|
|
| PMID |
|
|
| TITLE |
|
| Genome wide association study identifies variants in NBEA associated with migraine in bipolar disorder. |
|
| ABSTRACT |
|
| BACKGROUND |
NlmCategory: BACKGROUND |
| Migraine is a common comorbidity among individuals with bipolar disorder, but the underlying mechanisms for this co-occurrence are poorly understood. The aim of this study was to investigate the genetic background of bipolar patients with and without migraine. |
| METHODS |
NlmCategory: METHODS |
| Migraine is a common comorbidity among individuals with bipolar disorder, but the underlying mechanisms for this co-occurrence are poorly understood. The aim of this study was to investigate the genetic background of bipolar patients with and without migraine. We performed a genome-wide association analysis contrasting 460 bipolar migraneurs with 914 bipolar patients without migraine from the Bipolar Genome Study (BiGS). |
| RESULTS |
NlmCategory: RESULTS |
| Migraine is a common comorbidity among individuals with bipolar disorder, but the underlying mechanisms for this co-occurrence are poorly understood. The aim of this study was to investigate the genetic background of bipolar patients with and without migraine. We performed a genome-wide association analysis contrasting 460 bipolar migraneurs with 914 bipolar patients without migraine from the Bipolar Genome Study (BiGS). We identified one genome-wide significant association between migraine in bipolar disorder patients and rs1160720, an intronic single nucleotide polymorphism (SNP) in the NBEA gene (P=2.97 × 10(-8), OR: 1.82, 95% CI: 1.47-2.25), although this was not replicated in a smaller sample of 289 migraine cases. |
| LIMITATIONS |
NlmCategory: CONCLUSIONS |
| Migraine is a common comorbidity among individuals with bipolar disorder, but the underlying mechanisms for this co-occurrence are poorly understood. The aim of this study was to investigate the genetic background of bipolar patients with and without migraine. We performed a genome-wide association analysis contrasting 460 bipolar migraneurs with 914 bipolar patients without migraine from the Bipolar Genome Study (BiGS). We identified one genome-wide significant association between migraine in bipolar disorder patients and rs1160720, an intronic single nucleotide polymorphism (SNP) in the NBEA gene (P=2.97 × 10(-8), OR: 1.82, 95% CI: 1.47-2.25), although this was not replicated in a smaller sample of 289 migraine cases. Our study is based on self-reported migraine. |
| CONCLUSIONS |
NlmCategory: CONCLUSIONS |
| Migraine is a common comorbidity among individuals with bipolar disorder, but the underlying mechanisms for this co-occurrence are poorly understood. The aim of this study was to investigate the genetic background of bipolar patients with and without migraine. We performed a genome-wide association analysis contrasting 460 bipolar migraneurs with 914 bipolar patients without migraine from the Bipolar Genome Study (BiGS). We identified one genome-wide significant association between migraine in bipolar disorder patients and rs1160720, an intronic single nucleotide polymorphism (SNP) in the NBEA gene (P=2.97 × 10(-8), OR: 1.82, 95% CI: 1.47-2.25), although