Genetic Epidemiology, Translational Neurogenomics, Psychiatric Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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25288136
TITLE
Genome-wide meta-analysis identifies six novel loci associated with habitual coffee consumption.
ABSTRACT
Coffee, a major dietary source of caffeine, is among the most widely consumed beverages in the world and has received considerable attention regarding health risks and benefits. We conducted a genome-wide (GW) meta-analysis of predominately regular-type coffee consumption (cups per day) among up to 91,462 coffee consumers of European ancestry with top single-nucleotide polymorphisms (SNPs) followed-up in ~30 062 and 7964 coffee consumers of European and African-American ancestry, respectively. Studies from both stages were combined in a trans-ethnic meta-analysis. Confirmed loci were examined for putative functional and biological relevance. Eight loci, including six novel loci, met GW significance (log10Bayes factor (BF)>5.64) with per-allele effect sizes of 0.03-0.14 cups per day. Six are located in or near genes potentially involved in pharmacokinetics (ABCG2, AHR, POR and CYP1A2) and pharmacodynamics (BDNF and SLC6A4) of caffeine. Two map to GCKR and MLXIPL genes related to metabolic traits but lacking known roles in coffee consumption. Enhancer and promoter histone marks populate the regions of many confirmed loci and several potential regulatory SNPs are highly correlated with the lead SNP of each. SNP alleles near GCKR, MLXIPL, BDNF and CYP1A2 that were associated with higher coffee consumption have previously been associated with smoking initiation, higher adiposity and fasting insulin and glucose but lower blood pressure and favorable lipid, inflammatory and liver enzyme profiles (P<5 × 10(-8)).Our genetic findings among European and African-American adults reinforce the role of caffeine in mediating habitual coffee consumption and may point to molecular mechanisms underlying inter-individual variability in pharmacological and health effects of coffee.
DATE PUBLISHED
2015 May
HISTORY
PUBSTATUS PUBSTATUSDATE
received 2014/03/23
revised 2014/07/17
accepted 2014/07/22
aheadofprint 2014/10/07
entrez 2014/10/08 06:00
pmc-release 2016/05/01 00:00
pubmed 2014/10/08 06:00
medline 2016/01/20 06:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Coffee and Caffeine Genetics Consortium
Cornelis MC Cornelis M C MC 1] Channing Division of Network Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA [2] Department of Nutrition, Harvard School of Public Health, Boston, MA, USA.
Byrne EM Byrne E M EM Queensland Brain Institute, The University of Queensland, Queensland, Australia.
Esko T Esko T T 1] Estonian Genome Center, University of Tartu, Tartu, Estonia [2] Division of Endocrinology, Children's Hospital Boston, Boston, MA, USA [3] Department of Genetics, Harvard Medical School, Boston, MA, USA [4] Program in Medical and Population Genetics, Broad Institute, Cambridge, MA, USA.
Nalls MA Nalls M A MA Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health (NIH), Bethesda, MD, USA.
Ganna A Ganna A A Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Karolinska, Sweden.
Paynter N Paynter N N Division of Preventive Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Monda KL Monda K L KL Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Amin N Amin N N Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands.
Fischer K Fischer K K Estonian Genome Center, University of Tartu, Tartu, Estonia.
Renstrom F Renstrom F F Department of Clinical Sciences, Lund University, Malmö, Sweden.
Ngwa JS Ngwa J S JS Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA.
Huikari V Huikari V V Institute of Health Sciences, University of Oulu, Oulu, Finland.
Cavadino A Cavadino A A Centre for Paediatric Epidemiology and Biostatistics, Medical Research Council (MRC) Centre of Epidemiology for Child Health, University College London Institute of Child Health, London, UK.
Nolte IM Nolte I M IM Department of Epidemiology, University of Groningen, University Medical Center Groningen, The Netherlands.
Teumer A Teumer A A Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Germany.
Yu K Yu K K Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.
Marques-Vidal P Marques-Vidal P P Institute of Social and Preventive Medicine, Lausanne University Hospital, Lausanne, Switzerland.
Rawal R Rawal R R Institute of Genetic Epidemiology, Helmholtz Zentrum-München, Munich-Neuherberg, Germany.
Manichaikul A Manichaikul A A Center for Public Health Genomics, University of Virginia, Charlottesville, VA, USA.
