Genetic Epidemiology, Psychiatric Genetics, Asthma Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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25378557
TITLE
Fine-mapping of the HNF1B multicancer locus identifies candidate variants that mediate endometrial cancer risk.
ABSTRACT
Common variants in the hepatocyte nuclear factor 1 homeobox B (HNF1B) gene are associated with the risk of Type II diabetes and multiple cancers. Evidence to date indicates that cancer risk may be mediated via genetic or epigenetic effects on HNF1B gene expression. We previously found single-nucleotide polymorphisms (SNPs) at the HNF1B locus to be associated with endometrial cancer, and now report extensive fine-mapping and in silico and laboratory analyses of this locus. Analysis of 1184 genotyped and imputed SNPs in 6608 Caucasian cases and 37 925 controls, and 895 Asian cases and 1968 controls, revealed the best signal of association for SNP rs11263763 (P = 8.4 × 10(-14), odds ratio = 0.86, 95% confidence interval = 0.82-0.89), located within HNF1B intron 1. Haplotype analysis and conditional analyses provide no evidence of further independent endometrial cancer risk variants at this locus. SNP rs11263763 genotype was associated with HNF1B mRNA expression but not with HNF1B methylation in endometrial tumor samples from The Cancer Genome Atlas. Genetic analyses prioritized rs11263763 and four other SNPs in high-to-moderate linkage disequilibrium as the most likely causal SNPs. Three of these SNPs map to the extended HNF1B promoter based on chromatin marks extending from the minimal promoter region. Reporter assays demonstrated that this extended region reduces activity in combination with the minimal HNF1B promoter, and that the minor alleles of rs11263763 or rs8064454 are associated with decreased HNF1B promoter activity. Our findings provide evidence for a single signal associated with endometrial cancer risk at the HNF1B locus, and that risk is likely mediated via altered HNF1B gene expression.
The Author 2014. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.
DATE PUBLISHED
2015 Mar 1
HISTORY
PUBSTATUS PUBSTATUSDATE
aheadofprint 2014/11/06
entrez 2014/11/08 06:00
pubmed 2014/11/08 06:00
medline 2015/11/17 06:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Painter JN Painter Jodie N JN QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.
O'Mara TA O'Mara Tracy A TA QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.
Batra J Batra Jyotsna J Australian Prostate Cancer Research Centre-Qld, Institute of Health and Biomedical Innovation, and School of Biomedical Science and.
Cheng T Cheng Timothy T Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.
Lose FA Lose Felicity A FA QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.
Dennis J Dennis Joe J Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care and.
Michailidou K Michailidou Kyriaki K Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care and.
Tyrer JP Tyrer Jonathan P JP Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK.
Ahmed S Ahmed Shahana S Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK.
Ferguson K Ferguson Kaltin K QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.
Healey CS Healey Catherine S CS Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK.
Kaufmann S Kaufmann Susanne S QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.
Hillman KM Hillman Kristine M KM QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.
Walpole C Walpole Carina C Australian Prostate Cancer Research Centre-Qld, Institute of Health and Biomedical Innovation, and School of Biomedical Science and.
Moya L Moya Leire L Australian Prostate Cancer Research Centre-Qld, Institute of Health and Biomedical Innovation, and School of Biomedical Science and.
Pollock P Pollock Pamela P Institute of Health and Biomedical Innovation and School of Biomedical Science, Queensland University of Technology, Brisbane, QLD, Australia.
Jones A Jones Angela A Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.
Howarth K Howarth Kimberley K Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.
Martin L Martin Lynn L Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.
Gorman M Gorman Maggie M Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.
Hodgson S Hodgson Shirley S Department of Clinical Genetics, St George's Hospital Medical School, London, UK.
National Study of Endometrial Cancer Genetics Group (NSECG)
CHIBCHA Consortium
De Polanco MM De Polanco Ma Magdalena Echeverry MM Grupo de Investigación Citogenética, Filogenia y Evolución de Poblaciones, Universidad del Tolima, Ibagué, Tolima, Colombia.
Sans M Sans Monica M Department of Biological Anthropology, College of Humanities and Educational Sciences, University of the Republic, Magallanes, Montevideo, Uruguay.