this was not replicated in a smaller sample of 289 migraine cases. Our study is based on self-reported migraine. NBEA encodes neurobeachin, a scaffolding protein primarily expressed in the brain and involved in trafficking of vesicles containing neurotransmitter receptors. This locus has not previously been implicated in migraine per se. We found no evidence of association in data from the GWAS migraine meta-analysis consortium (n=118,710 participants) suggesting that the association might be specific to migraine co-morbid with bipolar disorder. |
| Copyright © 2014 The Authors. Published by Elsevier B.V. All rights reserved. |
|
| DATE PUBLISHED |
|
|
| HISTORY |
|
| PUBSTATUS |
PUBSTATUSDATE |
| received |
2014/05/19 |
| revised |
2014/10/02 |
| accepted |
2014/10/03 |
| entrez |
2014/12/03 06:00 |
| pubmed |
2014/12/03 06:00 |
| medline |
2016/10/26 06:00 |
|
| AUTHORS |
|
| NAME |
COLLECTIVENAME |
LASTNAME |
FORENAME |
INITIALS |
AFFILIATION |
AFFILIATIONINFO |
| Jacobsen KK |
|
Jacobsen |
Kaya K |
KK |
|
KG Jebsen Center for Neurophyciatric research, Department of Biomedicine, University of Bergen, Bergen, Norway; Center for Medical Genetics and Molecular Medicine, Haukeland University Hospital, Bergen, Norway. Electronic address: kja098@biomed.uib.no. |
| Nievergelt CM |
|
Nievergelt |
Caroline M |
CM |
|
Department of Psychiatry, University of California, San Diego, USA. |
| Zayats T |
|
Zayats |
Tetyana |
T |
|
KG Jebsen Center for Neurophyciatric research, Department of Biomedicine, University of Bergen, Bergen, Norway; Center for Medical Genetics and Molecular Medicine, Haukeland University Hospital, Bergen, Norway. |
| Greenwood TA |
|
Greenwood |
Tiffany A |
TA |
|
Department of Psychiatry, University of California, San Diego, USA. |
| Anttila V |
|
Anttila |
Verneri |
V |
|
Analytical and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA; Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland. |
| Akiskal HS |
|
Akiskal |
Hagop S |
HS |
|
Department of Psychiatry, University of California, San Diego, USA; Department of Psychiatry, VA Hospital, San Diego, USA. |
|
BiGS Consortium |
|
|
|
|
|
|
IHG Consortium |
|
|
|
|
|
| Haavik J |
|
Haavik |
Jan |
J |
|
KG Jebsen Center for Neurophyciatric research, Department of Biomedicine, University of Bergen, Bergen, Norway; Division of Psychiatry, Haukeland University Hospital, Bergen, Norway. |
| Bernt Fasmer O |
|
Bernt Fasmer |
Ole |
O |
|
KG Jebsen Center for Neurophyciatric research, Department of Clinical Medicine, University of Bergen, Bergen, Norway; Division of Psychiatry, Haukeland University Hospital, Bergen, Norway. |
| Kelsoe JR |
|
Kelsoe |
John R |
JR |
|
Department of Psychiatry, University of California, San Diego, USA; Department of Psychiatry, VA Hospital, San Diego, USA. |
| Johansson S |
|
Johansson |
Stefan |
S |
|
KG Jebsen Center for Neurophyciatric research, Department of Biomedicine, University of Bergen, Bergen, Norway; Center for Medical Genetics and Molecular Medicine, Haukeland University Hospital, Bergen, Norway; Department of Clinical Science, University of Bergen, Norway. |
| Oedegaard KJ |
|
Oedegaard |
Ketil J |
KJ |
|
