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| PMID |
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| TITLE |
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| LEFT VERSUS RIGHT HEMISPHERE DIFFERENCES IN BRAIN CONNECTIVITY: 4-TESLA HARDI TRACTOGRAPHY IN 569 TWINS. |
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| ABSTRACT |
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| Diffusion imaging can map anatomical connectivity in the living brain, offering new insights into fundamental questions such as how the left and right brain hemispheres differ. Anatomical brain asymmetries are related to speech and language abilities, but less is known about left/right hemisphere differences in brain wiring. To assess this, we scanned 457 young adults (age 23.4±2.0 SD years) and 112 adolescents (age 12-16) with 4-Tesla 105-gradient high-angular resolution diffusion imaging. We extracted fiber tracts throughout the brain with a Hough transform method. A 70×70 connectivity matrix was created, for each subject, based on the proportion of fibers intersecting 70 cortical regions. We identified significant differences in the proportions of fibers intersecting left and right hemisphere cortical regions. The degree of asymmetry in the connectivity matrices varied with age, as did the asymmetry in network topology measures such as the small-world effect. |
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| DATE PUBLISHED |
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| HISTORY |
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| PUBSTATUS |
PUBSTATUSDATE |
| entrez |
2014/11/19 06:00 |
| pubmed |
2012/05/01 00:00 |
| medline |
2012/05/01 00:00 |
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| AUTHORS |
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| NAME |
COLLECTIVENAME |
LASTNAME |
FORENAME |
INITIALS |
AFFILIATION |
AFFILIATIONINFO |
| Daianu M |
|
Daianu |
Madelaine |
M |
|
Laboratory of Neuro Imaging, Department of Neurology, UCLA School of Medicine, Los Angeles, CA. |
| Jahanshad N |
|
Jahanshad |
Neda |
N |
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Laboratory of Neuro Imaging, Department of Neurology, UCLA School of Medicine, Los Angeles, CA. |
| Dennis EL |
|
Dennis |
Emily L |
EL |
|
Laboratory of Neuro Imaging, Department of Neurology, UCLA School of Medicine, Los Angeles, CA. |
| Toga AW |
|
Toga |
Arthur W |
AW |
|
Laboratory of Neuro Imaging, Department of Neurology, UCLA School of Medicine, Los Angeles, CA. |
| McMahon KL |
|
McMahon |
Katie L |
KL |
|
Centre for Advanced Imaging, University of Queensland, Brisbane, Australia. |
| de Zubicaray GI |
|
de Zubicaray |
Greig I |
GI |
|
School of Psychology, University of Queensland, Brisbane, Australia. |
| Martin NG |
|
Martin |
Nicholas G |
NG |
|
Queensland Institute of Medical Research, Brisbane, Australia. |
| Wright MJ |
|
Wright |
Margaret J |
MJ |
|
Centre for Advanced Imaging, University of Queensland, Brisbane, Australia ; Queensland Institute of Medical Research, Brisbane, Australia. |
| Hickie IB |
|
Hickie |
Ian B |
IB |
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University of Sydney, Brain and Mind Research Institute, Australia. |
| Thompson PM |
|
Thompson |
Paul M |
PM |
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Laboratory of Neuro Imaging, Department of Neurology, UCLA School of Medicine, Los Angeles, CA. |
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| INVESTIGATORS |
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| JOURNAL |
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| VOLUME: 2012 |
| ISSUE: |
| TITLE: Proceedings / IEEE International Symposium on Biomedical Imaging: from nano to macro. IEEE International Symposium on Biomedical Imaging |
| ISOABBREVIATION: Proc IEEE Int Symp Biomed Imaging |
| YEAR: 2012 |
| MONTH: May |
| DAY: |
| MEDLINEDATE: |
| SEASON: |
| CITEDMEDIUM: Print |
| ISSN: 1945-7928 |
| ISSNTYPE: Print |
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| MEDLINE JOURNAL |
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| MEDLINETA: Proc IEEE Int Symp Biomed Imaging |
| COUNTRY: United States |
| ISSNLINKING: 1945-7928 |
| NLMUNIQUEID: 101492570 |
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| PUBLICATION TYPE |
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| PUBLICATIONTYPE TEXT |
| JOURNAL ARTICLE |
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| COMMENTS AND CORRECTIONS |
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| GRANTS |
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| GRANTID |
AGENCY |
COUNTRY |
| R01 EB008432 |
NIBIB NIH HHS |
United States |
| R01 HD050735 |
NICHD NIH HHS |
United States |
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| GENERAL NOTE |
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| KEYWORDS |
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| KEYWORD |
| connectome |
| high angular resolution diffusion imaging (HARDI) |
| laterality |
| small-world effect |
| tractography |
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| MESH HEADINGS |
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| SUPPLEMENTARY MESH |
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| GENE SYMBOLS |
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| CHEMICALS |
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