|
|
| PMID |
|
|
| TITLE |
|
| Novel approach identifies SNPs in SLC2A10 and KCNK9 with evidence for parent-of-origin effect on body mass index. |
|
| ABSTRACT |
|
|
|
| The phenotypic effect of some single nucleotide polymorphisms (SNPs) depends on their parental origin. We present a novel approach to detect parent-of-origin effects (POEs) in genome-wide genotype data of unrelated individuals. The method exploits increased phenotypic variance in the heterozygous genotype group relative to the homozygous groups. We applied the method to >56,000 unrelated individuals to search for POEs influencing body mass index (BMI). Six lead SNPs were carried forward for replication in five family-based studies (of ∼4,000 trios). Two SNPs replicated: the paternal rs2471083-C allele (located near the imprinted KCNK9 gene) and the paternal rs3091869-T allele (located near the SLC2A10 gene) increased BMI equally (beta = 0.11 (SD), P<0.0027) compared to the respective maternal alleles. Real-time PCR experiments of lymphoblastoid cell lines from the CEPH families showed that expression of both genes was dependent on parental origin of the SNPs alleles (P<0.01). Our scheme opens new opportunities to exploit GWAS data of unrelated individuals to identify POEs and demonstrates that they play an important role in adult obesity. |
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| DATE PUBLISHED |
|
|
| HISTORY |
|
| PUBSTATUS |
PUBSTATUSDATE |
| received |
2014/02/05 |
| accepted |
2014/05/14 |
| entrez |
2014/08/01 06:00 |
| pubmed |
2014/08/01 06:00 |
| medline |
2015/02/13 06:00 |
|
| AUTHORS |
|
| NAME |
COLLECTIVENAME |
LASTNAME |
FORENAME |
INITIALS |
AFFILIATION |
AFFILIATIONINFO |
| Hoggart CJ |
|
Hoggart |
Clive J |
CJ |
|
Department of Genomics of Common Disease, Imperial College London, London, United Kingdom. |
| Venturini G |
|
Venturini |
Giulia |
G |
|
Department of Medical Genetics, University of Lausanne, Lausanne, Switzerland. |
| Mangino M |
|
Mangino |
Massimo |
M |
|
Department of Twin Research & Genetic Epidemiology, King's College London, London, United Kingdom. |
| Gomez F |
|
Gomez |
Felicia |
F |
|
Department of Genetics, Division of Statistical Genomics, Washington University School of Medicine in St. Louis, St. Louis, Missouri, United States of America. |
| Ascari G |
|
Ascari |
Giulia |
G |
|
Department of Medical Genetics, University of Lausanne, Lausanne, Switzerland. |
| Zhao JH |
|
Zhao |
Jing Hua |
JH |
|
MRC-Epidemiology Unit, University of Cambridge, Cambridge, United Kingdom. |
| Teumer A |
|
Teumer |
Alexander |
A |
|
Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, Germany. |
| Winkler TW |
|
Winkler |
Thomas W |
TW |
|
Department of Genetic Epidemiology, University of Regensburg, Regensburg, Germany. |
| Tšernikova N |
|
Tšernikova |
Natalia |
N |
|
Estonian Genome Center, University of Tartu, Tartu, Estonia; Institute of Molecular and Cell Biology, University of Tartu, Tartu, Estonia. |
| Luan J |
|
Luan |
Jian'an |
J |
|
MRC-Epidemiology Unit, University of Cambridge, Cambridge, United Kingdom. |
| Mihailov E |
|
Mihailov |
Evelin |
E |
|
Estonian Genome Center, University of Tartu, Tartu, Estonia; Estonian Biocentre, Tartu, Estonia. |
