery studies. Uniquely, the measurements of additive genetic contribution performed in this study can be repeated using online genetic analysis tools provided by the HCP ConnectomeDB web application.
Copyright © 2015 Elsevier Inc. All rights reserved.
DATE PUBLISHED
2015 May 1
HISTORY
PUBSTATUS PUBSTATUSDATE
received 2014/10/23
revised 2015/01/10
accepted 2015/02/23
aheadofprint 2015/03/04
entrez 2015/03/10 06:00
pubmed 2015/03/10 06:00
medline 2016/04/08 06:00
pmc-release 2016/05/01 00:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Kochunov P Kochunov Peter P Maryland Psychiatric Research Center, University of MD School of Medicine, Baltimore USA. Electronic address: pkochunov@mprc.umaryland.edu.
Jahanshad N Jahanshad Neda N Imaging Genetics Center, Institute for Neuroimaging and Informatics, Department of Neurology Keck School of Medicine, University of Southern CA, Marina del Rey, USA.
Marcus D Marcus Daniel D Department of Radiology, Washington University School of Medicine, St. Louis, USA.
Winkler A Winkler Anderson A FMRIB Centre, Oxford University, Oxford, UK.
Sprooten E Sprooten Emma E Olin Neuropsychiatry Research Center, Institute of Living, Hartford Hospital, Hartford, USA.
Nichols TE Nichols Thomas E TE Department of Statistics, University of Warwick, Warwick, UK.
Wright SN Wright Susan N SN Maryland Psychiatric Research Center, University of MD School of Medicine, Baltimore USA.
Hong LE Hong L Elliot LE Maryland Psychiatric Research Center, University of MD School of Medicine, Baltimore USA.
Patel B Patel Binish B Maryland Psychiatric Research Center, University of MD School of Medicine, Baltimore USA.
Behrens T Behrens Timothy T FMRIB Centre, Oxford University, Oxford, UK.
Jbabdi S Jbabdi Saad S FMRIB Centre, Oxford University, Oxford, UK.
Andersson J Andersson Jesper J FMRIB Centre, Oxford University, Oxford, UK.
Lenglet C Lenglet Christophe C Center for Magnetic Resonance Research, Department of Radiology, University of Minnesota Medical School, Minneapolis, MN, USA.
Yacoub E Yacoub Essa E Center for Magnetic Resonance Research, Department of Radiology, University of Minnesota Medical School, Minneapolis, MN, USA.
Moeller S Moeller Steen S Center for Magnetic Resonance Research, Department of Radiology, University of Minnesota Medical School, Minneapolis, MN, USA.
Auerbach E Auerbach Eddie E Center for Magnetic Resonance Research, Department of Radiology, University of Minnesota Medical School, Minneapolis, MN, USA.
Ugurbil K Ugurbil Kamil K Center for Magnetic Resonance Research, Department of Radiology, University of Minnesota Medical School, Minneapolis, MN, USA.
Sotiropoulos SN Sotiropoulos Stamatios N SN FMRIB Centre, Oxford University, Oxford, UK.
Brouwer RM Brouwer Rachel M RM University Medical Center Utrecht, Utrecht, The Netherlands.
Landman B Landman Bennett B Vanderbilt University, Nashville, TN, USA.
Lemaitre H Lemaitre Hervé H INSERM-CEA-Faculté de Médecine Paris-Sud, Orsay France.
den Braber A den Braber Anouk A VU University, Amsterdam, The Netherlands.
Zwiers MP Zwiers Marcel P MP Radboud University, Nijmegen, The Netherlands.
Ritchie S Ritchie Stuart S University of Edinburgh, Edinburgh, UK.
van Hulzen K van Hulzen Kimm K Radboud University, Nijmegen, The Netherlands.
Almasy L Almasy Laura L Texas Biomedical Research Institute, San Antonio, TX, USA.
Curran J Curran Joanne J Texas Biomedical Research Institute, San Antonio, TX, USA.
deZubicaray GI deZubicaray Greig I GI University of Queensland, Brisbane, Australia.
Duggirala R Duggirala Ravi R Texas Biomedical Research Institute, San Antonio, TX, USA.
Fox P Fox Peter P University of Texas Health Science Center San Antonio, San Antonio, TX, USA.
Martin NG Martin Nicholas G NG QIMR Berghofer, Brisbane, Australia.