Carracedo A Carracedo Angel A Grupo de Medicina Xenómica, Fundación Galega de Medicina Xenómica (SERGAS) and CIBERER, Universidade de Santiago de Compostela, Santiago de Compostela, Spain, Center of Excellence in Genomic Medicine Research, King Abdulaziz University, Jeddah, KSA.
Castellvi-Bel S Castellvi-Bel Sergi S Genetic Predisposition to Colorectal Cancer Group, Gastrointestinal & Pancreatic Oncology Team, IDIBAPS/CIBERehd/Hospital Clínic, Centre Esther Koplowitz (CEK), Barcelona, Spain.
Rojas-Martinez A Rojas-Martinez Augusto A Universidad Autónoma de Nuevo León, Pedro de Alba s/n, San Nicolás de Los Garza, Nuevo León, Mexico.
Santos E Santos Erika E Hospital A.C. Camargo, São Paulo, Brazil.
Teixeira MR Teixeira Manuel R MR Department of Genetics, Portuguese Oncology Institute, Porto, Portugal, Biomedical Sciences Institute (ICBAS), University of Porto, Porto, Portugal.
Carvajal-Carmona L Carvajal-Carmona Luis L Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK, Grupo de Investigación Citogenética, Filogenia y Evolución de Poblaciones, Universidad del Tolima, Ibagué, Tolima, Colombia, Genome Center and Department of Biochemistry and Molecular Medicine, University of California, Davis, CA, USA.
Shu XO Shu Xiao-Ou XO Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN, USA.
Long J Long Jirong J Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN, USA.
Zheng W Zheng Wei W Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN, USA.
Xiang YB Xiang Yong-Bing YB Department of Epidemiology, Shanghai Cancer Institute, Shanghai, China.
Australian National Endometrial Cancer Study Group (ANECS)
Montgomery GW Montgomery Grant W GW QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.
Webb PM Webb Penelope M PM QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.
Scott RJ Scott Rodney J RJ Hunter Medical Research Institute and, Hunter Area Pathology Service, John Hunter Hospital, Newcastle, NSW, Australia, Centre for Information Based Medicine and School of Biomedical Science and Pharmacy.
McEvoy M McEvoy Mark M Centre for Clinical Epidemiology and Biostatistics, School of Medicine and Public Health.
Attia J Attia John J Hunter Medical Research Institute and, Centre for Clinical Epidemiology and Biostatistics, School of Medicine and Public Health.
Holliday E Holliday Elizabeth E Hunter Medical Research Institute and, Centre for Information Based Medicine and School of Medicine and Public Health.
Martin NG Martin Nicholas G NG QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.
Nyholt DR Nyholt Dale R DR QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.
Henders AK Henders Anjali K AK QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.
Fasching PA Fasching Peter A PA Division of Hematology/Oncology, Department of Medicine, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA, USA, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen, Germany.
Hein A Hein Alexander A University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen, Germany.
Beckmann MW Beckmann Matthias W MW University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen, Germany.
Renner SP Renner Stefan P SP University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen, Germany.
Dörk T Dörk Thilo T Gynaecology Research Unit and.
Hillemanns P Hillemanns Peter P Clinics of Gynaecology and Obstetrics, Hannover Medical School, Hannover, Germany.
Dürst M Dürst Matthias M Dept. of Gynaecology, Friedrich Schiller University Jena, Jena, Germany.
Runnebaum I Runnebaum Ingo I Dept. of Gynaecology, Friedrich Schiller University Jena, Jena, Germany.
Lambrechts D Lambrechts Diether D Vesalius Research Center, VIB, Leuven, Belgium, Department of Oncology, Laboratory for Translational Genetics.
Coenegrachts L Coenegrachts Lieve L Division of Gynaecological Oncology, Department of Oncology, University Hospital Leuven, KU Leuven, Belgium.
Schrauwen S Schrauwen Stefanie S Division of Gynaecological Oncology, Department of Oncology, University Hospital Leuven, KU Leuven, Belgium.
Amant F Amant Frederic F Division of Gynaecological Oncology, Department of Oncology, University Hospital Leuven, KU Leuven, Belgium.
Winterhoff B Winterhoff Boris B Division of Gynecologic Oncology, Department of Obstetrics and Gynecology.
Dowdy SC Dowdy Sean C SC Division of Gynecologic Oncology, Department of Obstetrics and Gynecology.