Wojczynski MK Wojczynski M K MK Washington University School of Medicine, Department of Genetics, Division of Statistical Genomics, St Louis, MO, USA.
Vink JM Vink J M JM Department of Biological Psychology/Netherlands Twin Register, VU University, Amsterdam, The Netherlands.
Zhao JH Zhao J H JH Medical Research Council (MRC) Epidemiology Unit, University of Cambridge, Cambridge, UK.
Burlutsky G Burlutsky G G Centre for Vision Research, Department of Ophthalmology and the Westmead Millennium Institute, University of Sydney, Sydney, New South Wales, Australia.
Lahti J Lahti J J 1] Institute of Behavioural Sciences, University of Helsinki, Helsinki, Finland [2] Folkhälsan Research Centre, Helsinki, Finland.
Mikkilä V Mikkilä V V 1] Department of Food and Environmental Sciences, University of Helsinki, Helsinki, Finland [2] Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku and Turku University Hospital, Turku, Finland.
Lemaitre RN Lemaitre R N RN Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.
Eriksson J Eriksson J J Centre for Bone and Arthritis Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Musani SK Musani S K SK University of Mississippi Medical Center, Jackson, MI, USA.
Tanaka T Tanaka T T Translational Gerontology Branch, National Institute on Aging, NIH, Baltimore, MD, USA.
Geller F Geller F F Statens Serum Institut, Department of Epidemiology Research, Copenhagen, Denmark.
Luan J Luan J J Medical Research Council (MRC) Epidemiology Unit, University of Cambridge, Cambridge, UK.
Hui J Hui J J 1] Busselton Population Medical Research Foundation Inc., Busselton, Western Australia, Australia [2] PathWest Laboratory Medicine WA, Nedlands, Western Australia, Australia [3] School of Pathology and Laboratory Medicine, The University of Western Australia, Nedlands, Western Australia, Australia [4] School of Population Health, The University of Western Australia, Nedlands, Western Australia, Australia.
Mägi R Mägi R R Estonian Genome Center, University of Tartu, Tartu, Estonia.
Dimitriou M Dimitriou M M Harokopio University, Athens, Greece.
Garcia ME Garcia M E ME Laboratory of Epidemiology and Population Sciences, National Institute on Aging, NIH, Bethesda, MD, USA.
Ho WK Ho W-K WK Department of Public Health and Primary Care, Institute of Public Health, University of Cambridge, Cambridge, UK.
Wright MJ Wright M J MJ QIMR Berghofer Medical Research Institute, Queensland, Australia.
Rose LM Rose L M LM Division of Preventive Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Magnusson PK Magnusson P K E PK Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Karolinska, Sweden.
Pedersen NL Pedersen N L NL Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Karolinska, Sweden.
Couper D Couper D D Department of Biostatistics, University of NC at Chapel Hill, Chapel Hill, NC, USA.
Oostra BA Oostra B A BA Department of Clinical Genetics, Erasmus MC, Rotterdam, The Netherlands.
Hofman A Hofman A A Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands.
Ikram MA Ikram M A MA 1] Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands [2] Department of Radiology, Erasmus Medical Center, Rotterdam, The Netherlands [3] Department of Neurology, Erasmus Medical Center, Rotterdam, The Netherlands.
Tiemeier HW Tiemeier H W HW 1] Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands [2] Department of Psychiatry, Erasmus Medical Center, Rotterdam, The Netherlands.
Uitterlinden AG Uitterlinden A G AG 1] Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands [2] Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands.
van Rooij FJ van Rooij F J A FJ Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands.
Barroso I Barroso I I 1] Wellcome Trust Sanger Institute, Hinxton, Cambridge, UK [2] University of Cambridge Metabolic Research Laboratories and NIHR Cambridge Biomedical Research Centre, Cambridge, UK.
Johansson I Johansson I I Department of Odontology, Umeå University, Umeå, Sweden.
Xue L Xue L L Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA.
Kaakinen M Kaakinen M M 1] Institute of Health Sciences, University of Oulu, Oulu, Finland [2] Biocenter Oulu, University of Oulu, Oulu, Finland [3] Department of Epidemiology and Biostatistics, MRC Health Protection Agency (HPE) Centre for Environment and Health, School of Public Health, Imperial College London, UK.
