Genetic Epidemiology, Translational Neurogenomics, Psychiatric Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
25041562
TITLE
Genetic variation in personality traits explains genetic overlap between borderline personality features and substance use disorders.
ABSTRACT
AIMS NlmCategory: OBJECTIVE
To examine the genetic overlap between borderline personality features (BPF) and substance use disorders (SUDs) and the extent to which variation in personality traits contributes to this covariance.
DESIGN NlmCategory: METHODS
Genetic structural equation modelling was used to partition the variance in and covariance between personality traits, BPF and SUDs into additive genetic, shared and individual-specific environmental factors.
SETTING NlmCategory: METHODS
All participants were registered with the Australian Twin Registry.
PARTICIPANTS NlmCategory: METHODS
A total of 3127 Australian adult twins participated in the study.
MEASUREMENTS NlmCategory: METHODS
Diagnoses of DSM-IV alcohol and cannabis abuse/dependence (AAD; CAD) and nicotine dependence (ND) were derived via computer-assisted telephone interview. BPF and five-factor model personality traits were derived via self-report questionnaires.
FINDINGS NlmCategory: RESULTS
Personality traits, BPF and substance use disorders were partially influenced by genetic factors with heritability estimates ranging from 0.38 (neuroticism; 95% confidence interval: 0.30-0.45) to 0.78 (CAD; 95% confidence interval: 0.67-0.86). Genetic and individual-specific environmental correlations between BPF and SUDs ranged from 0.33 to 0.56 (95% CI = 0.19-0.74) and 0.19-0.32 (95% CI = 0.06-0.43), respectively. Overall, there was substantial support for genetic influences that were specific to AAD, ND and CAD (30.76-68.60%). Finally, genetic variation in personality traits was responsible for 11.46% (extraversion for CAD) to 59.30% (neuroticism for AAD) of the correlation between BPF and SUDs.
CONCLUSIONS NlmCategory: CONCLUSIONS
Both genetic and individual-specific environmental factors contribute to comorbidity between borderline personality features and substance use disorders. A substantial proportion of this comorbidity can be attributed to variation in normal personality traits, particularly neuroticism.
© 2014 Society for the Study of Addiction.
DATE PUBLISHED
2014 Dec
HISTORY
PUBSTATUS PUBSTATUSDATE
received 2014/03/21
revised 2014/05/15
accepted 2014/07/11
aheadofprint 2014/08/19
entrez 2014/07/22 06:00
pubmed 2014/07/22 06:00
medline 2014/07/22 06:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Few LR Few Lauren R LR Department of Psychiatry, Washington University School of Medicine, St Louis, MO, USA.
Grant JD Grant Julia D JD
Trull TJ Trull Timothy J TJ
Statham DJ Statham Dixie J DJ
Martin NG Martin Nicholas G NG
Lynskey MT Lynskey Michael T MT
Agrawal A Agrawal Arpana A
INVESTIGATORS
JOURNAL
VOLUME: 109
ISSUE: 12
TITLE: Addiction (Abingdon, England)
ISOABBREVIATION: Addiction
YEAR: 2014
MONTH: Dec
DAY:
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN: 1360-0443
ISSNTYPE: Electronic
MEDLINE JOURNAL
MEDLINETA: Addiction
COUNTRY: England
ISSNLINKING: 0965-2140
NLMUNIQUEID: 9304118
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
COMMENTS AND CORRECTIONS
REFTYPE REFSOURCE REFPMID NOTE
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GRANTS
GRANTID AGENCY COUNTRY
DA18267 NIDA NIH HHS United States
DA23668 NIDA NIH HHS United States
K02 DA032573 NIDA NIH HHS United States
K02DA32573 NIDA NIH HHS United States
R01 DA018267 NIDA NIH HHS United States
R01 DA023668 NIDA NIH HHS United States
T32 DA007313 NIDA NIH HHS United States
T32DA007313 NIDA NIH HHS United States
GENERAL NOTE
KEYWORDS
KEYWORD
Alcohol use disorders
borderline personality disorder
cannabis use disorders
comorbidity
five-factor model
genetics
nicotine dependence
personality traits
substance use disorders
MESH HEADINGS
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
OTHER ID's
OTHERID SOURCE
NIHMS616296 NLM
PMC4229407 NLM
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