Goode EL Goode Ellen L EL Division of Epidemiology, Department of Health Science Research and.
Teoman A Teoman Attila A Division of Gynecologic Oncology, Department of Obstetrics and Gynecology.
Salvesen HB Salvesen Helga B HB Department of Clinical Science, Centre for Cancerbiomarkers, The University of Bergen, Norway, Department of Obstetrics and Gynecology, Haukeland University Hospital, Bergen, Norway.
Trovik J Trovik Jone J Department of Clinical Science, Centre for Cancerbiomarkers, The University of Bergen, Norway, Department of Obstetrics and Gynecology, Haukeland University Hospital, Bergen, Norway.
Njolstad TS Njolstad Tormund S TS Department of Clinical Science, Centre for Cancerbiomarkers, The University of Bergen, Norway, Department of Obstetrics and Gynecology, Haukeland University Hospital, Bergen, Norway.
Werner HM Werner Henrica M J HM Department of Clinical Science, Centre for Cancerbiomarkers, The University of Bergen, Norway, Department of Obstetrics and Gynecology, Haukeland University Hospital, Bergen, Norway.
Ashton K Ashton Katie K Hunter Area Pathology Service, John Hunter Hospital, Newcastle, NSW, Australia, Faculty of Health, Centre for Information Based Medicine and the Discipline of Medical Genetics, School of Biomedical Sciences and Pharmacy and.
Proietto T Proietto Tony T Faculty of Health, School of Medicine and Public Health, University of Newcastle, NSW, Australia.
Otton G Otton Geoffrey G Faculty of Health, School of Medicine and Public Health, University of Newcastle, NSW, Australia.
Tzortzatos G Tzortzatos Gerasimos G Department of Women's and Children's Health.
Mints M Mints Miriam M Department of Women's and Children's Health.
Tham E Tham Emma E Department of Molecular Medicine and Surgery and.
RENDOCAS
Hall P Hall Per P Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.
Czene K Czene Kamila K Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.
Liu J Liu Jianjun J Human Genetics, Genome Institute of Singapore, Singapore.
Li J Li Jingmei J Human Genetics, Genome Institute of Singapore, Singapore.
Hopper JL Hopper John L JL Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health and.
Southey MC Southey Melissa C MC Department of Pathology, Genetic Epidemiology Laboratory, The University of Melbourne, Melbourne, VIC, Australia.
Australian Ovarian Cancer Study (AOCS)
Ekici AB Ekici Arif B AB Institute of Human Genetics, University Hospital, Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen, Germany.
Ruebner M Ruebner Matthias M University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen, Germany.
Johnson N Johnson Nicola N Breakthrough Breast Cancer Research Centre.
Peto J Peto Julian J London School of Hygiene and Tropical Medicine, London, UK.
Burwinkel B Burwinkel Barbara B Molecular Biology of Breast Cancer, Department of Gynecology and Obstetrics, Molecular Epidemiology, C080.
Marme F Marme Frederik F Molecular Biology of Breast Cancer, Department of Gynecology and Obstetrics, National Center for Tumor Diseases, University of Heidelberg, Heidelberg, Germany.
Brenner H Brenner Hermann H Division of Clinical Epidemiology and Aging Research, German Cancer Consortium (DKTK), Heidelberg, Germany.
Dieffenbach AK Dieffenbach Aida K AK Division of Clinical Epidemiology and Aging Research, German Cancer Consortium (DKTK), Heidelberg, Germany.
Meindl A Meindl Alfons A Division of Tumor Genetics, Department of Obstetrics and Gynecology, Technical University of Munich, Munich, Germany.
Brauch H Brauch Hiltrud H Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology Stuttgart, University of Tuebingen, Germany.
GENICA Network
Lindblom A Lindblom Annika A Department of Molecular Medicine and Surgery and.
Depreeuw J Depreeuw Jeroen J Vesalius Research Center, VIB, Leuven, Belgium.
Moisse M Moisse Matthieu M Vesalius Research Center, VIB, Leuven, Belgium.
Chang-Claude J Chang-Claude Jenny J Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Rudolph A Rudolph Anja A Department of Cancer Epidemiology/Clinical Cancer Registry and Institute for Medical Biometrics and Epidemiology, University Clinic Hamburg-Eppendorf, Hamburg, Germany.