| Ehret GB |
|
Ehret |
Georg B |
GB |
|
McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Center for Complex Disease Genomics, Baltimore, Maryland, United States of America; Cardiology, Geneva University Hospitals, Geneva, Switzerland. |
| Zhang W |
|
Zhang |
Weihua |
W |
|
Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom. |
| Lamparter D |
|
Lamparter |
David |
D |
|
Department of Medical Genetics, University of Lausanne, Lausanne, Switzerland; Swiss Institute of Bioinformatics, Lausanne, Switzerland. |
| Esko T |
|
Esko |
Tõnu |
T |
|
Center for Basic and Translational Obesity Research and Divisions of Endocrinology and Genetics, Boston Children's Hospital, Boston, Massachusetts, United States of America; Metabolism Initiative and Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, United States of America; Department of Genetics, Harvard Medical School, Boston, Massachusetts, United States of America. |
| Macé A |
|
Macé |
Aurelien |
A |
|
Department of Medical Genetics, University of Lausanne, Lausanne, Switzerland; Swiss Institute of Bioinformatics, Lausanne, Switzerland. |
| Rüeger S |
|
Rüeger |
Sina |
S |
|
Department of Medical Genetics, University of Lausanne, Lausanne, Switzerland; Swiss Institute of Bioinformatics, Lausanne, Switzerland. |
| Bochud PY |
|
Bochud |
Pierre-Yves |
PY |
|
Infectious Diseases Service, Department of Medicine, Centre Hospitalier Universitaire Vaudois (CHUV), Lausanne, Switzerland. |
| Barcella M |
|
Barcella |
Matteo |
M |
|
Department of Health Sciences, University of Milan, Milan, Italy. |
| Dauvilliers Y |
|
Dauvilliers |
Yves |
Y |
|
INSERM-U1061, Montpellier, France; National Reference Network for Orphan Diseases (Narcolepsy and Idiopathic Hypersomnia), Department of Neurology, Gui-de-Chauliac Hospital, Montpellier, France. |
| Benyamin B |
|
Benyamin |
Beben |
B |
|
Queensland Brain Institute, University of Queensland, Brisbane, Australia; Genetic Epidemiology, QIMR Berghofer Institute of Medical Research, Brisbane, Australia. |
| Evans DM |
|
Evans |
David M |
DM |
|
MRC Integrative Epidemiology Unit, University of Bristol, Bristol, United Kingdom; School of Social and Community Medicine, University of Bristol, Bristol, United Kingdom; Diamantina Institute, Translational Research Institute, University of Queensland, Brisbane, Australia. |
| Hayward C |
|
Hayward |
Caroline |
C |
|
MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, Scotland, United Kingdom. |
| Lopez MF |
|
Lopez |
Mary F |
MF |
|
Center for Basic and Translational Obesity Research and Divisions of Endocrinology and Genetics, Boston Children's Hospital, Boston, Massachusetts, United States of America; Metabolism Initiative and Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, United States of America; Department of Medicine, Harvard Medical School, Boston, Massachusetts, United States of America. |
| Franke L |
|
Franke |
Lude |
L |
|
Department of Genetics, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands. |
| Russo A |
|
Russo |
Alessia |
A |
|
Genomic Variation in Human Populations and Complex Diseases Unit, Human Genetics Foundation and Dept. of Medical Sciences, University of Turin, Turin, Italy. |
