|
|
| PMID |
|
|
| TITLE |
|
| Overlapping genetic and environmental influences on nonsuicidal self-injury and suicidal ideation: different outcomes, same etiology? |
|
| ABSTRACT |
|
| IMPORTANCE |
NlmCategory: OBJECTIVE |
| Nonsuicidal self-injury (NSSI) and suicidal self-injury are very harmful behaviors and are associated with several psychiatric disorders. In the recently developed fifth edition of the DSM, NSSI and suicidal behavior disorder are for the first time introduced as conditions in their own right instead of symptoms of other psychiatric disorders. It is unclear to what extent NSSI and suicidal self-injury share the same underlying biological mechanisms and are influenced by the same environmental factors. |
| OBJECTIVE |
NlmCategory: OBJECTIVE |
| To determine the relative importance of genetic and environmental influences on the variation in NSSI and suicidal ideation and their covariation. |
| DESIGN, SETTING, AND PARTICIPANTS |
NlmCategory: METHODS |
| Classical twin design using a sample of 10,678 male and female adult twins (mean [SD] age, 32.76 [6.99] years) from the Australian Twin Registry, a population-based twin registry. Between 1996 and 2009, the twins participated in semistructured telephone interviews that primarily focused on psychiatric disorders. |
| MAIN OUTCOMES AND MEASURES |
NlmCategory: METHODS |
| Lifetime presence of self-reported NSSI and suicidal ideation. RESULTS The prevalences of NSSI and suicidal ideation were 4.7% and 26.5%, respectively, and individuals who engaged in self-harm were much more likely to report suicidal ideation (odds ratio = 8.39; 95% CI, 6.84-10.29). Results from a bivariate genetic model indicated that genetic factors explain a substantial part of the variance in both NSSI (37% for men and 59% for women) and suicidal ideation (41% for men and 55% for women), while residual influences (including nonshared environmental influences and measurement error) explain the remainder of the variance. Shared (family) environment did not seem to play a role. Moreover, both behaviors were strongly correlated (r = 0.49 for men and 0.61 for women), and this correlation was largely explained by overlapping genetic influences (76% for men and 62% for women), whereas residual influences accounted for the remainder of the phenotypic correlation. |
| CONCLUSIONS AND RELEVANCE |
NlmCategory: CONCLUSIONS |
| Results indicated that the substantial correlation between NSSI and suicidal ideation is largely driven by overlapping genetic factors, suggesting that the 2 behaviors share similar biological underpinnings. Overlapping residual influences also explain part of the covariance between the 2 traits. Future research should further investigate which genetic and environmental influences underlie the vulnerability to NSSI and suicidal ideation. |
|
| DATE PUBLISHED |
|
|
| HISTORY |
|
| PUBSTATUS |
PUBSTATUSDATE |
| entrez |
2014/04/25 06:00 |
| pubmed |
2014/04/25 06:00 |
| medline |
2014/08/13 06:00 |
| pmc-release |
2015/06/01 00:00 |
|
| AUTHORS |
|
| NAME |
COLLECTIVENAME |
LASTNAME |
FORENAME |
INITIALS |
AFFILIATION |
AFFILIATIONINFO |
| Maciejewski DF |
|
Maciejewski |
Dominique F |
DF |
|
Department of Developmental Psychology and EMGO Institute for Health and Care Research, VU University, Amsterdam, the Netherlands. |
| Creemers HE |
|
Creemers |
Hanneke E |
HE |
|
Department of Developmental Psychology and EMGO Institute for Health and Care Research, VU University, Amsterdam, the Netherlands. |
