|
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| PMID |
|
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| TITLE |
|
| Novel loci associated with usual sleep duration: the CHARGE Consortium Genome-Wide Association Study. |
|
| ABSTRACT |
|
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|
| Usual sleep duration is a heritable trait correlated with psychiatric morbidity, cardiometabolic disease and mortality, although little is known about the genetic variants influencing this trait. A genome-wide association study (GWAS) of usual sleep duration was conducted using 18 population-based cohorts totaling 47 180 individuals of European ancestry. Genome-wide significant association was identified at two loci. The strongest is located on chromosome 2, in an intergenic region 35- to 80-kb upstream from the thyroid-specific transcription factor PAX8 (lowest P=1.1 × 10(-9)). This finding was replicated in an African-American sample of 4771 individuals (lowest P=9.3 × 10(-4)). The strongest combined association was at rs1823125 (P=1.5 × 10(-10), minor allele frequency 0.26 in the discovery sample, 0.12 in the replication sample), with each copy of the minor allele associated with a sleep duration 3.1 min longer per night. The alleles associated with longer sleep duration were associated in previous GWAS with a more favorable metabolic profile and a lower risk of attention deficit hyperactivity disorder. Understanding the mechanisms underlying these associations may help elucidate biological mechanisms influencing sleep duration and its association with psychiatric, metabolic and cardiovascular disease. |
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| DATE PUBLISHED |
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| HISTORY |
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| PUBSTATUS |
PUBSTATUSDATE |
| received |
2013/11/11 |
| revised |
2014/09/01 |
| accepted |
2014/09/04 |
| aheadofprint |
2014/12/02 |
| entrez |
2014/12/04 06:00 |
| pmc-release |
2016/04/01 00:00 |
| pubmed |
2014/12/04 06:00 |
| medline |
2014/12/04 06:00 |
|
| AUTHORS |
|
| NAME |
COLLECTIVENAME |
LASTNAME |
FORENAME |
INITIALS |
AFFILIATION |
AFFILIATIONINFO |
| Gottlieb DJ |
|
Gottlieb |
D J |
DJ |
|
The NHLBI's Framingham Heart Study, Framingham, MA, USA. |
| Hek K |
|
Hek |
K |
K |
|
Epidemiological and Social Psychiatric Research Institute, Department of Psychiatry, Erasmus MC, Rotterdam, The Netherlands. |
| Chen TH |
|
Chen |
T-H |
TH |
|
Department of Medicine, Boston University School of Medicine, Boston, MA, USA. |
| Watson NF |
|
Watson |
N F |
NF |
|
UW Medicine Sleep Center, University of Washington, Seattle, WA, USA. |
| Eiriksdottir G |
|
Eiriksdottir |
G |
G |
|
Icelandic Heart Association, Kópavogur, Iceland. |
| Byrne EM |
|
Byrne |
E M |
EM |
|
Queensland Institute of Medical Research, Brisbane, QLD, Australia. |
| Cornelis M |
|
Cornelis |
M |
M |
|
Channing Division of Network Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. |
| Warby SC |
|
Warby |
S C |
SC |
|
Center for Sleep Sciences and Medicine, Stanford University, Palo Alto, CA, USA. |
| Bandinelli S |
|
Bandinelli |
S |
S |
|
Geriatric Unit, Azienda Sanitaria Firenze (ASF), Florence, Italy. |
| Cherkas L |
|
Cherkas |
L |
L |
|
Department of Twin Research and Genetic Epidemiology, King's College London, London, UK. |
| Evans DS |
|
Evans |
D S |
DS |
|
California Pacific Medical Center Research Institute, San Francisco, CA, USA. |
| Grabe HJ |
|
Grabe |
H J |
HJ |
|
Department of Psychiatry and Psychotherapy, HELIOS-Hospital Stralsund, University Medicine Greifswald, Greifswald, Germany. |
| Lahti J |
|
Lahti |
J |
J |
|
Folkhalsan Research Centre, Helsinki, Finland. |
| Li M |
|
Li |
M |
M |
|
Department of Epidemiology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD, USA. |
| Lehtimäki T |
|
Lehtimäki |
T |
T |
|
Department of Clinical Chemistry, Fimlab Laboratories and School of Medicine, University of Tampere, Tampere, Finland. |