Couch FJ Couch Fergus J FJ Departments of Laboratory Medicine and Pathology, and Health Science Research, Mayo Clinic, Rochester, MN, USA.
Olson JE Olson Janet E JE Division of Epidemiology, Department of Health Science Research and.
Giles GG Giles Graham G GG Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health and Cancer Epidemiology Centre, The Cancer Council Victoria, Melbourne, VIC, Australia, Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, VIC, Australia.
Bruinsma F Bruinsma Fiona F Cancer Epidemiology Centre, The Cancer Council Victoria, Melbourne, VIC, Australia.
Cunningham JM Cunningham Julie M JM Departments of Laboratory Medicine and Pathology, and Health Science Research, Mayo Clinic, Rochester, MN, USA.
Fridley BL Fridley Brooke L BL Department of Biostatistics, University of Kansas Medical Center, Kansas City, KS, USA.
Børresen-Dale AL Børresen-Dale Anne-Lise AL Department of Genetics, Institute for Cancer Research, The Norwegian Radium Hospital, Oslo, Norway, Faculty of Medicine, The K.G. Jebsen Center for Breast Cancer Research, Institute for Clinical Medicine, University of Oslo, Oslo, Norway.
Kristensen VN Kristensen Vessela N VN Department of Genetics, Institute for Cancer Research, The Norwegian Radium Hospital, Oslo, Norway, Faculty of Medicine, The K.G. Jebsen Center for Breast Cancer Research, Institute for Clinical Medicine, University of Oslo, Oslo, Norway, Division of Medicine, Department of Clinical Molecular Oncology, Akershus University Hospital, Ahus, Norway.
Cox A Cox Angela A Department of Oncology, Sheffield Cancer Research Centre, University of Sheffield, Sheffield, UK.
Swerdlow AJ Swerdlow Anthony J AJ Division of Genetics and Epidemiology and, Division of Breast Cancer Research, Institute of Cancer Research, London, UK.
Orr N Orr Nicholas N Division of Breast Cancer Research, Institute of Cancer Research, London, UK.
Bolla MK Bolla Manjeet K MK Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care and.
Wang Q Wang Qin Q Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care and.
Weber RP Weber Rachel Palmieri RP Department of Community and Family Medicine, Duke University School of Medicine, Durham, NC, USA.
Chen Z Chen Zhihua Z Division of Population Sciences, Department of Cancer Epidemiology, Moffitt Cancer Center, Tampa, FL, USA.
Shah M Shah Mitul M Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK.
French JD French Juliet D JD QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.
Pharoah PD Pharoah Paul D P PD Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK.
Dunning AM Dunning Alison M AM Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK.
Tomlinson I Tomlinson Ian I Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.
Easton DF Easton Douglas F DF Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care and Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK.
Edwards SL Edwards Stacey L SL QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.
Thompson DJ Thompson Deborah J DJ Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK.
Spurdle AB Spurdle Amanda B AB QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia, amanda.spurdle@qimrberghofer.edu.au.