Milani L Milani L L Estonian Genome Center, University of Tartu, Tartu, Estonia.
Power C Power C C Centre for Paediatric Epidemiology and Biostatistics, Medical Research Council (MRC) Centre of Epidemiology for Child Health, University College London Institute of Child Health, London, UK.
Snieder H Snieder H H Department of Epidemiology, University of Groningen, University Medical Center Groningen, The Netherlands.
Stolk RP Stolk R P RP Department of Epidemiology, University of Groningen, University Medical Center Groningen, The Netherlands.
Baumeister SE Baumeister S E SE Institute for Community Medicine, University Medicine Greifswald, Germany.
Biffar R Biffar R R Department of Prosthodontics, Gerodontology and Biomaterials, Center of Oral Health, University Medicine Greifswald, Germany.
Gu F Gu F F Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.
Bastardot F Bastardot F F Department of Internal Medicine, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, Switzerland.
Kutalik Z Kutalik Z Z 1] Department of Medical Genetics, University of Lausanne, Lausanne, Switzerland [2] Institute of Social and Preventive Medicine (IUMSP), Centre Hospitalier Universitaire Vaudois (CHUV), Lausanne, Switzerland [3] Swiss Institute of Bioinformatics, Lausanne, Switzerland.
Jacobs DR Jr Jacobs D R DR Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, MN, USA.
Forouhi NG Forouhi N G NG Medical Research Council (MRC) Epidemiology Unit, University of Cambridge, Cambridge, UK.
Mihailov E Mihailov E E Estonian Genome Center, University of Tartu, Tartu, Estonia.
Lind L Lind L L Department of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory, Uppsala University, Uppsala, Sweden.
Lindgren C Lindgren C C Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.
Michaëlsson K Michaëlsson K K Department of Surgical Sciences, Uppsala University, Uppsala, Sweden.
Morris A Morris A A Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.
Jensen M Jensen M M Department of Nutrition, Harvard School of Public Health, Boston, MA, USA.
Khaw KT Khaw K-T KT Department of Public Health and Primary Care, Institute of Public Health, University of Cambridge, Cambridge, UK.
Luben RN Luben R N RN Department of Public Health and Primary Care, Institute of Public Health, University of Cambridge, Cambridge, UK.
Wang JJ Wang J J JJ Centre for Vision Research, Department of Ophthalmology and the Westmead Millennium Institute, University of Sydney, Sydney, New South Wales, Australia.
Männistö S Männistö S S Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, Finland.
Perälä MM Perälä M-M MM Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, Finland.
Kähönen M Kähönen M M Department of Clinical Physiology, Tampere University Hospital and School of Medicine University of Tampere, Tampere, Finland.
Lehtimäki T Lehtimäki T T Department of Clinical Chemistry, Fimlab Laboratories, and School of Medicine, University of Tampere, Tampere, Finland.
Viikari J Viikari J J Department of Medicine, University of Turku and Turku University Hospital, Turku, Finland.
Mozaffarian D Mozaffarian D D 1] Channing Division of Network Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA [2] Department of Nutrition, Harvard School of Public Health, Boston, MA, USA [3] Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA [4] Friedman School of Nutrition Science and Policy, Tufts University, Boston, MA, USA.
Mukamal K Mukamal K K Beth Israel Deaconess Medical Center, Boston, MA, USA.
Psaty BM Psaty B M BM 1] Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA [2] Cardiovascular Health Research Unit, Department of Epidemiology, University of Washington, Seattle, WA, USA [3] Department of Health Services, University of Washington, Seattle, WA, USA [4] Group Health Research Institute, Group Health Cooperative, Seattle, WA, USA.
Döring A Döring A A Institute of Epidemiology, Helmholtz Zentrum-München, Munich-Neuherberg, Germany.
Heath AC Heath A C AC Department of Psychiatry, Washington University, St Louis, MO, USA.
Montgomery GW Montgomery G W GW QIMR Berghofer Medical Research Institute, Queensland, Australia.
Dahmen N Dahmen N N Department for Psychiatry, Johannes-Gutenberg-University, Mainz, Germany.
Carithers T Carithers T T School of Applied Sciences, University of Mississippi, Oxford, Mississippi, USA.
Tucker KL Tucker K L KL Clinical Laboratory and Nutritional Sciences, University of MA Lowell, Lowell, MA, USA.