| Lumley T |
|
Lumley |
T |
T |
|
Department of Statistics, University of Auckland, Auckland, New Zealand. |
| Marciante KD |
|
Marciante |
K D |
KD |
|
Cardiovascular Health Research Unit, University of Washington, Seattle, WA, USA. |
| Pérusse L |
|
Pérusse |
L |
L |
|
Institute of Nutrition and Functional Foods, Laval University, Quebec, Canada. |
| Psaty BM |
|
Psaty |
B M |
BM |
|
Group Health Research Institute, Group Health Cooperative, Seattle, WA, USA. |
| Robbins J |
|
Robbins |
J |
J |
|
Department of Internal Medicine, University of California Davis, Sacramento, CA, USA. |
| Tranah GJ |
|
Tranah |
G J |
GJ |
|
California Pacific Medical Center Research Institute, San Francisco, CA, USA. |
| Vink JM |
|
Vink |
J M |
JM |
|
Department of Biological Psychology, Netherlands Twin Register, VU University, Amsterdam, The Netherlands. |
| Wilk JB |
|
Wilk |
J B |
JB |
|
Precision Medicine, Cambridge, MA, USA. |
| Stafford JM |
|
Stafford |
J M |
JM |
|
Division of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, NC, USA. |
| Bellis C |
|
Bellis |
C |
C |
|
Texas Biomedical Research Institute, San Antonio, TX, USA. |
| Biffar R |
|
Biffar |
R |
R |
|
Department of Prosthodontics, Gerodontology and Dental Materials, Center of Oral Health, University Medicine Greifswald, Greifswald, Germany. |
| Bouchard C |
|
Bouchard |
C |
C |
|
Pennington Biomedical Research Center, Baton Rouge, LA, USA. |
| Cade B |
|
Cade |
B |
B |
|
Division of Sleep and Circadian Disorders, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA. |
| Curhan GC |
|
Curhan |
G C |
GC |
|
Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA. |
| Eriksson JG |
|
Eriksson |
J G |
JG |
|
Vasa Central Hospital, Vasa, Finland. |
| Ewert R |
|
Ewert |
R |
R |
|
Department of Internal Medicine B-Cardiology, Pulmonary Medicine, Infectious Diseases and Intensive Care Medicine, University Medicine Greifswald, Greifswald, Germany. |
| Ferrucci L |
|
Ferrucci |
L |
L |
|
Translational Gerontology Branch, National Institute on Aging, Baltimore, MD, USA. |
| Fülöp T |
|
Fülöp |
T |
T |
|
Department of Medicine, University of Mississippi Medical Center, Jackson, MS, USA. |
| Gehrman PR |
|
Gehrman |
P R |
PR |
|
Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. |
| Goodloe R |
|
Goodloe |
R |
R |
|
Center for Human Genetics Research, Vanderbilt University Medical Center, Nashville, TN, USA. |
| Harris TB |
|
Harris |
T B |
TB |
|
Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, Bethesda, MD, USA. |
| Heath AC |
|
Heath |
A C |
AC |
|
Department of Psychiatry, Washington University School of Medicine, St Louis, MO, USA. |
| Hernandez D |
|
Hernandez |
D |
D |
|
Laboratory of Neurogenetics, National Institute on Aging, Bethesda, MD, USA. |
| Hofman A |
|
Hofman |
A |
A |
|
Epidemiological and Social Psychiatric Research Institute, Department of Psychiatry, Erasmus MC, Rotterdam, The Netherlands. |
| Hottenga JJ |
|
Hottenga |
J-J |
JJ |
|
Department of Biological Psychology, Netherlands Twin Register, VU University, Amsterdam, The Netherlands. |
| Hunter DJ |
|
Hunter |
D J |
DJ |
|
Program in Molecular and Genetic Epidemiology, Harvard School of Public Health, Boston, MA, USA. |
| Jensen MK |
|
Jensen |
M K |
MK |
|
Department of Nutrition, Harvard School of Public Health, Boston, MA, USA. |
| Johnson AD |
|
Johnson |
A D |
AD |
|
NHLBI Cardiovascular Epidemiology and Human Genomics Branch, The Framingham Heart Study, Framingham, MA, USA. |
| Kähönen M |
|
Kähönen |
M |
M |
|
Department of Clinical Physiology, Tampere University Hospital and School of Medicine University of Tampere, Tampere, Finland. |
| Kao L |
|
Kao |
L |
L |
|
Department of Epidemiology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD, USA. |
| Kraft P |
|
Kraft |
P |
P |
|
Program in Molecular and Genetic Epidemiology, Harvard School of Public Health, Boston, MA, USA. |
| Larkin EK |
|
Larkin |
E K |
EK |
|
Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN, USA. |
| Lauderdale DS |
