|
|
| PMID |
|
|
| TITLE |
|
| Heritability of White Matter Fiber Tract Shapes: A HARDI Study of 198 Twins. |
|
| ABSTRACT |
|
|
|
| Genetic analysis of diffusion tensor images (DTI) shows great promise in revealing specific genetic variants that affect brain integrity and connectivity. Most genetic studies of DTI analyze voxel-based diffusivity indices in the image space (such as 3D maps of fractional anisotropy) and overlook tract geometry. Here we propose an automated workflow to cluster fibers using a white matter probabilistic atlas and perform genetic analysis on the shape characteristics of fiber tracts. We apply our approach to large study of 4-Tesla high angular resolution diffusion imaging (HARDI) data from 198 healthy, young adult twins (age: 20-30). Illustrative results show heritability for the shapes of several major tracts, as color-coded maps. |
|
| DATE PUBLISHED |
|
|
| HISTORY |
|
| PUBSTATUS |
PUBSTATUSDATE |
| entrez |
2014/10/28 06:00 |
| pubmed |
2011/01/01 00:00 |
| medline |
2011/01/01 00:00 |
|
| AUTHORS |
|
| NAME |
COLLECTIVENAME |
LASTNAME |
FORENAME |
INITIALS |
AFFILIATION |
AFFILIATIONINFO |
| Jin Y |
|
Jin |
Yan |
Y |
|
Laboratory of Neuro Imaging, Department of Neurology, School of Medicine, University of California, Los Angeles, CA 90095, USA. |
| Shi Y |
|
Shi |
Yonggang |
Y |
|
fMRI Laboratory, University of Queensland, Brisbane St. Lucia, QLD 4072, Australia. |
| Joshi SH |
|
Joshi |
Shantanu H |
SH |
|
Queensland Institute of Medical Research, Herston, QLD 4029, Australia. |
| Jahanshad N |
|
Jahanshad |
Neda |
N |
|
|
| Zhan L |
|
Zhan |
Liang |
L |
|
|
| de Zubicaray GI |
|
de Zubicaray |
Greig I |
GI |
|
|
| McMahon KL |
|
McMahon |
Katie L |
KL |
|
|
| Martin NG |
|
Martin |
Nicholas G |
NG |
|
|
| Wright MJ |
|
Wright |
Margaret J |
MJ |
|
|
| Toga AW |
|
Toga |
Arthur W |
AW |
|
|
| Thompson PM |
|
Thompson |
Paul M |
PM |
|
|
|
| INVESTIGATORS |
|
|
| JOURNAL |
|
| VOLUME: 2011 |
| ISSUE: |
| TITLE: Multimodal brain image analysis : first international workshop, MBIA 2011, held in conjunction with MICCAI 2011, Toronto, Canada, September 18, 2011 : proceedings / Tianming Liu ... [et al.], (eds.) |
| ISOABBREVIATION: Multimodal Brain Image Anal (2011) |
| YEAR: 2011 |
| MONTH: |
| DAY: |
| MEDLINEDATE: |
| SEASON: |
| CITEDMEDIUM: Print |
| ISSN: |
| ISSNTYPE: Print |
|
| MEDLINE JOURNAL |
|
| MEDLINETA: Multimodal Brain Image Anal (2011) |
| COUNTRY: |
| ISSNLINKING: |
| NLMUNIQUEID: 101571471 |
|
| PUBLICATION TYPE |
|
| PUBLICATIONTYPE TEXT |
| JOURNAL ARTICLE |
|
| COMMENTS AND CORRECTIONS |
|
|
| GRANTS |
|
| GRANTID |
AGENCY |
COUNTRY |
| R01 HD050735 |
NICHD NIH HHS |
United States |
|
| GENERAL NOTE |
|
|
| KEYWORDS |
|
| KEYWORD |
| Clustering |
| Curve Matching |
| Fiber Alignment |
| HARDI |
| Heritability |
| Image Registration |
| Tractography |
| White Matter Probabilistic Atlas |
|
| MESH HEADINGS |
|
|
| SUPPLEMENTARY MESH |
|
|
| GENE SYMBOLS |
|
|
| CHEMICALS |
|
|
| OTHER ID's |
|
|
|
