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| PMID |
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| TITLE |
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| Multi-site study of additive genetic effects on fractional anisotropy of cerebral white matter: Comparing meta and megaanalytical approaches for data pooling. |
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| ABSTRACT |
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| Combining datasets across independent studies can boost statistical power by increasing the numbers of observations and can achieve more accurate estimates of effect sizes. This is especially important for genetic studies where a large number of observations are required to obtain sufficient power to detect and replicate genetic effects. There is a need to develop and evaluate methods for joint-analytical analyses of rich datasets collected in imaging genetics studies. The ENIGMA-DTI consortium is developing and evaluating approaches for obtaining pooled estimates of heritability through meta-and mega-genetic analytical approaches, to estimate the general additive genetic contributions to the intersubject variance in fractional anisotropy (FA) measured from diffusion tensor imaging (DTI). We used the ENIGMA-DTI data harmonization protocol for uniform processing of DTI data from multiple sites. We evaluated this protocol in five family-based cohorts providing data from a total of 2248 children and adults (ages: 9-85) collected with various imaging protocols. We used the imaging genetics analysis tool, SOLAR-Eclipse, to combine twin and family data from Dutch, Australian and Mexican-American cohorts into one large "mega-family". We showed that heritability estimates may vary from one cohort to another. We used two meta-analytical (the sample-size and standard-error weighted) approaches and a mega-genetic analysis to calculate heritability estimates across-population. We performed leave-one-out analysis of the joint estimates of heritability, removing a different cohort each time to understand the estimate variability. Overall, meta- and mega-genetic analyses of heritability produced robust estimates of heritability. |
| Copyright © 2014 Elsevier Inc. All rights reserved. |
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| DATE PUBLISHED |
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| HISTORY |
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| PUBSTATUS |
PUBSTATUSDATE |
| received |
2013/10/05 |
| revised |
2014/02/21 |
| accepted |
2014/03/04 |
| aheadofprint |
2014/03/18 |
| entrez |
2014/03/25 06:00 |
| pubmed |
2014/03/25 06:00 |
| medline |
2015/01/13 06:00 |
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| AUTHORS |
|
| NAME |
COLLECTIVENAME |
LASTNAME |
FORENAME |
INITIALS |
AFFILIATION |
AFFILIATIONINFO |
| Kochunov P |
|
Kochunov |
Peter |
P |
|
Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD, USA. Electronic address: pkochunov@mprc.umaryland.edu. |
| Jahanshad N |
|
Jahanshad |
Neda |
N |
|
Imaging Genetics Center, Institute of Neuroimaging and Informatics, Department of Neurology, Keck School of Medicine of USC, Los Angeles, CA, USA. |
| Sprooten E |
|
Sprooten |
Emma |
E |
|
Olin Neuropsychiatry Research Center in the Institute of Living, Yale University School of Medicine, New Haven, CT, USA. |
| Nichols TE |
|
Nichols |
Thomas E |
TE |
|
Department of Statistics & Warwick Manufacturing Group, The University of Warwick, Coventry, UK; Oxford Centre for Functional MRI of the Brain (FMRIB), Nuffield Department of Clinical Neurosciences, Oxford University, UK. |
| Mandl RC |
|
Mandl |
René C |
RC |
|
Brain Center Rudolf Magnus, Department of Psychiatry, University Medical Center Utrecht, Utrecht, The Netherlands. |
| Almasy L |
|
Almasy |
Laura |
L |
|
Department of Genetics, Texas Biomedical Research Institute, San Antonio, TX, USA. |
| Booth T |
|
Booth |
Tom |
T |
|
Centre for Cognitive Ageing and Cognitive Epidemiology, Department of Psychology, The University of Edinburgh, Edinburgh, UK. |
| Brouwer RM |
|
Brouwer |
Rachel M |
RM |
|
Brain Center Rudolf Magnus, Department of Psychiatry, University Medical Center Utrecht, Utrecht, The Netherlands. |