| Heid IM |
|
Heid |
Iris M |
IM |
|
Department of Genetic Epidemiology, University of Regensburg, Regensburg, Germany. |
| Salvi E |
|
Salvi |
Erika |
E |
|
Department of Health Sciences, University of Milan, Milan, Italy. |
| Vendantam S |
|
Vendantam |
Sailaja |
S |
|
Center for Basic and Translational Obesity Research and Divisions of Endocrinology and Genetics, Boston Children's Hospital, Boston, Massachusetts, United States of America; Metabolism Initiative and Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, United States of America. |
| Arking DE |
|
Arking |
Dan E |
DE |
|
McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Center for Complex Disease Genomics, Baltimore, Maryland, United States of America. |
| Boerwinkle E |
|
Boerwinkle |
Eric |
E |
|
Human Genetics Center, Houston, Texas, United States of America. |
| Chambers JC |
|
Chambers |
John C |
JC |
|
Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom. |
| Fiorito G |
|
Fiorito |
Giovanni |
G |
|
Genomic Variation in Human Populations and Complex Diseases Unit, Human Genetics Foundation and Dept. of Medical Sciences, University of Turin, Turin, Italy. |
| Grallert H |
|
Grallert |
Harald |
H |
|
Research Unit Molecular Epidemiology, Helmholtz Zentrum München, Neuherberg, Germany. |
| Guarrera S |
|
Guarrera |
Simonetta |
S |
|
Genomic Variation in Human Populations and Complex Diseases Unit, Human Genetics Foundation, Turin, Italy. |
| Homuth G |
|
Homuth |
Georg |
G |
|
Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, Germany. |
| Huffman JE |
|
Huffman |
Jennifer E |
JE |
|
MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, Scotland, United Kingdom. |
| Porteous D |
|
Porteous |
David |
D |
|
Centre for Molecular Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, Scotland, United Kingdom. |
|
Generation Scotland Consortium |
|
|
|
|
|
|
LifeLines Cohort study |
|
|
|
|
|
|
GIANT Consortium |
|
|
|
|
|
| Moradpour D |
|
Moradpour |
Darius |
D |
|
Department of Medicine, Service of Gastroenterology and Hepatology, Lausanne, Switzerland. |
| Iranzo A |
|
Iranzo |
Alex |
A |
|
Neurology Service, Hospital Clinic, Barcelona, Spain. |
| Hebebrand J |
|
Hebebrand |
Johannes |
J |
|
Department of Child and Adolescent Psychiatry, University of Duisburg-Essen, Essen, Germany. |
| Kemp JP |
|
Kemp |
John P |
JP |
|
MRC Integrative Epidemiology Unit, University of Bristol, Bristol, United Kingdom; School of Social and Community Medicine, University of Bristol, Bristol, United Kingdom. |
| Lammers GJ |
|
Lammers |
Gert J |
GJ |
|
Department of Neurology, Leiden University Medical Centre, Leiden, The Netherlands; Sleep Wake Center SEIN, Heemstede, The Netherlands. |
| Aubert V |
|
Aubert |
Vincent |
V |
|
Division of Immunology and Allergy, Centre Hospitalier Universitaire Vaudois (CHUV), Lausanne, Switzerland. |
| Heim MH |
|
Heim |
Markus H |
MH |
|
Department of Gastroenterology, University Hospital Basel, Basel, Switzerland. |
| Martin NG |
|
Martin |
Nicholas G |
NG |
|
Genetic Epidemiology, QIMR Berghofer Institute of Medical Research, Brisbane, Australia. |
| Montgomery GW |
|
