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PMID |
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TITLE |
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Novel approach identifies SNPs in SLC2A10 and KCNK9 with evidence for parent-of-origin effect on body mass index. |
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ABSTRACT |
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The phenotypic effect of some single nucleotide polymorphisms (SNPs) depends on their parental origin. We present a novel approach to detect parent-of-origin effects (POEs) in genome-wide genotype data of unrelated individuals. The method exploits increased phenotypic variance in the heterozygous genotype group relative to the homozygous groups. We applied the method to >56,000 unrelated individuals to search for POEs influencing body mass index (BMI). Six lead SNPs were carried forward for replication in five family-based studies (of ∼4,000 trios). Two SNPs replicated: the paternal rs2471083-C allele (located near the imprinted KCNK9 gene) and the paternal rs3091869-T allele (located near the SLC2A10 gene) increased BMI equally (beta = 0.11 (SD), P<0.0027) compared to the respective maternal alleles. Real-time PCR experiments of lymphoblastoid cell lines from the CEPH families showed that expression of both genes was dependent on parental origin of the SNPs alleles (P<0.01). Our scheme opens new opportunities to exploit GWAS data of unrelated individuals to identify POEs and demonstrates that they play an important role in adult obesity. |
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DATE PUBLISHED |
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HISTORY |
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PUBSTATUS |
PUBSTATUSDATE |
received |
2014/02/05 |
accepted |
2014/05/14 |
entrez |
2014/08/01 06:00 |
pubmed |
2014/08/01 06:00 |
medline |
2015/02/13 06:00 |
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AUTHORS |
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NAME |
COLLECTIVENAME |
LASTNAME |
FORENAME |
INITIALS |
AFFILIATION |
AFFILIATIONINFO |
Hoggart CJ |
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Hoggart |
Clive J |
CJ |
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Department of Genomics of Common Disease, Imperial College London, London, United Kingdom. |
Venturini G |
|
Venturini |
Giulia |
G |
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Department of Medical Genetics, University of Lausanne, Lausanne, Switzerland. |
Mangino M |
|
Mangino |
Massimo |
M |
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Department of Twin Research & Genetic Epidemiology, King's College London, London, United Kingdom. |
Gomez F |
|
Gomez |
Felicia |
F |
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Department of Genetics, Division of Statistical Genomics, Washington University School of Medicine in St. Louis, St. Louis, Missouri, United States of America. |
Ascari G |
|
Ascari |
Giulia |
G |
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Department of Medical Genetics, University of Lausanne, Lausanne, Switzerland. |
Zhao JH |
|
Zhao |
Jing Hua |
JH |
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MRC-Epidemiology Unit, University of Cambridge, Cambridge, United Kingdom. |
Teumer A |
|
Teumer |
Alexander |
A |
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Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, Germany. |
Winkler TW |
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Winkler |
Thomas W |
TW |
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Department of Genetic Epidemiology, University of Regensburg, Regensburg, Germany. |
Tšernikova N |
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Tšernikova |
Natalia |
N |
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Estonian Genome Center, University of Tartu, Tartu, Estonia; Institute of Molecular and Cell Biology, University of Tartu, Tartu, Estonia. |
Luan J |
|
Luan |
Jian'an |
J |
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MRC-Epidemiology Unit, University of Cambridge, Cambridge, United Kingdom. |
Mihailov E |
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Mihailov |
Evelin |
E |
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Estonian Genome Center, University of Tartu, Tartu, Estonia; Estonian Biocentre, Tartu, Estonia. |
Ehret GB |
|
Ehret |
Georg B |
GB |
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McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Center for Complex Disease Genomics, Baltimore, Maryland, United States of America; Cardiology, Geneva University Hospitals, Geneva, Switzerland. |
Zhang W |
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Zhang |
Weihua |
W |
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Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom. |
Lamparter D |
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Lamparter |
David |
D |
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Department of Medical Genetics, University of Lausanne, Lausanne, Switzerland; Swiss Institute of Bioinformatics, Lausanne, Switzerland. |
Esko T |
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Esko |
Tõnu |
T |
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Center for Basic and Translational Obesity Research and Divisions of Endocrinology and Genetics, Boston Children's Hospital, Boston, Massachusetts, United States of America; Metabolism Initiative and Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, United States of America; Department of Genetics, Harvard Medical School, Boston, Massachusetts, United States of America. |
Macé A |
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Macé |
Aurelien |
A |
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Department of Medical Genetics, University of Lausanne, Lausanne, Switzerland; Swiss Institute of Bioinformatics, Lausanne, Switzerland. |
Rüeger S |