Ferrucci L Ferrucci L L Translational Gerontology Branch, National Institute on Aging, NIH, Baltimore, MD, USA.
Boyd HA Boyd H A HA Statens Serum Institut, Department of Epidemiology Research, Copenhagen, Denmark.
Melbye M Melbye M M Statens Serum Institut, Department of Epidemiology Research, Copenhagen, Denmark.
Treur JL Treur J L JL Department of Biological Psychology/Netherlands Twin Register, VU University, Amsterdam, The Netherlands.
Mellström D Mellström D D Centre for Bone and Arthritis Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Hottenga JJ Hottenga J J JJ Department of Biological Psychology/Netherlands Twin Register, VU University, Amsterdam, The Netherlands.
Prokopenko I Prokopenko I I 1] Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK [2] Department of Genomics of Common Diseases, Imperial College London, London, UK.
Tönjes A Tönjes A A 1] Medical Department, University of Leipzig, Leipzig, Germany [2] IFB Adiposity Diseases, University of Leipzig, Leipzig, Germany.
Deloukas P Deloukas P P 1] Wellcome Trust Sanger Institute, Hinxton, Cambridge, UK [2] William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK [3] King Abdulaziz University, Jeddah, Saudi Arabia.
Kanoni S Kanoni S S William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
Lorentzon M Lorentzon M M Centre for Bone and Arthritis Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Houston DK Houston D K DK Wake Forest School of Medicine, Winston-Salem, NC, USA.
Liu Y Liu Y Y Wake Forest University Health Sciences, Winston-Salem, NC, USA.
Danesh J Danesh J J Department of Public Health and Primary Care, Institute of Public Health, University of Cambridge, Cambridge, UK.
Rasheed A Rasheed A A Center for Non-Communicable Diseases, Pakistan.
Mason MA Mason M A MA Health Disparities Research Section, Clinical Research Branch, National Institute on Aging, NIH, Baltimore, MD, USA.
Zonderman AB Zonderman A B AB Laboratory of Personality and Cognition, National Institute on Aging, NIH, Baltimore, MD, USA.
Franke L Franke L L Department of Genetics, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Kristal BS Kristal B S BS 1] Department of Neurosurgery, Brigham and Women's Hospital, Boston, MA, USA [2] Department of Surgery, Harvard Medical School, Boston, MA, USA.
International Parkinson's Disease Genomics Consortium (IPDGC)
North American Brain Expression Consortium (NABEC)
UK Brain Expression Consortium (UKBEC)
Karjalainen J Karjalainen J J Department of Genetics, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Reed DR Reed D R DR Monell Chemical Senses Center, Philadelphia, Pennsylvania, USA.
Westra HJ Westra H-J HJ Department of Genetics, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Evans MK Evans M K MK Health Disparities Research Section, Clinical Research Branch, National Institute on Aging, NIH, Baltimore, MD, USA.
Saleheen D Saleheen D D 1] Department of Public Health and Primary Care, Institute of Public Health, University of Cambridge, Cambridge, UK [2] Center for Non-Communicable Diseases, Pakistan.
Harris TB Harris T B TB Laboratory of Epidemiology and Population Sciences, National Institute on Aging, NIH, Bethesda, MD, USA.
Dedoussis G Dedoussis G G Harokopio University, Athens, Greece.
Curhan G Curhan G G Channing Division of Network Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Stumvoll M Stumvoll M M 1] Medical Department, University of Leipzig, Leipzig, Germany [2] IFB Adiposity Diseases, University of Leipzig, Leipzig, Germany.
Beilby J Beilby J J 1] Busselton Population Medical Research Foundation Inc., Busselton, Western Australia, Australia [2] PathWest Laboratory Medicine WA, Nedlands, Western Australia, Australia [3] School of Pathology and Laboratory Medicine, The University of Western Australia, Nedlands, Western Australia, Australia.
Pasquale LR Pasquale L R LR 1] Channing Division of Network Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA [2] Mass Eye and Ear Infirmary, Boston, MA, USA.
Feenstra B Feenstra B B Statens Serum Institut, Department of Epidemiology Research, Copenhagen, Denmark.
Bandinelli S Bandinelli S S Geriatric Unit, Azienda Sanitaria Firenze, Florence, Italy.