Montgomery |
Grant W |
GW |
|
Molecular Epidemiology, QIMR Berghofer Institute of Medical Research, Brisbane, Australia. |
| Peraita-Adrados R |
|
Peraita-Adrados |
Rosa |
R |
|
Sleep and Epilepsy Unit - Clinical Neurophysiology Department, Gregorio Marañón University Hospital, Madrid, Spain. |
| Santamaria J |
|
Santamaria |
Joan |
J |
|
Neurology Service, Hospital Clinic, Barcelona, Spain. |
| Negro F |
|
Negro |
Francesco |
F |
|
Service of Gastroenterology and Hepatology, Service of Clinical Pathology, Geneva, Switzerland. |
| Schmidt CO |
|
Schmidt |
Carsten O |
CO |
|
Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany. |
| Scott RA |
|
Scott |
Robert A |
RA |
|
MRC-Epidemiology Unit, University of Cambridge, Cambridge, United Kingdom. |
| Spector TD |
|
Spector |
Tim D |
TD |
|
Department of Twin Research & Genetic Epidemiology, King's College London, London, United Kingdom. |
| Strauch K |
|
Strauch |
Konstantin |
K |
|
Institute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany; Institute of Medical Informatics, Biometry and Epidemiology, Chair of Genetic Epidemiology, Ludwig-Maximilians-Universität, Munich, Germany. |
| Völzke H |
|
Völzke |
Henry |
H |
|
Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany. |
| Wareham NJ |
|
Wareham |
Nicholas J |
NJ |
|
MRC-Epidemiology Unit, University of Cambridge, Cambridge, United Kingdom. |
| Yuan W |
|
Yuan |
Wei |
W |
|
Department of Twin Research & Genetic Epidemiology, King's College London, London, United Kingdom. |
| Bell JT |
|
Bell |
Jordana T |
JT |
|
Department of Twin Research & Genetic Epidemiology, King's College London, London, United Kingdom. |
| Chakravarti A |
|
Chakravarti |
Aravinda |
A |
|
McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Center for Complex Disease Genomics, Baltimore, Maryland, United States of America. |
| Kooner JS |
|
Kooner |
Jaspal S |
JS |
|
Cardiovascular Science, National Heart & Lung Institute, Imperial College London, London, United Kingdom. |
| Peters A |
|
Peters |
Annette |
A |
|
Institute of Epidemiology II, Helmholtz Zentrum München, Neuherberg, Germany; Deutsches Zentrum für Diabetes, Neuherberg, Germany. |
| Matullo G |
|
Matullo |
Giuseppe |
G |
|
Genomic Variation in Human Populations and Complex Diseases Unit, Human Genetics Foundation and Dept. of Medical Sciences, University of Turin, Turin, Italy. |
| Wallaschofski H |
|
Wallaschofski |
Henri |
H |
|
Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Greifswald, Germany. |
| Whitfield JB |
|
Whitfield |
John B |
JB |
|
Genetic Epidemiology, QIMR Berghofer Institute of Medical Research, Brisbane, Australia. |
| Paccaud F |
|
Paccaud |
Fred |
F |
|
Institute of Social and Preventive Medicine (IUMSP), Centre Hospitalier Universitaire Vaudois (CHUV), Lausanne, Switzerland. |
| Vollenweider P |
|
Vollenweider |
Peter |
P |
|
Department of Internal Medicine, Centre Hospitalier Universitaire Vaudois (CHUV), Lausanne, Switzerland. |
| Bergmann S |
|
Bergmann |
Sven |
S |
|
Department of Medical Genetics, University of Lausanne, Lausanne, Switzerland; Swiss Institute of Bioinformatics, Lausanne, Switzerland. |
| Beckmann JS |
|
Beckmann |
Jacques S |
