Genetic Epidemiology, Translational Neurogenomics, Psychiatric Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
25404993
TITLE
LEFT VERSUS RIGHT HEMISPHERE DIFFERENCES IN BRAIN CONNECTIVITY: 4-TESLA HARDI TRACTOGRAPHY IN 569 TWINS.
ABSTRACT
Diffusion imaging can map anatomical connectivity in the living brain, offering new insights into fundamental questions such as how the left and right brain hemispheres differ. Anatomical brain asymmetries are related to speech and language abilities, but less is known about left/right hemisphere differences in brain wiring. To assess this, we scanned 457 young adults (age 23.4±2.0 SD years) and 112 adolescents (age 12-16) with 4-Tesla 105-gradient high-angular resolution diffusion imaging. We extracted fiber tracts throughout the brain with a Hough transform method. A 70×70 connectivity matrix was created, for each subject, based on the proportion of fibers intersecting 70 cortical regions. We identified significant differences in the proportions of fibers intersecting left and right hemisphere cortical regions. The degree of asymmetry in the connectivity matrices varied with age, as did the asymmetry in network topology measures such as the small-world effect.
DATE PUBLISHED
2012 May
HISTORY
PUBSTATUS PUBSTATUSDATE
entrez 2014/11/19 06:00
pubmed 2012/05/01 00:00
medline 2012/05/01 00:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Daianu M Daianu Madelaine M Laboratory of Neuro Imaging, Department of Neurology, UCLA School of Medicine, Los Angeles, CA.
Jahanshad N Jahanshad Neda N Laboratory of Neuro Imaging, Department of Neurology, UCLA School of Medicine, Los Angeles, CA.
Dennis EL Dennis Emily L EL Laboratory of Neuro Imaging, Department of Neurology, UCLA School of Medicine, Los Angeles, CA.
Toga AW Toga Arthur W AW Laboratory of Neuro Imaging, Department of Neurology, UCLA School of Medicine, Los Angeles, CA.
McMahon KL McMahon Katie L KL Centre for Advanced Imaging, University of Queensland, Brisbane, Australia.
de Zubicaray GI de Zubicaray Greig I GI School of Psychology, University of Queensland, Brisbane, Australia.
Martin NG Martin Nicholas G NG Queensland Institute of Medical Research, Brisbane, Australia.
Wright MJ Wright Margaret J MJ Centre for Advanced Imaging, University of Queensland, Brisbane, Australia ; Queensland Institute of Medical Research, Brisbane, Australia.
Hickie IB Hickie Ian B IB University of Sydney, Brain and Mind Research Institute, Australia.
Thompson PM Thompson Paul M PM Laboratory of Neuro Imaging, Department of Neurology, UCLA School of Medicine, Los Angeles, CA.
INVESTIGATORS
JOURNAL
VOLUME: 2012
ISSUE:
TITLE: Proceedings / IEEE International Symposium on Biomedical Imaging: from nano to macro. IEEE International Symposium on Biomedical Imaging
ISOABBREVIATION: Proc IEEE Int Symp Biomed Imaging
YEAR: 2012
MONTH: May
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Print
ISSN: 1945-7928
ISSNTYPE: Print
MEDLINE JOURNAL
MEDLINETA: Proc IEEE Int Symp Biomed Imaging
COUNTRY: United States
ISSNLINKING: 1945-7928
NLMUNIQUEID: 101492570
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
JOURNAL ARTICLE
COMMENTS AND CORRECTIONS
GRANTS
GRANTID AGENCY COUNTRY
R01 EB008432 NIBIB NIH HHS United States
R01 HD050735 NICHD NIH HHS United States
GENERAL NOTE
KEYWORDS
KEYWORD
connectome
high angular resolution diffusion imaging (HARDI)
laterality
small-world effect
tractography
MESH HEADINGS
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
OTHER ID's