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| PMID |
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| TITLE |
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| Harmonization of Neuroticism and Extraversion phenotypes across inventories and cohorts in the Genetics of Personality Consortium: an application of Item Response Theory. |
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| ABSTRACT |
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| Mega- or meta-analytic studies (e.g. genome-wide association studies) are increasingly used in behavior genetics. An issue in such studies is that phenotypes are often measured by different instruments across study cohorts, requiring harmonization of measures so that more powerful fixed effect meta-analyses can be employed. Within the Genetics of Personality Consortium, we demonstrate for two clinically relevant personality traits, Neuroticism and Extraversion, how Item-Response Theory (IRT) can be applied to map item data from different inventories to the same underlying constructs. Personality item data were analyzed in >160,000 individuals from 23 cohorts across Europe, USA and Australia in which Neuroticism and Extraversion were assessed by nine different personality inventories. Results showed that harmonization was very successful for most personality inventories and moderately successful for some. Neuroticism and Extraversion inventories were largely measurement invariant across cohorts, in particular when comparing cohorts from countries where the same language is spoken. The IRT-based scores for Neuroticism and Extraversion were heritable (48 and 49 %, respectively, based on a meta-analysis of six twin cohorts, total N = 29,496 and 29,501 twin pairs, respectively) with a significant part of the heritability due to non-additive genetic factors. For Extraversion, these genetic factors qualitatively differ across sexes. We showed that our IRT method can lead to a large increase in sample size and therefore statistical power. The IRT approach may be applied to any mega- or meta-analytic study in which item-based behavioral measures need to be harmonized. |
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| DATE PUBLISHED |
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| HISTORY |
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| PUBSTATUS |
PUBSTATUSDATE |
| received |
2013/10/21 |
| accepted |
2014/03/20 |
| aheadofprint |
2014/05/15 |
| entrez |
2014/05/16 06:00 |
| pubmed |
2014/05/16 06:00 |
| medline |
2015/04/07 06:00 |
|
| AUTHORS |
|
| NAME |
COLLECTIVENAME |
LASTNAME |
FORENAME |
INITIALS |
AFFILIATION |
AFFILIATIONINFO |
| van den Berg SM |
|
van den Berg |
Stéphanie M |
SM |
|
Department of Research Methodology, Measurement and Data-Analysis, University of Twente, Enschede, The Netherlands, stephanie.vandenberg@utwente.nl. |
| de Moor MH |
|
de Moor |
Marleen H M |
MH |
|
|
| McGue M |
|
McGue |
Matt |
M |
|
|
| Pettersson E |
|
Pettersson |
Erik |
E |
|
|
| Terracciano A |
|
Terracciano |
Antonio |
A |
|
|
| Verweij KJ |
|
Verweij |
Karin J H |
KJ |
|
|
| Amin N |
|
Amin |
Najaf |
N |
|
|
| Derringer J |
|
Derringer |
Jaime |
J |
|
|
| Esko T |
|
Esko |
Tõnu |
T |
|
|
| van Grootheest G |
|
van Grootheest |
Gerard |
G |
|
|
| Hansell NK |
|
Hansell |
Narelle K |
NK |
|
|
| Huffman J |
|
Huffman |
Jennifer |
J |
|
|
| Konte B |
|
Konte |
Bettina |
B |
|
|
| Lahti J |
|
Lahti |
Jari |
J |
|
|
| Luciano M |
|
Luciano |
Michelle |
M |
|
|
| Matteson LK |
|
Matteson |
Lindsay K |
LK |
