Genetic Epidemiology, Translational Neurogenomics, Psychiatric Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
25346947
TITLE
Heritability of White Matter Fiber Tract Shapes: A HARDI Study of 198 Twins.
ABSTRACT
Genetic analysis of diffusion tensor images (DTI) shows great promise in revealing specific genetic variants that affect brain integrity and connectivity. Most genetic studies of DTI analyze voxel-based diffusivity indices in the image space (such as 3D maps of fractional anisotropy) and overlook tract geometry. Here we propose an automated workflow to cluster fibers using a white matter probabilistic atlas and perform genetic analysis on the shape characteristics of fiber tracts. We apply our approach to large study of 4-Tesla high angular resolution diffusion imaging (HARDI) data from 198 healthy, young adult twins (age: 20-30). Illustrative results show heritability for the shapes of several major tracts, as color-coded maps.
DATE PUBLISHED
2011
HISTORY
PUBSTATUS PUBSTATUSDATE
entrez 2014/10/28 06:00
pubmed 2011/01/01 00:00
medline 2011/01/01 00:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Jin Y Jin Yan Y Laboratory of Neuro Imaging, Department of Neurology, School of Medicine, University of California, Los Angeles, CA 90095, USA.
Shi Y Shi Yonggang Y fMRI Laboratory, University of Queensland, Brisbane St. Lucia, QLD 4072, Australia.
Joshi SH Joshi Shantanu H SH Queensland Institute of Medical Research, Herston, QLD 4029, Australia.
Jahanshad N Jahanshad Neda N
Zhan L Zhan Liang L
de Zubicaray GI de Zubicaray Greig I GI
McMahon KL McMahon Katie L KL
Martin NG Martin Nicholas G NG
Wright MJ Wright Margaret J MJ
Toga AW Toga Arthur W AW
Thompson PM Thompson Paul M PM
INVESTIGATORS
JOURNAL
VOLUME: 2011
ISSUE:
TITLE: Multimodal brain image analysis : first international workshop, MBIA 2011, held in conjunction with MICCAI 2011, Toronto, Canada, September 18, 2011 : proceedings / Tianming Liu ... [et al.], (eds.)
ISOABBREVIATION: Multimodal Brain Image Anal (2011)
YEAR: 2011
MONTH:
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Print
ISSN:
ISSNTYPE: Print
MEDLINE JOURNAL
MEDLINETA: Multimodal Brain Image Anal (2011)
COUNTRY:
ISSNLINKING:
NLMUNIQUEID: 101571471
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
JOURNAL ARTICLE
COMMENTS AND CORRECTIONS
GRANTS
GRANTID AGENCY COUNTRY
R01 HD050735 NICHD NIH HHS United States
GENERAL NOTE
KEYWORDS
KEYWORD
Clustering
Curve Matching
Fiber Alignment
HARDI
Heritability
Image Registration
Tractography
White Matter Probabilistic Atlas
MESH HEADINGS
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
OTHER ID's