Genetic Epidemiology, Psychiatric Genetics, Asthma Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
25744032
TITLE
Low Birth Weight in MZ Twins Discordant for Birth Weight is Associated with Shorter Telomere Length and lower IQ, but not Anxiety/Depression in Later Life.
ABSTRACT
NlmCategory: UNASSIGNED
Shorter telomere length (TL) has found to be associated with lower birth weight and with lower cognitive ability and psychiatric disorders. However, the direction of causation of these associations and the extent to which they are genetically or environmentally mediated are unclear. Within-pair comparisons of monozygotic (MZ) and dizygotic (DZ) twins can throw light on these questions. We investigated correlations of within pair differences in telomere length, IQ, and anxiety/depression in an initial sample from Brisbane (242 MZ pairs, 245 DZ same sex (DZSS) pairs) and in replication samples from Amsterdam (514 MZ pairs, 233 DZSS pairs) and Melbourne (19 pairs selected for extreme high or low birth weight difference). Intra-pair differences of birth weight and telomere length were significantly correlated in MZ twins, but not in DZSS twins. Greater intra-pair differences of telomere length were observed in the 10% of MZ twins with the greatest difference in birth weight compared to the bottom 90% in both samples and also in the Melbourne sample. Intra-pair differences of telomere length and IQ, but not of TL and anxiety/depression, were correlated in MZ twins, and to a smaller extent in DZSS twins. Our findings suggest that the same prenatal effects that reduce birth weight also influence telomere length in MZ twins. The association between telomere length and IQ is partly driven by the same prenatal effects that decrease birth weight.
DATE PUBLISHED
2015 Mar 6
HISTORY
PUBSTATUS PUBSTATUSDATE
entrez 2015/03/07 06:00
pubmed 2015/03/07 06:00
medline 2015/03/07 06:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Strohmaier J Strohmaier Jana J Division of Genetic Epidemiology in Psychiatry,Central Institute of Mental Health,Medical Faculty Mannheim,University of Heidelberg,68159 Mannheim,Germany.
van Dongen J van Dongen Jenny J Biological Psychology,VU University,1081 BT Amsterdam,The Netherlands.
Willemsen G Willemsen Gonneke G Biological Psychology,VU University,1081 BT Amsterdam,The Netherlands.
Nyholt DR Nyholt Dale R DR QIMR Berghofer Medical Research Institute,Brisbane,QLD 4006,Australia.
Zhu G Zhu Gu G QIMR Berghofer Medical Research Institute,Brisbane,QLD 4006,Australia.
Codd V Codd Veryan V Department of Cardiovascular Sciences,University of Leicester,Leicester LE3 9QP,UK.
Novakovic B Novakovic Boris B Murdoch Childrens Research Institute and University of Melbourne Department of Paediatrics,Royal Children's Hospital,Parkville VIC 3052,Australia.
Hansell N Hansell Narelle N QIMR Berghofer Medical Research Institute,Brisbane,QLD 4006,Australia.
Wright MJ Wright Margaret J MJ QIMR Berghofer Medical Research Institute,Brisbane,QLD 4006,Australia.
Rietschel L Rietschel Liz L QIMR Berghofer Medical Research Institute,Brisbane,QLD 4006,Australia.
Streit F Streit Fabian F Division of Genetic Epidemiology in Psychiatry,Central Institute of Mental Health,Medical Faculty Mannheim,University of Heidelberg,68159 Mannheim,Germany.
Henders AK Henders Anjali K AK QIMR Berghofer Medical Research Institute,Brisbane,QLD 4006,Australia.
Montgomery GW Montgomery Grant W GW QIMR Berghofer Medical Research Institute,Brisbane,QLD 4006,Australia.
Samani NJ Samani Nilesh J NJ Department of Cardiovascular Sciences,University of Leicester,Leicester LE3 9QP,UK.
Gillespie NA Gillespie Nathan A NA Virginia Institute of Psychiatric and Behavioral Genetics,Richmond,VA 23219-1534,USA.
Hickie IB Hickie Ian B IB Brain and Mind Research Institute,University of Sydney,Camperdown NSW 2050,Australia.
Craig JM Craig Jeffrey M JM Murdoch Childrens Research Institute and University of Melbourne Department of Paediatrics,Royal Children's Hospital,Parkville VIC 3052,Australia.
Saffery R Saffery Richard R Murdoch Childrens Research Institute and University of Melbourne Department of Paediatrics,Royal Children's Hospital,Parkville VIC 3052,Australia.
Boomsma DI Boomsma Dorret I DI Biological Psychology,VU University,1081 BT Amsterdam,The Netherlands.
Rietschel M Rietschel Marcella M Division of Genetic Epidemiology in Psychiatry,Central Institute of Mental Health,Medical Faculty Mannheim,University of Heidelberg,68159 Mannheim,Germany.
Martin NG Martin Nicholas G NG QIMR Berghofer Medical Research Institute,Brisbane,QLD 4006,Australia.
INVESTIGATORS
JOURNAL
VOLUME:
ISSUE:
TITLE: Twin research and human genetics : the official journal of the International Society for Twin Studies
ISOABBREVIATION: Twin Res Hum Genet
YEAR: 2015
MONTH: Mar
DAY: 6
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Print
ISSN: 1832-4274
ISSNTYPE: Print
MEDLINE JOURNAL
MEDLINETA: Twin Res Hum Genet
COUNTRY: England
ISSNLINKING: 1832-4274
NLMUNIQUEID: 101244624
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
JOURNAL ARTICLE
COMMENTS AND CORRECTIONS
GRANTS
GENERAL NOTE
KEYWORDS
KEYWORD
anxiety/depression
MESH HEADINGS
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
OTHER ID's