JS |
|
Swiss Institute of Bioinformatics, Lausanne, Switzerland. |
| Tafti M |
|
Tafti |
Mehdi |
M |
|
Center for Integrative Genomics (CIG), University of Lausanne, Lausanne, Switzerland; Center for Investigation and Research in Sleep (CIRS), Centre Hospitalier Universitaire Vaudois (CHUV), Lausanne, Switzerland. |
| Hastie ND |
|
Hastie |
Nicholas D |
ND |
|
MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, Scotland, United Kingdom. |
| Cusi D |
|
Cusi |
Daniele |
D |
|
Department of Health Sciences, University of Milan, Milan, Italy. |
| Bochud M |
|
Bochud |
Murielle |
M |
|
Institute of Social and Preventive Medicine (IUMSP), Centre Hospitalier Universitaire Vaudois (CHUV), Lausanne, Switzerland. |
| Frayling TM |
|
Frayling |
Timothy M |
TM |
|
University of Exeter Medical School, University of Exeter, Exeter, United Kingdom. |
| Metspalu A |
|
Metspalu |
Andres |
A |
|
Estonian Genome Center, University of Tartu, Tartu, Estonia; Institute of Molecular and Cell Biology, University of Tartu, Tartu, Estonia; Estonian Biocentre, Tartu, Estonia. |
| Jarvelin MR |
|
Jarvelin |
Marjo-Riitta |
MR |
|
Institute of Health Sciences, University of Oulu, Oulu, Finland; Biocenter Oulu, University of Oulu, Oulu, Finland; Department of Children and Young People and Families, National Institute for Health and Welfare, Oulu, Finland; Department of Epidemiology and Biostatistics, School of Public Health, MRC-HPA Centre for Environment and Health, Faculty of Medicine, Imperial College London, London, United Kingdom; Unit of Primary Care, Oulu University Hospital, Oulu, Finland. |
| Scherag A |
|
Scherag |
André |
A |
|
Institute for Medical Informatics, Biometry and Epidemiology, University Hospital of Essen, University of Duisburg-Essen, Essen, Germany; Clinical Epidemiology, Integrated Research and Treatment Center, Center for Sepsis Control and Care (CSCC), Jena University Hospital, Jena, Germany. |
| Smith GD |
|
Smith |
George Davey |
GD |
|
MRC Integrative Epidemiology Unit, University of Bristol, Bristol, United Kingdom; School of Social and Community Medicine, University of Bristol, Bristol, United Kingdom. |
| Borecki IB |
|
Borecki |
Ingrid B |
IB |
|
Department of Genetics, Division of Statistical Genomics, Washington University School of Medicine in St. Louis, St. Louis, Missouri, United States of America. |
| Rousson V |
|
Rousson |
Valentin |
V |
|
Institute of Social and Preventive Medicine (IUMSP), Centre Hospitalier Universitaire Vaudois (CHUV), Lausanne, Switzerland. |
| Hirschhorn JN |
|
Hirschhorn |
Joel N |
JN |
|
Center for Basic and Translational Obesity Research and Divisions of Endocrinology and Genetics, Boston Children's Hospital, Boston, Massachusetts, United States of America; Metabolism Initiative and Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, United States of America; Department of Genetics, Harvard Medical School, Boston, Massachusetts, United States of America. |
| Rivolta C |
|
Rivolta |
Carlo |
C |
|
Department of Medical Genetics, University of Lausanne, Lausanne, Switzerland. |
| Loos RJ |
|
Loos |
Ruth J F |
RJ |
|
