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| PMID |
|
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| TITLE |
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| Contrast effects and sex influence maternal and self-report dimensional measures of attention-deficit hyperactivity disorder. |
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| ABSTRACT |
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| The heritability of attention-deficit/hyperactivity disorder (ADHD) is higher for children than adults. This may be due to increasing importance of environment in symptom variation, measurement inaccuracy when two raters report behavior of a twin-pair, a contrast effect resulting from parental comparison of siblings and/or dimensionality of measures. We examine rater contrast and sex effects in ADHD subtypes using a dimensional scale and compare the aetiology of self, versus maternal-report. Data were collected using the Strengths and Weaknesses of ADHD and Normal Behaviour Scale (SWAN): maternal-report for 3,223 twins and siblings (mean age 21.2, SD = 6.3) and self-report for 1,617 twins and siblings (mean age 25.5, SD = 3.2). Contrast effects and magnitude of genetic and environmental contributions to variance of ADHD phenotypes (inattention, hyperactivity-impulsivity, combined behaviours) were examined using structural equation modeling. Contrast effects were evident for maternal-report hyperactivity-impulsivity (b = -0.04) and self-report inattention (-0.09) and combined ADHD (-0.08). Dominant genetic effects were shared by raters for inattention, hyperactivity-impulsivity and combined ADHD. Broad-sense heritability was equal across sex for maternal-report inattention, hyperactivity-impulsivity and combined ADHD (0.72, 0.83, 0.80). Heritability for corresponding subtypes in self-reported data were best represented by sex (0.46, 0.30, 0.39 for males; 0.69, 0.41, 0.65 for females). Heritability difference between maternal and self-report ADHD was due to greater variance of male specific environment in self-report data. Self-reported ADHD differed across sex by magnitude of specific environment and genetic effects. |
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| DATE PUBLISHED |
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| HISTORY |
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| PUBSTATUS |
PUBSTATUSDATE |
| received |
2014/01/17 |
| accepted |
2014/07/30 |
| aheadofprint |
2014/08/24 |
| entrez |
2014/08/25 06:00 |
| pubmed |
2014/08/26 06:00 |
| medline |
2016/03/08 06:00 |
|
| AUTHORS |
|
| NAME |
COLLECTIVENAME |
LASTNAME |
FORENAME |
INITIALS |
AFFILIATION |
AFFILIATIONINFO |
| Ebejer JL |
|
Ebejer |
J L |
JL |
|
Environmental and Rural Sciences, University of New England, Armidale, NSW, Australia, ebejer.j@gmail.com. |
| Medland SE |
|
Medland |
S E |
SE |
|
|
| van der Werf J |
|
van der Werf |
J |
J |
|
|
| J Wright M |
|
J Wright |
M |
M |
|
|
| Henders AK |
|
Henders |
A K |
AK |
|
|
| Gillespie NA |
|
Gillespie |
N A |
NA |
|
|
| Hickie IB |
|
Hickie |
I B |
IB |
|
|
| Martin NG |
|
Martin |
N G |
NG |
|
|
| Duffy DL |
|
Duffy |
D L |
DL |
|
|
|
| INVESTIGATORS |
|
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| JOURNAL |
|
| VOLUME: 45 |
| ISSUE: 1 |
| TITLE: Behavior genetics |
| ISOABBREVIATION: Behav. Genet. |
| YEAR: 2015 |
| MONTH: Jan |
| DAY: |
| MEDLINEDATE: |
| SEASON: |
| CITEDMEDIUM: Internet |
| ISSN: 1573-3297 |
| ISSNTYPE: Electronic |
|
| MEDLINE JOURNAL |
|
| MEDLINETA: Behav Genet |
| COUNTRY: United States |
| ISSNLINKING: 0001-8244 |
| NLMUNIQUEID: 0251711 |
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| PUBLICATION TYPE |
|
| PUBLICATIONTYPE TEXT |
| Journal Article |
| Research Support, Non-U.S. Gov't |
| Twin Study |
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| COMMENTS AND CORRECTIONS |
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| GRANTS |
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| GENERAL NOTE |
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| KEYWORDS |
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| MESH HEADINGS |
|
| DESCRIPTORNAME |
QUALIFIERNAME |
| Adolescent |
|
| Adult |
|
| Attention Deficit Disorder with Hyperactivity |
genetics |
| Child |
genetics |
| Data Collection |
genetics |
| Diseases in Twins |
genetics |
| Female |
genetics |
| Genes, Dominant |
genetics |
| Humans |
genetics |
| Impulsive Behavior |
genetics |
| Male |
genetics |
| Maternal Behavior |
genetics |
| Middle Aged |
genetics |
| Mothers |
genetics |
| Phenotype |
genetics |
| Retrospective Studies |
genetics |
| Sex Factors |
genetics |
| Siblings |
genetics |
| Young Adult |
genetics |
|
| SUPPLEMENTARY MESH |
|
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| GENE SYMBOLS |
|
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| CHEMICALS |
|
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| OTHER ID's |
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