|
Lauderdale |
D S |
DS |
|
Department of Health Studies, University of Chicago, Chicago, IL, USA. |
| Luik AI |
|
Luik |
A I |
AI |
|
Epidemiological and Social Psychiatric Research Institute, Department of Psychiatry, Erasmus MC, Rotterdam, The Netherlands. |
| Medici M |
|
Medici |
M |
M |
|
Department of Internal Medicine, Erasmus MC, Rotterdam, The Netherlands. |
| Montgomery GW |
|
Montgomery |
G W |
GW |
|
Queensland Institute of Medical Research, Brisbane, QLD, Australia. |
| Palotie A |
|
Palotie |
A |
A |
|
Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge, UK. |
| Patel SR |
|
Patel |
S R |
SR |
|
Division of Sleep and Circadian Disorders, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA. |
| Pistis G |
|
Pistis |
G |
G |
|
Dipartimento di Scienze Biomediche, Universita' di Sassari, Sassari, Italy. |
| Porcu E |
|
Porcu |
E |
E |
|
Dipartimento di Scienze Biomediche, Universita' di Sassari, Sassari, Italy. |
| Quaye L |
|
Quaye |
L |
L |
|
Department of Twin Research and Genetic Epidemiology, King's College London, London, UK. |
| Raitakari O |
|
Raitakari |
O |
O |
|
Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, and Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku, Finland. |
| Redline S |
|
Redline |
S |
S |
|
Division of Sleep and Circadian Disorders, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA. |
| Rimm EB |
|
Rimm |
E B |
EB |
|
Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA. |
| Rotter JI |
|
Rotter |
J I |
JI |
|
Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute and Department of Pediatrics, Harbor-UCLA Medical Center, Torrance, CA, USA. |
| Smith AV |
|
Smith |
A V |
AV |
|
University of Iceland, Reykjavik, Iceland. |
| Spector TD |
|
Spector |
T D |
TD |
|
Department of Twin Research and Genetic Epidemiology, King's College London, London, UK. |
| Teumer A |
|
Teumer |
A |
A |
|
Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany. |
| Uitterlinden AG |
|
Uitterlinden |
A G |
AG |
|
Netherlands Genomics Initiative-sponsored Netherlands Consortium for Healthy Aging, Leiden, The Netherlands. |
| Vohl MC |
|
Vohl |
M-C |
MC |
|
Department of Food Science and Nutrition, Laval University, Quebec, Canada. |
| Widen E |
|
Widen |
E |
E |
|
Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland. |
| Willemsen G |
|
Willemsen |
G |
G |
|
Department of Biological Psychology, Netherlands Twin Register, VU University, Amsterdam, The Netherlands. |
| Young T |
|
Young |
T |
T |
|
Department of Population Health Sciences, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, USA. |
| Zhang X |
|
Zhang |
X |
X |
|
NHLBI Cardiovascular Epidemiology and Human Genomics Branch, The Framingham Heart Study, Framingham, MA, USA. |
| Liu Y |
|
Liu |
Y |
Y |
|
Division of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, NC, USA. |
| Blangero J |
|
Blangero |
J |
J |
|
Texas Biomedical Research Institute, San Antonio, TX, USA. |
| Boomsma DI |
|
Boomsma |
D I |
DI |
|
Department of Biological Psychology, Netherlands Twin Register, VU University, Amsterdam, The Netherlands. |
| Gudnason V |
|
Gudnason |
V |
V |
|
University of Iceland, Reykjavik, Iceland. |
| Hu F |
|
Hu |
F |
F |
|
Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA. |
| Mangino M |
|
Mangino |
M |
M |
|
Department of Twin Research and Genetic Epidemiology, King's College London, London, UK. |
| Martin NG |
|
Martin |
N G |
NG |
|
Queensland Institute of Medical Research, Brisbane, QLD, Australia. |
| O'Connor GT |
|
O'Connor |
G T |
GT |
|
The NHLBI's Framingham Heart Study, Framingham, MA, USA. |
| Stone KL |
|
Stone |
K L |
KL |
|
California Pacific Medical Center Research Institute, San Francisco, CA, USA. |
| Tanaka T |
|
Tanaka |
T |
T |
|
Translational Gerontology Branch, National Institute on Aging, Baltimore, MD, USA. |
| Viikari J |
|
Viikari |
J |
J |
|
Department of Medicine, Turku University Hospital and University of Turku, Turku, Finland. |
| Gharib SA |
|
Gharib |
S A |
SA |