MRC-Epidemiology Unit, University of Cambridge, Cambridge, United Kingdom; The Charles Bronfman Institute of Personalized Medicine, The Icahn School of Medicine at Mount Sinai, New York, New York, United States of America; The Mindich Child Health and Development Institute, The Icahn School of Medicine at Mount Sinai, New York, New York, United States of America; The Genetics of Obesity and Related Metabolic Traits Program, The Icahn School of Medicine at Mount Sinai, New York, New York, United States of America. |
| Kutalik Z |
|
Kutalik |
Zoltán |
Z |
|
Department of Medical Genetics, University of Lausanne, Lausanne, Switzerland; Swiss Institute of Bioinformatics, Lausanne, Switzerland; Institute of Social and Preventive Medicine (IUMSP), Centre Hospitalier Universitaire Vaudois (CHUV), Lausanne, Switzerland. |
|
| INVESTIGATORS |
|
| LASTNAME |
FORENAME |
INITIALS |
AFFILIATION |
| de Bakker |
P |
P |
|
| Bültmann |
U |
U |
|
| Geleijnse |
M |
M |
|
| Harst |
P v d |
Pv |
|
| Koppelman |
G |
G |
|
| Rosmalen |
J G M |
JG |
|
| van Rossum |
L |
L |
|
| Smidt |
H |
H |
|
| Swertz |
M A |
MA |
|
| Stolk |
R P |
RP |
|
| Alizadeh |
B |
B |
|
| de Boer |
R |
R |
|
| Boezen |
H M |
HM |
|
| Bruinenberg |
M |
M |
|
| Franke |
L |
L |
|
| van der Harst |
P |
P |
|
| Hillege |
H |
H |
|
| van der Klauw |
M |
M |
|
| Navis |
G |
G |
|
| Ormel |
J |
J |
|
| Postma |
D |
D |
|
| Rosmalen |
J |
J |
|
| Slaets |
J |
J |
|
| Snieder |
H |
H |
|
| Stolk |
R |
R |
|
| Wolffenbuttel |
B |
B |
|
| Wijmenga |
C |
C |
|
| Berg |
Jonathan |
J |
|
| Blackwood |
Douglas |
D |
|
| Campbell |
Harry |
H |
|
| Cavanagh |
Jonathan |
J |
|
| Connell |
John |
J |
|
| Connor |
Mike |
M |
|
| Cunningham-Burley |
Sarah |
S |
|
| Deary |
Ian |
I |
|
| Dominiczak |
Anna |
A |
|
| Ellis |
Paul |
P |
|
| FitzPatrick |
Bridie |
B |
|
| Ford |
Ian |
I |
|
| Gertz |
Rena |
R |
|
| Grau |
Antonio |
A |
|
| Haddow |
Gill |
G |
|
| Jackson |
Cathy |
C |
|
| Kerr |
Shona |
S |
|
| Lindsay |
Robbie |
R |
|
| McGilchrist |
Mark |
M |
|
| McIntyre |
Donald |
D |
|
| Morris |
Andrew |
A |
|
| Morton |
Robin |
R |
|
| Muir |
Walter |
W |
|
| Murray |
Graeme |
G |
|
| Palmer |
Colin |
C |
|
| Pell |
Jill |
J |
|
| Philp |
Alastair |
A |
|
| Porteous |
David |
D |
|
| Porteous |
Mary |
M |
|
| Procter |
Rob |
R |
|
| Ralston |
Stuart |
S |
|
| Reid |
David |
D |
|
| Sinnott |
Richard |
R |
|
| Smith |
Blair |
B |
|
| Clair |
David St |
DS |
|
| Sullivan |
Frank |
F |
|
| Sweetland |
Mary |
M |
|
| Ure |
Jenny |
J |
|
| Watt |
Graham |
G |
|
| Wolf |
Roland |
R |
|
| Wright |
Alan |
A |
|
| Berndt |
Sonja I |
SI |
|
| Gustafsson |
Stefan |
S |
|
| Mägi |
Reedik |
R |
|
| Ganna |
Andrea |
A |
|
| Wheeler |
Eleanor |
E |
|
| Feitosa |
Mary F |
MF |
|
| Justice |
Anne E |
AE |
|
| Monda |
Keri L |
KL |
|
| Croteau- Chonka |
Damien C |
DC |
|
| Day |
Felix R |
FR |
|
| Esko |
Tonu |
T |
|
| Fall |
Tove |
T |
|
| Ferreira |
Teresa |
T |
|
| Gentilini |
Davide |
D |
|
| Jackson |
Anne U |
AU |
|
| Luan |
Jian'an |
J |
|
| Randall |
Joshua C |
JC |
|
| Vedantam |
Sailaja |
S |
|
| Willer |
Cristen J |
CJ |
|
| Winkler |
Thomas W |
TW |
|
| Wood |
Andrew R |
AR |
|
| Workalemahu |
Tsegaselassie |
T |
|
| Hu |
Yi-Juan |
YJ |
|
| Lee |
Sang Hong |
SH |
|