Ordovas JM Ordovas J M JM Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA, USA.
Chan AT Chan A T AT 1] Channing Division of Network Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA [2] Division of Gastroenterology, MA General Hospital, Boston, MA, USA.
Peters U Peters U U Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Ohlsson C Ohlsson C C Centre for Bone and Arthritis Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Gieger C Gieger C C Institute of Genetic Epidemiology, Helmholtz Zentrum-München, Munich-Neuherberg, Germany.
Martin NG Martin N G NG QIMR Berghofer Medical Research Institute, Queensland, Australia.
Waldenberger M Waldenberger M M Research Unit of Molecular Epidemiology, Helmholtz Zentrum-München, Munich-Neuherberg, Germany.
Siscovick DS Siscovick D S DS 1] Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA [2] Cardiovascular Health Research Unit, Department of Epidemiology, University of Washington, Seattle, WA, USA.
Raitakari O Raitakari O O 1] Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku and Turku University Hospital, Turku, Finland [2] Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku, Finland.
Eriksson JG Eriksson J G JG 1] Folkhälsan Research Centre, Helsinki, Finland [2] Department of General Practice and Primary Health Care, University of Helsinki, Helsinki, Finland [3] Helsinki University Central Hospital, Unit of General Practice, Helsinki, Finland.
Mitchell P Mitchell P P Centre for Vision Research, Department of Ophthalmology and the Westmead Millennium Institute, University of Sydney, Sydney, New South Wales, Australia.
Hunter DJ Hunter D J DJ 1] Channing Division of Network Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA [2] Program in Genetic Epidemiology and Statistical Genetics, Harvard School of Public Health, Boston, MA, USA.
Kraft P Kraft P P Program in Genetic Epidemiology and Statistical Genetics, Harvard School of Public Health, Boston, MA, USA.
Rimm EB Rimm E B EB 1] Channing Division of Network Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA [2] Department of Nutrition, Harvard School of Public Health, Boston, MA, USA [3] Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA.
Boomsma DI Boomsma D I DI Department of Biological Psychology/Netherlands Twin Register, VU University, Amsterdam, The Netherlands.
Borecki IB Borecki I B IB Washington University School of Medicine, Department of Genetics, Division of Statistical Genomics, St Louis, MO, USA.
Loos RJ Loos R J F RJ 1] Medical Research Council (MRC) Epidemiology Unit, University of Cambridge, Cambridge, UK [2] The Genetics of Obesity and Related Metabolic Traits Program, The Icahn School of Medicine at Mount Sinai, New York, NY, USA [3] The Charles Bronfman Institute for Personalized Medicine, The Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Wareham NJ Wareham N J NJ Medical Research Council (MRC) Epidemiology Unit, University of Cambridge, Cambridge, UK.
Vollenweider P Vollenweider P P Department of Internal Medicine, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, Switzerland.
Caporaso N Caporaso N N Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.
Grabe HJ Grabe H J HJ Department of Psychiatry and Psychotherapy, University Medicine Greifswald, HELIOS Hospital Stralsund, Germany.
Neuhouser ML Neuhouser M L ML Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Wolffenbuttel BH Wolffenbuttel B H R BH Department of Endocrinology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Hu FB Hu F B FB 1] Channing Division of Network Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA [2] Department of Nutrition, Harvard School of Public Health, Boston, MA, USA [3] Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA.
Hyppönen E Hyppönen E E 1] Centre for Paediatric Epidemiology and Biostatistics, Medical Research Council (MRC) Centre of Epidemiology for Child Health, University College London Institute of Child Health, London, UK [2] School of Population Health, University of South Australia, Adelaide, South Australia, Australia [3] South Australian Health and Medical Research Institute, Adelaide, South Australia, Australia.
Järvelin MR Järvelin M-R MR 1] Institute of Health Sciences, University of Oulu, Oulu, Finland [2] Biocenter Oulu, University of Oulu, Oulu, Finland [3] Department of Epidemiology and Biostatistics, MRC Health Protection Agency (HPE) Centre for Environment and Health, School of Public Health, Imperial College London, UK [4] Department of Children and Young People and Families, National Institute for Health and Welfare, Oulu, Finland [5] Unit of Primary Care, Oulu University Hospital, Oulu, Finland.