|
Department of Medicine, University of Washington, Seattle, WA, USA. |
| Punjabi NM |
|
Punjabi |
N M |
NM |
|
Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA. |
| Räikkönen K |
|
Räikkönen |
K |
K |
|
Institute of Behavioural Sciences, University of Helsinki, Helsinki, Finland. |
| Völzke H |
|
Völzke |
H |
H |
|
Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany. |
| Mignot E |
|
Mignot |
E |
E |
|
Center for Sleep Sciences and Medicine, Stanford University, Palo Alto, CA, USA. |
| Tiemeier H |
|
Tiemeier |
H |
H |
|
Department of Child and Adolescent Psychiatry, Erasmus MC, Rotterdam, The Netherlands. |
|
| INVESTIGATORS |
|
|
| JOURNAL |
|
| VOLUME: 20 |
| ISSUE: 10 |
| TITLE: Molecular psychiatry |
| ISOABBREVIATION: Mol. Psychiatry |
| YEAR: 2015 |
| MONTH: Oct |
| DAY: |
| MEDLINEDATE: |
| SEASON: |
| CITEDMEDIUM: Internet |
| ISSN: 1476-5578 |
| ISSNTYPE: Electronic |
|
| MEDLINE JOURNAL |
|
| MEDLINETA: Mol Psychiatry |
| COUNTRY: England |
| ISSNLINKING: 1359-4184 |
| NLMUNIQUEID: 9607835 |
|
| PUBLICATION TYPE |
|
| PUBLICATIONTYPE TEXT |
| Journal Article |
| Research Support, N.I.H., Extramural |
| Research Support, N.I.H., Intramural |
| Research Support, Non-U.S. Gov't |
|
| COMMENTS AND CORRECTIONS |
|
| REFTYPE |
REFSOURCE |
REFPMID |
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| GRANTS |
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AGENCY |
COUNTRY |
| 1R01AG030474-01A1 |
NIA NIH HHS |
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NHLBI NIH HHS |
United States |
| N01-HC-25195 |
NHLBI NIH HHS |
United States |
| N02-HL-6-4278 |
NHLBI NIH HHS |
United States |
| NS23724 |
NINDS NIH HHS |
United States |
| P30 DK063491 |
NIDDK NIH HHS |
United States |
| R01 AG005394 |
NIA NIH HHS |
United States |
| R01 AG005407 |
NIA NIH HHS |
United States |
| R01 AG026720 |
NIA NIH HHS |
United States |
| R01 AG026720 |
NIA NIH HHS |
United States |
| R01 AG027576 |
NIA NIH HHS |
United States |
| R01 AR35582 |
NIAMS NIH HHS |
United States |
| R01 AR35583 |
NIAMS NIH HHS |
United States |
| R01 AR35584 |
NIAMS NIH HHS |
United States |
| R01 HL070837 |
NHLBI NIH HHS |
United States |
| R01 HL070838 |
NHLBI NIH HHS |
United States |
| R01 HL070839 |
NHLBI NIH HHS |
United States |
| R01 HL070841 |
NHLBI NIH HHS |
United States |
| R01 HL070842 |
NHLBI NIH HHS |
United States |
| R01 HL070847 |
NHLBI NIH HHS |
United States |
| R01 HL070848 |
NHLBI NIH HHS |
United States |
| R01 HL071194 |
NHLBI NIH HHS |
United States |
| R01 HL113338 |
NHLBI NIH HHS |
United States |
| R01AG027574 |
NIA NIH HHS |
United States |
| R01D0042157-01A |
PHS HHS |
United States |
| R01HL086694 |
NHLBI NIH HHS |
United States |
| R01HL087641 |
NHLBI NIH HHS |
United States |
| R01HL59367 |
NHLBI NIH HHS |
United States |
| R01HL62252 |
NHLBI NIH HHS |
United States |
| RC2ARO58973 |
CCR NIH HHS |
United States |
| U01 AG18197 |
NIA NIH HHS |
United States |
| U01 AR066160 |
NIAMS NIH HHS |
United States |
| U01 AR45580 |
NIAMS NIH HHS |
United States |
| U01 AR45583 |
NIAMS NIH HHS |
United States |
| U01 AR45614 |
NIAMS NIH HHS |
United States |
| U01 AR45632 |
NIAMS NIH HHS |
United States |
| U01 AR45647 |
NIAMS NIH HHS |
United States |
| U01 AR45654 |
NIAMS NIH HHS |
United States |
| U01-AG027810 |
NIA NIH HHS |
United States |
| U01HG004402 |
NHGRI NIH HHS |
United States |
| U24 MH068457-06 |
NIMH NIH HHS |
United States |
| UL1 RR024140 |
NCRR NIH HHS |
United States |
| UL1 TR000124 |
NCATS NIH HHS |
United States |
| UL1RR025005 |
NCRR NIH HHS |
United States |
| UL1RR033176 |
NCRR NIH HHS |
United States |
| UL1TR000124 |
NCATS NIH HHS |
United States |
| WT089062 |
Wellcome Trust |
United Kingdom |
|
Intramural NIH HHS |
United States |
|
| GENERAL NOTE |
|
|
| KEYWORDS |
|
|
| MESH HEADINGS |
|
|
| SUPPLEMENTARY MESH |
|
|
| GENE SYMBOLS |
|
|
| CHEMICALS |
|
|
| OTHER ID's |
|
| OTHERID |
SOURCE |
| NIHMS682620 [Available on 04/01/16] |
NLM |
| PMC4430294 [Available on 04/01/16] |
NLM |
|
|