| Curran JE |
|
Curran |
Joanne E |
JE |
|
Department of Genetics, Texas Biomedical Research Institute, San Antonio, TX, USA. |
| de Zubicaray GI |
|
de Zubicaray |
Greig I |
GI |
|
School of Psychology, University of Queensland, Brisbane, Australia. |
| Dimitrova R |
|
Dimitrova |
Rali |
R |
|
Division of Psychiatry, University of Edinburgh, Royal Edinburgh Hospital, Edinburgh, UK. |
| Duggirala R |
|
Duggirala |
Ravi |
R |
|
Department of Genetics, Texas Biomedical Research Institute, San Antonio, TX, USA. |
| Fox PT |
|
Fox |
Peter T |
PT |
|
Research Imaging Institute, University of Texas Health Science Center San Antonio, San Antonio, TX, USA. |
| Hong LE |
|
Hong |
L Elliot |
LE |
|
Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD, USA. |
| Landman BA |
|
Landman |
Bennett A |
BA |
|
Department of Electrical Engineering, Vanderbilt University, Nashville, TN, USA. |
| Lemaitre H |
|
Lemaitre |
Hervé |
H |
|
U1000 Research Unit Neuroimaging and Psychiatry, INSERM-CEA-Faculté de Médecine Paris-Sud, Orsay, France. |
| Lopez LM |
|
Lopez |
Lorna M |
LM |
|
Centre for Cognitive Ageing and Cognitive Epidemiology, Department of Psychology, The University of Edinburgh, Edinburgh, UK. |
| Martin NG |
|
Martin |
Nicholas G |
NG |
|
QIMR Berghofer Medical Research Institute, Brisbane, Australia. |
| McMahon KL |
|
McMahon |
Katie L |
KL |
|
Centre for Advanced Imaging, University of Queensland, Brisbane, Australia. |
| Mitchell BD |
|
Mitchell |
Braxton D |
BD |
|
Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA. |
| Olvera RL |
|
Olvera |
Rene L |
RL |
|
Department of Psychiatry, University of Texas Health Science Center San Antonio, San Antonio, TX, USA. |
| Peterson CP |
|
Peterson |
Charles P |
CP |
|
Department of Genetics, Texas Biomedical Research Institute, San Antonio, TX, USA. |
| Starr JM |
|
Starr |
John M |
JM |
|
Centre for Cognitive Ageing and Cognitive Epidemiology, Department of Psychology, The University of Edinburgh, Edinburgh, UK; Alzheimer Scotland Dementia Research Centre, University of Edinburgh, Edinburgh, UK. |
| Sussmann JE |
|
Sussmann |
Jessika E |
JE |
|
Division of Psychiatry, University of Edinburgh, Royal Edinburgh Hospital, Edinburgh, UK. |
| Toga AW |
|
Toga |
Arthur W |
AW |
|
Imaging Genetics Center, Institute of Neuroimaging and Informatics, Department of Neurology, Keck School of Medicine of USC, Los Angeles, CA, USA. |
| Wardlaw JM |
|
Wardlaw |
Joanna M |
JM |
|
Centre for Cognitive Ageing and Cognitive Epidemiology, Department of Psychology, The University of Edinburgh, Edinburgh, UK; Brain Research Imaging Centre, Centre for Clinical Brain Sciences, University of Edinburgh, UK. |
| Wright MJ |
|
Wright |
Margaret J |
MJ |
|
QIMR Berghofer Medical Research Institute, Brisbane, Australia. |
| Wright SN |
|
Wright |
Susan N |
SN |
|
Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD, USA. |
| Bastin ME |
|
Bastin |
Mark E |
ME |
|
Centre for Cognitive Ageing and Cognitive Epidemiology, Department of Psychology, The University of Edinburgh, Edinburgh, UK; Brain Research Imaging Centre, Centre for Clinical Brain Sciences, University of Edinburgh, UK. |
| McIntosh AM |
|
McIntosh |
Andrew M |
AM |
|
Division of Psychiatry, University of Edinburgh, Royal Edinburgh Hospital, Edinburgh, UK. |
| Boomsma DI |
|
Boomsma |
Dorret I |
DI |
|
Department of Biological Psychology, VU University, Amsterdam, The Netherlands. |
| Kahn RS |
|
Kahn |
René S |
RS |
|
Brain Center Rudolf Magnus, Department of Psychiatry, University Medical Center Utrecht, Utrecht, The Netherlands. |
| den Braber A |
|
den Braber |
Anouk |
A |
|
Department of Biological Psychology, VU University, Amsterdam, The Netherlands. |
| de Geus EJ |
|
de Geus |
Eco J C |
EJ |
|
Department of Biological Psychology, VU University, Amsterdam, The Netherlands. |
| Deary IJ |
|
Deary |
Ian J |
IJ |
|
Centre for Cognitive Ageing and Cognitive Epidemiology, Department of Psychology, The University of Edinburgh, Edinburgh, UK. |
| Hulshoff Pol HE |
|
Hulshoff Pol |
Hilleke E |
HE |
|
Brain Center Rudolf Magnus, Department of Psychiatry, University Medical Center Utrecht, Utrecht, The Netherlands. |