KG Jebsen Center for Neurophyciatric research, Department of Clinical Medicine, University of Bergen, Bergen, Norway; Division of Psychiatry, Haukeland University Hospital, Bergen, Norway. |
|
| INVESTIGATORS |
|
| LASTNAME |
FORENAME |
INITIALS |
AFFILIATION |
| Kelsoe |
John R |
JR |
|
| Greenwood |
Tiffany A |
TA |
|
| Nievergelt |
Caroline M |
CM |
|
| McKinney |
Rebecca |
R |
|
| Shilling |
Paul D |
PD |
|
| Smith |
Erin N |
EN |
|
| Schork |
Nicholas J |
NJ |
|
| Bloss |
Cinnamon S |
CS |
|
| Nurnberger |
John I |
JI |
|
| Edenberg |
Howard J |
HJ |
|
| Foroud |
Tatiana |
T |
|
| Koller |
Daniel L |
DL |
|
| Gershon |
Elliot S |
ES |
|
| Badner |
Judith A |
JA |
|
| Liu |
Chunyu |
C |
|
| Scheftner |
William A |
WA |
|
| Lawson |
William B |
WB |
|
| Nwulia |
Evaristus A |
EA |
|
| Hipolito |
Maria |
M |
|
| Potash |
James |
J |
|
| Coryell |
William |
W |
|
| Rice |
John |
J |
|
| Byerley |
William |
W |
|
| McMahon |
Francis J |
FJ |
|
| Berrettini |
Wade H |
WH |
|
| Zandi |
Peter P |
PP |
|
| Mahon |
Pamela B |
PB |
|
| McInnis |
Melvin G |
MG |
|
| Zöllner |
Sebastian |
S |
|
| Zhang |
Peng |
P |
|
| Craig |
David W |
DW |
|
| Szelinger |
Szabolics |
S |
|
| Barrett |
Thomas B |
TB |
|
| Schulze |
Thomas G |
TG |
|
| Wedenoja |
Juho |
J |
|
| Kaunisto |
Mari A |
MA |
|
| Heikkilä |
Kauko |
K |
|
| Kaprio |
Jaakko |
J |
|
| Wessman |
Maija |
M |
|
| Kallela |
Mikko |
M |
|
| Färkkilä |
Markus |
M |
|
| Artto |
Ville |
V |
|
| Aromaa |
Arpo |
A |
|
| Eriksson |
Johan G |
JG |
|
| Winsvold |
Bendik S |
BS |
|
| Zwart |
John-Anker |
JA |
|
| Gormley |
Padhraig |
P |
|
| Palotie |
Aarno |
A |
|
| Kurth |
Tobias |
T |
|
| Rose |
Lynda M |
LM |
|
| Buring |
Julie E |
JE |
|
| Ridker |
Paul M |
PM |
|
| Chasman |
Daniel I |
DI |
|
| Bettella |
Francesco |
F |
|
| Steinberg |
Stacy |
S |
|
| Stefansson |
Hreinn |
H |
|
| Stefansson |
Kari |
K |
|
| McMahon |
George |
G |
|
| Davey-Smith |
George |
G |
|
| Malik |
Rainer |
R |
|
| Freilinger |
Tobias |
T |
|
| Erich Wichmann |
Heinz |
H |
|
| Dichgans |
Martin |
M |
|
| Muller-Myhsok |
Bertram |
B |
|
| Meitinger |
Thomas |
T |
|
| de Vries |
Boukje |
B |
|
| Terwindt |
Gisela |
G |
|
| Stam |
Anine H |
AH |
|
| Frants |
Rune R |
RR |
|
| Pelzer |
Nadine |
N |
|
| Weller |
Claudia M |
CM |
|
| Zielman |
Ronald |
R |
|
| Ferrari |
Michel D |
MD |
|
| van den Maagdenberg |
Arn M J M |
AM |
|
| Medland |
Sarah E |
SE |
|
| Montgomery |
Grant W |
GW |
|
| Martin |
Nicholas G |
NG |
|
| Nyholt |
Dale R |
DR |
|
| Todt |
Unda |
U |
|
| Borck |
Guntram |
G |
|
| Kubisch |
Christian |
C |
|
| Quaye |
Lydia |
L |
|
| Williams |
Frances M K |
FM |
|
| Cherkas |
Lynn |
L |
|
| Koiranen |
Markku |
M |
|
| Hartikainen |
Anna-Liisa |
AL |
|
| Pouta |
Anneli |
A |
|
| Jarvelin |
Marjo-Riitta |
MR |
|
| Ikram |
M Arfan |
MA |
|
| van den Ende |
Joyce |
J |
|
| Uitterlinden |
Andre G |
AG |
|
| Hofman |
Albert |
A |
|
| Amin |
Najaf |
N |
|
| van Duijn |
Cornelia |
C |
|
| Lehtimäki |
Terho |
T |
|
| Ligthart |
Lannie |
L |
|
| Hottenga |
Jouke-Jan |
JJ |
|
| Vink |
Jacqueline M |
JM |
|
| Penninx |
Brenda W |
BW |
|
| Boomsma |
Dorret I |
DI |
|
| Schürks |
Markus |
M |
|
| Jakobsson |
Finnbogi |
F |
|
| Schoenen |
Jean |
J |
|
| Heath |
Andrew C |
AC |
|
| Madden |
Pamela A F |
PA |
|