| Lynskey MT |
|
Lynskey |
Michael T |
MT |
|
Addictions Department, Institute of Psychiatry, King's College London, London, England. |
| Madden PA |
|
Madden |
Pamela A F |
PA |
|
Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri. |
| Heath AC |
|
Heath |
Andrew C |
AC |
|
Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri. |
| Statham DJ |
|
Statham |
Dixie J |
DJ |
|
Faculty of Arts and Social Sciences, University of the Sunshine Coast, Sippy Downs, Australia. |
| Martin NG |
|
Martin |
Nicholas G |
NG |
|
Genetic Epidemiology, QIMR Berghofer Medical Research Institute, Brisbane, Australia. |
| Verweij KJ |
|
Verweij |
Karin J H |
KJ |
|
Department of Developmental Psychology and EMGO Institute for Health and Care Research, VU University, Amsterdam, the Netherlands. |
|
| INVESTIGATORS |
|
|
| JOURNAL |
|
| VOLUME: 71 |
| ISSUE: 6 |
| TITLE: JAMA psychiatry |
| ISOABBREVIATION: JAMA Psychiatry |
| YEAR: 2014 |
| MONTH: Jun |
| DAY: |
| MEDLINEDATE: |
| SEASON: |
| CITEDMEDIUM: Internet |
| ISSN: 2168-6238 |
| ISSNTYPE: Electronic |
|
| MEDLINE JOURNAL |
|
| MEDLINETA: JAMA Psychiatry |
| COUNTRY: United States |
| ISSNLINKING: 2168-622X |
| NLMUNIQUEID: 101589550 |
|
| PUBLICATION TYPE |
|
| PUBLICATIONTYPE TEXT |
| Journal Article |
| Research Support, N.I.H., Extramural |
| Research Support, Non-U.S. Gov't |
| Twin Study |
|
| COMMENTS AND CORRECTIONS |
|
|
| GRANTS |
|
| GRANTID |
AGENCY |
COUNTRY |
| AA07535 |
NIAAA NIH HHS |
United States |
| AA0758O |
NIAAA NIH HHS |
United States |
| AA07728 |
NIAAA NIH HHS |
United States |
| AA10249 |
NIAAA NIH HHS |
United States |
| AA11998 |
NIAAA NIH HHS |
United States |
| AA13320 |
NIAAA NIH HHS |
United States |
| AA13321 |
NIAAA NIH HHS |
United States |
| AA14041 |
NIAAA NIH HHS |
United States |
| AA17688 |
NIAAA NIH HHS |
United States |
| DA012854 |
NIDA NIH HHS |
United States |
| DA018267 |
NIDA NIH HHS |
United States |
| DA018660 |
NIDA NIH HHS |
United States |
| DA019951 |
NIDA NIH HHS |
United States |
| DA23668 |
NIDA NIH HHS |
United States |
| K05 AA017688 |
NIAAA NIH HHS |
United States |
| K08 DA019951 |
NIDA NIH HHS |
United States |
| P50 AA011998 |
NIAAA NIH HHS |
United States |
| P60 AA011998 |
NIAAA NIH HHS |
United States |
| R01 AA007535 |
NIAAA NIH HHS |
United States |
| R01 AA007728 |
NIAAA NIH HHS |
United States |
| R01 AA010249 |
NIAAA NIH HHS |
United States |
| R01 AA013320 |
NIAAA NIH HHS |
United States |
| R01 AA013321 |
NIAAA NIH HHS |
United States |
| R01 AA014041 |
NIAAA NIH HHS |
United States |
| R01 DA012854 |
NIDA NIH HHS |
United States |
| R01 DA018267 |
NIDA NIH HHS |
United States |
| R01 DA018660 |
NIDA NIH HHS |
United States |
| R01 DA023668 |
NIDA NIH HHS |
United States |
| R56 DA012854 |
NIDA NIH HHS |
United States |
| T32 AA007580 |
NIAAA NIH HHS |
United States |
|
| GENERAL NOTE |
|
|
| KEYWORDS |
|
|
| MESH HEADINGS |
|
| DESCRIPTORNAME |
QUALIFIERNAME |
| Adult |
|
| Aged |
|
| Australia |
|
| Environment |
|
| Female |
|
| Humans |
|
| Male |
|
| Middle Aged |
|
| Models, Genetic |
|
| Registries |
|
| Self Report |
|
| Self-Injurious Behavior |
psychology |
| Sex Factors |
psychology |
| Suicidal Ideation |
psychology |
|
| SUPPLEMENTARY MESH |
|
|
| GENE SYMBOLS |
|
|
| CHEMICALS |
|
|
| OTHER ID's |
|
| OTHERID |
SOURCE |
| NIHMS642262 [Available on 06/01/15] |
NLM |
| PMC4241464 [Available on 06/01/15] |
NLM |
|
|