INVESTIGATORS
LASTNAME FORENAME INITIALS AFFILIATION
Spurdle A B AB
Webb P M PM
Young J J
McQuire L L
Baron-Hay S S
Bell D D
Bonaventura A A
Brand A A
Braye S S
Carter J J
Chan F F
Dalrymple C C
Ferrier A A
Gard G G
Hacker N N
Hogg R R
Houghton R R
Marsden D D
McIlroy K K
Otton G G
Pather S S
Proietto A A
Robertson G G
Scurry J J
Sharma R R
Wain G G
Wong F F
Armes J J
Crandon A A
Cummings M M
Land R R
Nicklin J J
Perrin L L
Obermair A A
Ward B B
Davy M M
Dodd T T
Miller J J
Oehler M M
Paramasivum S S
Pierides J J
Whitehead F F
Blomfield P P
Challis D D
Neesham D D
Pyman J J
Quinn M M
Rome R R
Weitzer M M
Brennan B B
Hammond I I
Leung Y Y
McCartney A A
Stewart C C
Thompson J J
O'Brien S S
Moore S S
Ferguson K K
Walsh M M
Cicero R R
Green L L
Griffith J J
Jackman L L
Ranieri B B
O'Brien M M
Schultz P P
Alexander B B
Baxter C C
Croy H H
Fitzgerald A A
Herron E E
Hill C C
Jones M M
Maidens J J
Marshall A A
Martin K K
Mayhew J J
Minehan E E
Roffe D D
Shirley H H
Steane H H
Stenlake A A
Ward A A
Webb S S
White J J
de Polanco Ma Magdalena Echeverry M
Bohórquez Mabel Elena ME
Prieto Rodrigo R
Criollo Angel A
Ramírez Carolina C
Estrada Ana Patricia AP
Suárez Jhon Jairo JJ
Martinez Augusto Rojas AR
Rogatto Silvia S
Jnr Samuel Aguiar SA
Santos Ericka Maria Monteiro EM
Sans Monica M
Colistro Valentina V
Hidalgo Pedro C PC
Mut Patricia P
Carracedo Angel A
Ponte Clara Ruiz CR
Garcia Ines Quntela IQ
Castellvi-Bel Sergi S
Teixeira Manuel M
de Almeida António Bernardino AB
Hamann Ute U
Gilbert Michael M
Tomlinson Ian I
Adams M M
Al-Samarraie A A
Anwar S S
Athavale R R
Awad S S
Bali A A
Barnes A A
Cawdell G G
Chan S S
Chin K K
Cornes P P
Crawford M M
Cullimore J J
Ghaem-Maghami S S
Gornall R R
Green J J
Hall M M
Harvey M M
Hawe J J
Head A A
Herod J J
Hingorani M M
Hocking M M
Holland C C
Hollingsworth T T
Hollingworth J J
Ind T T
Irvine R R
Irwin C C
Katesmark M M
Kehoe S S
Kheng-Chew G G
Lankester K K
Linder A A
Luesley D D
B-Lynch C C
McFarlane V V
Naik R R
Nicholas N N
Nugent D D
Oates S S
Oladipo A A
Papadopoulos A A
Pearson S S
Radstone D D
Raju S S
Rathmell A A
Redman C C
Rymer M M
Sarhanis P P
Sparrow G G
Stuart N N
Sundar S S
Thompson A A
Tinkler S S
Trent S S
Tristram A A
Walji N N
Woolas R R
Lindblom Annika A
Tzortzatos Gerasimos G
Mints Miriam M
Tham Emma E
Castro Ofra O
Gemzell-Danielsson Kristina K
Baker Helen H
Baynes Caroline C
Conroy Don D
Curzon Bridget B
Harrington Patricia P
Irvine Sue S
Luccarini Craig C
Mayes Rebecca R
Munday Hannah H
Perkins Barbara B
Pharoah Daisy D
Platte Radka R
Stafford Anne A
West Judy J
Shu Xiao Ou XO
Zheng Wei W
Long Jirong J
Cai Qiuyin Q
Dai Qi Q
Cai Hui H
Delahanty Ryan R
Li Chun C
Xiang Yong-Bing YB
Gao Yutang Y
Xu Wang-Hong WH
Lu Wei W
Zheng Ying Y
Gu Kai K
Stuart-Harris R R
Kirsten F F
Rutovitz J J
Clingan P P
Glasgow A A
Proietto A A
Braye S S
Otton G G
Shannon J J
Bonaventura T T
Stewart J J
Begbie S S
Friedlander M M
Bell D D
Baron-Hay S S
Ferrier A A
Gard G G
Nevell D D
Pavlakis N N
Valmadre S S
Young B B
Camaris C C
Crouch R R
Edwards L L
Hacker N N
Marsden D D
Robertson G G
Beale P P
Beith J J
Carter J J
Dalrymple C C
Houghton R R
Russell P P
Anderson L L
Links M M
Grygiel J J
Hill J J
Brand A A
Byth K K
Jaworski R R
Harnett P P
Sharma R R
Wain G G
Purdie D D
Whiteman D D
Ward B B
Papadimos D D
Crandon A A
Cummings M M
Horwood K K
Obermair A A
Perrin L L
Wyld D D
Nicklin J J
Davy M M