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Rüeger |
Sina |
S |
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Department of Medical Genetics, University of Lausanne, Lausanne, Switzerland; Swiss Institute of Bioinformatics, Lausanne, Switzerland. |
Bochud PY |
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Bochud |
Pierre-Yves |
PY |
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Infectious Diseases Service, Department of Medicine, Centre Hospitalier Universitaire Vaudois (CHUV), Lausanne, Switzerland. |
Barcella M |
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Barcella |
Matteo |
M |
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Department of Health Sciences, University of Milan, Milan, Italy. |
Dauvilliers Y |
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Dauvilliers |
Yves |
Y |
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INSERM-U1061, Montpellier, France; National Reference Network for Orphan Diseases (Narcolepsy and Idiopathic Hypersomnia), Department of Neurology, Gui-de-Chauliac Hospital, Montpellier, France. |
Benyamin B |
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Benyamin |
Beben |
B |
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Queensland Brain Institute, University of Queensland, Brisbane, Australia; Genetic Epidemiology, QIMR Berghofer Institute of Medical Research, Brisbane, Australia. |
Evans DM |
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Evans |
David M |
DM |
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MRC Integrative Epidemiology Unit, University of Bristol, Bristol, United Kingdom; School of Social and Community Medicine, University of Bristol, Bristol, United Kingdom; Diamantina Institute, Translational Research Institute, University of Queensland, Brisbane, Australia. |
Hayward C |
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Hayward |
Caroline |
C |
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MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, Scotland, United Kingdom. |
Lopez MF |
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Lopez |
Mary F |
MF |
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Center for Basic and Translational Obesity Research and Divisions of Endocrinology and Genetics, Boston Children's Hospital, Boston, Massachusetts, United States of America; Metabolism Initiative and Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, United States of America; Department of Medicine, Harvard Medical School, Boston, Massachusetts, United States of America. |
Franke L |
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Franke |
Lude |
L |
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Department of Genetics, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands. |
Russo A |
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Russo |
Alessia |
A |
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Genomic Variation in Human Populations and Complex Diseases Unit, Human Genetics Foundation and Dept. of Medical Sciences, University of Turin, Turin, Italy. |
Heid IM |
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Heid |
Iris M |
IM |
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Department of Genetic Epidemiology, University of Regensburg, Regensburg, Germany. |
Salvi E |
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Salvi |
Erika |
E |
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Department of Health Sciences, University of Milan, Milan, Italy. |
Vendantam S |
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Vendantam |
Sailaja |
S |
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Center for Basic and Translational Obesity Research and Divisions of Endocrinology and Genetics, Boston Children's Hospital, Boston, Massachusetts, United States of America; Metabolism Initiative and Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, United States of America. |
Arking DE |
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Arking |
Dan E |
DE |
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McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Center for Complex Disease Genomics, Baltimore, Maryland, United States of America. |
Boerwinkle E |
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Boerwinkle |
Eric |
E |
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Human Genetics Center, Houston, Texas, United States of America. |
Chambers JC |
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Chambers |
John C |
JC |
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Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom. |
Fiorito G |
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Fiorito |
Giovanni |
G |
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Genomic Variation in Human Populations and Complex Diseases Unit, Human Genetics Foundation and Dept. of Medical Sciences, University of Turin, Turin, Italy. |
Grallert H |
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Grallert |
Harald |
H |
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Research Unit Molecular Epidemiology, Helmholtz Zentrum München, Neuherberg, Germany. |
Guarrera S |
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Guarrera |
Simonetta |
S |
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Genomic Variation in Human Populations and Complex Diseases Unit, Human Genetics Foundation, Turin, Italy. |
Homuth G |
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Homuth |
Georg |
G |
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Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, Germany. |
Huffman JE |
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Huffman |
Jennifer E |
JE |
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MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, Scotland, United Kingdom. |
Porteous D |
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Porteous |
David |
D |
