Genetic Epidemiology, Translational Neurogenomics, Psychiatric Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
25199620
TITLE
Genetic architecture of subcortical brain regions: common and region-specific genetic contributions.
ABSTRACT
Understanding the aetiology of patterns of variation within and covariation across brain regions is key to advancing our understanding of the functional, anatomical and developmental networks of the brain. Here we applied multivariate twin modelling and principal component analysis (PCA) to investigate the genetic architecture of the size of seven subcortical regions (caudate nucleus, thalamus, putamen, pallidum, hippocampus, amygdala and nucleus accumbens) in a genetically informative sample of adolescents and young adults (N = 1038; mean age = 21.6 ± 3.2 years; including 148 monozygotic and 202 dizygotic twin pairs) from the Queensland Twin IMaging (QTIM) study. Our multivariate twin modelling identified a common genetic factor that accounts for all the heritability of intracranial volume (0.88) and a substantial proportion of the heritability of all subcortical structures, particularly those of the thalamus (0.71 out of 0.88), pallidum (0.52 out of 0.75) and putamen (0.43 out of 0.89). In addition, we also found substantial region-specific genetic contributions to the heritability of the hippocampus (0.39 out of 0.79), caudate nucleus (0.46 out of 0.78), amygdala (0.25 out of 0.45) and nucleus accumbens (0.28 out of 0.52). This provides further insight into the extent and organization of subcortical genetic architecture, which includes developmental and general growth pathways, as well as the functional specialization and maturation trajectories that influence each subcortical region.
© 2014 John Wiley & Sons Ltd and International Behavioural and Neural Genetics Society.
DATE PUBLISHED
2014 Nov
HISTORY
PUBSTATUS PUBSTATUSDATE
received 2014/06/12
revised 2014/09/01
accepted 2014/09/07
aheadofprint 2014/10/08
entrez 2014/09/10 06:00
pubmed 2014/09/10 06:00
medline 2015/07/24 06:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Rentería ME Rentería M E ME QIMR Berghofer Medical Research Institute, Herston, QLD, Australia; School of Psychology, University of Queensland, St Lucia, QLD, Australia.
Hansell NK Hansell N K NK
Strike LT Strike L T LT
McMahon KL McMahon K L KL
de Zubicaray GI de Zubicaray G I GI
Hickie IB Hickie I B IB
Thompson PM Thompson P M PM
Martin NG Martin N G NG
Medland SE Medland S E SE
Wright MJ Wright M J MJ
INVESTIGATORS
JOURNAL
VOLUME: 13
ISSUE: 8
TITLE: Genes, brain, and behavior
ISOABBREVIATION: Genes Brain Behav.
YEAR: 2014
MONTH: Nov
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN: 1601-183X
ISSNTYPE: Electronic
MEDLINE JOURNAL
MEDLINETA: Genes Brain Behav
COUNTRY: England
ISSNLINKING: 1601-183X
NLMUNIQUEID: 101129617
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Twin Study
COMMENTS AND CORRECTIONS
REFTYPE REFSOURCE REFPMID NOTE
Cites Cereb Cortex. 2001 Jun;11(6):490-7 11375910
Cites Cereb Cortex. 2015 Jul;25(7):1835-41 24436319
Cites Am J Phys Anthropol. 2002 Aug;118(4):341-58 12124914
Cites Twin Res. 2003 Oct;6(5):361-76 14624720
Cites Neurobiol Aging. 2004 Mar;25(3):377-96 15123343
Cites Br J Psychol. 1970 Aug;61(3):303-21 5457503
Cites Cereb Cortex. 1997 Apr-May;7(3):268-82 9143446
Cites Cereb Cortex. 1998 Jun;8(4):372-84 9651132
Cites J Neurosci. 2005 Sep 7;25(36):8303-10 16148238
Cites Cereb Cortex. 2005 Nov;15(11):1676-89 15703252
Cites J Clin Endocrinol Metab. 2006 Jul;91(7):2514-9 16670160
Cites J Child Psychol Psychiatry. 2006 Oct;47(10):987-93 17073977
Cites Neuroimage. 2007 Jul 15;36(4):1065-73 17513132
Cites Nat Rev Neurosci. 2008 Mar;9(3):182-94 18270514
Cites J Neurosci. 2008 Apr 2;28(14):3586-94 18385317
Cites Hum Brain Mapp. 2008 Nov;29(11):1302-12 17935179
Cites J Neurosci. 2009 Feb 18;29(7):2212-24 19228974
Cites Behav Brain Res. 2009 Apr 12;199(1):53-60 19059285
Cites Neuroimage. 2009 Apr 15;45(3):855-66 19162198
Cites PLoS Biol. 2009 Jul;7(7):e1000157 19621066
Cites J Neurosci. 2009 Sep 23;29(38):11772-82 19776264
Cites Neuroimage. 2010 Jan 15;49(2):1213-23 19786105
Cites Neuroimage. 2010 Jul 15;51(4):1334-44 20338250
Cites Neuroimage. 2010 Aug 15;52(2):455-69 20430102
Cites Curr Biol. 2011 Jan 11;21(1):34-8 21167712
Cites Hum Brain Mapp. 2011 Apr;32(4):641-53 20572207
Cites J Neurosci. 2011 May 4;31(18):6764-70 21543606
Cites J Neurosci. 2011 Jul 27;31(30):10882-90 21795540
Cites Neuroimage. 2012 Jan 16;59(2):1023-7 21930215
Cites Nat Genet. 2012 May;44(5):552-61 22504417
Cites Nat Genet. 2012 May;44(5):539-44 22504418
Cites Nat Genet. 2012 May;44(5):545-51 22504421
Cites Twin Res Hum Genet. 2012 Jun;15(3):351-71 22856370
Cites Hum Brain Mapp. 2013 Sep;34(9):2313-29 22815187
Cites Neuroimage. 2013 Dec;83:98-102 23770413
Cites Proc Natl Acad Sci U S A. 2014 Jan 28;111(4):1592-7 24474784
Cites Brain Imaging Behav. 2014 Jun;8(2):153-82 24399358
Cites Cereb Cortex. 2015 Jan;25(1):26-34 23960203
Cites Neuron. 2002 Jan 31;33(3):341-55 11832223
GRANTS
GRANTID AGENCY COUNTRY
P41 EB015922 NIBIB NIH HHS United States
R01 HD050735 NICHD NIH HHS United States
R01 HD050735 NICHD NIH HHS United States
RF1 AG041915 NIA NIH HHS United States
U54 EB020403 NIBIB NIH HHS United States
GENERAL NOTE
KEYWORDS
KEYWORD
Covariation
heritability
multivariate
structural MRI
subcortical volumes
twin study
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Adolescent
Adult
Cerebrum anatomy & histology
Female anatomy & histology
Humans anatomy & histology
Male anatomy & histology
Organ Size genetics
Twins genetics
Young Adult genetics
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
OTHER ID's
OTHERID SOURCE
NIHMS627793 NLM
PMC4241157 NLM
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