| Göbel |
Hartmut |
H |
|
| Heinze |
Axel |
A |
|
| Heinze-Kuhn |
Katja |
K |
|
| Schreiber |
Stefan |
S |
|
| Anttila |
Verneri |
V |
|
| Daly |
Mark J |
MJ |
|
| Alexander |
Michael |
M |
|
| Raitakari |
Olli |
O |
|
| Strachan |
David P |
DP |
|
|
| JOURNAL |
|
| VOLUME: 172 |
| ISSUE: |
| TITLE: Journal of affective disorders |
| ISOABBREVIATION: J Affect Disord |
| YEAR: 2015 |
| MONTH: Feb |
| DAY: 01 |
| MEDLINEDATE: |
| SEASON: |
| CITEDMEDIUM: Internet |
| ISSN: 1573-2517 |
| ISSNTYPE: Electronic |
|
| MEDLINE JOURNAL |
|
| MEDLINETA: J Affect Disord |
| COUNTRY: Netherlands |
| ISSNLINKING: 0165-0327 |
| NLMUNIQUEID: 7906073 |
|
| PUBLICATION TYPE |
|
| PUBLICATIONTYPE TEXT |
| Journal Article |
| Research Support, N.I.H., Extramural |
| Research Support, N.I.H., Intramural |
|
| COMMENTS AND CORRECTIONS |
|
| REFTYPE |
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|
| GRANTS |
|
| GRANTID |
AGENCY |
COUNTRY |
| MH059567 |
NIMH NIH HHS |
United States |
| R01 MH059556 |
NIMH NIH HHS |
United States |
| R01 MH078151 |
NIMH NIH HHS |
United States |
| Z01 MH002810 |
Intramural NIH HHS |
United States |
| R01 MH059535 |
NIMH NIH HHS |
United States |
| R01 MH059567 |
NIMH NIH HHS |
United States |
| R01MH59545 |
NIMH NIH HHS |
United States |
| R01 MH059545 |
NIMH NIH HHS |
United States |
| R01MH59533 |
NIMH NIH HHS |
United States |
| 1Z01MH002810-01 |
NIMH NIH HHS |
United States |
| R01MH059534 |
NIMH NIH HHS |
United States |
| U01 MH46282 |
NIMH NIH HHS |
United States |
| R01 MH068503 |
NIMH NIH HHS |
United States |
| R01 MH059548 |
NIMH NIH HHS |
United States |
| R01 MH093500 |
NIMH NIH HHS |
United States |
| R01 MH059534 |
NIMH NIH HHS |
United States |
| R01 MH59535 |
NIMH NIH HHS |
United States |
| R01 MH59553 |
NIMH NIH HHS |
United States |
| U01 MH46274 |
NIMH NIH HHS |
United States |
| R01 MH081804 |
NIMH NIH HHS |
United States |
| R01 MH60068 |
NIMH NIH HHS |
United States |
| R01 MH059533 |
NIMH NIH HHS |
United States |
| MH68503 |
NIMH NIH HHS |
United States |
| U01 MH092758 |
NIMH NIH HHS |
United States |
| MH081804 |
NIMH NIH HHS |
United States |
| R01 MH59567 |
NIMH NIH HHS |
United States |
| U01 MH46280 |
NIMH NIH HHS |
United States |
| R01 MH059553 |
NIMH NIH HHS |
United States |
| M01 RR000827 |
NCRR NIH HHS |
United States |
| MH078151 |
NIMH NIH HHS |
United States |
| K01 MH087889 |
NIMH NIH HHS |
United States |
| R01 MH060068 |
NIMH NIH HHS |
United States |
|
| GENERAL NOTE |
|
|
| KEYWORDS |
|
| KEYWORD |
| Bipolar disorder |
| Genetics |
| Migraine |
| NBEA |
| Neurobeachin |
|
| MESH HEADINGS |
|
| DESCRIPTORNAME |
QUALIFIERNAME |
| Adult |
|
| Bipolar Disorder |
genetics |
| Carrier Proteins |
genetics |
| Comorbidity |
genetics |
| Female |
genetics |
| Genetic Predisposition to Disease |
genetics |
| Genome-Wide Association Study |
genetics |
| Humans |
genetics |
| Male |
genetics |
| Migraine Disorders |
genetics |
| Nerve Tissue Proteins |
genetics |
| Polymorphism, Single Nucleotide |
genetics |
|
| SUPPLEMENTARY MESH |
|
|
| GENE SYMBOLS |
|
|
| CHEMICALS |
|
| REGISTRYNUMBER |
NAMEOFSUBSTANCE |
| 0 |
Carrier Proteins |
| 0 |
NBEA protein, human |
| 0 |
Nerve Tissue Proteins |
|
| OTHER ID's |
|
|
|
