Genetic Epidemiology, Psychiatric Genetics, Asthma Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
25419442
TITLE
LABELING WHITE MATTER TRACTS IN HARDI BY FUSING MULTIPLE TRACT ATLASES WITH APPLICATIONS TO GENETICS.
ABSTRACT
Accurate identification of white matter structures and segmentation of fibers into tracts is important in neuroimaging and has many potential applications. Even so, it is not trivial because whole brain tractography generates hundreds of thousands of streamlines that include many false positive fibers. We developed and tested an automatic tract labeling algorithm to segment anatomically meaningful tracts from diffusion weighted images. Our multi-atlas method incorporates information from multiple hand-labeled fiber tract atlases. In validations, we showed that the method outperformed the standard ROI-based labeling using a deformable, parcellated atlas. Finally, we show a high-throughput application of the method to genetic population studies. We use the sub-voxel diffusion information from fibers in the clustered tracts based on 105-gradient HARDI scans of 86 young normal twins. The whole workflow shows promise for larger population studies in the future.
DATE PUBLISHED
2013 Apr
HISTORY
PUBSTATUS PUBSTATUSDATE
entrez 2014/11/25 06:00
pubmed 2013/04/01 00:00
medline 2013/04/01 00:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Jin Y Jin Yan Y Imaging Genetics Center, Laboratory of Neuro Imaging, UCLA School of Medicine, Los Angeles CA, 90095 USA.
Shi Y Shi Yonggang Y Imaging Genetics Center, Laboratory of Neuro Imaging, UCLA School of Medicine, Los Angeles CA, 90095 USA.
Zhan L Zhan Liang L Imaging Genetics Center, Laboratory of Neuro Imaging, UCLA School of Medicine, Los Angeles CA, 90095 USA.
de Zubicaray GI de Zubicaray Greig I GI University of Queensland, Brisbane St. Lucia, QLD 4072, Australia.
McMahon KL McMahon Katie L KL University of Queensland, Brisbane St. Lucia, QLD 4072, Australia.
Martin NG Martin Nicholas G NG Queensland Institute of Medical Research, Herston, QLD 4029, Australia.
Wright MJ Wright Margaret J MJ Queensland Institute of Medical Research, Herston, QLD 4029, Australia.
Thompson PM Thompson Paul M PM Imaging Genetics Center, Laboratory of Neuro Imaging, UCLA School of Medicine, Los Angeles CA, 90095 USA.
INVESTIGATORS
JOURNAL
VOLUME: 2013
ISSUE:
TITLE: Proceedings / IEEE International Symposium on Biomedical Imaging: from nano to macro. IEEE International Symposium on Biomedical Imaging
ISOABBREVIATION: Proc IEEE Int Symp Biomed Imaging
YEAR: 2013
MONTH: Apr
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Print
ISSN: 1945-7928
ISSNTYPE: Print
MEDLINE JOURNAL
MEDLINETA: Proc IEEE Int Symp Biomed Imaging
COUNTRY: United States
ISSNLINKING: 1945-7928
NLMUNIQUEID: 101492570
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
JOURNAL ARTICLE
COMMENTS AND CORRECTIONS
GRANTS
GRANTID AGENCY COUNTRY
K01 EB013633 NIBIB NIH HHS United States
P41 EB015922 NIBIB NIH HHS United States
R01 HD050735 NICHD NIH HHS United States
GENERAL NOTE
KEYWORDS
KEYWORD
Fiber Clustering
Genetic Heritability
HARDI
Label Fusion
Tractography
MESH HEADINGS
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
OTHER ID's