McMahon KL McMahon Katie L KL University of Queensland, Brisbane, Australia.
Mitchell B Mitchell Braxton B University of Maryland, Baltimore, MD, USA.
Olvera RL Olvera Rene L RL University of Texas Health Science Center San Antonio, San Antonio, TX, USA.
Peterson C Peterson Charles C Texas Biomedical Research Institute, San Antonio, TX, USA.
Starr J Starr John J University of Edinburgh, Edinburgh, UK.
Sussmann J Sussmann Jessika J University of Edinburgh, Edinburgh, UK.
Wardlaw J Wardlaw Joanna J University of Edinburgh, Edinburgh, UK.
Wright M Wright Margie M QIMR Berghofer, Brisbane, Australia.
Boomsma DI Boomsma Dorret I DI VU University, Amsterdam, The Netherlands.
Kahn R Kahn Rene R University Medical Center Utrecht, Utrecht, The Netherlands.
de Geus EJ de Geus Eco J C EJ VU University, Amsterdam, The Netherlands.
Williamson DE Williamson Douglas E DE University of Texas Health Science Center San Antonio, San Antonio, TX, USA.
Hariri A Hariri Ahmad A Duke University, Durham, NC, USA.
van 't Ent D van 't Ent Dennis D VU University, Amsterdam, The Netherlands.
Bastin ME Bastin Mark E ME University of Edinburgh, Edinburgh, UK.
McIntosh A McIntosh Andrew A University of Edinburgh, Edinburgh, UK.
Deary IJ Deary Ian J IJ University of Edinburgh, Edinburgh, UK.
Hulshoff Pol HE Hulshoff Pol Hilleke E HE University Medical Center Utrecht, Utrecht, The Netherlands.
Blangero J Blangero John J Texas Biomedical Research Institute, San Antonio, TX, USA.
Thompson PM Thompson Paul M PM Imaging Genetics Center, Institute for Neuroimaging and Informatics, Department of Neurology Keck School of Medicine, University of Southern CA, Marina del Rey, USA.
Glahn DC Glahn David C DC Olin Neuropsychiatry Research Center, Institute of Living, Hartford Hospital, Hartford, USA.
Van Essen DC Van Essen David C DC Anatomy & Neurobiology Department, Washington University in St. Louis, St. Louis, USA.
INVESTIGATORS
JOURNAL
VOLUME: 111
ISSUE:
TITLE: NeuroImage
ISOABBREVIATION: Neuroimage
YEAR: 2015
MONTH: May
DAY: 1
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN: 1095-9572
ISSNTYPE: Electronic
MEDLINE JOURNAL
MEDLINETA: Neuroimage
COUNTRY: United States
ISSNLINKING: 1053-8119
NLMUNIQUEID: 9215515
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Comparative Study
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Twin Study
COMMENTS AND CORRECTIONS
REFTYPE REFSOURCE REFPMID NOTE
Cites Am J Hum Genet. 1994 Mar;54(3):535-43 8116623
Cites Neuroimage. 2004;23 Suppl 1:S97-107 15501104
Cites J Magn Reson B. 1996 Jun;111(3):209-19 8661285
Cites Nature. 1997 Jan 23;385(6614):313-8 9002514
Cites Neuroimage. 2014 Jul 15;95:136-50 24657781
Cites Neuroimage. 2014 Oct 15;100:358-69 24945661
Cites Neuroimage. 1999 Dec;10(6):724-37 10600418
Cites Hum Brain Mapp. 2005 Nov;26(3):210-20 16161162
Cites Neuroimage. 2006 Jul 15;31(4):1487-505 16624579
Cites Cereb Cortex. 2008 Aug;18(8):1973-80 18079129
Cites Med Image Comput Comput Assist Interv. 2008;11(Pt 1):1060-7 18979850
Cites Behav Genet. 2010 Mar;40(2):146-56 20087642
Cites J Neurosci. 2010 Jun 2;30(22):7569-74 20519531
Cites Neuroimage. 2010 Aug 15;52(2):455-69 20430102
Cites Neuroimage. 2010 Nov 15;53(3):1126-34 20035879
Cites Neuroimage. 2010 Nov 15;53(3):1109-16 20117221
