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| PMID |
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| TITLE |
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| Low Birth Weight in MZ Twins Discordant for Birth Weight is Associated with Shorter Telomere Length and lower IQ, but not Anxiety/Depression in Later Life. |
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| ABSTRACT |
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NlmCategory: UNASSIGNED |
| Shorter telomere length (TL) has found to be associated with lower birth weight and with lower cognitive ability and psychiatric disorders. However, the direction of causation of these associations and the extent to which they are genetically or environmentally mediated are unclear. Within-pair comparisons of monozygotic (MZ) and dizygotic (DZ) twins can throw light on these questions. We investigated correlations of within pair differences in telomere length, IQ, and anxiety/depression in an initial sample from Brisbane (242 MZ pairs, 245 DZ same sex (DZSS) pairs) and in replication samples from Amsterdam (514 MZ pairs, 233 DZSS pairs) and Melbourne (19 pairs selected for extreme high or low birth weight difference). Intra-pair differences of birth weight and telomere length were significantly correlated in MZ twins, but not in DZSS twins. Greater intra-pair differences of telomere length were observed in the 10% of MZ twins with the greatest difference in birth weight compared to the bottom 90% in both samples and also in the Melbourne sample. Intra-pair differences of telomere length and IQ, but not of TL and anxiety/depression, were correlated in MZ twins, and to a smaller extent in DZSS twins. Our findings suggest that the same prenatal effects that reduce birth weight also influence telomere length in MZ twins. The association between telomere length and IQ is partly driven by the same prenatal effects that decrease birth weight. |
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| DATE PUBLISHED |
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| HISTORY |
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| PUBSTATUS |
PUBSTATUSDATE |
| entrez |
2015/03/07 06:00 |
| pubmed |
2015/03/07 06:00 |
| medline |
2015/03/07 06:00 |
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| AUTHORS |
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| NAME |
COLLECTIVENAME |
LASTNAME |
FORENAME |
INITIALS |
AFFILIATION |
AFFILIATIONINFO |
| Strohmaier J |
|
Strohmaier |
Jana |
J |
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Division of Genetic Epidemiology in Psychiatry,Central Institute of Mental Health,Medical Faculty Mannheim,University of Heidelberg,68159 Mannheim,Germany. |
| van Dongen J |
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van Dongen |
Jenny |
J |
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Biological Psychology,VU University,1081 BT Amsterdam,The Netherlands. |
| Willemsen G |
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Willemsen |
Gonneke |
G |
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Biological Psychology,VU University,1081 BT Amsterdam,The Netherlands. |
| Nyholt DR |
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Nyholt |
Dale R |
DR |
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QIMR Berghofer Medical Research Institute,Brisbane,QLD 4006,Australia. |
| Zhu G |
|
Zhu |
Gu |
G |
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QIMR Berghofer Medical Research Institute,Brisbane,QLD 4006,Australia. |
| Codd V |
|
Codd |
Veryan |
V |
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Department of Cardiovascular Sciences,University of Leicester,Leicester LE3 9QP,UK. |
| Novakovic B |
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Novakovic |
Boris |
B |
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Murdoch Childrens Research Institute and University of Melbourne Department of Paediatrics,Royal Children's Hospital,Parkville VIC 3052,Australia. |
| Hansell N |
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Hansell |
Narelle |
N |
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QIMR Berghofer Medical Research Institute,Brisbane,QLD 4006,Australia. |
| Wright MJ |
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Wright |
Margaret J |
MJ |
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QIMR Berghofer Medical Research Institute,Brisbane,QLD 4006,Australia. |
| Rietschel L |
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Rietschel |
Liz |
L |
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QIMR Berghofer Medical Research Institute,Brisbane,QLD 4006,Australia. |
| Streit F |
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Streit |
Fabian |
F |
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Division of Genetic Epidemiology in Psychiatry,Central Institute of Mental Health,Medical Faculty Mannheim,University of Heidelberg,68159 Mannheim,Germany. |
| Henders AK |
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Henders |
Anjali K |
AK |
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QIMR Berghofer Medical Research Institute,Brisbane,QLD 4006,Australia. |
| Montgomery GW |
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Montgomery |
Grant W |
GW |
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QIMR Berghofer Medical Research Institute,Brisbane,QLD 4006,Australia. |
| Samani NJ |
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Samani |
Nilesh J |
NJ |
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Department of Cardiovascular Sciences,University of Leicester,Leicester LE3 9QP,UK. |
| Gillespie NA |
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Gillespie |
Nathan A |
NA |
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Virginia Institute of Psychiatric and Behavioral Genetics,Richmond,VA 23219-1534,USA. |
| Hickie IB |
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Hickie |
Ian B |
IB |
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Brain and Mind Research Institute,University of Sydney,Camperdown NSW 2050,Australia. |
| Craig JM |
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Craig |
Jeffrey M |
JM |
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Murdoch Childrens Research Institute and University of Melbourne Department of Paediatrics,Royal Children's Hospital,Parkville VIC 3052,Australia. |
| Saffery R |
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Saffery |
Richard |
R |
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Murdoch Childrens Research Institute and University of Melbourne Department of Paediatrics,Royal Children's Hospital,Parkville VIC 3052,Australia. |
| Boomsma DI |
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Boomsma |
Dorret I |
DI |
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Biological Psychology,VU University,1081 BT Amsterdam,The Netherlands. |
| Rietschel M |
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Rietschel |
Marcella |
M |
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Division of Genetic Epidemiology in Psychiatry,Central Institute of Mental Health,Medical Faculty Mannheim,University of Heidelberg,68159 Mannheim,Germany. |
| Martin NG |
|
Martin |
Nicholas G |
NG |
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QIMR Berghofer Medical Research Institute,Brisbane,QLD 4006,Australia. |
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| INVESTIGATORS |
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| JOURNAL |
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| VOLUME: |
| ISSUE: |
| TITLE: Twin research and human genetics : the official journal of the International Society for Twin Studies |
| ISOABBREVIATION: Twin Res Hum Genet |
| YEAR: 2015 |
| MONTH: Mar |
| DAY: 6 |
| MEDLINEDATE: |
| SEASON: |
| CITEDMEDIUM: Print |
| ISSN: 1832-4274 |
| ISSNTYPE: Print |
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| MEDLINE JOURNAL |
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| MEDLINETA: Twin Res Hum Genet |
| COUNTRY: England |
| ISSNLINKING: 1832-4274 |
| NLMUNIQUEID: 101244624 |
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| PUBLICATION TYPE |
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| PUBLICATIONTYPE TEXT |
| JOURNAL ARTICLE |
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| COMMENTS AND CORRECTIONS |
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| GENERAL NOTE |
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| KEYWORDS |
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| KEYWORD |
| anxiety/depression |
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