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Centre for Molecular Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, Scotland, United Kingdom. |
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Generation Scotland Consortium |
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LifeLines Cohort study |
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GIANT Consortium |
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Moradpour D |
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Moradpour |
Darius |
D |
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Department of Medicine, Service of Gastroenterology and Hepatology, Lausanne, Switzerland. |
Iranzo A |
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Iranzo |
Alex |
A |
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Neurology Service, Hospital Clinic, Barcelona, Spain. |
Hebebrand J |
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Hebebrand |
Johannes |
J |
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Department of Child and Adolescent Psychiatry, University of Duisburg-Essen, Essen, Germany. |
Kemp JP |
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Kemp |
John P |
JP |
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MRC Integrative Epidemiology Unit, University of Bristol, Bristol, United Kingdom; School of Social and Community Medicine, University of Bristol, Bristol, United Kingdom. |
Lammers GJ |
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Lammers |
Gert J |
GJ |
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Department of Neurology, Leiden University Medical Centre, Leiden, The Netherlands; Sleep Wake Center SEIN, Heemstede, The Netherlands. |
Aubert V |
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Aubert |
Vincent |
V |
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Division of Immunology and Allergy, Centre Hospitalier Universitaire Vaudois (CHUV), Lausanne, Switzerland. |
Heim MH |
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Heim |
Markus H |
MH |
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Department of Gastroenterology, University Hospital Basel, Basel, Switzerland. |
Martin NG |
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Martin |
Nicholas G |
NG |
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Genetic Epidemiology, QIMR Berghofer Institute of Medical Research, Brisbane, Australia. |
Montgomery GW |
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Montgomery |
Grant W |
GW |
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Molecular Epidemiology, QIMR Berghofer Institute of Medical Research, Brisbane, Australia. |
Peraita-Adrados R |
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Peraita-Adrados |
Rosa |
R |
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Sleep and Epilepsy Unit - Clinical Neurophysiology Department, Gregorio Marañón University Hospital, Madrid, Spain. |
Santamaria J |
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Santamaria |
Joan |
J |
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Neurology Service, Hospital Clinic, Barcelona, Spain. |
Negro F |
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Negro |
Francesco |
F |
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Service of Gastroenterology and Hepatology, Service of Clinical Pathology, Geneva, Switzerland. |
Schmidt CO |
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Schmidt |
Carsten O |
CO |
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Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany. |
Scott RA |
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Scott |
Robert A |
RA |
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MRC-Epidemiology Unit, University of Cambridge, Cambridge, United Kingdom. |
Spector TD |
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Spector |
Tim D |
TD |
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Department of Twin Research & Genetic Epidemiology, King's College London, London, United Kingdom. |
Strauch K |
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Strauch |
Konstantin |
K |
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Institute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany; Institute of Medical Informatics, Biometry and Epidemiology, Chair of Genetic Epidemiology, Ludwig-Maximilians-Universität, Munich, Germany. |
Völzke H |
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Völzke |
Henry |
H |
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Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany. |
Wareham NJ |
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Wareham |
Nicholas J |
NJ |
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MRC-Epidemiology Unit, University of Cambridge, Cambridge, United Kingdom. |
Yuan W |
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Yuan |
Wei |
W |
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Department of Twin Research & Genetic Epidemiology, King's College London, London, United Kingdom. |
Bell JT |
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Bell |
Jordana T |
JT |
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Department of Twin Research & Genetic Epidemiology, King's College London, London, United Kingdom. |
Chakravarti A |
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Chakravarti |
Aravinda |
A |
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McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Center for Complex Disease Genomics, Baltimore, Maryland, United States of America. |
Kooner JS |
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Kooner |
Jaspal S |
JS |
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Cardiovascular Science, National Heart & Lung Institute, Imperial College London, London, United Kingdom. |
Peters A |
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Peters |
Annette |
A |