|
|
| Viktorin A |
|
Viktorin |
Alexander |
A |
|
|
| Wouda J |
|
Wouda |
Jasper |
J |
|
|
| Agrawal A |
|
Agrawal |
Arpana |
A |
|
|
| Allik J |
|
Allik |
Jüri |
J |
|
|
| Bierut L |
|
Bierut |
Laura |
L |
|
|
| Broms U |
|
Broms |
Ulla |
U |
|
|
| Campbell H |
|
Campbell |
Harry |
H |
|
|
| Smith GD |
|
Smith |
George Davey |
GD |
|
|
| Eriksson JG |
|
Eriksson |
Johan G |
JG |
|
|
| Ferrucci L |
|
Ferrucci |
Luigi |
L |
|
|
| Franke B |
|
Franke |
Barbera |
B |
|
|
| Fox JP |
|
Fox |
Jean-Paul |
JP |
|
|
| de Geus EJ |
|
de Geus |
Eco J C |
EJ |
|
|
| Giegling I |
|
Giegling |
Ina |
I |
|
|
| Gow AJ |
|
Gow |
Alan J |
AJ |
|
|
| Grucza R |
|
Grucza |
Richard |
R |
|
|
| Hartmann AM |
|
Hartmann |
Annette M |
AM |
|
|
| Heath AC |
|
Heath |
Andrew C |
AC |
|
|
| Heikkilä K |
|
Heikkilä |
Kauko |
K |
|
|
| Iacono WG |
|
Iacono |
William G |
WG |
|
|
| Janzing J |
|
Janzing |
Joost |
J |
|
|
| Jokela M |
|
Jokela |
Markus |
M |
|
|
| Kiemeney L |
|
Kiemeney |
Lambertus |
L |
|
|
| Lehtimäki T |
|
Lehtimäki |
Terho |
T |
|
|
| Madden PA |
|
Madden |
Pamela A F |
PA |
|
|
| Magnusson PK |
|
Magnusson |
Patrik K E |
PK |
|
|
| Northstone K |
|
Northstone |
Kate |
K |
|
|
| Nutile T |
|
Nutile |
Teresa |
T |
|
|
| Ouwens KG |
|
Ouwens |
Klaasjan G |
KG |
|
|
| Palotie A |
|
Palotie |
Aarno |
A |
|
|
| Pattie A |
|
Pattie |
Alison |
A |
|
|
| Pesonen AK |
|
Pesonen |
Anu-Katriina |
AK |
|
|
| Polasek O |
|
Polasek |
Ozren |
O |
|
|
| Pulkkinen L |
|
Pulkkinen |
Lea |
L |
|
|
| Pulkki-Råback L |
|
Pulkki-Råback |
Laura |
L |
|
|
| Raitakari OT |
|
Raitakari |
Olli T |
OT |
|
|
| Realo A |
|
Realo |
Anu |
A |
|
|
| Rose RJ |
|
Rose |
Richard J |
RJ |
|
|
| Ruggiero D |
|
Ruggiero |
Daniela |
D |
|
|
| Seppälä I |
|
Seppälä |
Ilkka |
I |
|
|
| Slutske WS |
|
Slutske |
Wendy S |
WS |
|
|
| Smyth DC |
|
Smyth |
David C |
DC |
|
|
| Sorice R |
|
Sorice |
Rossella |
R |
|
|
| Starr JM |
|
Starr |
John M |
JM |
|
|
| Sutin AR |
|
Sutin |
Angelina R |
AR |
|
|
| Tanaka T |
|
Tanaka |
Toshiko |
T |
|
|
| Verhagen J |
|
Verhagen |
Josine |
J |
|
|
| Vermeulen S |
|
Vermeulen |
Sita |
S |
|
|
| Vuoksimaa E |
|
Vuoksimaa |
Eero |
E |
|
|
| Widen E |
|
Widen |
Elisabeth |
E |
|
|
| Willemsen G |
|
Willemsen |
Gonneke |
G |
|
|
| Wright MJ |
|
Wright |
Margaret J |
MJ |
|
|
| Zgaga L |
|
Zgaga |
Lina |
L |
|
|
| Rujescu D |
|
Rujescu |
Dan |
D |
|
|
| Metspalu A |
|
Metspalu |
Andres |
A |
|
|
| Wilson JF |
|
Wilson |
James F |
JF |
|
|
| Ciullo M |
|
Ciullo |
Marina |
M |
|
|
| Hayward C |
|
Hayward |
Caroline |
C |
|
|
| Rudan I |
|
Rudan |
Igor |
I |
|
|
| Deary IJ |
|
Deary |
Ian J |
IJ |
|
|
| Räikkönen K |
|
Räikkönen |
Katri |
K |
|
|
| Arias Vasquez A |
|
Arias Vasquez |
Alejandro |
A |
|
|
| Costa PT |
|
Costa |
Paul T |
PT |
|
|
| Keltikangas-Järvinen L |
|
Keltikangas-Järvinen |
Liisa |
L |
|
|
| van Duijn CM |
|
van Duijn |
Cornelia M |
CM |
|
|
| Penninx BW |
|
Penninx |
Brenda W J H |
BW |
|
|
| Krueger RF |
|
Krueger |
Robert F |
RF |
|
|
| Evans DM |
|
Evans |
David M |
DM |
|
|
| Kaprio J |
|
Kaprio |
Jaakko |
J |
|
|
| Pedersen NL |
|
Pedersen |
Nancy L |
NL |
|
|
| Martin NG |
|
Martin |
Nicholas G |
NG |
|
|
| Boomsma DI |
|
Boomsma |
Dorret I |
DI |
|
|
|
| INVESTIGATORS |
|
|
| JOURNAL |
|
| VOLUME: 44 |
| ISSUE: 4 |
| TITLE: Behavior genetics |
| ISOABBREVIATION: Behav. Genet. |
| YEAR: 2014 |
| MONTH: Jul |
| DAY: |
| MEDLINEDATE: |
| SEASON: |
| CITEDMEDIUM: Internet |
| ISSN: 1573-3297 |
| ISSNTYPE: Electronic |
|
| MEDLINE JOURNAL |
|
| MEDLINETA: Behav Genet |