Cupples LA Cupples L A LA 1] Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA [2] The Framingham Heart Study, Framingham, MA, USA.
Franks PW Franks P W PW 1] Department of Nutrition, Harvard School of Public Health, Boston, MA, USA [2] Department of Clinical Sciences, Lund University, Malmö, Sweden [3] Department of Public Health and Clinical Medicine, Section for Medicine, Umeå University, Umeå, Sweden.
Ridker PM Ridker P M PM Division of Preventive Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
van Duijn CM van Duijn C M CM 1] Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands [2] Netherlands Consortium for Healthy Ageing and National Genomics Initiative, Leiden, The Netherlands.
Heiss G Heiss G G Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Metspalu A Metspalu A A Estonian Genome Center, University of Tartu, Tartu, Estonia.
North KE North K E KE Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Ingelsson E Ingelsson E E 1] Department of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory, Uppsala University, Uppsala, Sweden [2] Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.
Nettleton JA Nettleton J A JA Division of Epidemiology, Human Genetics and Environmental Sciences, University of Texas Health Science Center at Houston, Houston, TX, USA.
van Dam RM van Dam R M RM Saw Swee Hock School of Public Health and Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore and National University Health System, Singapore.
Chasman DI Chasman D I DI Division of Preventive Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
INVESTIGATORS
LASTNAME FORENAME INITIALS AFFILIATION
Nalls Michael A MA
Plagnol Vincent V
Hernandez Dena G DG
Sharma Manu M
Sheerin Una-Marie UM
Saad Mohamad M
Simón-Sánchez Javier J
Schulte Claudia C
Lesage Suzanne S
Sveinbjörnsdóttir Sigurlaug S
Arepalli Sampath S
Barker Roger R
Ben-Shlomo Yoav Y
Berendse Henk W HW
Berg Daniela D
Bhatia Kailash K
de Bie Rob M A RM
Biffi Alessandro A
Bloem Bas B
Bochdanovits Zoltan Z
Bonin Michael M
Bras M M
Brockmann Kathrin K
Brooks Janet J
Burn David J DJ
Charlesworth Gavin G
Chen Honglei H
Chinnery Patrick F PF
Chong Sean S
Clarke Carl E CE
Cookson Mark R MR
Cooper J Mark JM
Corvol Jean Christophe JC
Counsell Carl C
Damier Philippe P
Dartigues Jean-François JF
Deloukas Panos P
Deuschl Günther G
Dexter David T DT
van Dijk Karin D KD
Dillman Allissa A
Durif Frank F
Dürr Alexandra A
Edkins Sarah S
Evans Jonathan R JR
Foltynie Thomas T
Dong Jing J
Gardner Michelle M
Gibbs J Raphael JR
Goate Alison A
Gray Emma E
Guerreiro Rita R
Harris Clare C
van Hilten Jacobus J JJ
Hofman Albert A
Hollenbeck Albert A
Holton Janice J
Hu Michele M
Huang Xuemei X
Hershey Milton S MS
Wurster Isabel I
Mätzler Walter W
Hudson Gavin G
Hunt Sarah E SE
Huttenlocher Johanna J
Illig Thomas T
München Helmholtz Zentrum HZ
Jónsson Pálmi V PV
Lambert Jean-Charles JC
Langford Cordelia C
Lees Andrew A
Lichtner Peter P
München Helmholtz Zentrum HZ
Limousin Patricia P
Lopez Grisel G
Lorenz Delia D
McNeill Alisdair A
Moorby Catriona C
Moore Matthew M
Morris Huw R HR
Morrison Karen E KE
O' Sullivan Sean S SS
Pearson Justin J
Perlmutter Joel S JS
Pétursson Hjörvar H
Pollak Pierre P
Potter Simon S
Ravina Bernard B
Revesz Tamas T
Riess Olaf O
Rivadeneira Fernando F
Rizzu Patrizia P
Ryten Mina M
Sawcer Stephen S
Schapira Anthony A
Scheffer Hans H
Shaw Karen K
Sidransky Ellen E
Smith Colin C
Spencer Chris C A CC
Stefánsson Hreinn H
Bettella Francesco F
Stockton Joanna D JD
Strange Amy A
Talbot Kevin K
Tanner M M