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Institute of Epidemiology II, Helmholtz Zentrum München, Neuherberg, Germany; Deutsches Zentrum für Diabetes, Neuherberg, Germany. |
Matullo G |
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Matullo |
Giuseppe |
G |
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Genomic Variation in Human Populations and Complex Diseases Unit, Human Genetics Foundation and Dept. of Medical Sciences, University of Turin, Turin, Italy. |
Wallaschofski H |
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Wallaschofski |
Henri |
H |
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Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Greifswald, Germany. |
Whitfield JB |
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Whitfield |
John B |
JB |
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Genetic Epidemiology, QIMR Berghofer Institute of Medical Research, Brisbane, Australia. |
Paccaud F |
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Paccaud |
Fred |
F |
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Institute of Social and Preventive Medicine (IUMSP), Centre Hospitalier Universitaire Vaudois (CHUV), Lausanne, Switzerland. |
Vollenweider P |
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Vollenweider |
Peter |
P |
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Department of Internal Medicine, Centre Hospitalier Universitaire Vaudois (CHUV), Lausanne, Switzerland. |
Bergmann S |
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Bergmann |
Sven |
S |
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Department of Medical Genetics, University of Lausanne, Lausanne, Switzerland; Swiss Institute of Bioinformatics, Lausanne, Switzerland. |
Beckmann JS |
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Beckmann |
Jacques S |
JS |
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Swiss Institute of Bioinformatics, Lausanne, Switzerland. |
Tafti M |
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Tafti |
Mehdi |
M |
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Center for Integrative Genomics (CIG), University of Lausanne, Lausanne, Switzerland; Center for Investigation and Research in Sleep (CIRS), Centre Hospitalier Universitaire Vaudois (CHUV), Lausanne, Switzerland. |
Hastie ND |
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Hastie |
Nicholas D |
ND |
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MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, Scotland, United Kingdom. |
Cusi D |
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Cusi |
Daniele |
D |
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Department of Health Sciences, University of Milan, Milan, Italy. |
Bochud M |
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Bochud |
Murielle |
M |
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Institute of Social and Preventive Medicine (IUMSP), Centre Hospitalier Universitaire Vaudois (CHUV), Lausanne, Switzerland. |
Frayling TM |
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Frayling |
Timothy M |
TM |
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University of Exeter Medical School, University of Exeter, Exeter, United Kingdom. |
Metspalu A |
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Metspalu |
Andres |
A |
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Estonian Genome Center, University of Tartu, Tartu, Estonia; Institute of Molecular and Cell Biology, University of Tartu, Tartu, Estonia; Estonian Biocentre, Tartu, Estonia. |
Jarvelin MR |
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Jarvelin |
Marjo-Riitta |
MR |
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Institute of Health Sciences, University of Oulu, Oulu, Finland; Biocenter Oulu, University of Oulu, Oulu, Finland; Department of Children and Young People and Families, National Institute for Health and Welfare, Oulu, Finland; Department of Epidemiology and Biostatistics, School of Public Health, MRC-HPA Centre for Environment and Health, Faculty of Medicine, Imperial College London, London, United Kingdom; Unit of Primary Care, Oulu University Hospital, Oulu, Finland. |
Scherag A |
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Scherag |
André |
A |
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Institute for Medical Informatics, Biometry and Epidemiology, University Hospital of Essen, University of Duisburg-Essen, Essen, Germany; Clinical Epidemiology, Integrated Research and Treatment Center, Center for Sepsis Control and Care (CSCC), Jena University Hospital, Jena, Germany. |
Smith GD |
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Smith |
George Davey |
GD |
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MRC Integrative Epidemiology Unit, University of Bristol, Bristol, United Kingdom; School of Social and Community Medicine, University of Bristol, Bristol, United Kingdom. |
Borecki IB |
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Borecki |
Ingrid B |
IB |
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Department of Genetics, Division of Statistical Genomics, Washington University School of Medicine in St. Louis, St. Louis, Missouri, United States of America. |
Rousson V |
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Rousson |
Valentin |
V |
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Institute of Social and Preventive Medicine (IUMSP), Centre Hospitalier Universitaire Vaudois (CHUV), Lausanne, Switzerland. |
Hirschhorn JN |
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Hirschhorn |
Joel N |
JN |
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Center for Basic and Translational Obesity Research and Divisions of Endocrinology and Genetics, Boston Children's Hospital, Boston, Massachusetts, United States of America; Metabolism Initiative and Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, United States of America; Department of Genetics, Harvard Medical School, Boston, Massachusetts, United States of America. |