| Williamson DE |
|
Williamson |
Douglas E |
DE |
|
Department of Psychiatry, University of Texas Health Science Center San Antonio, San Antonio, TX, USA. |
| Blangero J |
|
Blangero |
John |
J |
|
Department of Genetics, Texas Biomedical Research Institute, San Antonio, TX, USA. |
| van 't Ent D |
|
van 't Ent |
Dennis |
D |
|
Department of Biological Psychology, VU University, Amsterdam, The Netherlands. |
| Thompson PM |
|
Thompson |
Paul M |
PM |
|
Imaging Genetics Center, Institute of Neuroimaging and Informatics, Department of Neurology, Keck School of Medicine of USC, Los Angeles, CA, USA; Department of Neurology, Pediatrics, Engineering, Psychiatry, Radiology, & Ophthalmology, University of Southern California, Los Angeles, CA, USA. |
| Glahn DC |
|
Glahn |
David C |
DC |
|
Olin Neuropsychiatry Research Center in the Institute of Living, Yale University School of Medicine, New Haven, CT, USA. |
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| INVESTIGATORS |
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| JOURNAL |
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| VOLUME: 95 |
| ISSUE: |
| TITLE: NeuroImage |
| ISOABBREVIATION: Neuroimage |
| YEAR: 2014 |
| MONTH: Jul |
| DAY: 15 |
| MEDLINEDATE: |
| SEASON: |
| CITEDMEDIUM: Internet |
| ISSN: 1095-9572 |
| ISSNTYPE: Electronic |
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| MEDLINE JOURNAL |
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| MEDLINETA: Neuroimage |
| COUNTRY: United States |
| ISSNLINKING: 1053-8119 |
| NLMUNIQUEID: 9215515 |
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| PUBLICATION TYPE |
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| PUBLICATIONTYPE TEXT |
| Comparative Study |
| Journal Article |
| Multicenter Study |
| Research Support, N.I.H., Extramural |
| Research Support, Non-U.S. Gov't |
| Twin Study |
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| COMMENTS AND CORRECTIONS |
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| REFTYPE |
REFSOURCE |
REFPMID |
NOTE |
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| GRANTS |
|
| GRANTID |
AGENCY |
COUNTRY |
| 087727/Z/08/Z |
Wellcome Trust |
United Kingdom |
| 100309 |
Wellcome Trust |
United Kingdom |
| BB/F019394/1 |
Biotechnology and Biological Sciences Research Council |
United Kingdom |
| EB007813 |
NIBIB NIH HHS |
United States |
| EB008281 |
NIBIB NIH HHS |
United States |
| EB008432 |
NIBIB NIH HHS |
United States |
| G0700704 |
Medical Research Council |
United Kingdom |
| G0701120 |
Medical Research Council |
United Kingdom |
| G1001245 |
Medical Research Council |
United Kingdom |
| MH0708143 |
NIMH NIH HHS |
United States |
| MH083824 |
NIMH NIH HHS |
United States |
| MH59490 |
NIMH NIH HHS |
United States |
| MR/K026992/1 |
Medical Research Council |
United Kingdom |
| P41 EB015922 |
NIBIB NIH HHS |
United States |
| R01 EB015611 |
NIBIB NIH HHS |
United States |
| R01 EB015611 |
NIBIB NIH HHS |
United States |
| R01 HD050735 |
NICHD NIH HHS |
United States |
| R01AA016274 |
NIAAA NIH HHS |
United States |
|
| GENERAL NOTE |
|
|
| KEYWORDS |
|
| KEYWORD |
| Diffusion tensor imaging (DTI) |
| Heritability |
| Imaging genetics |
| Meta-analysis |
| Multi-site |
| Reliability |
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| MESH HEADINGS |
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| DESCRIPTORNAME |
QUALIFIERNAME |
| Adolescent |
|
| Adult |
|
| Aged |
|
| Aged, 80 and over |
|
| Anisotropy |
|
| Brain |
|
| Child |
|
| Diffusion Tensor Imaging |
|
| Female |
|
| Genetic Variation |
|
| Humans |
|
| Male |
|
| Meta-Analysis as Topic |
|
| Middle Aged |
|
| White Matter |
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| Young Adult |
|
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| SUPPLEMENTARY MESH |
|
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| GENE SYMBOLS |
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| CHEMICALS |
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| OTHER ID's |
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| OTHERID |
SOURCE |
| NIHMS578312 |
NLM |
| PMC4043878 |
NLM |
|
|