Tashakkori-Ghanbaria Avazeh A
Tison François F
Trabzuni Daniah D
Traynor Bryan J BJ
Uitterlinden André G AG
Velseboer Daan D
Vidailhet Marie M
Walker Robert R
van de Warrenburg Bart B
Wickremaratchi Mirdhu M
Williams Nigel N
Williams-Gray Caroline H CH
Winder-Rhodes Sophie S
Stefánsson Kári K
Martinez Maria M
Sabatier Paul P
Wood Nicholas W NW
Hardy John J
Heutink Peter P
Brice Alexis A
Gasser Thomas T
Singleton Andrew B AB
Singleton Andrew A
Cookson Mark M
Gibbs J Raphael J
Hernandez Dena D
Dillman Allissa A
Nalls Michael M
Zonderman Alan A
Arepalli Sampath S
Ferrucci Luigi L
Johnson Robert R
Longo Dan D
O'Brien Richard R
Traynor Bryan B
Troncoso Juan J
van der Brug Marcel M
Zielke Ronald R
Hardy John J
Weale Michael M
Ryten Mina M
Ramasamy Adaikalavan A
Trabzuni Daniah D
Box P O PO
Smith Colin C
Walker Robert R
JOURNAL
VOLUME: 20
ISSUE: 5
TITLE: Molecular psychiatry
ISOABBREVIATION: Mol. Psychiatry
YEAR: 2015
MONTH: May
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN: 1476-5578
ISSNTYPE: Electronic
MEDLINE JOURNAL
MEDLINETA: Mol Psychiatry
COUNTRY: England
ISSNLINKING: 1359-4184
NLMUNIQUEID: 9607835
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
Meta-Analysis
Review
COMMENTS AND CORRECTIONS
REFTYPE REFSOURCE REFPMID NOTE
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Cites Am J Hum Genet. 2011 Jan 7;88(1):76-82 21167468
Cites PLoS Genet. 2011 Apr;7(4):e1002033 21490707
Cites Hum Mol Genet. 2011 May 15;20(10):2071-7 21357676
Cites Proc Natl Acad Sci U S A. 2011 Apr 26;108(17):7119-24 21471458
Cites Nature. 2011 May 5;473(7345):43-9 21441907
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Cites J Biol Chem. 2012 May 11;287(20):16791-800 22442142
Cites Prog Mol Biol Transl Sci. 2012;108:293-322 22656382
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Cites Pharmacol Ther. 2013 May;138(2):229-54 23353702
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Cites Pharmacogenet Genomics. 2013 May;23(5):279-85 23492908
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GRANTS
GRANTID AGENCY COUNTRY
090532 Wellcome Trust United Kingdom
14136 Cancer Research UK United Kingdom
G1000143 Medical Research Council United Kingdom
MC_U106179471 Medical Research Council United Kingdom
MC_UP_A100_1003 Medical Research Council United Kingdom
MC_UU_12015/1 Medical Research Council United Kingdom
MC_UU_12015/5 Medical Research Council United Kingdom
MR/L003120/1 Medical Research Council United Kingdom
P60 AA011998 NIAAA NIH HHS United States
R01 EY015473 NEI NIH HHS United States
RG/08/014/24067 British Heart Foundation United Kingdom
U01 HG004728 NHGRI NIH HHS United States
GENERAL NOTE
KEYWORDS
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Adaptor Proteins, Signal Transducing genetics
Basic Helix-Loop-Helix Leucine Zipper Transcription Factors genetics
Brain-Derived Neurotrophic Factor genetics
Coffea metabolism
Cytochrome P-450 CYP1A2 genetics
Food Habits genetics
Genome-Wide Association Study genetics
Humans genetics
Phenotype genetics
Polymorphism, Single Nucleotide genetics
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
REGISTRYNUMBER NAMEOFSUBSTANCE
0 Adaptor Proteins, Signal Transducing
0 Basic Helix-Loop-Helix Leucine Zipper Transcription Factors
0 Brain-Derived Neurotrophic Factor
0 GCKR protein, human
0 MLXIPL protein, human
EC 1.14.14.1 Cytochrome P-450 CYP1A2
OTHER ID's
OTHERID SOURCE
NIHMS648794 [Available on 05/01/16] NLM
PMC4388784 [Available on 05/01/16] NLM
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Last Modified: Oct 15 2007