Rivolta C |
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Rivolta |
Carlo |
C |
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Department of Medical Genetics, University of Lausanne, Lausanne, Switzerland. |
Loos RJ |
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Loos |
Ruth J F |
RJ |
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MRC-Epidemiology Unit, University of Cambridge, Cambridge, United Kingdom; The Charles Bronfman Institute of Personalized Medicine, The Icahn School of Medicine at Mount Sinai, New York, New York, United States of America; The Mindich Child Health and Development Institute, The Icahn School of Medicine at Mount Sinai, New York, New York, United States of America; The Genetics of Obesity and Related Metabolic Traits Program, The Icahn School of Medicine at Mount Sinai, New York, New York, United States of America. |
Kutalik Z |
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Kutalik |
Zoltán |
Z |
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Department of Medical Genetics, University of Lausanne, Lausanne, Switzerland; Swiss Institute of Bioinformatics, Lausanne, Switzerland; Institute of Social and Preventive Medicine (IUMSP), Centre Hospitalier Universitaire Vaudois (CHUV), Lausanne, Switzerland. |
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INVESTIGATORS |
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LASTNAME |
FORENAME |
INITIALS |
AFFILIATION |
de Bakker |
P |
P |
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Bültmann |
U |
U |
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Geleijnse |
M |
M |
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Harst |
P v d |
Pv |
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Koppelman |
G |
G |
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Rosmalen |
J G M |
JG |
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van Rossum |
L |
L |
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Smidt |
H |
H |
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Swertz |
M A |
MA |
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Stolk |
R P |
RP |
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Alizadeh |
B |
B |
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de Boer |
R |
R |
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Boezen |
H M |
HM |
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Bruinenberg |
M |
M |
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Franke |
L |
L |
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van der Harst |
P |
P |
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Hillege |
H |
H |
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van der Klauw |
M |
M |
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Navis |
G |
G |
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Ormel |
J |
J |
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Postma |
D |
D |
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Rosmalen |
J |
J |
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Slaets |
J |
J |
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Snieder |
H |
H |
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Stolk |
R |
R |
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Wolffenbuttel |
B |
B |
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Wijmenga |
C |
C |
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Berg |
Jonathan |
J |
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Blackwood |
Douglas |
D |
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Campbell |
Harry |
H |
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Cavanagh |
Jonathan |
J |
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Connell |
John |
J |
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Connor |
Mike |
M |
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Cunningham-Burley |
Sarah |
S |
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Deary |
Ian |
I |
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Dominiczak |
Anna |
A |
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Ellis |
Paul |
P |
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FitzPatrick |
Bridie |
B |
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Ford |
Ian |
I |
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Gertz |
Rena |
R |
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Grau |
Antonio |
A |
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Haddow |
Gill |
G |
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Jackson |
Cathy |
C |
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Kerr |
Shona |
S |
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Lindsay |
Robbie |
R |
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McGilchrist |
Mark |
M |
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McIntyre |
Donald |
D |
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Morris |
Andrew |
A |
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Morton |
Robin |
R |
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Muir |
Walter |
W |
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Murray |
Graeme |
G |
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Palmer |
Colin |
C |
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Pell |
Jill |
J |
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Philp |
Alastair |
A |
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Porteous |
David |
D |
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Porteous |
Mary |
M |
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Procter |
Rob |
R |
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Ralston |
Stuart |
S |
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Reid |
David |
D |
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Sinnott |
Richard |
R |
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Smith |
Blair |
B |
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Clair |