| Liang |
Liming |
L |
|
| Lin |
Dan-Yu |
DY |
|
| Min |
Josine L |
JL |
|
| Neale |
Benjamin M |
BM |
|
| Thorleifsson |
Gudmar |
G |
|
| Yang |
Jian |
J |
|
| Albrecht |
Eva |
E |
|
| Amin |
Najaf |
N |
|
| Bragg-Gresham |
Jennifer L |
JL |
|
| Cadby |
Gemma |
G |
|
| den Heijer |
Martin |
M |
|
| Eklund |
Niina |
N |
|
| Fischer |
Krista |
K |
|
| Goel |
Anuj |
A |
|
| Hottenga |
Jouke-Jan |
JJ |
|
| Huffman |
Jennifer E |
JE |
|
| Jarick |
Ivonne |
I |
|
| Johansson |
Asa |
A |
|
| Johnson |
Toby |
T |
|
| Kanoni |
Stavroula |
S |
|
| Kleber |
Marcus E |
ME |
|
| König |
Inke R |
IR |
|
| Kristiansson |
Kati |
K |
|
| Kutalik |
Zoltán |
Z |
|
| Lamina |
Claudia |
C |
|
| Lecoeur |
Cecile |
C |
|
| Li |
Guo |
G |
|
| Mangino |
Massimo |
M |
|
| McArdle |
Wendy L |
WL |
|
| Medina-Gomez |
Carolina |
C |
|
| Müller-Nurasyid |
Martina |
M |
|
| Ngwa |
Julius S |
JS |
|
| Nolte |
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|
| JOURNAL |
|
| VOLUME: 10 |
| ISSUE: 7 |
| TITLE: PLoS genetics |
| ISOABBREVIATION: PLoS Genet |
| YEAR: 2014 |
| MONTH: Jul |
| DAY: |
| MEDLINEDATE: |
| SEASON: |
| CITEDMEDIUM: Internet |
| ISSN: 1553-7404 |
| ISSNTYPE: Electronic |
|
| MEDLINE JOURNAL |
|
| MEDLINETA: PLoS Genet |
| COUNTRY: United States |
| ISSNLINKING: 1553-7390 |
| NLMUNIQUEID: 101239074 |
|
| PUBLICATION TYPE |
|
| PUBLICATIONTYPE TEXT |
| Journal Article |
| Meta-Analysis |
| Research Support, N.I.H., Extramural |
| Research Support, Non-U.S. Gov't |
|
| COMMENTS AND CORRECTIONS |
|
| REFTYPE |
REFSOURCE |
REFPMID |
NOTE |
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|
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United Kingdom |
| 5R01HL087679-02 |
NHLBI NIH HHS |
United States |
| BB/F019394/1 |
Biotechnology and Biological Sciences Research Council |
United Kingdom |
| RL1 MH083268 |
NIMH NIH HHS |
United States |
| AA07535 |
NIAAA NIH HHS |
United States |
| WT083431MA |
Wellcome Trust |
United Kingdom |
| T32 HL007055 |
NHLBI NIH HHS |
United States |
| G9815508 |
Medical Research Council |
United Kingdom |
| R01 AA013320 |
NIAAA NIH HHS |
United States |
| R01HL086694 |
NHLBI NIH HHS |
United States |
| G0600705 |
Medical Research Council |
United Kingdom |
| G0700931 |
Medical Research Council |
United Kingdom |
|
| GENERAL NOTE |
|
|
| KEYWORDS |
|
|
| MESH HEADINGS |
|
| DESCRIPTORNAME |
QUALIFIERNAME |
| Adult |
|
| Body Mass Index |
|
| European Continental Ancestry Group |
genetics |
| Female |
genetics |
| Gene Expression Regulation |
genetics |
| Genetic Predisposition to Disease |
genetics |
| Genome-Wide Association Study |
genetics |
| Genomic Imprinting |
genetics |
| Genotype |
genetics |
| Glucose Transport Proteins, Facilitative |
genetics |
| Humans |
genetics |
| Male |
genetics |
| Obesity |
pathology |
| Polymorphism, Single Nucleotide |
genetics |
| Potassium Channels, Tandem Pore Domain |
genetics |
|
| SUPPLEMENTARY MESH |
|
|
| GENE SYMBOLS |
|
|
| CHEMICALS |
|
| REGISTRYNUMBER |
NAMEOFSUBSTANCE |
| 0 |
Glucose Transport Proteins, Facilitative |
| 0 |
KCNK9 protein, human |
| 0 |
Potassium Channels, Tandem Pore Domain |
| 0 |
SLC2A10 protein, human |
|
| OTHER ID's |
|
|
|
