|
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| PMID |
|
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| TITLE |
|
| Heritability of head motion during resting state functional MRI in 462 healthy twins. |
|
| ABSTRACT |
|
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| Head motion (HM) is a critical confounding factor in functional MRI. Here we investigate whether HM during resting state functional MRI (RS-fMRI) is influenced by genetic factors in a sample of 462 twins (65% female; 101 MZ (monozygotic) and 130 DZ (dizygotic) twin pairs; mean age: 21 (SD = 3.16), range 16-29). Heritability estimates for three HM components-mean translation (MT), maximum translation (MAXT) and mean rotation (MR)-ranged from 37 to 51%. We detected a significant common genetic influence on HM variability, with about two-thirds (genetic correlations range 0.76-1.00) of the variance shared between MR, MT and MAXT. A composite metric (HM-PC1), which aggregated these three, was also moderately heritable (h(2) = 42%). Using a sub-sample (N = 35) of the twins we confirmed that mean and maximum translational and rotational motions were consistent "traits" over repeated scans (r = 0.53-0.59); reliability was even higher for the composite metric (r = 0.66). In addition, phenotypic and cross-trait cross-twin correlations between HM and resting state functional connectivities (RS-FCs) with Brodmann areas (BA) 44 and 45, in which RS-FCs were found to be moderately heritable (BA44: h(2) = 0.23 (sd = 0.041), BA45: h(2) = 0.26 (sd = 0.061)), indicated that HM might not represent a major bias in genetic studies using FCs. Even so, the HM effect on FC was not completely eliminated after regression. HM may be a valuable endophenotype whose relationship with brain disorders remains to be elucidated. |
| Copyright © 2014 Elsevier Inc. All rights reserved. |
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| DATE PUBLISHED |
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| HISTORY |
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| PUBSTATUS |
PUBSTATUSDATE |
| received |
2013/02/11 |
| revised |
2014/08/01 |
| accepted |
2014/08/05 |
| aheadofprint |
2014/08/13 |
| entrez |
2014/08/19 06:00 |
| pubmed |
2014/08/19 06:00 |
| medline |
2015/08/04 06:00 |
|
| AUTHORS |
|
| NAME |
COLLECTIVENAME |
LASTNAME |
FORENAME |
INITIALS |
AFFILIATION |
AFFILIATIONINFO |
| Couvy-Duchesne B |
|
Couvy-Duchesne |
Baptiste |
B |
|
QIMR Berghofer Medical Research Institute, Brisbane, Australia; School of Psychology, University of Queensland, Brisbane, Australia; Centre for Advanced Imaging, University of Queensland, Brisbane, Australia. Electronic address: baptiste.couvyduchesne@qimrberghofer.edu.au. |
| Blokland GA |
|
Blokland |
Gabriëlla A M |
GA |
|
QIMR Berghofer Medical Research Institute, Brisbane, Australia; School of Psychology, University of Queensland, Brisbane, Australia. |
| Hickie IB |
|
Hickie |
Ian B |
IB |
|
Brain & Mind Research Institute, University of Sydney, Australia. |
| Thompson PM |
|
Thompson |
Paul M |
PM |
|
Imaging Genetics Center, Laboratory of Neuro-Imaging, Dept. of Neurology & Psychiatry, UCLA School of Medicine, Los Angeles, CA, USA. |
| Martin NG |
|
Martin |
Nicholas G |
NG |
|
QIMR Berghofer Medical Research Institute, Brisbane, Australia. |
| de Zubicaray GI |
|
de Zubicaray |
Greig I |
GI |
|
School of Psychology, University of Queensland, Brisbane, Australia. |
| McMahon KL |
|
McMahon |
Katie L |
KL |
|
Centre for Advanced Imaging, University of Queensland, Brisbane, Australia. |
| Wright MJ |
|
Wright |
Margaret J |
MJ |
|
QIMR Berghofer Medical Research Institute, Brisbane, Australia. |
|
| INVESTIGATORS |
|
|
| JOURNAL |
|
| VOLUME: 102 Pt 2 |
| ISSUE: |
| TITLE: NeuroImage |
| ISOABBREVIATION: Neuroimage |
| YEAR: 2014 |
| MONTH: Nov |
| DAY: 15 |
| MEDLINEDATE: |
| SEASON: |
| CITEDMEDIUM: Internet |
| ISSN: 1095-9572 |
| ISSNTYPE: Electronic |
|
| MEDLINE JOURNAL |
|
| MEDLINETA: Neuroimage |
| COUNTRY: United States |
| ISSNLINKING: 1053-8119 |
| NLMUNIQUEID: 9215515 |
|
| PUBLICATION TYPE |
|
| PUBLICATIONTYPE TEXT |
| Journal Article |
| Research Support, N.I.H., Extramural |
| Research Support, U.S. Gov't, Non-P.H.S. |
| Twin Study |
|
| COMMENTS AND CORRECTIONS |
|
| REFTYPE |
REFSOURCE |
REFPMID |
NOTE |
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|
| GRANTS |
|
| GRANTID |
AGENCY |
COUNTRY |
| R01 AG040060 |
NIA NIH HHS |
United States |
| R01 HD050735 |
NICHD NIH HHS |
United States |
| R01HD050735 |
NICHD NIH HHS |
United States |
| RF1 AG041915 |
NIA NIH HHS |
United States |
| U54 EB020403 |
NIBIB NIH HHS |
United States |
|
| GENERAL NOTE |
|
|
| KEYWORDS |
|
| KEYWORD |
| Broca's area |
| Head motion |
| Heritability |
| Resting state fMRI |
| Twin study |
|
| MESH HEADINGS |
|
| DESCRIPTORNAME |
QUALIFIERNAME |
| Adolescent |
|
| Adult |
|
| Brain |
physiology |
| Brain Mapping |
physiology |
| Endophenotypes |
physiology |
| Female |
physiology |
| Head Movements |
physiology |
| Humans |
physiology |
| Magnetic Resonance Imaging |
physiology |
| Male |
physiology |
| Nerve Net |
physiology |
| Rest |
physiology |
| Twins, Dizygotic |
physiology |
| Twins, Monozygotic |
physiology |
| Young Adult |
physiology |
|
| SUPPLEMENTARY MESH |
|
|
| GENE SYMBOLS |
|
|
| CHEMICALS |
|
|
| OTHER ID's |
|
| OTHERID |
SOURCE |
| NIHMS622545 |
NLM |
| PMC4252775 |
NLM |
|
|