| COUNTRY: United States |
| ISSNLINKING: 0001-8244 |
| NLMUNIQUEID: 0251711 |
|
| PUBLICATION TYPE |
|
| PUBLICATIONTYPE TEXT |
| Journal Article |
| Research Support, N.I.H., Extramural |
| Research Support, N.I.H., Intramural |
| Research Support, Non-U.S. Gov't |
|
| COMMENTS AND CORRECTIONS |
|
| REFTYPE |
REFSOURCE |
REFPMID |
NOTE |
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|
| GRANTS |
|
| GRANTID |
AGENCY |
COUNTRY |
| 092731 |
Wellcome Trust |
United Kingdom |
| 15/SAG09977 |
Biotechnology and Biological Sciences Research Council |
United Kingdom |
| AA-00145 |
NIAAA NIH HHS |
United States |
| AA-09203 |
NIAAA NIH HHS |
United States |
| AA-12502 |
NIAAA NIH HHS |
United States |
| AA014041 |
NIAAA NIH HHS |
United States |
| AA06781 |
NIAAA NIH HHS |
United States |
| AA07535 |
NIAAA NIH HHS |
United States |
| AA07580 |
NIAAA NIH HHS |
United States |
| AA07728 |
NIAAA NIH HHS |
United States |
| AA10248 |
NIAAA NIH HHS |
United States |
| AA11998 |
NIAAA NIH HHS |
United States |
| AA13320 |
NIAAA NIH HHS |
United States |
| AA13321 |
NIAAA NIH HHS |
United States |
| AA13326 |
NIAAA NIH HHS |
United States |
| AA15416 |
NIAAA NIH HHS |
United States |
| AGO4954 |
PHS HHS |
United States |
| BB/F019394/1 |
Biotechnology and Biological Sciences Research Council |
United Kingdom |
| CZB/4/505 |
Chief Scientist Office |
United Kingdom |
| CZB/4/710 |
Chief Scientist Office |
United Kingdom |
| CZG/3/2/79 |
Chief Scientist Office |
United Kingdom |
| DA019951 |
NIDA NIH HHS |
United States |
| DA12854 |
NIDA NIH HHS |
United States |
| DK U01-066134 |
NIDDK NIH HHS |
United States |
| ETM/55 |
Chief Scientist Office |
United Kingdom |
| G0700704 |
Medical Research Council |
United Kingdom |
| G9815508 |
Medical Research Council |
United Kingdom |
| GM30250 |
NIGMS NIH HHS |
United States |
| HHSN271200477451C |
PHS HHS |
United States |
| K05 AA017688 |
NIAAA NIH HHS |
United States |
| MC_PC_15018 |
Medical Research Council |
United Kingdom |
| MH40828 |
NIMH NIH HHS |
United States |
| MH66206 |
NIMH NIH HHS |
United States |
| MR/K026992/1 |
Medical Research Council |
United Kingdom |
| P01 CA089392 |
NCI NIH HHS |
United States |
| R01 AA009367 |
NIAAA NIH HHS |
United States |
| R01 AA011886 |
NIAAA NIH HHS |
United States |
| R01 AA012502 |
NIAAA NIH HHS |
United States |
| R01 DA013240 |
NIDA NIH HHS |
United States |
| R01 MH066140 |
NIMH NIH HHS |
United States |
| R01AA009367 |
NIAAA NIH HHS |
United States |
| R01AA011886 |
NIAAA NIH HHS |
United States |
| R01DA013240 |
NIDA NIH HHS |
United States |
| R01MH066140 |
NIMH NIH HHS |
United States |
| R37 DA005147 |
NIDA NIH HHS |
United States |
| R37DA005147 |
NIDA NIH HHS |
United States |
| U01 HG004422 |
NHGRI NIH HHS |
United States |
| U01 HG004446 |
NHGRI NIH HHS |
United States |
| U10 AA008401 |
NIAAA NIH HHS |
United States |
| U10AA008401 |
NIAAA NIH HHS |
United States |
|
Intramural NIH HHS |
United States |
|
Medical Research Council |
United Kingdom |
|
| GENERAL NOTE |
|
|
| KEYWORDS |
|
|
| MESH HEADINGS |
|
| DESCRIPTORNAME |
QUALIFIERNAME |
| Anxiety Disorders |
genetics |
| Extraversion (Psychology) |
genetics |
| Genome-Wide Association Study |
genetics |
| Humans |
genetics |
| Models, Statistical |
genetics |
| Personality |
genetics |
| Personality Assessment |
genetics |
| Phenotype |
genetics |
|
| SUPPLEMENTARY MESH |
|
| SUPPLMESHNAME |
SUPPLMESHTYPE |
| Neuroticism |
Disease |
|
| GENE SYMBOLS |
|
|
| CHEMICALS |
|
|
| OTHER ID's |
|
| OTHERID |
SOURCE |
| PMC4057636 |
NLM |
|
|