David St |
DS |
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Sullivan |
Frank |
F |
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Sweetland |
Mary |
M |
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Ure |
Jenny |
J |
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Watt |
Graham |
G |
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Wolf |
Roland |
R |
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Wright |
Alan |
A |
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Berndt |
Sonja I |
SI |
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Gustafsson |
Stefan |
S |
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Mägi |
Reedik |
R |
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Ganna |
Andrea |
A |
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Wheeler |
Eleanor |
E |
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Feitosa |
Mary F |
MF |
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Justice |
Anne E |
AE |
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Monda |
Keri L |
KL |
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Croteau- Chonka |
Damien C |
DC |
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Day |
Felix R |
FR |
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Esko |
Tonu |
T |
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Fall |
Tove |
T |
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Ferreira |
Teresa |
T |
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Gentilini |
Davide |
D |
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Jackson |
Anne U |
AU |
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Luan |
Jian'an |
J |
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Randall |
Joshua C |
JC |
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Vedantam |
Sailaja |
S |
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Willer |
Cristen J |
CJ |
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Winkler |
Thomas W |
TW |
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Wood |
Andrew R |
AR |
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Workalemahu |
Tsegaselassie |
T |
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Hu |
Yi-Juan |
YJ |
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Lee |
Sang Hong |
SH |
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Liang |
Liming |
L |
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Lin |
Dan-Yu |
DY |
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Min |
Josine L |
JL |
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Neale |
Benjamin M |
BM |
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Thorleifsson |
Gudmar |
G |
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Yang |
Jian |
J |
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Albrecht |
Eva |
E |
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Amin |
Najaf |
N |
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Bragg-Gresham |
Jennifer L |
JL |
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Cadby |
Gemma |
G |
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den Heijer |
Martin |
M |
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Eklund |
Niina |
N |
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Fischer |
Krista |
K |
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Goel |
Anuj |
A |
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Hottenga |
Jouke-Jan |
JJ |
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Huffman |
Jennifer E |
JE |
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Jarick |
Ivonne |
I |
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Johansson |
Asa |
A |
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Johnson |
Toby |
T |
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Kanoni |
Stavroula |
S |
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Kleber |
Marcus E |
ME |
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König |
Inke R |
IR |
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Kristiansson |
Kati |
K |
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Kutalik |
Zoltán |
Z |
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Lamina |
Claudia |
C |
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Lecoeur |
Cecile |
C |
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Li |
Guo |
G |
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Mangino |
Massimo |
M |
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McArdle |
Wendy L |
WL |
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Medina-Gomez |
Carolina |
C |
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Müller-Nurasyid |
Martina |
M |
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Ngwa |
Julius S |
JS |
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Nolte |
Ilja M |
IM |
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Paternoster |
Lavinia |
L |
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Pechlivanis |
Sonali |
S |
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Perola |
Markus |
M |
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Peters |
Marjolein J |
MJ |
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Preuss |
Michael |
M |
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Rose |
Lynda M |
LM |
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Shi |
Jianxin |
J |
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Shungin |
Dmitry |
D |
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Smith |
Albert Vernon |
AV |
|
Strawbridge |
Rona J |
RJ |
|
Surakka |
Ida |
I |
|
Teumer |
Alexander |
A |
|
Trip |
Mieke D |
MD |
|
Tyrer |
Jonathan |
J |
|
Van Vliet- Ostaptchouk |
Jana V |
JV |
|
Vandenput |
Liesbeth |
L |
|
Waite |
Lindsay L |
LL |
|
Zhao |
Jing Hua |
JH |
|
Absher |
Devin |
D |
|
Asselbergs |
Folkert W |
FW |
|
Atalay |
Mustafa |
M |
|
Attwood |
Antony P |
AP |
|
Balmforth |
Anthony J |
AJ |
|
Basart |
Hanneke |