Oehler M K MK
Hall C C
Dodd T T
Healy T T
Pittman K K
Henderson D D
Miller J J
Pierdes J J
Achan A A
Blomfield P P
Challis D D
McIntosh R R
Parker A A
Brown B B
Rome R R
Allen D D
Grant P P
Hyde S S
Robbie R Laurie M RL
Healy D D
Jobling T T
Manolitsas T T
McNealage J J
Rogers P P
Susil B B
Sumithran E E
Simpson I I
Haviv I I
Phillips K K
Rischin D D
Fox S S
Johnson D D
Lade S S
Waring P P
Loughrey M M
O'Callaghan N N
Murray B B
Mileshkin L L
Allan P P
Billson V V
Pyman J J
Neesham D D
Quinn M M
Hamilton A A
Underhill C C
Bell R R
Ng L F LF
Blum R R
Ganju V V
Hammond I I
McCartney A A
Stewart C C
Leung Y Y
Buck M M
Zeps N N
Bowtell D D L DD
Green A C AC
Chenevix-Trench G G
deFazio A A
Gertig D D
Webb P M PM
Bugert Peter P
Arndt Volker V
Müller Heiko H
Stegmaier Christa C
Lo Wing-Yee WY
Justenhoven Christina C
Hamann Ute U
Brüning Thomas T
Pesch Beate B
Ko Yon-Dschun YD
Rabstein Sylvia S
Lotz Anne A
Baisch Christina C
Fischer Hans-Peter HP
Harth Volker V
JOURNAL
VOLUME: 24
ISSUE: 5
TITLE: Human molecular genetics
ISOABBREVIATION: Hum. Mol. Genet.
YEAR: 2015
MONTH: Mar
DAY: 1
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN: 1460-2083
ISSNTYPE: Electronic
MEDLINE JOURNAL
MEDLINETA: Hum Mol Genet
COUNTRY: England
ISSNLINKING: 0964-6906
NLMUNIQUEID: 9208958
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
COMMENTS AND CORRECTIONS
REFTYPE REFSOURCE REFPMID NOTE
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GRANTS
GRANTID AGENCY COUNTRY
068545/Z/02 Wellcome Trust United Kingdom
085475 Wellcome Trust United Kingdom
090532 Wellcome Trust United Kingdom
1U19 CA148065 NCI NIH HHS United States
1U19 CA148112 NCI NIH HHS United States
1U19 CA148537 NCI NIH HHS United States
C12292/A11174 Cancer Research UK United Kingdom
C1281/A12014 Cancer Research UK United Kingdom
C1287/A 10710 Cancer Research UK United Kingdom
C1287/A10118 Cancer Research UK United Kingdom
C1287/A12014 Cancer Research UK United Kingdom
C490/A10124 Cancer Research UK United Kingdom
C5047/A10692 Cancer Research UK United Kingdom
C5047/A15007 Cancer Research UK United Kingdom
C5047/A8384 Cancer Research UK United Kingdom
CA128978 NCI NIH HHS United States
G0000934 Medical Research Council United Kingdom
P30 CA015083 NCI NIH HHS United States
P50 CA136393 NCI NIH HHS United States
R01 CA 092585 NCI NIH HHS United States
R01 CA122443 NCI NIH HHS United States
R01 CA64277 NCI NIH HHS United States
R01 CA90899 NCI NIH HHS United States
U19 CA148112 NCI NIH HHS United States
Canadian Institutes of Health Research Canada
GENERAL NOTE
KEYWORDS
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Alleles
Case-Control Studies
Cell Line, Tumor
Chromosome Mapping
Computational Biology
Databases, Genetic
Endometrial Neoplasms genetics
Epigenesis, Genetic genetics
European Continental Ancestry Group genetics
Female genetics
Genetic Loci genetics
Genetic Variation genetics
Genome-Wide Association Study genetics
Genotype genetics
Haplotypes genetics
Hepatocyte Nuclear Factor 1-beta metabolism
Humans metabolism
Linkage Disequilibrium metabolism
Polymorphism, Single Nucleotide metabolism
Promoter Regions, Genetic metabolism
RNA, Messenger metabolism
Risk Factors metabolism
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
REGISTRYNUMBER NAMEOFSUBSTANCE
0 HNF1B protein, human
0 RNA, Messenger
138674-15-4 Hepatocyte Nuclear Factor 1-beta
OTHER ID's
OTHERID SOURCE
PMC4321445 NLM