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PMID |
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TITLE |
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Intelligence: shared genetic basis between Mendelian disorders and a polygenic trait. |
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ABSTRACT |
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NlmCategory: UNASSIGNED |
Multiple inquiries into the genetic etiology of human traits indicated an overlap between genes underlying monogenic disorders (eg, skeletal growth defects) and those affecting continuous variability of related quantitative traits (eg, height). Extending the idea of a shared genetic basis between a Mendelian disorder and a classic polygenic trait, we performed an association study to examine the effect of 43 genes implicated in autosomal recessive cognitive disorders on intelligence in an unselected Dutch population (N=1316). Using both single-nucleotide polymorphism (SNP)- and gene-based association testing, we detected an association between intelligence and the genes of interest, with genes ELP2, TMEM135, PRMT10, and RGS7 showing the strongest associations. This is a demonstration of the relevance of genes implicated in monogenic disorders of intelligence to normal-range intelligence, and a corroboration of the utility of employing knowledge on monogenic disorders in identifying the genetic variability underlying complex traits.European Journal of Human Genetics advance online publication, 25 February 2015; doi:10.1038/ejhg.2015.3. |
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DATE PUBLISHED |
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HISTORY |
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PUBSTATUS |
PUBSTATUSDATE |
received |
2014/02/12 |
revised |
2014/12/16 |
accepted |
2014/12/25 |
entrez |
2015/02/26 06:00 |
pubmed |
2015/02/26 06:00 |
medline |
2015/02/26 06:00 |
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AUTHORS |
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NAME |
COLLECTIVENAME |
LASTNAME |
FORENAME |
INITIALS |
AFFILIATION |
AFFILIATIONINFO |
Franić S |
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Franić |
Sanja |
S |
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Department of Biological Psychology, VU University Amsterdam, Amsterdam, The Netherlands. |
Groen-Blokhuis MM |
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Groen-Blokhuis |
Maria M |
MM |
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Department of Biological Psychology, VU University Amsterdam, Amsterdam, The Netherlands. |
Dolan CV |
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Dolan |
Conor V |
CV |
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1] Department of Biological Psychology, VU University Amsterdam, Amsterdam, The Netherlands [2] Department of Psychological Methods, University of Amsterdam, Amsterdam, The Netherlands. |
Kattenberg MV |
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Kattenberg |
Mathijs V |
MV |
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Department of Biological Psychology, VU University Amsterdam, Amsterdam, The Netherlands. |
Pool R |
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Pool |
René |
R |
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Department of Biological Psychology, VU University Amsterdam, Amsterdam, The Netherlands. |
Xiao X |
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Xiao |
Xiangjun |
X |
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Division of OVP, Cancer Prevention and Population Sciences, Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. |
Scheet PA |
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Scheet |
Paul A |
PA |
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Division of OVP, Cancer Prevention and Population Sciences, Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. |
Ehli EA |
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Ehli |
Erik A |
EA |
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Avera Institute for Human Genetics, Avera McKennan Hospital, University Health Center, Sioux Falls, SD, USA. |
Davies GE |
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Davies |
Gareth E |
GE |
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Avera Institute for Human Genetics, Avera McKennan Hospital, University Health Center, Sioux Falls, SD, USA. |
van der Sluis S |
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van der Sluis |
Sophie |
S |
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Section Functional Genomics, Department of Clinical Genetics, VU Medical Center Amsterdam, Amsterdam, The Netherlands. |
Abdellaoui A |
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Abdellaoui |
Abdel |
A |
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Department of Biological Psychology, VU University Amsterdam, Amsterdam, The Netherlands. |
Hansell NK |
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Hansell |
Narelle K |
NK |
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Genetic Epidemiology, Molecular Epidemiology and Neurogenetics Laboratories, Queensland Institute of Medical Research, Brisbane, Australia. |
Martin NG |
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Martin |
Nicholas G |
NG |
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Genetic Epidemiology, Molecular Epidemiology and Neurogenetics Laboratories, Queensland Institute of Medical Research, Brisbane, Australia. |
Hudziak JJ |
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Hudziak |
James J |
JJ |
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Department of Psychiatry and Medicine, University of Vermont, Burlington, VT, USA. |
van Beijsterveldt CE |
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van Beijsterveldt |
Catherina E M |
CE |
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Department of Biological Psychology, VU University Amsterdam, Amsterdam, The Netherlands. |
Swagerman SC |
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Swagerman |
Suzanne C |
SC |
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Department of Biological Psychology, VU University Amsterdam, Amsterdam, The Netherlands. |
Hulshoff Pol HE |
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Hulshoff Pol |
Hilleke E |
HE |
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Neuroimaging Research Group, University Medical Center Utrecht, Utrecht, The Netherlands. |
de Geus EJ |
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de Geus |
Eco J C |
EJ |
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Department of Biological Psychology, VU University Amsterdam, Amsterdam, The Netherlands. |
Bartels M |
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Bartels |
Meike |
M |
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Department of Biological Psychology, VU University Amsterdam, Amsterdam, The Netherlands. |
Ropers HH |
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Ropers |
H Hilger |
HH |
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Department of Human Molecular Genetics, Max Planck Institute for Molecular Genetics, Berlin, Germany. |
Hottenga JJ |
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Hottenga |
Jouke-Jan |
JJ |
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Department of Biological Psychology, VU University Amsterdam, Amsterdam, The Netherlands. |
Boomsma DI |
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Boomsma |
Dorret I |
DI |
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Department of Biological Psychology, VU University Amsterdam, Amsterdam, The Netherlands. |
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JOURNAL |
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VOLUME: |
ISSUE: |
TITLE: European journal of human genetics : EJHG |
ISOABBREVIATION: Eur. J. Hum. Genet. |
YEAR: 2015 |
MONTH: Feb |
DAY: 25 |
MEDLINEDATE: |
SEASON: |
CITEDMEDIUM: Internet |
ISSN: 1476-5438 |
ISSNTYPE: Electronic |
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MEDLINE JOURNAL |
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MEDLINETA: Eur J Hum Genet |
COUNTRY: England |
ISSNLINKING: 1018-4813 |
NLMUNIQUEID: 9302235 |
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