Cites J Anat. 2010 Oct;217(4):400-17 20609031
Cites Magn Reson Imaging. 2011 Jan;29(1):111-25 20933352
Cites Neuroimage. 2011 Feb 1;54(3):2308-17 20950689
Cites Neuroimage. 2011 Feb 14;54(4):2557-62 21087671
Cites Brain Res. 2011 Feb 23;1375:41-8 21172320
Cites Neuroimage. 2011 Apr 15;55(4):1577-86 21256236
Cites Annu Rev Clin Psychol. 2011;7:63-85 21219189
Cites Psychol Med. 2011 Jul;41(7):1497-505 21054919
Cites Neuroimage. 2011 Sep 1;58(1):41-9 21640837
Cites Biol Psychiatry. 2011 Aug 15;70(4):350-6 21429475
Cites J Neurosci Methods. 2011 Sep 30;201(1):213-9 21835201
Cites Neuroimage. 2012 Feb 15;59(4):3784-804 22108644
Cites J Alzheimers Dis. 2012;29(2):405-29 22330833
Cites PLoS One. 2012;7(4):e32316 22514599
Cites Am J Med Genet B Neuropsychiatr Genet. 2012 Jul;159B(5):537-48 22585743
Cites PLoS One. 2012;7(7):e37021 22768288
Cites Neuroimage. 2012 Oct 1;62(4):2222-31 22366334
Cites J Alzheimers Dis. 2012;31 Suppl 3:S33-47 22992380
Cites Brain Res. 2012 Oct 10;1478:1-15 22954903
Cites PLoS One. 2012;7(11):e45996 23139736
Cites J Magn Reson Imaging. 2013 Feb;37(2):372-81 23034880
Cites Biol Psychiatry. 2013 Mar 1;73(5):482-91 23200529
Cites Neuroimage. 2013 Oct 15;80:105-24 23668970
Cites Neuroimage. 2013 Oct 15;80:80-104 23702417
Cites Neuroimage. 2013 Oct 15;80:125-43 23702418
Cites Neuroimage. 2013 Oct 15;80:202-19 23707591
Cites Neuroimage. 2013 Nov 1;81:455-69 23629049
Cites Hum Brain Mapp. 2013 Sep;34(9):2353-65 22461372
Cites Proc Natl Acad Sci U S A. 2013 Nov 19;110(47):19006-11 24191011
Cites Neurobiol Aging. 2014 Apr;35(4):937.e5-18 24231518
Cites Brain Imaging Behav. 2014 Jun;8(2):153-82 24399358
Cites J Comput Assist Tomogr. 2001 Sep-Oct;25(5):805-16 11584245
Cites Neuroimage. 2002 Oct;17(2):922-7 12377166
Cites Magn Reson Med. 2003 Nov;50(5):1077-88 14587019
Cites Biophys J. 1994 Jan;66(1):259-67 8130344
GRANTS
GRANTID AGENCY COUNTRY
087727/Z/08/Z Wellcome Trust United Kingdom
100309 Wellcome Trust United Kingdom
104036 Wellcome Trust United Kingdom
EB007813 NIBIB NIH HHS United States
G0700704 Medical Research Council United Kingdom
MH0708143 NIMH NIH HHS United States
MH078111 NIMH NIH HHS United States
MH083824 NIMH NIH HHS United States
MH59490 NIMH NIH HHS United States
MR/K026992/1 Medical Research Council United Kingdom
P41 EB015922 NIBIB NIH HHS United States
R01 AG040060 NIA NIH HHS United States
R01 DA033369 NIDA NIH HHS United States
R01 EB008281 NIBIB NIH HHS United States
R01 EB008432 NIBIB NIH HHS United States
R01 EB015611 NIBIB NIH HHS United States
R01 EB015611 NIBIB NIH HHS United States
RF1 AG041915 NIA NIH HHS United States
U54 EB020403 NIBIB NIH HHS United States
U54 EB020403 NIBIB NIH HHS United States
U54 MH091657 NIMH NIH HHS United States
GENERAL NOTE
KEYWORDS
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Adult
Anisotropy
Cohort Studies
Connectome methods
Diffusion Tensor Imaging methods
Female methods
Genetic Phenomena methods
Humans methods
Male methods
Nerve Net anatomy & histology
Registries anatomy & histology
White Matter anatomy & histology
Young Adult anatomy & histology
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
OTHER ID's
OTHERID SOURCE
NIHMS669356 [Available on 05/01/16] NLM
PMC4387079 [Available on 05/01/16] NLM
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