H |
|
Beilby |
John |
J |
|
Bonnycastle |
Lori L |
LL |
|
Brambilla |
Paolo |
P |
|
Bruinenberg |
Marcel |
M |
|
Campbell |
Harry |
H |
|
Chasman |
Daniel I |
DI |
|
Chines |
Peter S |
PS |
|
Collins |
Francis S |
FS |
|
Connell |
John M |
JM |
|
Cookson |
William |
W |
|
de Faire |
Ulf |
U |
|
de Vegt |
Femmie |
F |
|
Dei |
Mariano |
M |
|
Dimitriou |
Maria |
M |
|
Edkins |
Sarah |
S |
|
Estrada |
Karol |
K |
|
Evans |
David M |
DM |
|
Farrall |
Martin |
M |
|
Ferrario |
Marco M |
MM |
|
Ferrières |
Jean |
J |
|
Franke |
Lude |
L |
|
Frau |
Francesca |
F |
|
Gejman |
Pablo V |
PV |
|
Grallert |
Harald |
H |
|
Grönberg |
Henrik |
H |
|
Gudnason |
Vilmundur |
V |
|
Hall |
Alistair S |
AS |
|
Hall |
Per |
P |
|
Hartikainen |
Anna-Liisa |
AL |
|
Hayward |
Caroline |
C |
|
Heard-Costa |
Nancy L |
NL |
|
Heath |
Andrew C |
AC |
|
Hebebrand |
Johannes |
J |
|
Homuth |
Georg |
G |
|
Hu |
Frank B |
FB |
|
Hunt |
Sarah E |
SE |
|
Hyppönen |
Elina |
E |
|
Iribarren |
Carlos |
C |
|
Jacobs |
Kevin B |
KB |
|
Jansson |
John-Olov |
JO |
|
Jula |
Antti |
A |
|
Kähönen |
Mika |
M |
|
Kathiresan |
Sekar |
S |
|
Kee |
Frank |
F |
|
Khaw |
Kay-Tee |
KT |
|
Kivimaki |
Mika |
M |
|
Koenig |
Wolfgang |
W |
|
Kraja |
Aldi T |
AT |
|
Kumari |
Meena |
M |
|
Kuulasmaa |
Kari |
K |
|
Kuusisto |
Johanna |
J |
|
Laitinen |
Jaana H |
JH |
|
Lakka |
Timo A |
TA |
|
Langenberg |
Claudia |
C |
|
Launer |
Lenore J |
LJ |
|
Lind |
Lars |
L |
|
Lindström |
Jaana |
J |
|
Liu |
Jianjun |
J |
|
Liuzzi |
Antonio |
A |
|
Lokki |
Marja-Liisa |
ML |
|
Lorentzon |
Mattias |
M |
|
Madden |
Pamela A |
PA |
|
Magnusson |
Patrik K |
PK |
|
Manunta |
Paolo |
P |
|
Marek |
Diana |
D |
|
März |
Winfried |
W |
|
Mateo Leach |
Irene |
I |
|
McKnight |
Barbara |
B |
|
Medland |
Sarah E |
SE |
|
Mihailov |
Evelin |
E |
|
Milani |
Lili |
L |
|
Montgomery |
Grant W |
GW |
|
Mooser |
Vincent |
V |
|
Mühleisen |
Thomas W |
TW |
|
Munroe |
Patricia B |
PB |
|
Musk |
Arthur W |
AW |
|
Narisu |
Narisu |
N |
|
Navis |
Gerjan |
G |
|
Nicholson |
George |
G |
|
Nohr |
Ellen A |
EA |
|
Ong |
Ken K |
KK |
|
Oostra |
Ben A |
BA |
|
Palmer |
Colin N A |
CN |
|
Palotie |
Aarno |
A |
|
Peden |
John F |
JF |
|
Pedersen |
Nancy |
N |
|
Peters |
Annette |
A |
|
Polasek |
Ozren |
O |
|
Pouta |
Anneli |
A |
|
Pramstaller |
Peter P |
PP |
|
Prokopenko |
Inga |
I |
|
Pütter |
Carolin |
C |
|
Radhakrishnan |
Aparna |
A |
|
Raitakari |
Olli |
O |
|
Rendon |
Augusto |
A |
|
Rivadeneira |
Fernando |
F |
|
Rudan |
Igor |
I |
|
Saaristo |
Timo E |
TE |
|
Sambrook |
Jennifer G |
JG |
|
Sanders |
Alan R |
AR |
|
Sanna |
Serena |
S |
|
Saramies |
Jouko |
J |
|
Schipf |
Sabine |
S |
|
Schreiber |
Stefan |
S |
|
Schunkert |
Heribert |
H |
|
Shin |
So-Youn |
SY |
|
Signorini |
Stefano |
S |
|
Sinisalo |
Juha |
J |
|
Skrobek |
Boris |
B |
|
Soranzo |
Nicole |
N |
|
Stancakova |
Alena |
A |
|
Stark |
Klaus |
K |
|
Stephens |
Jonathan C |
JC |
|
Stirrups |
Kathleen |
K |
|
Stolk |
Ronald P |
RP |
|
Stumvoll |
Michael |
M |
|
Swift |
Amy J |
AJ |
|
Theodoraki |
Eirini V |
EV |
|
Thorand |
Barbara |
B |
|
Tregouet |
David-Alexandre |
DA |
|
Tremoli |
Elena |
E |
|
Van der Klauw |
Melanie M |
MM |
|
van Meurs |
Joyce B J |
JB |
|
Vermeulen |
Sita H |
SH |
|
Viikari |
Jorma |
J |
|
Virtamo |
Jarmo |
J |
|
Vitart |
Veronique |
V |
|
Waeber |
Gérard |
G |
|
Wang |
Zhaoming |
Z |
|
Widen |
Elisabeth |
E |
|
Wild |
Sarah H |
SH |
|
Willemsen |
Gonneke |
G |
|
Winkelmann |
Bernhard R |
BR |
|
Witteman |
Jacqueline C M |
JC |
|
Wolffenbuttel |
Bruce H R |
BH |
|
Wong |
Andrew |
A |
|
Wright |
Alan F |
AF |
|
Zillikens |
M Carola |
M |
|
Amouyel |
Philippe |
P |
|
Boehm |
Bernhard O |
BO |
|
Boerwinkle |
Eric |
E |
|
Boomsma |
Dorret I |
DI |
|
Caulfield |
Mark J |
MJ |
|
Chanock |
Stephen J |
SJ |
|
Cupples |
L Adrienne |
L |
|
Cusi |
Daniele |
D |
|
Dedoussis |
George V |
GV |
|
Erdmann |
Jeanette |
J |
|
Eriksson |
Johan G |
JG |
|
Franks |
Paul W |
PW |
|
Froguel |
Philippe |
P |
|
Gieger |
Christian |
C |
|
Gyllensten |
Ulf |
U |
|
Hamsten |
Anders |
A |
|
Harris |
Tamara B |
TB |
|
Hengstenberg |
Christian |
C |
|
Hicks |
Andrew A |
AA |
|
Hingorani |
Aroon |
A |
|
Hinney |
Anke |
A |
|
Hofman |
Albert |
A |
|
Hovingh |
Kees G |
KG |
|
Hveem |
Kristian |
K |
|
Illig |
Thomas |
T |
|
Jarvelin |
Marjo-Riitta |
MR |
|
Jöckel |
Karl-Heinz |
KH |
|
Keinanen-Kiukaanniemi |
Sirkka M |
SM |
|
Kiemeney |
Lambertus A |
LA |
|
Kuh |
Diana |
D |
|
Laakso |
Markku |
M |
|
Lehtimäki |
Terho |
T |
|
Levinson |
Douglas F |
DF |
|
Martin |
Nicholas G |
NG |
|
Metspalu |
Andres |
A |
|
Morris |
Andrew D |
AD |
|
Nieminen |
Markku S |
MS |
|
Njølstad |
Inger |
I |
|
Ohlsson |
Claes |
C |
|
Oldehinkel |
Albertine J |
AJ |
|
Ouwehand |
Willem H |
WH |
|
Palmer |
Lyle J |
LJ |
|
Penninx |
Brenda |
B |
|
Power |
Chris |
C |
|
Province |
Michael A |
MA |
|
Psaty |
Bruce M |
BM |
|
Qi |
Lu |
L |
|
Rauramaa |
Rainer |
R |
|
Ridker |
Paul M |
PM |
|
Ripatti |
Samuli |
S |
|
Salomaa |
Veikko |
V |
|
Samani |
Nilesh J |
NJ |
|
Snieder |
Harold |
H |
|
Sørensen |
Thorkild I A |
TI |
|
Spector |
Timothy D |
TD |
|
Stefansson |
Kari |
K |
|
Tönjes |
Anke |
A |
|
Tuomilehto |
Jaakko |
J |
|
Uitterlinden |
André G |
AG |
|
Uusitupa |
Matti |
M |
|
van der Harst |
Pim |
P |
|
Vollenweider |
Peter |
P |
|
Wallaschofski |
Henri |
H |
|
Wareham |
Nicholas J |
NJ |
|
Watkins |
Hugh |
H |
|
Wichmann |
H -Erich |
H- |
|
Wilson |
James F |
JF |
|
Abecasis |
Goncalo R |
GR |
|
Assimes |
Themistocles L |
TL |
|
Barroso |
Ines |
I |
|
Boehnke |
Michael |
M |
|
Borecki |
Ingrid B |
IB |
|
Deloukas |
Panos |
P |
|
Fox |
Caroline S |
CS |
|
Frayling |
Timothy |
T |
|
Groop |
Leif C |
LC |
|
Haritunian |
Talin |
T |
|
Heid |
Iris M |
IM |
|
Hunter |
David |
D |
|
Kaplan |
Robert C |
RC |
|
Karpe |
Fredrik |
F |
|
Moffatt |
Miriam |
M |
|
Mohlke |
Karen L |
KL |
|
O'Connell |
Jeffrey R |
JR |
|
Pawitan |
Yudi |
Y |
|
Schadt |
Eric E |
EE |
|
Schlessinger |
David |
D |
|
Steinthorsdottir |
