Genetic Epidemiology, Psychiatric Genetics, Asthma Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
25475840
TITLE
A twin study of breastfeeding with a preliminary genome-wide association scan.
ABSTRACT
Breastfeeding has been an important survival trait during human history, though it has long been recognized that individuals differ in their exact breastfeeding behavior. Here our aims were, first, to explore to what extent genetic and environmental influences contributed to the individual differences in breastfeeding behavior; second, to detect possible genetic variants related to breastfeeding; and lastly, to test if the genetic variants associated with breastfeeding have been previously found to be related with breast size. Data were collected from a large community-based cohort of Australian twins, with 3,364 women participating in the twin modelling analyses and 1,521 of them included in the genome-wide association study (GWAS). Monozygotic (MZ) twin correlations (r MZ = 0.52, 95% CI 0.46-0.57) were larger than dizygotic (DZ) twin correlations (r DZ = 0.35, 95% CI 0.25-0.43) and the best-fitting model was the one composed by additive genetics and unique environmental factors, explaining 53% and 47% of the variance in breastfeeding behavior, respectively. No breastfeeding-related genetic variants reached genome-wide significance. The polygenic risk score analyses showed no significant results, suggesting breast size does not influence breastfeeding. This study confers a replication of a previous one exploring the sources of variance of breastfeeding and, to our knowledge, is the first one to conduct a GWAS on breastfeeding and look at the overlap with variants for breast size.
DATE PUBLISHED
2015 Feb
HISTORY
PUBSTATUS PUBSTATUSDATE
aheadofprint 2014/12/05
entrez 2014/12/06 06:00
pubmed 2014/12/06 06:00
medline 2015/10/10 06:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Colodro-Conde L Colodro-Conde Lucia L QIMR Berghofer Medical Research Institute,Brisbane,Queensland,Australia.
Zhu G Zhu Gu G QIMR Berghofer Medical Research Institute,Brisbane,Queensland,Australia.
Power RA Power Robert A RA MRC Social Genetic & Developmental Psychiatry Centre,Institute of Psychiatry,King's College London,DeCrespigny Park,Denmark Hill,London,UK.
Henders A Henders Anjali A QIMR Berghofer Medical Research Institute,Brisbane,Queensland,Australia.
Heath AC Heath Andrew C AC School of Psychiatry,Washington University School of Medicine,St. Louis,MO,USA.
Madden PA Madden Pamela A F PA School of Psychiatry,Washington University School of Medicine,St. Louis,MO,USA.
Montgomery GW Montgomery Grant W GW QIMR Berghofer Medical Research Institute,Brisbane,Queensland,Australia.
Medland S Medland Sarah S QIMR Berghofer Medical Research Institute,Brisbane,Queensland,Australia.
Ordoñana JR Ordoñana Juan R JR Murcia Twin Registry,Department of Human Anatomy and Psychobiology,University of Murcia,IMIB-Arrixaca,Murcia,Spain.
Martin NG Martin Nicholas G NG QIMR Berghofer Medical Research Institute,Brisbane,Queensland,Australia.
INVESTIGATORS
JOURNAL
VOLUME: 18
ISSUE: 1
TITLE: Twin research and human genetics : the official journal of the International Society for Twin Studies
ISOABBREVIATION: Twin Res Hum Genet
YEAR: 2015
MONTH: Feb
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Print
ISSN: 1832-4274
ISSNTYPE: Print
MEDLINE JOURNAL
MEDLINETA: Twin Res Hum Genet
COUNTRY: England
ISSNLINKING: 1832-4274
NLMUNIQUEID: 101244624
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Comparative Study
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Twin Study
COMMENTS AND CORRECTIONS
REFTYPE REFSOURCE REFPMID NOTE
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GRANTS
GRANTID AGENCY COUNTRY
AA011998 NIAAA NIH HHS United States
AA013320 NIAAA NIH HHS United States
AA013321 NIAAA NIH HHS United States
AA013326 NIAAA NIH HHS United States
AA017688 NIAAA NIH HHS United States
K05 AA017688 NIAAA NIH HHS United States
P60 AA011998 NIAAA NIH HHS United States
R01 AA013320 NIAAA NIH HHS United States
R01 AA013321 NIAAA NIH HHS United States
R01 AA013326 NIAAA NIH HHS United States
GENERAL NOTE
KEYWORDS
KEYWORD
genome-wide association study
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Adult
Aged
Aged, 80 and over
Australia
Breast Feeding trends
Chromosomes, Human genetics
Cohort Studies genetics
Female genetics
Genome-Wide Association Study genetics
Genotyping Techniques genetics
Humans genetics
Male genetics
Middle Aged genetics
Oligonucleotide Array Sequence Analysis genetics
Polymorphism, Single Nucleotide genetics
Reproductive History genetics
Retrospective Studies genetics
Self Report genetics
Surveys and Questionnaires genetics
Twins, Dizygotic statistics & numerical data
Twins, Monozygotic statistics & numerical data
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
OTHER ID's
OTHERID SOURCE
NIHMS677559 NLM
PMC4416224 NLM