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PMID |
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TITLE |
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LABELING WHITE MATTER TRACTS IN HARDI BY FUSING MULTIPLE TRACT ATLASES WITH APPLICATIONS TO GENETICS. |
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ABSTRACT |
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Accurate identification of white matter structures and segmentation of fibers into tracts is important in neuroimaging and has many potential applications. Even so, it is not trivial because whole brain tractography generates hundreds of thousands of streamlines that include many false positive fibers. We developed and tested an automatic tract labeling algorithm to segment anatomically meaningful tracts from diffusion weighted images. Our multi-atlas method incorporates information from multiple hand-labeled fiber tract atlases. In validations, we showed that the method outperformed the standard ROI-based labeling using a deformable, parcellated atlas. Finally, we show a high-throughput application of the method to genetic population studies. We use the sub-voxel diffusion information from fibers in the clustered tracts based on 105-gradient HARDI scans of 86 young normal twins. The whole workflow shows promise for larger population studies in the future. |
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DATE PUBLISHED |
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HISTORY |
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PUBSTATUS |
PUBSTATUSDATE |
entrez |
2014/11/25 06:00 |
pubmed |
2013/04/01 00:00 |
medline |
2013/04/01 00:00 |
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AUTHORS |
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NAME |
COLLECTIVENAME |
LASTNAME |
FORENAME |
INITIALS |
AFFILIATION |
AFFILIATIONINFO |
Jin Y |
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Jin |
Yan |
Y |
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Imaging Genetics Center, Laboratory of Neuro Imaging, UCLA School of Medicine, Los Angeles CA, 90095 USA. |
Shi Y |
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Shi |
Yonggang |
Y |
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Imaging Genetics Center, Laboratory of Neuro Imaging, UCLA School of Medicine, Los Angeles CA, 90095 USA. |
Zhan L |
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Zhan |
Liang |
L |
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Imaging Genetics Center, Laboratory of Neuro Imaging, UCLA School of Medicine, Los Angeles CA, 90095 USA. |
de Zubicaray GI |
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de Zubicaray |
Greig I |
GI |
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University of Queensland, Brisbane St. Lucia, QLD 4072, Australia. |
McMahon KL |
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McMahon |
Katie L |
KL |
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University of Queensland, Brisbane St. Lucia, QLD 4072, Australia. |
Martin NG |
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Martin |
Nicholas G |
NG |
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Queensland Institute of Medical Research, Herston, QLD 4029, Australia. |
Wright MJ |
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Wright |
Margaret J |
MJ |
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Queensland Institute of Medical Research, Herston, QLD 4029, Australia. |
Thompson PM |
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Thompson |
Paul M |
PM |
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Imaging Genetics Center, Laboratory of Neuro Imaging, UCLA School of Medicine, Los Angeles CA, 90095 USA. |
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INVESTIGATORS |
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JOURNAL |
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VOLUME: 2013 |
ISSUE: |
TITLE: Proceedings / IEEE International Symposium on Biomedical Imaging: from nano to macro. IEEE International Symposium on Biomedical Imaging |
ISOABBREVIATION: Proc IEEE Int Symp Biomed Imaging |
YEAR: 2013 |
MONTH: Apr |
DAY: |
MEDLINEDATE: |
SEASON: |
CITEDMEDIUM: Print |
ISSN: 1945-7928 |
ISSNTYPE: Print |
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MEDLINE JOURNAL |
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MEDLINETA: Proc IEEE Int Symp Biomed Imaging |
COUNTRY: United States |
ISSNLINKING: 1945-7928 |
NLMUNIQUEID: 101492570 |
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PUBLICATION TYPE |
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PUBLICATIONTYPE TEXT |
JOURNAL ARTICLE |
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COMMENTS AND CORRECTIONS |
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GRANTS |
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GRANTID |
AGENCY |
COUNTRY |
K01 EB013633 |
NIBIB NIH HHS |
United States |
P41 EB015922 |
NIBIB NIH HHS |
United States |
R01 HD050735 |
NICHD NIH HHS |
United States |
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GENERAL NOTE |
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KEYWORDS |
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KEYWORD |
Fiber Clustering |
Genetic Heritability |
HARDI |
Label Fusion |
Tractography |
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MESH HEADINGS |
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SUPPLEMENTARY MESH |
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GENE SYMBOLS |
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CHEMICALS |
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OTHER ID's |
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