Valgerdur |
V |
|
Strachan |
David P |
DP |
|
Thorsteinsdottir |
Unnur |
U |
|
van Duijn |
Cornelia M |
CM |
|
Visscher |
Peter M |
PM |
|
Di Blasio |
Anna Maria |
AM |
|
Hirschhorn |
Joel N |
JN |
|
Lindgren |
Cecilia M |
CM |
|
Morris |
Andrew P |
AP |
|
Meyre |
David |
D |
|
Scherag |
André |
A |
|
McCarthy |
Mark I |
MI |
|
Speliotes |
Elizabeth K |
EK |
|
North |
Kari E |
KE |
|
Loos |
Ruth J F |
RJ |
|
Ingelsson |
Erik |
E |
|
|
JOURNAL |
|
VOLUME: 10 |
ISSUE: 7 |
TITLE: PLoS genetics |
ISOABBREVIATION: PLoS Genet |
YEAR: 2014 |
MONTH: Jul |
DAY: |
MEDLINEDATE: |
SEASON: |
CITEDMEDIUM: Internet |
ISSN: 1553-7404 |
ISSNTYPE: Electronic |
|
MEDLINE JOURNAL |
|
MEDLINETA: PLoS Genet |
COUNTRY: United States |
ISSNLINKING: 1553-7390 |
NLMUNIQUEID: 101239074 |
|
PUBLICATION TYPE |
|
PUBLICATIONTYPE TEXT |
Journal Article |
Meta-Analysis |
Research Support, N.I.H., Extramural |
Research Support, Non-U.S. Gov't |
|
COMMENTS AND CORRECTIONS |
|
REFTYPE |
REFSOURCE |
REFPMID |
NOTE |
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17357068 |
|
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18991601 |
|
|
GRANTS |
|
GRANTID |
AGENCY |
COUNTRY |
R01 AA007535 |
NIAAA NIH HHS |
United States |
R01 AA014041 |
NIAAA NIH HHS |
United States |
R01HL087641 |
NHLBI NIH HHS |
United States |
HHSN268201100005I |
NHLBI NIH HHS |
United States |
AA014041 |
NIAAA NIH HHS |
United States |
G0500539 |
Medical Research Council |
United Kingdom |
R01 HL087641 |
NHLBI NIH HHS |
United States |
084723/Z/08/Z |
Wellcome Trust |
United Kingdom |
AA13326 |
NIAAA NIH HHS |
United States |
HHSN268201100012C |
NHLBI NIH HHS |
United States |
UL1RR025005 |
NCRR NIH HHS |
United States |
G0601966 |
Medical Research Council |
United Kingdom |
HHSN268201100009I |
NHLBI NIH HHS |
United States |
G0100266 |
Medical Research Council |
United Kingdom |
R01 MH063706 |
NIMH NIH HHS |
United States |
RP-PG-0310-1002 |
Department of Health |
United Kingdom |
R01HL59367 |
NHLBI NIH HHS |
United States |
HHSN268201100010C |
NHLBI NIH HHS |
United States |
UL1 RR025005 |
NCRR NIH HHS |
United States |
G1002319 |
Medical Research Council |
United Kingdom |
AA13320 |
NIAAA NIH HHS |
United States |
MC_U106179471 |
Medical Research Council |
United Kingdom |
HHSN268201100008C |
NHLBI NIH HHS |
United States |
R01 HL087679 |
NHLBI NIH HHS |
United States |
HHSN268201100005G |
NHLBI NIH HHS |
United States |
HHSN268201100008I |
NHLBI NIH HHS |
United States |
0927310 |
Wellcome Trust |
United Kingdom |
R01DK8925601 |
NIDDK NIH HHS |
United States |
R01 HL059367 |
NHLBI NIH HHS |
United States |
HHSN268201100007C |
NHLBI NIH HHS |
United States |
DA12854 |
NIDA NIH HHS |
United States |
AA13321 |
NIAAA NIH HHS |
United States |
AA10248 |
NIAAA NIH HHS |
United States |
0927310 |
Medical Research Council |
United Kingdom |
5R01MH63706:02 |
NIMH NIH HHS |
United States |
HHSN268201100011I |
NHLBI NIH HHS |
United States |
P30 DK079637 |
NIDDK NIH HHS |
United States |
HHSN268201100011C |
NHLBI NIH HHS |
United States |
R01 HL086694 |
NHLBI NIH HHS |
United States |
T32 HL091823 |
NHLBI NIH HHS |
United States |
R01 AA013326 |
NIAAA NIH HHS |
United States |
R56 DA012854 |
NIDA NIH HHS |
United States |
1RL1MH083268-01 |
NIMH NIH HHS |
United States |
MC_UP_0801/1 |
Medical Research Council |
United Kingdom |
HHSN268200625226C |
PHS HHS |
United States |
U01 HG004402 |
NHGRI NIH HHS |
United States |
MR/K026992/1 |
Medical Research Council |
United Kingdom |
102215 |
Wellcome Trust |
United Kingdom |
MC_UU_12015/1 |
Medical Research Council |
United Kingdom |
U01HG004402 |
NHGRI NIH HHS |
United States |
R01 AA013321 |
NIAAA NIH HHS |
United States |
MC_PC_15018 |
Medical Research Council |
United Kingdom |
HHSN268201100006C |
NHLBI NIH HHS |
United States |
097117 |
Wellcome Trust |
United Kingdom |
MC_UU_12013/1 |
Medical Research Council |
United Kingdom |
G0701863 |
Medical Research Council |
United Kingdom |
MC_UU_12013/4 |
Medical Research Council |
United Kingdom |
CZD/16/6/4 |
Chief Scientist Office |
United Kingdom |
MC_PC_U127561128 |
Medical Research Council |
United Kingdom |
RG/09/012/28096 |
British Heart Foundation |
United Kingdom |
R01 DA012854 |
NIDA NIH HHS |
United States |
MR/K006584/1 |
Medical Research Council |
United Kingdom |
MR/K013351/1 |
Medical Research Council |
United Kingdom |
HHSN268201100009C |
NHLBI NIH HHS |
United States |
HHSN268201100005C |
NHLBI NIH HHS |
United States |
HHSN268201100007I |
NHLBI NIH HHS |
United States |
|
Wellcome Trust |
United Kingdom |
5R01HL087679-02 |
NHLBI NIH HHS |
United States |
BB/F019394/1 |
Biotechnology and Biological Sciences Research Council |
United Kingdom |
RL1 MH083268 |
NIMH NIH HHS |
United States |
AA07535 |
NIAAA NIH HHS |
United States |
WT083431MA |
Wellcome Trust |
United Kingdom |
T32 HL007055 |
NHLBI NIH HHS |
United States |
G9815508 |
Medical Research Council |
United Kingdom |
R01 AA013320 |
NIAAA NIH HHS |
United States |
R01HL086694 |
NHLBI NIH HHS |
United States |
G0600705 |
Medical Research Council |
United Kingdom |
G0700931 |
Medical Research Council |
United Kingdom |
|
GENERAL NOTE |
|
|
KEYWORDS |
|
|
MESH HEADINGS |
|
DESCRIPTORNAME |
QUALIFIERNAME |
Adult |
|
Body Mass Index |
|
European Continental Ancestry Group |
genetics |
Female |
genetics |
Gene Expression Regulation |
genetics |
Genetic Predisposition to Disease |
genetics |
Genome-Wide Association Study |
genetics |
Genomic Imprinting |
genetics |
Genotype |
genetics |
Glucose Transport Proteins, Facilitative |
genetics |
Humans |
genetics |
Male |
genetics |
Obesity |
pathology |
Polymorphism, Single Nucleotide |
genetics |
Potassium Channels, Tandem Pore Domain |
genetics |
|
SUPPLEMENTARY MESH |
|
|
GENE SYMBOLS |
|
|
CHEMICALS |
|
REGISTRYNUMBER |
NAMEOFSUBSTANCE |
0 |
Glucose Transport Proteins, Facilitative |
0 |
KCNK9 protein, human |
0 |
Potassium Channels, Tandem Pore Domain |
0 |
SLC2A10 protein, human |
|
OTHER ID's |
|
|
|