Genetic Epidemiology, Translational Neurogenomics, Psychiatric Genetics and Statistical Genetics Laboratories investigate the pattern of disease in families, particularly identical and non-identical twins, to assess the relative importance of genes and environment in a variety of important health problems.
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PMID
24747738
TITLE
Automatic clustering and population analysis of white matter tracts using maximum density paths.
ABSTRACT
We introduce a framework for population analysis of white matter tracts based on diffusion-weighted images of the brain. The framework enables extraction of fibers from high angular resolution diffusion images (HARDI); clustering of the fibers based partly on prior knowledge from an atlas; representation of the fiber bundles compactly using a path following points of highest density (maximum density path; MDP); and registration of these paths together using geodesic curve matching to find local correspondences across a population. We demonstrate our method on 4-Tesla HARDI scans from 565 young adults to compute localized statistics across 50 white matter tracts based on fractional anisotropy (FA). Experimental results show increased sensitivity in the determination of genetic influences on principal fiber tracts compared to the tract-based spatial statistics (TBSS) method. Our results show that the MDP representation reveals important parts of the white matter structure and considerably reduces the dimensionality over comparable fiber matching approaches.
Copyright © 2014 Elsevier Inc. All rights reserved.
DATE PUBLISHED
2014 Aug 15
HISTORY
PUBSTATUS PUBSTATUSDATE
received 2013/11/04
revised 2014/03/24
accepted 2014/04/08
aheadofprint 2014/04/18
entrez 2014/04/22 06:00
pubmed 2014/04/22 06:00
medline 2015/02/07 06:00
AUTHORS
NAME COLLECTIVENAME LASTNAME FORENAME INITIALS AFFILIATION AFFILIATIONINFO
Prasad G Prasad Gautam G Imaging Genetics Center, Institute for Neuroimaging & Informatics, University of Southern California, Los Angeles, CA, USA; Laboratory of Neuro Imaging, Institute for Neuroimaging & Informatics, University of Southern California, Los Angeles, CA, USA.
Joshi SH Joshi Shantanu H SH Department of Neurology, University of California Los Angeles, CA, USA.
Jahanshad N Jahanshad Neda N Imaging Genetics Center, Institute for Neuroimaging & Informatics, University of Southern California, Los Angeles, CA, USA; Laboratory of Neuro Imaging, Institute for Neuroimaging & Informatics, University of Southern California, Los Angeles, CA, USA.
Villalon-Reina J Villalon-Reina Julio J Imaging Genetics Center, Institute for Neuroimaging & Informatics, University of Southern California, Los Angeles, CA, USA; Laboratory of Neuro Imaging, Institute for Neuroimaging & Informatics, University of Southern California, Los Angeles, CA, USA.
Aganj I Aganj Iman I Martinos Center for Biomedical Imaging, Radiology Department, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Lenglet C Lenglet Christophe C Center for Magnetic Resonance Research, Department of Radiology, University of Minnesota, Minneapolis, MN, USA.
Sapiro G Sapiro Guillermo G Dept. of Electrical and Computer Engineering, Computer Science, Duke University, NC, USA; Dept. of Biomedical Engineering, Duke University, NC, USA.
McMahon KL McMahon Katie L KL Center for Advanced Imaging, University of Queensland, Brisbane, Australia.
de Zubicaray GI de Zubicaray Greig I GI School of Psychology, University of Queensland, Brisbane, Australia.
Martin NG Martin Nicholas G NG QIMR Berghofer Medical Research Institute, Herston, Australia.
Wright MJ Wright Margaret J MJ School of Psychology, University of Queensland, Brisbane, Australia; QIMR Berghofer Medical Research Institute, Herston, Australia.
Toga AW Toga Arthur W AW Imaging Genetics Center, Institute for Neuroimaging & Informatics, University of Southern California, Los Angeles, CA, USA; Laboratory of Neuro Imaging, Institute for Neuroimaging & Informatics, University of Southern California, Los Angeles, CA, USA; Dept. of Neurology, Psychiatry, Engineering, Radiology, University of Southern California, Los Angeles, CA, USA; Dept. of Ophthalmology, University of Southern California, Los Angeles, CA, USA.
Thompson PM Thompson Paul M PM Imaging Genetics Center, Institute for Neuroimaging & Informatics, University of Southern California, Los Angeles, CA, USA; Laboratory of Neuro Imaging, Institute for Neuroimaging & Informatics, University of Southern California, Los Angeles, CA, USA; Department of Neurology, University of California Los Angeles, CA, USA; Dept. of Neurology, Psychiatry, Engineering, Radiology, University of Southern California, Los Angeles, CA, USA; Dept. of Ophthalmology, University of Southern California, Los Angeles, CA, USA; Department of Pediatrics, University of Southern California, Los Angeles, CA, USA. Electronic address: pthomp@usc.edu.
INVESTIGATORS
JOURNAL
VOLUME: 97
ISSUE:
TITLE: NeuroImage
ISOABBREVIATION: Neuroimage
YEAR: 2014
MONTH: Aug
DAY: 15
MEDLINEDATE:
SEASON:
CITEDMEDIUM: Internet
ISSN: 1095-9572
ISSNTYPE: Electronic
MEDLINE JOURNAL
MEDLINETA: Neuroimage
COUNTRY: United States
ISSNLINKING: 1053-8119
NLMUNIQUEID: 9215515
PUBLICATION TYPE
PUBLICATIONTYPE TEXT
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
COMMENTS AND CORRECTIONS
REFTYPE REFSOURCE REFPMID NOTE
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GRANTS
GRANTID AGENCY COUNTRY
AG040060 NIA NIH HHS United States
EB008432 NIBIB NIH HHS United States
MH097268 NIMH NIH HHS United States
NS080655 NINDS NIH HHS United States
P41 EB015922 NIBIB NIH HHS United States
R01 AG040060 NIA NIH HHS United States
R01 EB008432 NIBIB NIH HHS United States
R01 MH097268 NIMH NIH HHS United States
R01 NS080655 NINDS NIH HHS United States
GENERAL NOTE
KEYWORDS
KEYWORD
Atlas
Brain
Clustering
Connectivity
Curve registration
Dijkstra
Geodesic distance
HARDI
Hough
Longest path
MRI
Maximum density path
Shortest path
Tractography
MESH HEADINGS
DESCRIPTORNAME QUALIFIERNAME
Algorithms
Anisotropy
Cluster Analysis
Diffusion Tensor Imaging methods
Female methods
Humans methods
Image Processing, Computer-Assisted methods
Male methods
Nerve Fibers methods
Neural Pathways cytology
Reproducibility of Results cytology
White Matter cytology
Young Adult cytology
SUPPLEMENTARY MESH
GENE SYMBOLS
CHEMICALS
OTHER ID's
OTHERID SOURCE
NIHMS587313 NLM
PMC4065851 NLM
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